start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=9-10
article-no=
start-page=961
end-page=968
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=第118回　岡山外科会
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=
en-copyright=
kn-copyright=

en-aut-name=HirakawaMasahisa
en-aut-sei=Hirakawa
en-aut-mei=Masahisa
kn-aut-name=平川方久
kn-aut-sei=平川
kn-aut-mei=方久
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=9-10
article-no=
start-page=931
end-page=941
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Thermographic findings as a prognostic indicator for breast cancer : Correlation between temperature increase and angioarchitecture
kn-title=乳癌サーモグラフｨ所見と予後の検討;サーモグラフｨにおける温度上昇と血管構築の変化
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The thermographic findings of 191 patients with Satges I-III breast cancer were retrospectively evaluated to determine the prognostic indicators of disease-free survival in both the whole study population and in each histological stage. The angioarchitecture of 75 breast cancer specimens was subsequently examined morphometrically using an immunohistochemical method, and was then compared with the extent of increase in the temperature at the tumor site. The extent of increase in the temperature was more closely related to the prognosis than was the thermal pattern. In stage II cancer (n=57), patients with lesions that showed a temperature increase > 1.5℃ had a poorer prognosis than the patients with hypothermic regions. (p<0.05). The range of skin temperature elevation at the tumor site correlated with the vascular changes in the skin above the tumor rather than with changes within or around the tumor in all of the patients. The increase in temperature above a tumor was concluded to be useful for assessing the prognosis and the grade of malignancy of breast cancer. The skin blood flow was also suggested to have the closest relationship with thermographic findings and the extent of the increase in blood flow to be a prognostic indicator for breast cancer.
en-copyright=
kn-copyright=

en-aut-name=MurakamiMasakazu
en-aut-sei=Murakami
en-aut-mei=Masakazu
kn-aut-name=村上正和
kn-aut-sei=村上
kn-aut-mei=正和
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=Thermography
kn-keyword=Thermography
en-keyword=Breast cancer
kn-keyword=Breast cancer
en-keyword=Prognostic factor
kn-keyword=Prognostic factor
en-keyword=Malignant grade
kn-keyword=Malignant grade
en-keyword=Angioarchitecture
kn-keyword=Angioarchitecture
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=9-10
article-no=
start-page=923
end-page=929
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Combined resection of lung cancer and invaded aorta with the use of simple temporary bypass : A case reort
kn-title=肺癌における簡易式一時バイパス法を用いた大動脈合併切除の一例
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Left pneumonectomy and concomitant resection of the invaded aorta were performed by the simple temporary bypass method. The patient was a 59-year-old male with the chief complaint of left thoracic pain. The 57×43×35 mm tumor was in a region centering on segment 6 of the left lung and had infiltrated the descending aorta. It was diagnosed as T4NOMO, Stage IIIb. A bypass for blood flow was established between the aortic arch avobe the invasion and the left femoral artery, after ligation of the pulmonary artery and vein and closure of the left bronchial stump. Vascular blocking forceps were applied to the descending aorta above and below the tumor infiltration, and two thirds of the circumference of the invaded aortic wall, 4.0×3.0 cm, along with the tumor, was resected. Reconstruction was performed with an 18mm Cooly double velour graft. Blood pressure was monitored with a pressure probe inserted into the right femoral artery. It did not fall below 60 mmHg during the operation. Local recurrence was observed 10 montns post-operatively, and the patient is now receiving radiation therapy.
en-copyright=
kn-copyright=

en-aut-name=InoueFumiyuki
en-aut-sei=Inoue
en-aut-mei=Fumiyuki
kn-aut-name=井上文之
kn-aut-sei=井上
kn-aut-mei=文之
aut-affil-num=1
ORCID=

en-aut-name=KamikawaYasuaki
en-aut-sei=Kamikawa
en-aut-mei=Yasuaki
kn-aut-name=上川康明
kn-aut-sei=上川
kn-aut-mei=康明
aut-affil-num=2
ORCID=

en-aut-name=NaomotoYoshio
en-aut-sei=Naomoto
en-aut-mei=Yoshio
kn-aut-name=猶本良夫
kn-aut-sei=猶本
kn-aut-mei=良夫
aut-affil-num=3
ORCID=

