Effects of antioxidants, such as superoxide dismutase, vitamin C, vitamin E, 4-(0-benzylphenoxy)-N-methylbutylamine hydrochloride (bifemelane), and selenite on survival of adult rat hepatocytes were examined under normoxic and hyperoxic conditions in serum-free primary culture. The tested antioxidants, except for vitamin C, significantly increased the survival rate of hepatocytes under the normoxic condition (under air). Thus, even the normoxic culture condition is hyperoxic for hepatocytes. Elevation of oxygen tension (40% O2) caused severe morphologic degeneration of hepatocytes and remarkable decrease in the survival rate of the cells. Addition of the antioxidants effectively protected hepatocytes from the morphologic degeneration, and significantly improved the survival of the cells under the hyperoxic condition. These findings indicate that the antioxidants can maintain the long-term survival of hepatocytes in serum-free primary culture.
en-copyright= kn-copyright= en-aut-name=MiyazakiMasahiro en-aut-sei=Miyazaki en-aut-mei=Masahiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=BaiLiyan en-aut-sei=Bai en-aut-mei=Liyan kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=TsuboiSo en-aut-sei=Tsuboi en-aut-mei=So kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=SeshimoKen en-aut-sei=Seshimo en-aut-mei=Ken kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NambaMasayoshi en-aut-sei=Namba en-aut-mei=Masayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University en-keyword=oxugen tension kn-keyword=oxugen tension en-keyword=hepatocytes kn-keyword=hepatocytes en-keyword=serum-free primary culture kn-keyword=serum-free primary culture en-keyword=survival kn-keyword=survival en-keyword=antioxidants kn-keyword=antioxidants END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=6 article-no= start-page=457 end-page=459 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Intradermal hepatitis B virus vaccination for low- or non-responded health-care workers. en-subtitle= kn-subtitle= en-abstract= kn-abstract=Immune responses to hepatitis B virus (HBV) vaccine in six low- or non-responded health-care workers were tested with an intradermal low dose (5 micrograms) of the recombinant vaccine. The injection was repeated three or four times at fortnightly intervals. These successive doses of the vaccine induced a high concentration of antibodies with delayed-type hypersensitivity (DTH) skin reactions in all six subjects. A few minor temporary side effects, such as irritation and itching at the injection site, were reported by some of the vaccinees. The results suggest low-dose of intradermal HBV vaccinations for low- or non-responders are safe and readily effective.
en-copyright= kn-copyright= en-aut-name=YasumuraSatoshi en-aut-sei=Yasumura en-aut-mei=Satoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=ShimizuYukihiro en-aut-sei=Shimizu en-aut-mei=Yukihiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YasuyamaToshifumi en-aut-sei=Yasuyama en-aut-mei=Toshifumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=HirokiOsamu en-aut-sei=Hiroki en-aut-mei=Osamu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OkadaKazuhiko en-aut-sei=Okada en-aut-mei=Kazuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=TsukishiroTakashi en-aut-sei=Tsukishiro en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=TsuchidaToshiriro en-aut-sei=Tsuchida en-aut-mei=Toshiriro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HiguchiKiyohiro en-aut-sei=Higuchi en-aut-mei=Kiyohiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=WatanabeAkiharu en-aut-sei=Watanabe en-aut-mei=Akiharu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Toyama Medical and Pharmaceutical University affil-num=2 en-affil= kn-affil=Toyama Medical and Pharmaceutical University affil-num=3 en-affil= kn-affil=Toyama Medical and Pharmaceutical University affil-num=4 en-affil= kn-affil=Toyama Medical and Pharmaceutical University affil-num=5 en-affil= kn-affil=Toyama Medical and Pharmaceutical University affil-num=6 en-affil= kn-affil=Toyama Medical and