start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=1013 end-page=1018 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Lymph node metastases of right colon cancer kn-title=右側結腸癌に対するリンパ節郭清範囲の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The lymph node metastases of the right side colon were studied. Among 58 cases of right side colon, nodal involvements were found in 53.4%. Metastases to the epicolic and paracolic nodes were confined to an area within 10 cm from the tumor margin. Metastases to the intermediate nodes were found in 20.7% and metastases to the main nodes in 15.5%. Jumping metastases were recognized in 5 out of 31 cases of nodal involvement (16.1%). As the rate of jumping metastases is unexpectedly high, lymph node dissection for right colon cancer should be done as far as the main nodes. en-copyright= kn-copyright= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=1 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=2 ORCID= en-aut-name=HamadaFumihiro en-aut-sei=Hamada en-aut-mei=Fumihiro kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=3 ORCID= en-aut-name=ShiikiShigeo en-aut-sei=Shiiki en-aut-mei=Shigeo kn-aut-name=椎木滋雄 kn-aut-sei=椎木 kn-aut-mei=滋雄 aut-affil-num=4 ORCID= en-aut-name=MatsubaraNagahide en-aut-sei=Matsubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=5 ORCID= en-aut-name=AkazaiYoshihiro en-aut-sei=Akazai en-aut-mei=Yoshihiro kn-aut-name=赤在義浩 kn-aut-sei=赤在 kn-aut-mei=義浩 aut-affil-num=6 ORCID= en-aut-name=SuzakiKiichi en-aut-sei=Suzaki en-aut-mei=Kiichi kn-aut-name=須崎紀一 kn-aut-sei=須崎 kn-aut-mei=紀一 aut-affil-num=7 ORCID= en-aut-name=WatanabeTetsuya en-aut-sei=Watanabe en-aut-mei=Tetsuya kn-aut-name=渡辺哲也 kn-aut-sei=渡辺 kn-aut-mei=哲也 aut-affil-num=8 ORCID= en-aut-name=NonakaYasuyuki en-aut-sei=Nonaka en-aut-mei=Yasuyuki kn-aut-name=野中泰幸 kn-aut-sei=野中 kn-aut-mei=泰幸 aut-affil-num=9 ORCID= en-aut-name=KimuraToshikazu en-aut-sei=Kimura en-aut-mei=Toshikazu kn-aut-name=木村臣一 kn-aut-sei=木村 kn-aut-mei=臣一 aut-affil-num=10 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=11 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=右側結腸癌 kn-keyword=右側結腸癌 en-keyword=リンパ節転移率 kn-keyword=リンパ節転移率 en-keyword=跳躍転移 kn-keyword=跳躍転移 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=1005 end-page=1012 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Pharmacological interaction between serotonin(2) and α(2)-adrenergic receptors in the human platelet aggregation kn-title=ヒト血小板凝集能におけるセロトニン(2)およびアルファ(2)-アドレナージック受容体の薬理学的相互作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To investigate the interaction between serotonin (5HT)(2) and α(2)-adrenergic receptors in the human platelet membrane, the inhibitory effects of calcium (Ca) antagonists, 5HT(2) antagonists, α(2) antagonists and adenosine (AE) receptor (A(2)) agonists on 5HT plus ADP ([5HT＋ADP]) and adrenaline (ADR) plus ADP ([ADR＋ADP])-induced washed platelet aggregation were examined. In the [5HT＋ADP] -induced aggregation. The inhibitory activity was in the order of (−)-desmethoxyverapamil (D888), mianserin (MA), ketanserin, AE>diltiazem, nicardipine, yohimbine. On the other hand, in the [ADR＋ADP] -induced aggregation, the inhibitory activity was in the order of MA, YH>D888, AE, and the rest had no significant effect even at 10 μM. Only AE among these drugs inhibited ADP-induced aggregation. The present findings indicate that the Ca antagonist D888, 5HT(2) antagonist MA and α(2) antagonist YH acted simultaneously as 5HT(2) and α(2) receptor inhibitors and imply an apparent interaction between these receptors. Since both of the aggregation responses required extracellular Ca(2+) and were modulated by Ca(2+) concentrations, the mechanism of interaction may be attributed to intracellular Ca(2+)-signaling systems. en-copyright= kn-copyright= en-aut-name=OkadaHidetoshi en-aut-sei=Okada en-aut-mei=Hidetoshi kn-aut-name=岡田英俊 kn-aut-sei=岡田 kn-aut-mei=英俊 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部脳代謝研究施設病態生化学部門 en-keyword=platelet aggregation kn-keyword=platelet aggregation en-keyword=serotonin(2) receptors kn-keyword=serotonin(2) receptors en-keyword=α(2)-adrenergic receptors kn-keyword=α(2)-adrenergic receptors en-keyword=calcium antagonists kn-keyword=calcium antagonists END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=993 end-page=1003 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Ultrastructural study of left ventricular myocardium in aortic regurgitation : Correlations with preoperative cardiac functions at rest kn-title=大動脈弁閉鎖不全症における左室心筋の組織構造変化と安静時心機能との関連に対する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=We collected tissue samples from the left ventricular myocardium in 20 patients with aortic regurgitation, examined the correlation between myocardial ultrastructure and cardiac function at rest and obtained the following results. The extent of fibrosis in the myocardium and ultrastructural changes in the myocardial cells were respectively expressed in LM-Score and EM-Score. Furthermore, the myofibril changes expressed by the EM-Score were added to the LM-Score (Myo＋LM-Score), and each score was calculated and compared with the parameters of cardiac function. There was no significant correlation between EM-Score and parameters of cardiac function. LM-Score was correlated with Max dv/dt at r＝−0.471 (p<0.05) and with endodiastole (D/L) at r＝−0.567 (p<0.01) significantly, showing a negative linear correlation. Myo＋LM-Score was correlated with EF at r＝−0.574 (p<0.01) and with△ D at r＝−0.577 (p<0.01) significantly, showing a negative linear correlation. Among the cardiac functions at rest in patients with AR, the morphologic and diastolic parameters were closely related with the extent of fibrosis, and the contractility was closely related both with a change in myofibrils and with the extent of fibrosis. Thus, the cardiac functions at rest in patients with AR were correlated with the myocardial factors. en-copyright= kn-copyright= en-aut-name=TsujiHisashi en-aut-sei=Tsuji en-aut-mei=Hisashi kn-aut-name=辻尚志 kn-aut-sei=辻 kn-aut-mei=尚志 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二外科学教室 en-keyword=大動脈弁閉鎖不全症 kn-keyword=大動脈弁閉鎖不全症 en-keyword=安静時左心機能 kn-keyword=安静時左心機能 en-keyword=心筋組織構造変化 kn-keyword=心筋組織構造変化 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=983 end-page=992 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Evaluation of health examination program for 3 year old children : Follow-up study on screening of urine examination kn-title=三歳児健康診査の評価―検尿の意義と判定方法― en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study focuses on the health examination programs for 3 year old children from a public health point of view. The methodology, items tested, criteria and follow-up systems of urine examination were evaluated. Results of urine examinations of 8,615 children(male : 4,490, female : 4,125), who had been in the health examination program from 1980 to 1985, were studied in the area of K-ku in Y-city. Moreover a follow-up study was performed to discuss the significance of urine examination as mass screening. In the health examination program for 3 year old children, it is efficient to classify those with a score of more than “one plus” into the high risk group with regard to proteinuria and hematuria. It is possible to reduce the false positive rate by checking first morning urine at re-examination. A bettr information net work system must be established to utilize the results of mass health examinations for three year old children. en-copyright= kn-copyright= en-aut-name=TanakaKatsuko en-aut-sei=Tanaka en-aut-mei=Katsuko kn-aut-name=田中克子 kn-aut-sei=田中 kn-aut-mei=克子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部衛生学教室 