en-aut-name=GouchiAkira
en-aut-sei=Gouchi
en-aut-mei=Akira
kn-aut-name=合地明
kn-aut-sei=合地
kn-aut-mei=明
aut-affil-num=4
ORCID=

en-aut-name=OritaKunzo
en-aut-sei=Orita
en-aut-mei=Kunzo
kn-aut-name=折田薫三
kn-aut-sei=折田
kn-aut-mei=薫三
aut-affil-num=5
ORCID=

en-aut-name=HataTakato
en-aut-sei=Hata
en-aut-mei=Takato
kn-aut-name=畑隆登
kn-aut-sei=畑
kn-aut-mei=隆登
aut-affil-num=6
ORCID=

en-aut-name=KuinoseMasahiko
en-aut-sei=Kuinose
en-aut-mei=Masahiko
kn-aut-name=杭ノ瀬昌彦
kn-aut-sei=杭ノ瀬
kn-aut-mei=昌彦
aut-affil-num=7
ORCID=

en-aut-name=NanbaHirofumi
en-aut-sei=Nanba
en-aut-mei=Hirofumi
kn-aut-name=難波宏文
kn-aut-sei=難波
kn-aut-mei=宏文
aut-affil-num=8
ORCID=

en-aut-name=TaniguchiGyou
en-aut-sei=Taniguchi
en-aut-mei=Gyou
kn-aut-name=谷口堯
kn-aut-sei=谷口
kn-aut-mei=堯
aut-affil-num=9
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=2
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=3
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=4
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=5
en-affil=
kn-affil=岡山大学医学部第一外科学教室

affil-num=6
en-affil=
kn-affil=心臓病センター榊原病院外科

affil-num=7
en-affil=
kn-affil=心臓病センター榊原病院外科

affil-num=8
en-affil=
kn-affil=心臓病センター榊原病院外科

affil-num=9
en-affil=
kn-affil=心臓病センター榊原病院外科
en-keyword=簡易式一時バイパス
kn-keyword=簡易式一時バイパス
en-keyword=大動脈合併切除
kn-keyword=大動脈合併切除
en-keyword=進行性肺癌
kn-keyword=進行性肺癌
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=9-10
article-no=
start-page=915
end-page=922
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Development of double cancer in small cell lung cancer patients treated with intensive chemotherapy
kn-title=肺小細胞癌化学療法実施例における重複癌の発生に関する研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Development of double cancer was evaluated in 337 small cell lung cancer patients who had received intensive chemotherapy with or without radiotherapy. Of them, 14 patients (4.2%) developed a second malignancy: non-small cell lung cancer in six, stomach cancer in four, acute myelogenous leukemia in two, liver cancer in one, and esophagus cancer in one. The relative risk for the development of double cancer calculated by person-year method utilizing age and sex adjusted cancer incidence in Japan was 2.75-fold (P<0.01). The risk of non-small cell lung cancer (8.75-fold) and acute myelogenous leukemia (37.82-fold) was particularly high. The cumulative risk for the development of double cancer was 2.0% at 1 year, 4.1% at 2 years, 14.3% at 3 years, and 100% at 8.1 years. Of 27 patients who survived disease-free for more than 2 years, 10 patients died; five patients (50%) died of double cancer, two died of infectious disease, and only three patients died from recurrent small cell lung cancer. These findings indicate that a cautious follow-up program for the detection of double cancer is indicated in patients with small cell lung cancer.
en-copyright=
kn-copyright=

