JaLCDOI 10.18926/AMO/31891
FullText URL fulltext.pdf
Author Kimura, Ikuro| Miyake, Tsuyoshi| Kodani, Ri-ichi|
Abstract

The serum iron contents and the number of sideroblasts from various patients and the radioactivity of erythroblasts from the same patients incubated with Fe55 have been observed. The results have proved that in the case with accelerated erythropoietic function like polycythemia vera and in the iron deficient state like idiopathic hypochromic anemia, the serum iron level and the number of sideroblast are lower than those in normal persons and higher in radioactivity in erythroblasts, whereas in the case with low erythropoietic function like hypoplastic anemia the former values are higher and lower in radioactivity of erythroblasts. There is an inverse correlation between the average number of stainable iron granules and the average rate of radioactive iron appearance in erythroblasts, and the observation on these factors will give an important clue for judging the utilization process of iron in each disease. The limitation of the iron uptake correlating with the hemoglobin synthesis have been discussed.

Amo Type Article
Publication Title Acta Medicinae Okayama
Published Date 1960-06
Volume volume14
Issue issue2
Publisher Okayama University Medical School
Start Page 105
End Page 117
NCID AA00041342
Content Type Journal Article
language English
File Version publisher
Refereed True
NAID 120002312392
JaLCDOI 10.18926/AMO/31892
FullText URL fulltext.pdf
Author Yamamoto, Sinro|
Abstract

1. Adrenalin, when acting directly on eosinophils, brings about a diminution in the wandering velocity of eosinophils but it has no influence on the number of the cells. Judging from the movement patterns of eosinophils this drug acts as to impede the motive function. 2. Acting directly on eosinophils, cortisone markedly decreases the wandering velocity of these cells and also brings about the diminution in the number of the cells. Likewise from the movement patterns of eosinophils, this drug markedly impedes the motive function of the cells. 3. ACTH (adrenocorticotropic hormone), when acting directly on eosinophils, enhances the wandering velocity of eosinophils but it in no way affects the number of eosinophils. Judging from the eosinophil movement patterns, this drug markedly promotes the motive function. 4. Although adrenalin brings about a decrease in the number of peripheral eosinophils in hypophysectomized dogs, the rate of the decrease is less than that observable in the case of normal dogs. 5. Cortisone brings about no significant change in the number of peripheral eosinophils in hypophysectomized dogs, but is induces a decrease in peripheral eosinophils of normal dogs. 6. ACTH acts as to decrease the number of peripheral eosinophils to an equal. degree in both hypophysectomized and normal dogs. 7. When cortisone is administered simultaneously with Adrex, a marked decrease in peripheral eosinophils is brought about in hypophysectomized dogs. 8. By means of the bone-marrow tissue culture of hypophysectomized dogs it has been confirmed that the blood plasma of hypophysectomized dogs lacks an essential factor for cortisone to induce eosinopenia in perpheral blood. 9. The decrease in eosinophils of peripheral blood induced by cortisone has been proved to be dependent upon the presence or absence of the pituitary body. 10. Taking the decrease in peripheral eosinophils by cortisone administration as the criterion, the author has carried out clinical observations with this method and obtained anticipated results.

Amo Type Article
Publication Title Acta Medicinae Okayama
Published Date 1960-06
Volume volume14
Issue issue2
Publisher Okayama University Medical School
Start Page 118
End Page 138
NCID AA00041342
Content Type Journal Article
language English
File Version publisher
Refereed True
NAID 120002312415
JaLCDOI 10.18926/AMO/31893
FullText URL fulltext.pdf
Author Kimoto, Tetsuo| Utsumi, Kozo| Matsuoka, Iwao| Seno, Satimaru|
Abstract

By the repeated injection of RNase into mice the histological, cytochemical and electronmicroscope observations of several tissues and the quantitative estimation of DNA contents per cell in liver have been conducted. The observations proved that the most marked changes occur in basophilia, ER (endoplasmic reticulum) and Palade's granules; the dissociation of the granules from ER and their agglomeration, and the final disappearance of the granules and ER. The increase of the granules in number surrounding the nucleus seen in liver cells and the appearance of the ring form ER in the pancreatic exocrine cells and its development from the nuclear membrane have been traced morphologically and these are comprehended as the regenerating picture of ER and granules from the nuclear outer membrane. DNA contents in liver cell increase in the early stage and decrease to the normal level in the later stage. The former is attributed to the cessation of mitosis by the damage of cell center without interference on DNA synthesis and the latter to the disappearance of the cells of tetraproidy by degeneration.

Amo Type Article
Publication Title Acta Medicinae Okayama
Published Date 1960-06
Volume volume14
Issue issue2
Publisher Okayama University Medical School
Start Page 77
End Page 103
NCID AA00041342
Content Type Journal Article
language English
File Version publisher
Refereed True
NAID 120002312732