en-keyword=3歳児健康診査 kn-keyword=3歳児健康診査 en-keyword=検尿 kn-keyword=検尿 en-keyword=健康診査の評価 kn-keyword=健康診査の評価 en-keyword=追跡調査 kn-keyword=追跡調査 en-keyword=学童健診 kn-keyword=学童健診 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=973 end-page=981 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The effect of quercetin on thermotolerance in NIH 3T3 cells : From a view point of cell survival kn-title=NIH 3T3 細胞の温熱耐性に対するケルセチンの作用　第1編　細胞の生存率からみたケルセチンの作用 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The inhibition of thermotolerance development by quercetin was examined in NIH 3T3 cells. The cytotoxicity of quercetin increased with the increase in the concentration (10,100μg/ml) and duration (12,48,72 hours) of treatment. The cell killing effect of heat was not enhanced by quercetin (10μg/ml) itself. Quercetin (10μg/ml) inhibited the proliferation of cells for about 72 hours. Quercetin (10μg/ml) delayed the development of thermotolerance, but did not decrease the degree of maximum thermotolerance. Quercetin (10μg/ml) exibited no effect on the decay of thermotolerance. en-copyright= kn-copyright= en-aut-name=KurodaMasahiro en-aut-sei=Kuroda en-aut-mei=Masahiro kn-aut-name=黒田昌宏 kn-aut-sei=黒田 kn-aut-mei=昌宏 aut-affil-num=1 ORCID= en-aut-name=HirakiYoshio en-aut-sei=Hiraki en-aut-mei=Yoshio kn-aut-name=平木祥夫 kn-aut-sei=平木 kn-aut-mei=祥夫 aut-affil-num=2 ORCID= en-aut-name=KawasakiShouji en-aut-sei=Kawasaki en-aut-mei=Shouji kn-aut-name=川崎祥二 kn-aut-sei=川崎 kn-aut-mei=祥二 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部放射線医学教室 affil-num=3 en-affil= kn-affil=岡山大学医療技術短期大学部 en-keyword=ケルセチン kn-keyword=ケルセチン en-keyword=温熱耐性 kn-keyword=温熱耐性 en-keyword=温熱療法 kn-keyword=温熱療法 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=963 end-page=972 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis of pathogenic factors of Proteus mirabilis isolated from urinary tract infection kn-title=尿路感染症患者分離 Proteus mirabilis の病原性発現因子の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Proteus mirabilis has several pathogenic factors such as adherent ability to urinary tract epitherial cells, urease, motility and resistance to urine. The pathogenic activities of clinically isolated P. mirabilis were analyzed. Higher pathogenic strains (No. 25 and No. 30) which had morphologically different pili but had a higher density of pili showed strong adherent activity to bladder epithelial cells of mouse and rat. These strains also showed a clear chemotaxis to urinary tract tissue extracts. These findings indicate that the combination of adherent, chemotaxis and urease activities is essential for causing of tipical kidney infection by P. mirabilis. en-copyright= kn-copyright= en-aut-name=MurotaniKatsuhisa en-aut-sei=Murotani en-aut-mei=Katsuhisa kn-aut-name=室谷勝久 kn-aut-sei=室谷 kn-aut-mei=勝久 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部細菌学教室 en-keyword=P. mirabilis kn-keyword=P. mirabilis en-keyword=尿路感染 kn-keyword=尿路感染 en-keyword=病原因子 kn-keyword=病原因子 en-keyword=走化性 kn-keyword=走化性 en-keyword=ウレアーゼ kn-keyword=ウレアーゼ en-keyword=付着性 kn-keyword=付着性 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=951 end-page=962 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=The cyclic AMP-generating system of cobalt-induced epileptic cerebral cortex kn-title=コバルト誘導てんかん性大脳皮質のサイクリック AMP 合成系に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A cobalt chloride solution was injected into the unilateral sensorimotor cortex of rats to induce epileptic activity. The cyclic AMP contents of slices incubated with or without adenosine and 2-chloroadenosine were determined in four cortical areas after electroencephalography and behavioral examination in cobalt-injected rats. Electrographic spike activity appeared immediately after injection of cobalt. In the majority of cobalt-injected rats, the spike activity was dominant in the primary epileptic region of the cortex. The spike frequency reached a maximum level two to three weeks after the injection and declined thereafter. The electrographic activity was followed by abnormal behavior. Adenosine and 2-chloroadenosine elevated the cyclic AMP levels in the cortical slices 6-to 10-fold and 10-to 16-fold, respectively. The elicitation of cyclic AMP accumulation was strongly inhibited by the adenosine antagonist 8-phenyltheophylline. The cyclic AMP accumulation elicited by adenosine or 2-chloroadenosine was increased in the primary cortical area of cobalt-induced epilepsy, but in the other cortical areas there was no deviation in cyclic AMP accumulation. The increase in cyclic AMP accumulation was observed regardless of the presence or absence of the adenosine uptake inhibitor dipyridamole, phosphodiesterase inhibitor Ro 20-1724, and adenosine deaminase. The increased accumulation of cyclic AMP in the primary epileptic cortex was detected as early as 8 days after the injection. The cyclic AMP accumulation slightly increased thereafter. It reached a plateau 17 to 19 days after the injection and then turned to the control levels, in harmony with the electrographic and behavioral profiles. These findings suggest that alterations in adenosine-sensitive generation of cyclic AMP in the primary epileptic region of the cortex are part of the neurochemical process of cobalt-induced epilepsy. en-copyright= kn-copyright= en-aut-name=AsakiHideki en-aut-sei=Asaki en-aut-mei=Hideki kn-aut-name=浅木秀樹 kn-aut-sei=浅木 kn-aut-mei=秀樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一生理学教室 en-keyword=サイクリック AMP kn-keyword=サイクリック AMP en-keyword=アデノシン kn-keyword=アデノシン en-keyword=2 - クロロアデノシン kn-keyword=2 - クロロアデノシン en-keyword=コバルト誘導てんかん kn-keyword=コバルト誘導てんかん en-keyword=ラット大脳皮質 kn-keyword=ラット大脳皮質 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=945 end-page=949 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Four cases of villous adenoma of rectum in our department : Comparative study of 88 cases of villous adenoma in Japan kn-title=直腸絨毛腺腫の4例―本邦報告88例についての検討― en-subtitle= kn-subtitle= en-abstract= kn-abstract=We reviewed the charts of 4 patients with villous adenoma of the rectum seen at the First Dept. of Surg., Okayama Univ. Med. School between 1971 and 1990. This study included 2 men and 2 women, ranging in age from 52 to 83 years. Polypectomy was performed on 3 patients with villous adenoma and low anterior resection was performed on 1 patient. Recurrent tumors developed in one of the 3 patients who had undergone polypectomy. In addition, a series of 88 patients with villous adenoma of the rectum reported in Japan were also reviewed. The average age of the patients with villous adenoma was 62.9. There were 47 men and 41 women. The presenting symptoms of the 69 patients with tumor were mainly bleeding and watery or mucinous diarrhea. The tumor size and invasiveness of malignancy were also examined. The likelihood of malignancy correlated with size of tumor, and none of the lesions smaller than 2cm contained a malignant tumor site. Surgeons should consider the size, location and malignant change of the villous tumor with as much precise examination before and during operation so that unnecessary over surgery is avoided. en-copyright= kn-copyright= en-aut-name=MatsubaraNagahide en-aut-sei=Matsubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=1 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=2 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=3 ORCID= en-aut-name=OokuraToshihiro en-aut-sei=Ookura en-aut-mei=Toshihiro kn-aut-name=大倉充博 kn-aut-sei=大倉 kn-aut-mei=充博 aut-affil-num=4 ORCID= en-aut-name=AkazaiYoshihiro en-aut-sei=Akazai en-aut-mei=Yoshihiro kn-aut-name=赤在義浩 kn-aut-sei=赤在 kn-aut-mei=義浩 aut-affil-num=5 