en-aut-name=MiyakeKenichi
en-aut-sei=Miyake
en-aut-mei=Kenichi
kn-aut-name=三宅賢一
kn-aut-sei=三宅
kn-aut-mei=賢一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=肺小細胞癌
kn-keyword=肺小細胞癌
en-keyword=化学療法
kn-keyword=化学療法
en-keyword=重複癌
kn-keyword=重複癌
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=9-10
article-no=
start-page=905
end-page=913
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on cell biology and chemotherapy of lung cancer using tissue culture techniques Part 2. Biological characteristics of five newly established small cell lung cancer cell lines
kn-title=組織培養法を用いた肺癌の細胞生物学並びに治療に関する研究 第2編 肺小細胞癌細胞株の樹立とその生物学的特徴
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Five small cell lung cancer (SCLC) cell lines in culture were established and designated as SBC-1, 2, 3, 4 and 5. SBC-1, 2, 4 and 5 were derived from tumors of intermediate cell histology, and SBC-3 was from a tumor of oat cell histology. All the cell lines represented a characteristic cytomorphology of SCLC when examined by papanicolaou staining and by electron microscopy. Their biological characterstics such as doubling time, clonogenic activity, heterotransplantability in nude mice, and capacity of hormone production in culture revealed that each cell line had a distinct biological feature. The SCLC cell lines reported here would be useful as a tool for cellular pharmacology of new drugs and drug resistance.
en-copyright=
kn-copyright=

en-aut-name=KishimotoNobuyasu
en-aut-sei=Kishimoto
en-aut-mei=Nobuyasu
kn-aut-name=岸本信康
kn-aut-sei=岸本
kn-aut-mei=信康
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=small cell lung cancer
kn-keyword=small cell lung cancer
en-keyword=cell line
kn-keyword=cell line
en-keyword=characterization
kn-keyword=characterization
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=9-10
article-no=
start-page=897
end-page=904
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Studies on cell biology and chemotherapy of lung cancer using tissue culture techniques Part 1. Drug sensitivity test in lung cancer using human tumor clonogenic assay
kn-title=組織培養法を用いた肺癌の細胞生物学並びに治療に関する研究 第1編 Human Tumor Clonogenic Assay を用いた制癌剤感受性試験の検討―肺癌を中心として―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The selection of a series of effective drugs for individual patients in advance of drug therapy should increase the success of cancer chemotherapy. The human tumor clonogenic assay was evaluated as a drug sensitivity test mainly in patients with lung cancer. Tumor cells from malignant pleural effusion, tumor-positive bone marrow aspirates, and tumor tissues from the primary or metastases were used as sepcimens. Prior to plating, tumor cells were exposed to 4-hydroperoxy ifosfamide, adriamycin, mitomycin C, methotrerxate, and cisplatin for one hour at graded concentrations which were achievable in man. Of 151 specimens tested, 93(62%) yielded at least 5 colonies in the control plates containing no durgs. Colony growth (≧5/plate) was seen in 80% of squamous cell carcinoma, in 73% of small cell carcinoma, in 62% of adenocarcinoma, and in 40% of large cell carcinoma. Among the 93 specimens with colony growth, 62 yielded more than 30 colonies in the control plates and were put in force for drug sensitivity testing. Of 37 instances in which the clinical response to a certain drug was examined, 34(92%) showed an in vitro-in vivo correlation, showing a true positive rate of 57% and a true negative rate of 100%. In summary, the human tumor clonogenic assay would be an excellent technique for testing the drug sensitivity of the tumor in individual patients tumor.
en-copyright=
kn-copyright=

en-aut-name=KishimotoNobuyasu
en-aut-sei=Kishimoto
en-aut-mei=Nobuyasu
kn-aut-name=岸本信康
kn-aut-sei=岸本
kn-aut-mei=信康
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二内科学教室
en-keyword=human tumor clonogenic assay
kn-keyword=human tumor clonogenic assay
en-keyword=drug sensitivity
kn-keyword=drug sensitivity
en-keyword=lung cancer
kn-keyword=lung cancer
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=9-10
article-no=
start-page=885
end-page=895
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=The effect of nutritional intake on energy metabolism in postoperative patients after gastrointestinal surgery
kn-title=間接熱量測定による消化器手術後のエネルギー代謝の検討―投与量･投与経路の比較―
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Many studies have shown that enteral nutrition (EN) has nutritional effects comparable to total parenteral nutrition (TPN). However, the energy metabolism of the two different nutritioanl methods remains undefined. The two nutritional methods were compared by measuring the resting energy expenditure (REE) and nutritional assessment in postoperative patients after gastrointestinal surgery. The effects of different amounts of EN were also evaluated. Patients were diveded into three groups : Patients who were fed by EN of 30 Cal/kg/day (Group I, EN 30 : n=8), patients who were fed by EN of 40 Cal/kg/day (Group II, EN 40 : n=8), and patients who were fed by TPN of 30 Cal/kg/day (Group III, TPN : n=8). REE was measured by the Datex indirect calorimetry and nutritional assessment included the measurements of triceps skinfold thickness (TSF), arm muscle circumference (AMC), albumin and rapid turnover proteins. ％REE/BEE of EN30, EN40 and TPN was 122.5±14.3%, 138.2±16.8% and 107.6±10.5% respectively. The RQ for the three groups was about 1.0, which means the energy source of all regimens is carbohydrate. The TPN group showed a significantly higher RQ than the EN groups, but there was no difference in albumin or transferrin. There was no difference in nutritional effect between EN 30 and EN 40. No difference was found in anthropometric effects among the three groups. These findings suggest that 30 Cal/kg/day would be preferable to 40 Cal/kg/day in energy supply of enteral nutrition and that the energy expenditure of EN is higher than that of TPN under 30 Cal/kg/day nutrition. There is no difference among the three mehtods in terms of nutritional effects.
en-copyright=
kn-copyright=

