start-ver=1.4
cd-journal=joma
no-vol=42
cd-vols=
no-issue=1
article-no=
start-page=11
end-page=19
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=201301
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Utility of Contrast-Enhanced FDG-PET/CT in the Clinical Management of Pancreatic Cancer Impact on Diagnosis, Staging, Evaluation of Treatment Response, and Detection of Recurrence
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Objectives: Fluorodeoxyglucose (FDG)-positron emission tomography/contrast-enhanced computed tomography (PET/CE-CT) involving whole-body scanning first by non-CE-CT and FDG-PET followed by CE-CT has been used for detailed examination of pancreatic lesions. We evaluated PET/CE-CT images with regard to differential diagnosis, staging, treatment response, and postoperative recurrence in pancreatic cancer. 

Methods: Positron emission tomography/CE-CT was conducted in 108 patients with pancreatic cancer and in 41 patients with other pancreatic tumor diseases. 

Results: The maximum standardized uptake value (SUVmax) overlapped in benign and malignant cases, suggesting that differential diagnosis of pancreatic tumors based on the SUVmax is difficult. In the evaluation of staging in 31 resectable pancreatic cancer by PET/CE-CT, the diagnostic accuracy rate was more than 80% for most factors concerning local invasion and 94% for distant metastasis but only 42% for lymph node metastasis. Significant positive correlations were found between the SUVmax and tumor size/markers, suggesting that SUVmax may be a useful indicator for the treatment response. Regarding the diagnosis of the postoperative recurrence, PET/CE-CT correctly detected local recurrence in all the 11 cases of recurrence, whereas abdominal CE-CT detected only 7 of 11 cases, suggesting that PET/CE-CT is superior in this context. 

Conclusions: Positron emission tomography/CE-CT is useful for the clinical management of pancreatic cancer.
en-copyright=
kn-copyright=

en-aut-name=AsagiAkinori
en-aut-sei=Asagi
en-aut-mei=Akinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=OhtaKoji
en-aut-sei=Ohta
en-aut-mei=Koji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NasuJunichirou
en-aut-sei=Nasu
en-aut-mei=Junichirou
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TanadaMinoru
en-aut-sei=Tanada
en-aut-mei=Minoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NadanoSeijin
en-aut-sei=Nadano
en-aut-mei=Seijin
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=NishimuraRieko
en-aut-sei=Nishimura
en-aut-mei=Rieko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TeramotoNorihiro
en-aut-sei=Teramoto
en-aut-mei=Norihiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=YamamotoKazuhide
en-aut-sei=Yamamoto
en-aut-mei=Kazuhide
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=InoueTakeshi
en-aut-sei=Inoue
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=IguchiHaruo
en-aut-sei=Iguchi
en-aut-mei=Haruo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=Shikoku Canc Ctr, Dept Gastroenterol

affil-num=2
en-affil=
kn-affil=Shikoku Canc Ctr, Dept Surg Gastroenterol

affil-num=3
en-affil=
kn-affil=Shikoku Canc Ctr, Dept Gastroenterol

affil-num=4
en-affil=
kn-affil=Shikoku Canc Ctr, Dept Surg Gastroenterol

affil-num=5
en-affil=
kn-affil=Shikoku Canc Ctr, Dept Gastroenterol

affil-num=6
en-affil=
kn-affil=Shikoku Canc Ctr, Dept Pathol

affil-num=7
en-affil=
kn-affil=Shikoku Canc Ctr, Dept Pathol

affil-num=8
en-affil=
kn-affil=Okayama Univ, Grad Sch Med, Dept Gastroenterol & Hepatol

affil-num=9
en-affil=
kn-affil=Shikoku Canc Ctr, Dept Diagnost Radiol

affil-num=10
en-affil=
kn-affil=Shikoku Canc Ctr, Dept Gastroenterol
en-keyword=contrast-enhanced PET/CT
kn-keyword=contrast-enhanced PET/CT
en-keyword=differential diagnosis
kn-keyword=differential diagnosis
en-keyword=clinical management
kn-keyword=clinical management
en-keyword=pancreatic cancer
kn-keyword=pancreatic cancer
END