ORCID= en-aut-name=WatanabeTetsuya en-aut-sei=Watanabe en-aut-mei=Tetsuya kn-aut-name=渡辺哲也 kn-aut-sei=渡辺 kn-aut-mei=哲也 aut-affil-num=6 ORCID= en-aut-name=SuzakiKiichi en-aut-sei=Suzaki en-aut-mei=Kiichi kn-aut-name=須崎紀一 kn-aut-sei=須崎 kn-aut-mei=紀一 aut-affil-num=7 ORCID= en-aut-name=YamashitaHiroshi en-aut-sei=Yamashita en-aut-mei=Hiroshi kn-aut-name=山下博士 kn-aut-sei=山下 kn-aut-mei=博士 aut-affil-num=8 ORCID= en-aut-name=HamadaFumihiro en-aut-sei=Hamada en-aut-mei=Fumihiro kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=9 ORCID= en-aut-name=GouchiAkira en-aut-sei=Gouchi en-aut-mei=Akira kn-aut-name=合地明 kn-aut-sei=合地 kn-aut-mei=明 aut-affil-num=10 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=11 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=直腸 kn-keyword=直腸 en-keyword=絨毛腺腫 kn-keyword=絨毛腺腫 en-keyword=癌化 kn-keyword=癌化 en-keyword=電解質異常 kn-keyword=電解質異常 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=927 end-page=943 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Neuropathological study on neuronal swelling degeneration in the substantia nigra of Olivo-Ponto-Cerebellar Atrophy (OPCA) kn-title=Olivo-Ponto-Cerebellar Atrophy (OPCA) の中脳黒質ニューロンの腫脹性病変について en-subtitle= kn-subtitle= en-abstract= kn-abstract=In 6 out of 7 autopsy cases of olivopontocerebellar atrophy, we found characteristic features of neuronal swelling degeneration (abbr. NSD) in the nerve cell of the substantia nigra. NSD was classified into 4 types according to the microscopic features. The cell body of the type A NSD is much larger than the usual nerve cell, contains melanin granules, is round in shape and appears granular. This cell sometimes contains a shrunken nucleus, Marinesco body, Nissl granules and rest of melanin pigment, suggesting its origin in the degenerating melanin containing nerve cell. In type B NSD the periphery of the swollen cell body appears to be frosted glass with a Nissl Substance. A part of the type B NSD was suggested to have its origin in the nerve cell which has no melanin pigment. Type C NSD is round or irregular in shape and appears to be vacuolar, suggesting its origin in the dendritic process. Type D NSD is sharply bounded from the surrounding tissue and amorphous structures. Judging from its staining characteristics, its origin was suggested to be in the axon. The significance and pathogenesis of the NSD are discussed with special reference to its relation to glutamic acid. en-copyright= kn-copyright= en-aut-name=NambaMasuyuki en-aut-sei=Namba en-aut-mei=Masuyuki kn-aut-name=難波益之 kn-aut-sei=難波 kn-aut-mei=益之 aut-affil-num=1 ORCID= en-aut-name=TanakaTakaho en-aut-sei=Tanaka en-aut-mei=Takaho kn-aut-name=田中隆穂 kn-aut-sei=田中 kn-aut-mei=隆穂 aut-affil-num=2 ORCID= en-aut-name=IshinoHirosi en-aut-sei=Ishino en-aut-mei=Hirosi kn-aut-name=石野博志 kn-aut-sei=石野 kn-aut-mei=博志 aut-affil-num=3 ORCID= en-aut-name=SenoHaruo en-aut-sei=Seno en-aut-mei=Haruo kn-aut-name=妹尾晴夫 kn-aut-sei=妹尾 kn-aut-mei=晴夫 aut-affil-num=4 ORCID= en-aut-name=IshizuHideki en-aut-sei=Ishizu en-aut-mei=Hideki kn-aut-name=石津秀樹 kn-aut-sei=石津 kn-aut-mei=秀樹 aut-affil-num=5 ORCID= en-aut-name=KurodaSigetosi en-aut-sei=Kuroda en-aut-mei=Sigetosi kn-aut-name=黒田重利 kn-aut-sei=黒田 kn-aut-mei=重利 aut-affil-num=6 ORCID= en-aut-name=KuyamaKeisuke en-aut-sei=Kuyama en-aut-mei=Keisuke kn-aut-name=久山圭介 kn-aut-sei=久山 kn-aut-mei=圭介 aut-affil-num=7 ORCID= affil-num=1 en-affil= kn-affil=慈圭精神医学研究所 affil-num=2 en-affil= kn-affil=西宇部病院 affil-num=3 en-affil= kn-affil=島根医科大学神経精神医学教室 affil-num=4 en-affil= kn-affil=島根医科大学神経精神医学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部神経精神医学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部神経精神医学教室 en-keyword=OPCA kn-keyword=OPCA en-keyword=Substantia nigra kn-keyword=Substantia nigra en-keyword=neuronal swelling degeneration kn-keyword=neuronal swelling degeneration en-keyword=glutamate kn-keyword=glutamate END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=917 end-page=926 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Changes in the subjective symptoms of fatigue, flicker value and excretion of urinary protein in childern after dance exercise kn-title=女子児童におけるダンス負荷前後の自覚症状，フリッカー値ならびに尿蛋白質排泄量の変動 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To determine the effects of physical loading on the health status of children who attend a dance class after school, changes in subjective and objective symptoms of the children caused by the exercise were studied. In addition, the situation of outdoor exercise in daily life was analyzed, and the fundamental problems of health care for children examined. In the present investigation, eleven elementary school students (girls) exercised in a dance room for 60 minutes, and subjective symptoms of fatigue, flicker fusion values, and excretion of urinary protein were determined before and after dancing. The subjective symptoms of fatigue were not changed by the dance exercise, though symptoms of "wanting to lie down" and "thirsty" were frequent complaints (73%) before dancing, which suggests that these symptoms were of fatigue caused before 16 : 00 p. m. Flicker fusion values before and after physical loading were not changed by dance exercises. The specific gravity of urine and urinary pH were not changed after dancing. The concentration of urinary protein and the excretion of urine per hour tended to increase after dancing. A comparison was made in urinary volume and protein between swimming and dance practice. The urinary volume was increased after swimming, and it was not changed by dance practice. The concentration of urinary protein was significantly decreased after swimming (p<0.01), though it was increased after dancing (p<0.10). en-copyright= kn-copyright= en-aut-name=MaehashiAkira en-aut-sei=Maehashi en-aut-mei=Akira kn-aut-name=前橋明 kn-aut-sei=前橋 kn-aut-mei=明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学講座 en-keyword=女子児童 kn-keyword=女子児童 en-keyword=ダンス前後の疲労感 kn-keyword=ダンス前後の疲労感 en-keyword=フリッカー値 kn-keyword=フリッカー値 en-keyword=尿蛋白質排泄量 kn-keyword=尿蛋白質排泄量 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=905 end-page=915 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Changes in the subjective symptoms of fatigue of American college students after physical education activity kn-title=アメリカの大学生における体育実技前後の疲労感の変動 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To understand the effects of physical loading on the health status of the college students who attend the physical education activity classes, the subjective changes in their living body caused by exercise were studied according to sex and type of activity. In this investigation, 225 college students attending their physical education class for 50 minutes, were asked of their subjective symptoms of fatigue before and after the physical education activities (tennis, racketball, bowling and weight training) by questionnaire. The score of subjective symptoms of fatigue group I ; "drowsiness and dullness" was decreased in those after the tennis games. The symptoms of "thirsty" (P<0.05) and "hands and legs trembling" (p<0.01) were significantly increased after the tennis games in men. The subjective symptoms of fatigue group I ; "drowsiness and dullness" showed a decreasing trend after racketball games in both men and women, though symptoms of "tired legs" and "thirsty" were significantly increased after the racketball games (p<0.01). "Feeling like yawning" and "feeling sleepy" were significantly decreased after the bowling games (p<0.01) though symptom of "thirsty" was significantly increased (p<0.05). The symptoms of "feeling exhausted" , "tired legs", "thirsty" and "hands and legs trembling" were significantly increased after