Pharmaceutical University affil-num=7 en-affil= kn-affil=Toyama Medical and Pharmaceutical University affil-num=8 en-affil= kn-affil=Toyama Medical and Pharmaceutical University affil-num=9 en-affil= kn-affil=Toyama Medical and Pharmaceutical University en-keyword=skin reaction kn-keyword=skin reaction en-keyword=recombinant HBV vaccine kn-keyword=recombinant HBV vaccine END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=6 article-no= start-page=401 end-page=408 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Radical-promoting "free" iron level in the serum of rats treated with ferric nitrilotriacetate: comparison with other iron chelate complexes. en-subtitle= kn-subtitle= en-abstract= kn-abstract=<p>Iron plays a critical role in the production of activated oxygen species and the activity of chelated iron in the biological system depends on the chemical forms of the chelators. In the present study, we used ferric nitrolotriacetate (Fe-NTA, molar ratio of iron to chelators = 1:3), ferric ethylenediaminetetraacetate (Fe-EDTA, 1:3 complex) and ferric Desferal (Fe-Des, 1:1.1 complex) to see their "free" iron content in aqueous solutions in vitro and in the serum obtained after a single intraperitoneal injection of the chelates to rats (7.5 mg of iron/kg). "Free" iron was measured by the bleomycin-assay system. When Fe-NTA was dissolved in water, "free" iron increased linearly with total iron concentration up to 10 microM, whereas Fe-EDTA and Fe-Des showed no "free" iron with corresponding iron concentrations. When these three ferric chelates were dissolved in normal rat serum, "free" iron in Fe-NTA increased abruptly between 40 microM and 60 microM iron concentrations, then increased slowly up to 100 microM. Fe-Des did not show any "free" iron at comparable iron concentrations. Fe-EDTA had an intermediate "free" iron level in the serum. Among the ferric chelate complexes, Fe-NTA showed a much faster increase of and a higher content of "free" iron in the serum than the other two complexes after a single injection of the chelates into rats.(ABSTRACT TRUNCATED AT 250 WORDS)</p>
en-copyright= kn-copyright= en-aut-name=LiuMiao en-aut-sei=Liu en-aut-mei=Miao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=OkadaShigeru en-aut-sei=Okada en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=KawabataTeruyuki en-aut-sei=Kawabata en-aut-mei=Teruyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University en-keyword="free" iron kn-keyword="free" iron en-keyword= ferric nitrilotriacetate (Fe-NTA) kn-keyword= ferric nitrilotriacetate (Fe-NTA) en-keyword= ferric ethylenediaminetetraacetate (Fe-EDTA) kn-keyword= ferric ethylenediaminetetraacetate (Fe-EDTA) en-keyword=ferric desferrioxamine (Fe-Desferal kn-keyword=ferric desferrioxamine (Fe-Desferal en-keyword= Fe-Des) kn-keyword= Fe-Des) en-keyword=free radecal kn-keyword=free radecal END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=6 article-no= start-page=433 end-page=440 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Use of ventricular assist devices in patients with postcardiotomy shock. en-subtitle= kn-subtitle= en-abstract= kn-abstract=Over the last three years, we have used ventricular assist devices (VAD) in 7 patients. Of these 7, four patients with combined aortic and mitral valvular disease underwent double valve replacement; one patient with annuloaortic ectasia underwent a Cabrol's operation; another had aortic valve replacement; the last patient had triple coronary artery bypass grafts. The only patient who could be weaned from CPB developed cardiogenic shock after the operation. LVADs supported 6 patients for 4 to 8 days and a BVAD supported one patient for 9 days. All patients survived the weaning procedure. Three were discharged from the hospital and survived 7 to 21 months. The 4 other patients died of multiple organ failure. Three of these four suffered from both renal failure and infection, while one patient had arrhythmia and died of ileus. These data suggest that renal failure and major infection can be serious detrimental complications to VAD support.
