start-ver=1.4
cd-journal=joma
no-vol=96
cd-vols=
no-issue=4-1
article-no=
start-page=042410
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=20171019
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Numerical calculation on a two-step subdiffusion behavior of lateral protein movement in plasma membranes
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= A two-step subdiffusion behavior of lateral movement of transmembrane proteins in plasma membranes has been observed by using single-molecule experiments. A nested double-compartment model where large compartments are divided into several smaller ones has been proposed in order to explain this observation. These compartments are considered to be delimited by membrane-skeleton "fences" and membrane-protein "pickets" bound to the fences. We perform numerical simulations of a master equation using a simple two-dimensional lattice model to investigate the heterogeneous diffusion dynamics behavior of transmembrane proteins within plasma membranes. We show that the experimentally observed two-step subdiffusion process can be described using fence and picket models combined with decreased local diffusivity of transmembrane proteins in the vicinity of the pickets. This allows us to explain the two-step subdiffusion behavior without explicitly introducing nested double compartments.
en-copyright=
kn-copyright=

en-aut-name=SumiTomonari
en-aut-sei=Sumi
en-aut-mei=Tomonari
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OkumotoAtsushi
en-aut-sei=Okumoto
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=GotoHitoshi
en-aut-sei=Goto
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=SekinoHideo
en-aut-sei=Sekino
en-aut-mei=Hideo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

affil-num=1
en-affil=Research Institute for Interdisciplinary Science and Department of Chemistry, Faculty of Science, Okayama University
kn-affil=

affil-num=2
en-affil= Department of Computer Science and Engineering, Graduate School of Engineering, Toyohashi University of Technology
kn-affil=

affil-num=3
en-affil= Department of Computer Science and Engineering, Graduate School of Engineering, Toyohashi University of Technology
kn-affil=

affil-num=4
en-affil= Department of Computer Science and Engineering, Graduate School of Engineering, Toyohashi University of Technology
kn-affil=
END