weight training exercises (p<0.01) though symptoms of "feeling like yawning" and "feeling sleepy" were significantly decreased in men (p<0.01). However, the symptoms of fatigue before and after physical loading were not increased though the symptom of "tired eyes" was significantly decreased (p<0.01) in women. In conclusion, physical loading had little effect on the health status of the students. Therefore the physical education classes in this investigation could be expected to be of recreational benefit for the students. en-copyright= kn-copyright= en-aut-name=MaehashiAkira en-aut-sei=Maehashi en-aut-mei=Akira kn-aut-name=前橋明 kn-aut-sei=前橋 kn-aut-mei=明 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学講座 en-keyword=アメリカ kn-keyword=アメリカ en-keyword=大学生 kn-keyword=大学生 en-keyword=体育実技前後の疲労感 kn-keyword=体育実技前後の疲労感 en-keyword=疲労・自覚症状 kn-keyword=疲労・自覚症状 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=899 end-page=903 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=High-performance liquid chromatographic determination of ascorbic acid and total ascorbic acid in Chinese vegetables kn-title=高速液体クロマトグラフィーによる中国野菜中のアスコルビン酸および総アスコルビン酸の定量 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A Simple high-performance liquid chromatographic method is described for the rapid estimation of ascorbic acid and total ascorbic acid. Use of tetra-n-butylammonium bromide as an ion-pairing reagent in the mobile phase yielded reproducible retention for ascorbic acid. Total ascorbic acid is determined by reducing the dehydroascorbic acid to ascorbic acid by treatment with DL-homocysteine. This high-performance liquid chromatographic method has been applied to the analysis of several Chinese vegetables. These Chinese vegetables contained more total ascorbic acid than any other vegetables on the market. en-copyright= kn-copyright= en-aut-name=ShimadaYoshihiro en-aut-sei=Shimada en-aut-mei=Yoshihiro kn-aut-name=嶋田義弘 kn-aut-sei=嶋田 kn-aut-mei=義弘 aut-affil-num=1 ORCID= en-aut-name=KoSanae en-aut-sei=Ko en-aut-mei=Sanae kn-aut-name=高早苗 kn-aut-sei=高 kn-aut-mei=早苗 aut-affil-num=2 ORCID= en-aut-name=OgataMasana en-aut-sei=Ogata en-aut-mei=Masana kn-aut-name=緒方正名 kn-aut-sei=緒方 kn-aut-mei=正名 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部公衆衛生学講座 affil-num=2 en-affil= kn-affil=岡山大学医学部公衆衛生学講座 affil-num=3 en-affil= kn-affil=岡山大学医学部公衆衛生学講座 en-keyword=高速液体クロマトグラフィー kn-keyword=高速液体クロマトグラフィー en-keyword=イオン対試薬 kn-keyword=イオン対試薬 en-keyword=アスコルビン酸 kn-keyword=アスコルビン酸 en-keyword=総アスコルビン酸 kn-keyword=総アスコルビン酸 en-keyword=中国野菜 kn-keyword=中国野菜 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=889 end-page=898 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Detection of alcohol dehydrogenase and aldehyde dehydrogenase isozymes in liver of medico-legal autopsy cases kn-title=剖検死体のアルコール脱水素酵素及びアルデヒド脱水素酵素について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Examination of liver alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) isozymes together with the estimation of alcohol in the body fluids of the deceased, may help to estimate more accurately the grade of their drunkenness. However, in medico-legal cases the body is sometimes putrefied or burnt. In the present study, the effects of putrefaction and heat on the activities of human liver ADH and ALDH isozymes were investigated by thin layer polyacrylamide gel isoelectric focusing. When the liver homogenates were left at 5℃, identification of typical type and atypical type of ADH became impossible within 10 days and 6 days, respectively. In some of the homogenates left at the same terperature, the activity of normal type and deficient type of ALDH2 isozyme was detected for 21 days. When the homogenates were stored at 25℃, the activities of the ADH and ALDH disappeared within 2 days and 3 days, respectively. Identification of ADH typical type, ADH atypical type, ALDH2 normal type and ALDH2 deficient type of the homogenates stored at 37℃ became impossible within 12 hours, 3 hours, 24 hours and 21 hours, respectively. These results indicate that the activity of the ADH disappears faster than that of the ALDH at room temperature and that atypical type of ADH is more sensitive to putrefaction than its typical type. The same phenomena were also observed in liver of decomposed corpses. When liver homogenates were stored at 50℃, it was possible to identify the type of ADH for about 5 hours. In the homogenates stored at the same temperature, the activity of the ALDH2 isozyme disappeared within about 1 hour though the ALDH1 isozyme was stable for 5-6 hours. The activities of ADH and ALDH of the homogenates quickly disappeared when heated at 70℃ and 100℃. In burnt bodies whose liver almost remained intact, the activities of the ADH and ALDH enzymes did not decrease though they were badly charred. However, only the ALDH2 band disappeared in some parts of the liver burnt slightly though the ALDH1 band was visible. In such a burnt body, therefore, it is necessary to examine the ALDH isozymes of the liver and kidney not to misjudge ALDH2 normal type as ALDH2 deficient type. Ten human corpses, which were of alcohol-consumers, all showed normal type of ALDH2 isozymes. The frequency of ALDH2 deficiency was about 21% in our medico-legal autopsy cases though it is about 50% among the Japnese. en-copyright= kn-copyright= en-aut-name=XuYang en-aut-sei=Xu en-aut-mei=Yang kn-aut-name=徐揚 kn-aut-sei=徐 kn-aut-mei=揚 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部法医学教室 en-keyword=Alcohol dehydrogenase kn-keyword=Alcohol dehydrogenase en-keyword=Aldehyde dehydrogenase kn-keyword=Aldehyde dehydrogenase en-keyword=Isozymes kn-keyword=Isozymes en-keyword=Polymorphism kn-keyword=Polymorphism en-keyword=Isoelectric focusing kn-keyword=Isoelectric focusing END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=879 end-page=888 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Regulation of transferrin receptor (TfR) expression on erythroblasts from patients with myelodysplastic syndrome Part 2. Analysis of TfR expression using stainable iron granules in myelodysplastic syndrome kn-title=骨髄異形成症候群におけるヒト赤芽球トランスフェリン受容体発現に関する研究　第2編　骨髄異形成症候群におけるトランスフェリン受容体発現の特徴について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Expression of TfR on the cell surface is known to be regulated by the cellular iron content. We previously reported an inverse correlation between mean number of TfR expressed and stainable iron granules (SIGs) of erythroblasts (EBLs) in normal subjects. In MDS, EBLs contain an increased number of SIGs, though the mechanism of this phenomenon is not well understood. In this report, expression of surface transferrin receptor (TfR) on bone marrow EBLs was examined in comparison with the number of SIGs in 11 patients with myelodysplastic syndrome (MDS) and 11 patients with acute leukemia (AL). The mean numbers of TfR from MDS (5.56±1.35x10(5)) and AL (5.73±2.25x10(5)) were not different from those of normal subjects (5.00±1.80x10(5)). However, in MDS the mean number of TfR from 8 patients (72%) was similar to the normal level in spite of the increased mean number of SIG. Four of the 11 patients with AL showed a similar change such as MDS in TfR, but notably 2 of those 4 patients were AL transformed from MDS. There is a correlation (r＝0.61) between TfR and MCV in MDS different from that in healthy subject. These findings suggest that TfR expression on EBLs, from MDS may escape from the regulation by the cellular iron content as iron-TfR regulation disturbance. en-copyright= kn-copyright= en-aut-name=TsuyunoRitsurou en-aut-sei=Tsuyuno en-aut-mei=Ritsurou kn-aut-name=露野理津朗 kn-aut-sei=露野 kn-aut-mei=理津朗 