en-copyright= kn-copyright= en-aut-name=MurakamiTaiji en-aut-sei=Murakami en-aut-mei=Taiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=IshinoKozo en-aut-sei=Ishino en-aut-mei=Kozo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=NakayamaHironobu en-aut-sei=Nakayama en-aut-mei=Hironobu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=KinoKoichi en-aut-sei=Kino en-aut-mei=Koichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=AraiSadahiko en-aut-sei=Arai en-aut-mei=Sadahiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=NakayamaYorikazu en-aut-sei=Nakayama en-aut-mei=Yorikazu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=SugawaraEiji en-aut-sei=Sugawara en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=SenooYoshimasa en-aut-sei=Senoo en-aut-mei=Yoshimasa kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=TeramotoShigeru en-aut-sei=Teramoto en-aut-mei=Shigeru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Okayama University affil-num=9 en-affil= kn-affil=Okayama University en-keyword=ventricular assist device kn-keyword=ventricular assist device en-keyword=postcaediotomy shock kn-keyword=postcaediotomy shock en-keyword=multiorgan failure kn-keyword=multiorgan failure END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=6 article-no= start-page=423 end-page=432 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Histochemical and immunohistochemical analyses of primary carcinoma of the liver. en-subtitle= kn-subtitle= en-abstract= kn-abstract=Hematoxylin and eosin (H-E) stained liver sections of 47 autopsy cases of hepatic malignancies were examined. There were 43 cases of hepatocellular carcinoma (subtypes of 30 trabecular, 7 solid, 5 pseudoglandular, and one scirrhous carcinoma), 3 of cholangiocellular carcinoma and one of mixed carcinoma. After immunohistochemical staining, benign hepatocytes reacted positively with anti-epithelial membrane antigen (EMA). Hepatocellular carcinoma cells reacted more weakly than benign hepatocytes. It was noted that the microtubular structure, which could not be demonstrated even by alcian blue or cationic ferric hydroxide colloid stabilized with cacodylate (Fe-CaC), was clearly detected with anti-EMA. The EMA-positive microtubular structures may indicate terminal cholangiolar differentiation. Based on EMA, seven more cases formerly classified as hepatocellular carcinoma by H-E were reclassified as mixed carcinoma, totaling eight (17.0%). The histologic classification of "mixed carcinoma" has been 1.5 to 2.0% of primary liver cancers in Japan, but we suggest there may be more cases of "mixed carcinoma" identified in the future. In conclusion, we emphasize that EMA staining is useful for more accurate classification of hepatic tumors.
en-copyright= kn-copyright= en-aut-name=SachoMasanori en-aut-sei=Sacho en-aut-mei=Masanori kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SetsuKoujun en-aut-sei=Setsu en-aut-mei=Koujun kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=HayashiKeiki en-aut-sei=Hayashi en-aut-mei=Keiki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama University affil-num=3 en-affil= kn-affil=Okayama University en-keyword=primary liver carcinoma kn-keyword=primary liver carcinoma en-keyword=immunohistochemistry kn-keyword=immunohistochemistry en-keyword=histochemistory kn-keyword=histochemistory en-keyword=epithelial membrane antigen kn-keyword=epithelial membrane antigen END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=6 article-no= start-page=409 end-page=416 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Aldehyde dehydrogenase deficiency, flush patterns and prevalence of alcoholism: an interethnic comparison. en-subtitle= kn-subtitle= en-abstract= kn-abstract=A study was performed to verify that the prevalence of alcohol abuse and dependence in Formosan aborigines differs from that of Taiwanese (Chinese Han people), using analysis of aldehyde dehydrogenase (ALDH) isozymes and flush patterns on randomly sampled 70 Atayal, 66 Paiwan, 61 Yami and 94 Taiwanese subjects were studied. The activity of an isomer of ALDH having a low Km (ALDH-I) in hair roots was analysed by isoelectric focusing assay. The subjective experience of flushing response after alcohol ingestion was assessed. Results showed that the rate of ALDH-I deficiency in Taiwanese (51.1%) was significantly higher than in aborigines, i.e., 6.4%, 3.9%, and 0% in Atayal, Paiwan, and Yami subjects, respectively. The percentage occurrence of ALDH-I deficiency and prevalence of alcohol dependence in Taiwanese and aborigines were negatively correlated. The predominant pattern of self-reported flush response after alcohol use among aborigines was of slow onset. The flush response to alcohol ingestion was examined in relation to aldehyde metabolizing enzyme. Since alcohol sensitivity is an important factor in the development and maintenance of the alcohol ingestion habit in humans, our results support the hypothesis that there is a biological basis in the different rates of alcohol abuse and dependence among different ethnic groups.