en-aut-name=YoshizaneKen
en-aut-sei=Yoshizane
en-aut-mei=Ken
kn-aut-name=吉實憲
kn-aut-sei=吉實
kn-aut-mei=憲
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部第二外科学教室
en-keyword=間接熱量計
kn-keyword=間接熱量計
en-keyword=経腸栄養
kn-keyword=経腸栄養
en-keyword=経静脈栄養
kn-keyword=経静脈栄養
en-keyword=代謝熱量
kn-keyword=代謝熱量
END

start-ver=1.4
cd-journal=joma
no-vol=104
cd-vols=
no-issue=9-10
article-no=
start-page=871
end-page=884
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=1992
dt-pub=199210
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=Experimental study on cerebral venous circulatory disturbance
kn-title=脳静脈環流障害に関する実験的研究
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A new experimental model of cerebral venous occlusion was developed and the cerebral hemodynamics and water content using this model were studied. An anatomical study of the cerebral venous system using methacyrl resin showed that the venous system was composed of superficial and deep veins. The superficial veins drained into the superior sagittal sinus (SSS). The SSS was connected to internal and external jugular veins via the transverse sinuses and diploic veins (DV), respectively. The cats were divided into three groups on the basis of the occlusion sites as follows ; Group I : SSS occlusion, Group II : DV occlusion, Group III : occlusion of both the SSS and DV. Intracranial pressure (ICP) and cerebral blood volume (CBV, photoelectric method) were monitored continuously. Local cerebral blood flow (1-CBF) and water content were measured by hydrogen clearance and gravimetric methods, respectively. Somatosensory evoked potential (SEP) was also recorded. Evans blue was injected intravenously to evaluate blood brain barrier permeability. There were no siginificant changes in ICP, 1-CBF or N1 latency of SEP after the occlusioon in Group I or II. However, in Group III, 1-CBF decreased significantly 2 hours after the occlusion as ICP increased gradually. N1 latency of SEP was prolonged and water content increased significantly. CBV increased immediately after the occlusion. There was no extravasated Evans blue. The increase in CBV and water content during sinus occlusion appeared to have led to intracranial hypertension and decrease of 1-CBF, which resulted in neural dysfunction. The brain edema in this model seemed to be hydrostatic edema or cytotoxic edema.
en-copyright=
kn-copyright=

en-aut-name=SaijoToshikazu
en-aut-sei=Saijo
en-aut-mei=Toshikazu
kn-aut-name=西条寿一
kn-aut-sei=西条
kn-aut-mei=寿一
aut-affil-num=1
ORCID=

affil-num=1
en-affil=
kn-affil=岡山大学医学部脳神経外科学教室
en-keyword=cerebral venous circulatory disturbance
kn-keyword=cerebral venous circulatory disturbance
en-keyword=dural sinus occlusion
kn-keyword=dural sinus occlusion
en-keyword=brain edema
kn-keyword=brain edema
en-keyword=cerebral blood flow
kn-keyword=cerebral blood flow
en-keyword=cerebral blood volume
kn-keyword=cerebral blood volume
END