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=transferrin receptor kn-keyword=transferrin receptor en-keyword=stainable iron granule kn-keyword=stainable iron granule en-keyword=myelodysplastic syndrome kn-keyword=myelodysplastic syndrome en-keyword=acute leukemia kn-keyword=acute leukemia END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=869 end-page=877 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Regulation of transferrin receptor (TfR) expression on erythroblasts from patients with myelodysplastic syndrome Part 1. Influence of cell maturation, hemoglobin concentration and stainable iron granules on TfR expression kn-title=骨髄異形成症候群におけるヒト赤芽球トランスフェリン受容体発現に関する研究　第1編　赤芽球トランスフェリン受容体発現に及ぼす形態，成熟度，ヘモグロビン濃度，可染性鉄顆粒数の影響について en-subtitle= kn-subtitle= en-abstract= kn-abstract=Erythroblasts (EBLs) as well as thrombocytes and myelocytes show changes in patients with myelodysplastic syndrome (MDS). The changes include increse in sideroblasts and maturation delay. Expression of the transferrin receptor (TfR) has been known to correlate with stainable iron and cell maturation. To clarify whether the regulation mechanism of TfR on bone marrow EBLs is altered in MDS and acute leukemia (AL), TfR expression on EBL from MDS and AL were measured in individual cells as well as cell morphology, stainable iron granules (SIGs) in EBLs and cellular hemoglobin content using the morphometric method established in our laboratory. Generally, the number of TfR and density of TfR on EBLs decreased along with cell maturation. The density of TfR was negatively correlated with hemoglobin concentration (r＝−0.76), but SIGs showed no significant correlation with TfR density. In a patint with RARS, there was no difference in TfR density between ringed and non-ringed sideroblasts. By contrast, in a patient with AL, the TfR density of EBLs with morphological changes in nucleus was lower than that of normal EBLs. These findings suggest that the regulation mechanism of TfR in MDS was similar to normal subjects in cell maturation, hemogulobin concentration and SIGs, leaving the question why EBLs in MDS contain numerous SIGs in future. en-copyright= kn-copyright= en-aut-name=TsuyunoRitsurou en-aut-sei=Tsuyuno en-aut-mei=Ritsurou kn-aut-name=露野理津朗 kn-aut-sei=露野 kn-aut-mei=理津朗 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=transferrin receptor kn-keyword=transferrin receptor en-keyword=hemoglobin kn-keyword=hemoglobin en-keyword=stainable iron granule kn-keyword=stainable iron granule en-keyword=myelodysplastic syndrome kn-keyword=myelodysplastic syndrome en-keyword=acute leukemia kn-keyword=acute leukemia END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=859 end-page=867 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Persistent herpes simplex virus type 2 infection in a hamster kidney cell line with a characteristic to grow at a high culture temperature kn-title=ハムスター腎臓由来株化細胞の高温馴化亜株における単純ヘルペスウイルス2型の持続感染 en-subtitle= kn-subtitle= en-abstract= kn-abstract=A subline of the baby hamster kidney cell line (BHK-21), which was adapted to grow at 41℃ and named BHK-21H, was used to examine the effect of pre-treatment of host cells with a high culture temperature on the growth of herpes simplex virus (HSV). BHK-21H cells were infected with HSV type 2 (HSV-2) at 41℃ and maintained for 7 days at the same temperature. When these cells were further cultivated after shift-down to 36℃, persistent infections were established. These infections were characterized by a carrier culture state ; the infected cultures were composed of infected and non-infected cells, and cell destruction and regrowth of cells caused a balanced state of culture. Two to 3 months after the establishment of the persistent infections, virus production in the cultures stopped spontaneously and colonial regrowth of uninfected cells was observed. A subline (BHK-21R) which was cured of the persistent infection was obtained. Cells of this subline showed resistance to reinfection of HSV. Persistent HSV-2 Infection was also established by pre-treatment of BHK-21H cells at 41℃ before virus infection and maintenance of the infected cultures at 36℃. These findings indicate that establishment of the persistent HSV-2 infection is mainly attributable to reduced permissiveness of BHK-21H cells for virus growth caused after heat treatment of the cells. en-copyright= kn-copyright= en-aut-name=KitamuraTetsuro en-aut-sei=Kitamura en-aut-mei=Tetsuro kn-aut-name=喜多村哲朗 kn-aut-sei=喜多村 kn-aut-mei=哲朗 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部小児科学教室 en-keyword=herpes simplex virus kn-keyword=herpes simplex virus en-keyword=persistent infection kn-keyword=persistent infection en-keyword=supraoptimal temperature kn-keyword=supraoptimal temperature en-keyword=carrier culture state kn-keyword=carrier culture state en-keyword=permissiveness kn-keyword=permissiveness END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=841 end-page=857 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Experimental study on the hepatic effects of sevoflurane anesthesia kn-title=セボフルレン麻酔の肝に及ぼす影響に関する実験的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The hepatic effects of sevoflurane administered under different inspiratory oxygen concentrations were examined. Male rats pretreated with phenobarbital for 5 days and fasted for 24 hours were anesthetized with 2.4% sevoflurane administered under different oxygen concentrations (10%, 14%, 21% or 100%). The rats administered sevoflurane under 21% oxygen were used as the control. The amount of microsomal protein, the content and activity of hepatic microsomal enzymes, and the amount of enzymes released from the liver cells (GPT, OCT) of each group of rats were measured for 7 days after these procedures. The content of cytochrome P-450 and the activity of aminopyrine demethylation and aniline dehydration were decreased significantly to about 58%, 43% and 40% that of the control, respectively. Furthermore the plasma level of GPT and OCT was elevated to 1,107±620 IU/L and 422±270 IU/L respectively soon after sevoflurane anesthesia only in the group of rats administered sevoflurane under a 10% oxygen concentration. In this study, severe damage to the liver of the rats was observed after sevoflurane anesthesia under 10% oxygen following enzyme induction and fasting. en-copyright= kn-copyright= en-aut-name=OkadaNaoki en-aut-sei=Okada en-aut-mei=Naoki kn-aut-name=岡田尚起 kn-aut-sei=岡田 kn-aut-mei=尚起 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部麻酔・蘇生学教室 en-keyword=セボフルレン麻酔 kn-keyword=セボフルレン麻酔 en-keyword=吸入酸素濃度 kn-keyword=吸入酸素濃度 en-keyword=チトクローム　P-450 kn-keyword=チトクローム　P-450 en-keyword=肝障害 kn-keyword=肝障害 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=833 end-page=839 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A report of thirteen cases of familial polyposis coli kn-title=教室における家族性大腸ポリポーシス症例の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Familial polyposis coli (FPC) is an inherited nonsex linked mendelian dominant disease in which there exist at least 100 adenomatous polyps throughout the entire large bowel. Thirteen patients with FPC, of whom 7 were male and 6 female, visited our department between 1966 and 1990. The mean age of the patients was 33.5. Eight of the 13 patients (61.5%) had gastric and/or duodenal polyps, and eight of the 13 patients (61.5%) had colorectal carcinomas at admission. Colectomy with ileorectal anastomosis (IRA) was performed on 2 patients. The functional results were good bowel frequency, good sphincter control and lack of dietary restriction. Clinical experience tended to suggest that the risk of rectal cancer following IRA is extreme and unacceptable, although