en-copyright= kn-copyright= en-aut-name=ChenChiao-Chicy en-aut-sei=Chen en-aut-mei=Chiao-Chicy kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HwuHai-Gwo en-aut-sei=Hwu en-aut-mei=Hai-Gwo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=YehEng-Kung en-aut-sei=Yeh en-aut-mei=Eng-Kung kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=MorimotoKiyoshi en-aut-sei=Morimoto en-aut-mei=Kiyoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=OtsukiSaburo en-aut-sei=Otsuki en-aut-mei=Saburo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= affil-num=1 en-affil= kn-affil=Taipei City Psychiatric Center affil-num=2 en-affil= kn-affil=College of Medicine affil-num=3 en-affil= kn-affil=College of Medicine affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University en-keyword=aldehyde dehydrogenase deficiency kn-keyword=aldehyde dehydrogenase deficiency en-keyword=flush patterns kn-keyword=flush patterns en-keyword=prevalence of alcoholism kn-keyword=prevalence of alcoholism en-keyword=Taiwanese kn-keyword=Taiwanese en-keyword=aborigines kn-keyword=aborigines END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=6 article-no= start-page=451 end-page=456 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=An autopsy case of spinal arteriovenous malformation (Foix-Alajouanine syndrome). en-subtitle= kn-subtitle= en-abstract= kn-abstract=An autopsy case of spinal arteriovenous malformation (AVM) was reported. The patient was a 75-year-old male and his initial neurologic symptoms were paraplegia, paresthesia below the umbilical level and urination difficulty. Subsequently night delirium and parkinsonism also appeared. The clinical and pathological findings in this case are identical with those in the spinal AVM except for Parkinson's disease. In addition, the lateral funiculus of the spinal cord in the middle thoracic segment showed pallor: Under light microscopy, the funiculus was spongiform, with a thinner wall of the myelin sheath, enlargement of the axon and the perivascular infiltration of phagocytes without plasma exudation. The changes in the lateral funiculus seemed to indicate early congestive changes.
en-copyright= kn-copyright= en-aut-name=KurodaShigetoshi en-aut-sei=Kuroda en-aut-mei=Shigetoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HayashiYasuaki en-aut-sei=Hayashi en-aut-mei=Yasuaki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=IshizuHideki en-aut-sei=Ishizu en-aut-mei=Hideki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=OdaTeruyuki en-aut-sei=Oda en-aut-mei=Teruyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=KuyamaKeisuke en-aut-sei=Kuyama en-aut-mei=Keisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=OtsukiSuburo en-aut-sei=Otsuki en-aut-mei=Suburo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Okayama National Hospital affil-num=3 en-affil= kn-affil=Okayama University affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University en-keyword=Foex-Alajouanine syndrome kn-keyword=Foex-Alajouanine syndrome en-keyword=mid-thoracic lesion kn-keyword=mid-thoracic lesion en-keyword=early congestive change kn-keyword=early congestive change END start-ver=1.4 cd-journal=joma no-vol=45 cd-vols= no-issue=6 article-no= start-page=445 end-page=449 dt-received= dt-revised= dt-accepted= dt-pub-year=1991 dt-pub=199112 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A human T cell leukemia virus type-I carrier with recurrent thrombocytopenia and various autoantibodies. en-subtitle= kn-subtitle= en-abstract= kn-abstract=A 34-year-old woman infected with human T cell leukemia virus type-I(HTLV-I) with recurrent thrombocytopenia and various autoantibodies is described. The platelet counts fluctuated between 1.3 x 10(4)/microliters and 14.8 x 10(4)/microliters without any medical treatment, and thrombocytopenia improved with a decrease of platelet-associated IgG (PA-IgG). Autoantibodies such as rheumatoid factor, antinuclear factor, anti-Sm, anti-RNP and anti-SSA antibodies were also recognized. Marker analysis of peripheral mononuclear cells showed an increase in the proportion of CD 25+ cells, CD 3+ HLA-DR+ cells, CD4+ HLA-DR+ cells and CD8+ HLA-DR+ cells. The recurrent thrombocytopenia and development of various autoantibodies in this HTLV-I carrier are speculated to be due to the alteration of B cell functions by T cells infected with HTLV-I.
