ID | 54805 |
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Author |
Yamashita, Miho
Department of Pediatrics, Okayama University Hospital
Hasegawa, Kosei
Department of Pediatrics, Okayama University Hospital
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Higuchi, Yousuke
Department of Pediatrics, Okayama University Hospital
Miyai, Takayuki
Department of Pediatrics, Okayama University Hospital
Okada, Ayumi
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Tanaka, Hiroyuki
Department of Pediatrics, Okayama Saiseikai General Hospital
Tsukahara, Hirokazu
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Abstract | The urinary cross-linked N-terminal telopeptide of type I collagen (uNTx) levels in infantile osteogenesis imperfecta (OI) have not been well studied. Here we investigated the levels of uNTx in infants with OI and healthy infants. We collected spot urine samples from 30 infants with OI (male/female, 14/16; Sillence classification, I/II/III/IV: 15/3/6/6; age, 5.2±4.4 months) and 120 healthy infants (male/female, 75/45; age, 5.1±4.1 months) for the measurement of uNTx levels. The uNTx levels of the OI infants were significantly lower than those of the healthy infants (mean±SD, 1,363.7±530.1 vs. 2,622.2±1,202.6 nmol BCE/mmol Cr; p<0.001). The uNTx levels of the infants with type I OI were significantly lower than those of the age-matched healthy infants, although an overlap was observed between the 2 groups. Among the 1-month-old infants, the uNTx levels of the infants with types I, III or IV OI were significantly lower than those of the healthy infants, without overlap (1,622.5±235.8 vs. 3,781.0±1,027.1 nmol BCE/mmol Cr; p<0.001). These results indicate that uNTx levels are significantly lower in infants with OI than in healthy infants, and they suggest that uNTx might be useful as a reference for diagnosing OI.
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Keywords | bone resorption marker
bone turnover
bone mass
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Amo Type | Original Article
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Publication Title |
Acta Medica Okayama
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Published Date | 2016-12
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Volume | volume70
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Issue | issue6
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Publisher | Okayama University Medical School
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Start Page | 435
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End Page | 439
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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