our two cases were still free of rectal cancer. Since 1980, the total colectomy with mucosal proctectomy and ileal pouch-anal anastomosis was the procedure of choice in our department. Good results were obtained on the six patients on whom this procedure was performed. en-copyright= kn-copyright= en-aut-name=WatanabeKazuhiko en-aut-sei=Watanabe en-aut-mei=Kazuhiko kn-aut-name=渡辺和彦 kn-aut-sei=渡辺 kn-aut-mei=和彦 aut-affil-num=1 ORCID= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=2 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=3 ORCID= en-aut-name=ShiikiShigeo en-aut-sei=Shiiki en-aut-mei=Shigeo kn-aut-name=椎木滋雄 kn-aut-sei=椎木 kn-aut-mei=滋雄 aut-affil-num=4 ORCID= en-aut-name=MatubaraNagahide en-aut-sei=Matubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=5 ORCID= en-aut-name=AkazaiYoshihiro en-aut-sei=Akazai en-aut-mei=Yoshihiro kn-aut-name=赤在義浩 kn-aut-sei=赤在 kn-aut-mei=義浩 aut-affil-num=6 ORCID= en-aut-name=WatanabeTetsuya en-aut-sei=Watanabe en-aut-mei=Tetsuya kn-aut-name=渡辺哲也 kn-aut-sei=渡辺 kn-aut-mei=哲也 aut-affil-num=7 ORCID= en-aut-name=SuzakiKiichi en-aut-sei=Suzaki en-aut-mei=Kiichi kn-aut-name=須崎紀一 kn-aut-sei=須崎 kn-aut-mei=紀一 aut-affil-num=8 ORCID= en-aut-name=HamadaFumihiro en-aut-sei=Hamada en-aut-mei=Fumihiro kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=9 ORCID= en-aut-name=GouchiAkira en-aut-sei=Gouchi en-aut-mei=Akira kn-aut-name=合地明 kn-aut-sei=合地 kn-aut-mei=明 aut-affil-num=10 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=11 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=家族性大腸ポリポーシス kn-keyword=家族性大腸ポリポーシス en-keyword=胃・十二指腸ポリープ kn-keyword=胃・十二指腸ポリープ en-keyword=癌化 kn-keyword=癌化 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=823 end-page=831 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Medico-legal studies on the sex-identification of biological materials by DNA analysis kn-title=DNA 分析による生物試料の性別判定に関する法医学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Sex identification of human blood, bloodstains, saliva, hair roots and bone marrow was conducted by DNA analysis. The effects of various contaminants in samples on sex identification were studied, using 32-week-old contaminated bloodstains. The effect of heat or decomposition on sex identification was examined by using the blood obtained from autopsy-cases. A 2.12 kb band with male DNA, digested with Hae V and electrophoresed, was observed by Southern hybridization using a human Y chromosome-specific probe, while a faint 2.00 kb band with female DNA was also sometimes detected. The male 2.12 kb band was detected even in 5-year-old bloodstains. The 2.12 kb band was also detected frequently in contaminated bloodstains as old as 32 weeks. The band was observed by Southern hybridization analysis in decomposed blood as old as 7 days, while it could not be detected in heated and decomposed blood after 3 days. en-copyright= kn-copyright= en-aut-name=NakaiMiyoko en-aut-sei=Nakai en-aut-mei=Miyoko kn-aut-name=中井三代子 kn-aut-sei=中井 kn-aut-mei=三代子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部法医学教室 en-keyword=sex identification kn-keyword=sex identification en-keyword=deoxyribonucleic acid (DNA) kn-keyword=deoxyribonucleic acid (DNA) en-keyword=forensic science kn-keyword=forensic science en-keyword=bloodstains kn-keyword=bloodstains END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=813 end-page=821 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on pathogenesis in iron deficiency anemia Part 2. Anemia induced by administration of puromycin aminonucleoside kn-title=鉄欠乏性貧血の発症要因に関する研究　第2編　鉄漏出性貧血の動物モデル作製の試みとその評価 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Iron deficiency anemia results from various factors, such as blood loss, malabsorption, and increased demand for iron due to pregnancy or growth. However, iron hyper-excretion has not been reported except in the cases of bleeding. Previously, we found increased iron excretion in the urine in patients with iron-losing anemia, such as idiopathic hypochromic anemia. To examine the relationship between iron excretion and anemia, puromycin aminonucleoside (PA) was administered in rats to induce anemia. In such rats, considerable amounts of iron were continuously excreted in the urine and the animals became anemic. However, the anemia in this model was normocytic and normochromic, and the liver iron content was reversely increased. In conclusion, PA administration in rats induces not only iron deficiency as hyper-excretion but also abnormalities of iron metabolism as indicated by the other pathological findings, such as inflammatory change and renal failure. en-copyright= kn-copyright= en-aut-name=NakanishiNorihiko en-aut-sei=Nakanishi en-aut-mei=Norihiko kn-aut-name=中西徳彦 kn-aut-sei=中西 kn-aut-mei=徳彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=iron deficiency anemia kn-keyword=iron deficiency anemia en-keyword=iron-losing anemia kn-keyword=iron-losing anemia en-keyword=puromycin aminonucleoside kn-keyword=puromycin aminonucleoside END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=803 end-page=811 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the pathogenesis in iron deficiency anemia Part 1. Urinary iron excretion in iron deficiency anemia patients and rats in various iron states kn-title=鉄欠乏性貧血の発症要因に関する研究　第1編　尿中鉄排泄の臨床的並びに実験的検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=In the "iron excretion test" , urinary iron excretion after injection of saccharated iron oxide has been reported to be accelerated in relapsing idiopathic iron deficiency anemia. To determine the relevance of urinary iron excretion to clinical factors other than iron metabolism, 15 clinical parameters were evaluated. The serum creatinine level was positively and the serum albumin level was negatively correlated with urinary iron excretion, showing coefficients of r＝0.97,−0.86 respectively, and suggesting a relationship between urinary iron excretion and subclinical abnormalities of kidney function. In experimental studies, the relation of urinary iron excretion to the renal function was examined by administration of iron in various forms to rats. Only saccharated iron oxide was excreted; chondroitin sulfate Fe, Tf-Fe and ferric chloride were not excreted in the urine. Then, iron excretion was examined in iron deficient, iron overloaded and puromycin aminonucleoside (PA)-treated animals. Iron deficient rats did not show any change in urinary iron excretion compared to the controls. Urinary iron excretion was increased in iron overloaded rats, and was further increased in the PA-treated group. These findings suggest that the subclinical abnormality in kidney function leads to the increased urinary iron excretion as a possible factor in the pathogenesis of relapsisg iron deficiency. en-copyright= kn-copyright= en-aut-name=NakanishiNorihiko en-aut-sei=Nakanishi en-aut-mei=Norihiko kn-aut-name=中西徳彦 kn-aut-sei=中西 kn-aut-mei=徳彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=iron deficiency anemia kn-keyword=iron deficiency anemia en-keyword=urinary iron excretion kn-keyword=urinary iron excretion END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=791 end-page=801 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the regulation of eosinophils in bronchial asthma Part 2. Migratory responses of eosinophils from asthmatics kn-title=気管支喘息における好酸球動態の調節に関する研究　第2編　喘息患者末梢血好酸球の遊走能に関する検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Eosinophil infiltration in lung tissue is one of the characteristic features of bronchial asthma. Such cell infiltration seems to be induced by the eosinophil chemotactic factor (ECF). PAF and IL-5 are potent chemoattractants and activators