ID | 54595 |
JaLCDOI | |
FullText URL | |
Author |
Noda, Yasuko
Department of Anti-Aging Food Sciences, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Masumizu, Toshiki
Faculty of Pharmaceutical Science, Sojo University
Mori, Akitane
Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
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Abstract | Methylguanidine (MG) is a known nephrotoxin and neurotoxin, and an intracisternal injection of MG can induce convulsions in experimental animals. In this in vitro study, we examined the inhibitory effects of the antiepileptic agent zonisamide (ZNS) on hydroxyl radicals (•OH) generated from MG by using an electron spin resonance (ESR) technique. ZNS scavenged •OH generated from MG in a dose-dependent manner through direct scavenging during the auto-oxidation of MG. The rate constant of ZNS reacting with the •OH was at a near diffusion-controlled rate. These findings indicate that ZNS might detoxify MG and could thus protect against convulsive disorders.
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Keywords | methylguanidine
zonisamide
convulsions
hydroxyl radical
electron spin resonance
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Amo Type | Short Communication
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Publication Title |
Acta Medica Okayama
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Published Date | 2016-10
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Volume | volume70
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Issue | issue5
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Publisher | Okayama University Medical School
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Start Page | 371
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End Page | 375
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ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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Copyright Holders | CopyrightⒸ 2016 by Okayama University Medical School
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |