ID | 31343 |
JaLCDOI | |
FullText URL | |
Author |
Suemaru, Katsuya
Kawakami, Yasuhiro
Araki, Hiroaki
Gomita, Yutaka
Tanizaki, Yoshiro
|
Abstract | The effect of 6-hydroxydopamine on repeated nicotine-induced tail-tremor was investigated in rats. Tail-tremor induced by nicotine (0.5 mg/kg/day, subcutaneously) became more pronounced in intensity with daily administration for 9 days. Rats pretreated with 6-hydroxydopamine (250 micrograms, intracerebroventricularly) showed almost the maximum degree of tail-tremor during the whole experimental period. However, in rats pretreated with 6-hydroxydopamine plus desipramine, enhancement of tail-tremor was slight in the beginning but increased with the daily nicotine administration. Fourteen-day administration of nicotine did not result in significant changes in noradrenaline and dopamine levels in the cortex, hypothalamus, striatum and nucleus accumbens. These results suggest that nicotine-induced tail-tremor is associated with the supersensitivity of postsynaptic catecholaminergic receptors in the central nervous system, and that the noradrenergic system may be more important than the dopaminergic system in this phenomenon. |
Keywords | nicotine
tail-tremor
6-hydroxydopamine
noradrenaline
dopamine
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Amo Type | Article
|
Publication Title |
Acta Medica Okayama
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Published Date | 1998-02
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Volume | volume52
|
Issue | issue1
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Publisher | Okayama University Medical School
|
Start Page | 49
|
End Page | 53
|
ISSN | 0386-300X
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NCID | AA00508441
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Content Type |
Journal Article
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language |
English
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File Version | publisher
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Refereed |
True
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PubMed ID | |
Web of Science KeyUT |