for eosinophils. To evaluate the reactivity of eosinophils in asthmatics under various conditions, the migratory function of eosinophils to PAF and IL-5 was investigated by the modified Boyden chamber method. Eosinophils of asthmatics were highly purified using a flow cytometric method previously reported. The migratory response of the eosinophils of asthmatics was greater than that of healthy suljects. Eosinophils from atopic asthmatics showed a higher response to PAF than those from non-atopic asthmatics. Eosinophils in the attack stage showed a higher response than those in the non-attack stage. Hypodense eosinophils showed an increased migratory response. The migratory response was correlated to the serum concentration of ECP and blood eosinophil count. These findings suggest that the reactivity of eosinophils is heterogenous and relates to the degree of eosinophilia, and that IL-5 as well as PAF plays an important role in the pathogenesis of bronchial asthma. en-copyright= kn-copyright= en-aut-name=TakahashiHisaho en-aut-sei=Takahashi en-aut-mei=Hisaho kn-aut-name=高橋寿保 kn-aut-sei=高橋 kn-aut-mei=寿保 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=Eosinophil migratory response kn-keyword=Eosinophil migratory response en-keyword=Platelet-activating factor kn-keyword=Platelet-activating factor en-keyword=Interleukin-5 kn-keyword=Interleukin-5 en-keyword=Eosinophil heterogeneity kn-keyword=Eosinophil heterogeneity END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=779 end-page=789 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Studies on the regulation of eosinophils in bronchial asthma Part 1. Characterization of eosinophil chemotactic factor (ECF) derived from peripheral blood mononuclear cells stimulated with Candida antigen kn-title=気管支喘息における好酸球動態の調節に関する研究　第1編　喘息患者末梢血単核球由来の好酸球遊走因子（ECF）の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Eosinophilic infiltration in bronchial tissue is characteristic in the pathogenesis of bronchial asthma. The eosinophil chemotactic factor (ECF) derived from mononuclear cells has been reported to have some effect on the cell infiltration, and interleukin-5 (IL-5), a lymphokine derived from T lymphocytes, to be a factor related to growth, chemotaxis and activation for eosinophils. Lymphocytes accumulated in the bronchoalveolar lavage fluids of non-atopic and severe asthmatics have been shown to be highly responsive to Candida antigen, and high ECF production was observed in non-atopic and severe asthmatics by measurement of ECF activity in the supernatant of peripheral blood mononuclear cells cultured with Candida antigen. In this report, the molecular weight by gel filtration and inhibition test using anti-murine IL-5 antibody were studied to characterize the lymphocyte-derived ECF. Gel filtration analysis of the ECF indicated a molecular weight of 20,000 to 65,000 Da with a peak of activity around 40,000 to 50,000 Da. The ECF activity was reduced by incubation with anti-murine IL-5 antibody, which suggests that the supernatant contains IL-5. ECF from mononuclear cells, containing IL-5, may play an important role in the pathogenesis of eosinophil infiltration in non-atopic and severe asthmatics. en-copyright= kn-copyright= en-aut-name=TakahashiHisaho en-aut-sei=Takahashi en-aut-mei=Hisaho kn-aut-name=高橋寿保 kn-aut-sei=高橋 kn-aut-mei=寿保 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第二内科学教室 en-keyword=Bronchial asthma kn-keyword=Bronchial asthma en-keyword=Candida antigen Eosinophil chemotactic factor kn-keyword=Candida antigen Eosinophil chemotactic factor en-keyword=Interleukin-5 kn-keyword=Interleukin-5 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=769 end-page=778 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Striatal extracellular levels of dopamine and its metabolites during kainate-induced limbic seizures in freely-moving rats measured by brain microdialysis kn-title=カイニン酸誘発けいれんにおける細胞外ドパミン量の経時的変化―脳内微小透析法を用いた実験的研究― en-subtitle= kn-subtitle= en-abstract= kn-abstract=To investigate the role of brain dopaminergic systems in epilepsy, striatal extracellular levels of dopamins (DA) and its metabolites (3,4-dihydroxyphenylacetic acid : DOPAC and homovanillic acid : HVA) were measured during kainate-induced limbic seizures in freely-moving rats, using brain microdialysis. DA and its metabolites were measured by high performance liquid chromatography. Systemic injection of kainate (10mg/s, i. p.), which caused stable limbic seizures, significantly decreased the levels of DA and its metabolites. Intrahippocampal injection of kainae (2.5nmol), which also caused limbic seizures, significantly decreased only the DA levels, while DOPAC and HVA levels were unchanged. Similar to the results of the systemic injectjon, intrastriatal perfusion of kainate (10(-2) or 10(-6) M) significantly decreased the levels of DA, DOPAC and HVA in a dose-dependent manner. These findings indicate that, during kainate-induced limbic seizures, DA release was significantly reduced in the striatum. In conclusion, the hypofunction of striatal dopaminergic systems is related to the initiation and progress in epileptic seizures. en-copyright= kn-copyright= en-aut-name=OhnishiMasaru en-aut-sei=Ohnishi en-aut-mei=Masaru kn-aut-name=大西勝 kn-aut-sei=大西 kn-aut-mei=勝 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 en-keyword=kainate kn-keyword=kainate en-keyword=brain microdialysis kn-keyword=brain microdialysis en-keyword=dopamine kn-keyword=dopamine en-keyword=striatum kn-keyword=striatum en-keyword=epilepsy kn-keyword=epilepsy END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=759 end-page=768 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Analysis on the mechanism of the temperature-sensitive melibiose metabolism in Lactobacillus plantarum kn-title=Lactobacillus plantarum におけるメリビオース代謝の高温感受性機構の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract=L. plantarum can grow on melibiose when incubated at 30℃ but not when incubated at 37℃. In this study, the temperature sensitivity of melibiose metabolism was analyzed. The melibiose metabolism seemed to consist of the melibiose transport system and hydrolyzing enzyme, α-galactosidase. α-Galactosidase was induced with melibiose at 30℃ but not at 37℃. This enzyme induced at 30℃ hydrolyzed colorimetric substrate, α-ONPG at 30℃ and 37℃. On the other hand, lactose induced α-galactosidase at both temperatures. These findings suggested that the temperature sensitivity of melibiose metabolism was not due to the induction and/or function of α-galactosidase. Thus, the effect of temperature on induction and function of the melibiose transport system was examined. Cells grown on melibiose at 30℃ exhibited the rapid uptake of [(3)H] -melibiose at 30℃ and 37℃, while [(3)H] -melibiose was not taken up by the cells grown at 37℃. The induction of the melibiose transport system seemed to be temperature-sensitive because the transport system was not inactivated by exposure of the cells to 37℃ for 3 hours. In conclusion, the temperature sensitivity of melibiose metabolism was attributed to the temperature sensitivity of the induction of melibiose transport system. en-copyright= kn-copyright= en-aut-name=TamuraChiyuki en-aut-sei=Tamura en-aut-mei=Chiyuki kn-aut-name=田村千幸 kn-aut-sei=田村 kn-aut-mei=千幸 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部細菌学教室 en-keyword=Lactobacillus plantarum kn-keyword=Lactobacillus plantarum en-keyword=メリビオース kn-keyword=メリビオース en-keyword=高温感受性 kn-keyword=高温感受性 en-keyword=α-ガラクトシダーゼ kn-keyword=α-ガラクトシダーゼ en-keyword=メリビオース輸送系 kn-keyword=メリビオース輸送系 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=749 end-page=757 