en-copyright= kn-copyright= en-aut-name=TakahashiIsao en-aut-sei=Takahashi en-aut-mei=Isao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=SanoMasayuki en-aut-sei=Sano en-aut-mei=Masayuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=OkamotoHideyuki en-aut-sei=Okamoto en-aut-mei=Hideyuki kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShiromotoMasayoshi en-aut-sei=Shiromoto en-aut-mei=Masayoshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=NakamuraToru en-aut-sei=Nakamura en-aut-mei=Toru kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=UenoKatsumi en-aut-sei=Ueno en-aut-mei=Katsumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=NakadaHiroshi en-aut-sei=Nakada en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HarutaYuro en-aut-sei=Haruta en-aut-mei=Yuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=SetoTakumi en-aut-sei=Seto en-aut-mei=Takumi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamashitaJiro en-aut-sei=Yamashita en-aut-mei=Jiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=YorimitsuSeiichi en-aut-sei=Yorimitsu en-aut-mei=Seiichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=MiyakeSusumu en-aut-sei=Miyake en-aut-mei=Susumu kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=MachidaKenichi en-aut-sei=Machida en-aut-mei=Kenichi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= en-aut-name=KondaKeiji en-aut-sei=Konda en-aut-mei=Keiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=14 ORCID= en-aut-name=TamuraTetuo en-aut-sei=Tamura en-aut-mei=Tetuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=15 ORCID= en-aut-name=ImajouKenji en-aut-sei=Imajou en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=16 ORCID= en-aut-name=KimuraIkuro en-aut-sei=Kimura en-aut-mei=Ikuro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=17 ORCID= affil-num=1 en-affil= kn-affil=Okayama University affil-num=2 en-affil= kn-affil=Kochi Municipal Central Hospital affil-num=3 en-affil= kn-affil=Kochi Municipal Central Hospital affil-num=4 en-affil= kn-affil=Okayama University affil-num=5 en-affil= kn-affil=Okayama University affil-num=6 en-affil= kn-affil=Okayama University affil-num=7 en-affil= kn-affil=Okayama University affil-num=8 en-affil= kn-affil=Kochi Municipal Central Hospital affil-num=9 en-affil= kn-affil=Kochi Municipal Central Hospital affil-num=10 en-affil= kn-affil=Okayama University affil-num=11 en-affil= kn-affil=Kochi Municipal Central Hospital affil-num=12 en-affil= kn-affil=Kochi Municipal Central Hospital affil-num=13 en-affil= kn-affil=Kochi Municipal Central Hospital affil-num=14 en-affil= kn-affil=Kochi Municipal Central Hospital affil-num=15 en-affil= kn-affil=Kochi Municipal Sukumo Hospital affil-num=16 en-affil= kn-affil=Okayama University affil-num=17 en-affil= kn-affil=Okayama University en-keyword=recurrent thrombocytopenia kn-keyword=recurrent thrombocytopenia en-keyword=HTLV-I kn-keyword=HTLV-I en-keyword=HTLV-I carier kn-keyword=HTLV-I carier END