| ID | 54829 |
| FullText URL | |
| Author |
Iwasaki, Yuka
Department of Pediatrics, Kochi Health Sciences Center
Nishiuchi, Rituo
Department of Pediatrics, Kochi Health Sciences Center
Aoe, Michinori
Division of Medical Support, cDepartment of Pediatrics, Okayama University Hospital
Takahashi, Takahide
Division of Medical Support, cDepartment of Pediatrics, Okayama University Hospital
Watanabe, Hirokazu
Department of Pediatrics, Kochi Health Sciences Center
Tokorotani, Chiho
Department of Pediatrics, Kochi Health Sciences Center
Kikkawa, Kiyoshi
Department of Pediatrics, Kochi Health Sciences Center
|
| Abstract | Acute myeloid leukemia (AML) patients with fms-related tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) often have a poor prognosis, even after hematopoietic stem cell transplantation (HSCT). We report a case of AML with FLT3-ITD identified upon initial diagnosis, who received HSCT at complete remission after 3 consecutive chemotherapies. However, the patient relapsed when the same FLT3-ITD clone emerged, and finally died. Retrospective analysis revealed an allelic ratio of FLT3-ITD/wild type of 1.1 and 0.0096 upon initial diagnosis and before HSCT, respectively. The detection of any minimal residual FLT3-ITD clone before HSCT is useful in the treatment of AML with FLT3-ITD.
|
| Keywords | acute myeloid leukemia
relapse
FLT3-ITD
HSCT
minimal residual disease
|
| Published Date | 2017-02
|
| Publication Title |
Acta Medica Okayama
|
| Volume | volume71
|
| Issue | issue1
|
| Publisher | Okayama University Medical School
|
| Start Page | 79
|
| End Page | 83
|
| ISSN | 0386-300X
|
| NCID | AA00508441
|
| Content Type |
Journal Article
|
| language |
English
|
| Copyright Holders | CopyrightⒸ 2017 by Okayama University Medical School
|
| File Version | publisher
|
| Refereed |
True
|
| PubMed ID | |
| Amo Type | Case Report
|
| Submission Path | amo/vol71/iss1/11
|
| JaLCDOI |