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Role of sigma sites in the modulation of neuroleptics-induced dystonia in rats kn-title=抗精神病薬によるジストニアの発現機序に関する実験的研究―σ (sigma) sites の関与について― en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recent findings have suggested that neuroleptics exhibit a strong affinity for not only dopamine receptors, but also the sigma sites. Therefore, some clinical or adverse effects of neuroleptics may be due to their action on the sigma sites. This study showed that intrarubral microinjection of 1,3-di-o-tolylguanidine (DTG) or (＋) -3- (3-hydroxyphenyl) -N-1-propyl) piperidine, sigma ligands, and several neuroleptics such as haloperidol caused dystonic reactions in rats resembling tha acute dystonic reaction in humans. The intensity and duration of the dystonia induced by these drugs showed a correlation with their affinities for the sigma sites. These findings raise the possibility that the acute dystonic reaction, one of the motor side effects of neuroleptics, might be mediated via the sigma sites. On the other hand, BMY 14802, an atypical neuroleptic, never caused dystonia after intrarubral microinjection. Furthermore, BMY 14802 still inhibited the dystonia induced by intrarubral microinjection of DTG. This reduction in DTG-induced dystonia by BMY 14802 may result its direct inhibitory effects against DTG at the sites, because BMY 14802 possesses potent sigma affinty. These findings imply that sigma ligands may be divided into two categories, dystonia-reinforcing and -reducing groups. Application of this theory should lead to the elucidation of the mechanism of neuroleptics-induced dystonia and other motor side effects. en-copyright= kn-copyright= en-aut-name=OkumuraKazuya en-aut-sei=Okumura en-aut-mei=Kazuya kn-aut-name=奥村一哉 kn-aut-sei=奥村 kn-aut-mei=一哉 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部神経精神医学教室 en-keyword=sigma sites kn-keyword=sigma sites en-keyword=dystonia kn-keyword=dystonia en-keyword=1, 3 -di-o-tolylguanidine (DTG) kn-keyword=1, 3 -di-o-tolylguanidine (DTG) en-keyword=BMY 14802 kn-keyword=BMY 14802 en-keyword=neuroleptics kn-keyword=neuroleptics END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=741 end-page=747 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Lateral lymph node metastasis of rectal carcinoma kn-title=教室における直腸癌側方リンパ節転移の検討 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The records of 182 consecutive rectal carcinomas treated in this department between JAN 1978 and DEC 1990 were reviewed to assess the outcome of the patients presenting with lateral pelvic lymph node infiltration. Lateral lymph node dissection was carried out in 24 (42.1%) of the 57 Ra tumors and 63 (72.4%) of the 87 Rb tumors, but in none of the 38 cases of Rs tumors. Lymph node involvement was detected 0% and 15.9% of the Ra and Rb tumors, respectively. In this series, none of the cases in which the tumors were confined to m, sm and pm had positive lymph nodes. However, 23.3% of the 43 cases in which invasion was beyond pm showed positive lymph node invasion. The main lymph nodes involved were located in the roots of the middle rectal arteries. Half of the patients presented with distant metastases within one year, with poorer prognosis considering the mean survival rate of 1.8 years. In conclusion, we advocate that in Rb rectal tumors with circular invasion or invasion beyond the pm, careful lateral lymph nede dissection should be carried out. On the other hand, we suggest the use of preoperative radiation therapy which could improve the curability, the disease-free interval, and survival rates. en-copyright= kn-copyright= en-aut-name=IwagakiHiromi en-aut-sei=Iwagaki en-aut-mei=Hiromi kn-aut-name=岩垣博巳 kn-aut-sei=岩垣 kn-aut-mei=博巳 aut-affil-num=1 ORCID= en-aut-name=FuchimotoSadanori en-aut-sei=Fuchimoto en-aut-mei=Sadanori kn-aut-name=淵本定儀 kn-aut-sei=淵本 kn-aut-mei=定儀 aut-affil-num=2 ORCID= en-aut-name=HamadaFumihiro en-aut-sei=Hamada en-aut-mei=Fumihiro kn-aut-name=浜田史洋 kn-aut-sei=浜田 kn-aut-mei=史洋 aut-affil-num=3 ORCID= en-aut-name=ShiikiShigeo en-aut-sei=Shiiki en-aut-mei=Shigeo kn-aut-name=椎木滋雄 kn-aut-sei=椎木 kn-aut-mei=滋雄 aut-affil-num=4 ORCID= en-aut-name=YasuiYoshimasa en-aut-sei=Yasui en-aut-mei=Yoshimasa kn-aut-name=安井義政 kn-aut-sei=安井 kn-aut-mei=義政 aut-affil-num=5 ORCID= en-aut-name=MatsubaraNagahide en-aut-sei=Matsubara en-aut-mei=Nagahide kn-aut-name=松原長秀 kn-aut-sei=松原 kn-aut-mei=長秀 aut-affil-num=6 ORCID= en-aut-name=AkazaiYoshihiro en-aut-sei=Akazai en-aut-mei=Yoshihiro kn-aut-name=赤在義浩 kn-aut-sei=赤在 kn-aut-mei=義浩 aut-affil-num=7 ORCID= en-aut-name=WatanabeTetsuya en-aut-sei=Watanabe en-aut-mei=Tetsuya kn-aut-name=渡辺哲也 kn-aut-sei=渡辺 kn-aut-mei=哲也 aut-affil-num=8 ORCID= en-aut-name=GouchiAkira en-aut-sei=Gouchi en-aut-mei=Akira kn-aut-name=合地明 kn-aut-sei=合地 kn-aut-mei=明 aut-affil-num=9 ORCID= en-aut-name=HizutaAkio en-aut-sei=Hizuta en-aut-mei=Akio kn-aut-name=日伝晶夫 kn-aut-sei=日伝 kn-aut-mei=晶夫 aut-affil-num=10 ORCID= en-aut-name=KamikawaYasuaki en-aut-sei=Kamikawa en-aut-mei=Yasuaki kn-aut-name=上川康明 kn-aut-sei=上川 kn-aut-mei=康明 aut-affil-num=11 ORCID= en-aut-name=OritaKunzo en-aut-sei=Orita en-aut-mei=Kunzo kn-aut-name=折田薫三 kn-aut-sei=折田 kn-aut-mei=薫三 aut-affil-num=12 ORCID= affil-num=1 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=2 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=3 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=4 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=5 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=6 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=7 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=8 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=9 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=10 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=11 en-affil= kn-affil=岡山大学医学部第一外科学教室 affil-num=12 en-affil= kn-affil=岡山大学医学部第一外科学教室 en-keyword=直腸癌 kn-keyword=直腸癌 en-keyword=側方郭清 kn-keyword=側方郭清 en-keyword=側方転移 kn-keyword=側方転移 END start-ver=1.4 cd-journal=joma no-vol=103 cd-vols= no-issue=7-8 article-no= start-page=735 end-page=739 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199108 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=A clinical survey of spina bifida at Kagawa Prefectural Rehabilitation Center kn-title=当施設における二分脊椎の調査 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Spina bifida is a congenital central nervous system disorder due to malformation of the vertebral canal. The prevalence of this entity in Japan is about one-tenth that in Western countries. It is classified into occult and cystic types based on appearance. Various techniques of surgery used, and the orthopedic and urological problems encountered in 18 cases of spina bifida cystica are discussed. The outcome of brain surgery and urological control were found to be satisfactory in these patients and no serious complications were observed. Twelve patients were able to walk. en-copyright= kn-copyright= en-aut-name=SakanoToshikazu en-aut-sei=Sakano en-aut-mei=Toshikazu kn-aut-name=坂野稔一 kn-aut-sei=坂野 kn-aut-mei=稔一 aut-affil-num=1 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=中込直 kn-aut-sei=中込 kn-aut-mei=直 aut-affil-num=2 ORCID= en-aut-name= en-aut-sei= en-aut-mei= kn-aut-name=藤岡一平 kn-aut-sei=藤岡 kn-aut-mei=一平 aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=香川県身体障害者総合リハビリテーションセンター整形外科 affil-num=2 en-affil= kn-affil=香川県身体障害者総合リハビリテーションセンター整形外科 affil-num=3 en-affil= kn-affil=香川県身体障害者総合リハビリテーションセンター整形外科 en-keyword=spina bifida kn-keyword=spina bifida en-keyword=dislocation of hip kn-keyword=dislocation of hip en-keyword=clean intermittent catheterization kn-keyword=clean intermittent catheterization END