start-ver=1.4 cd-journal=joma no-vol=116 cd-vols= no-issue=10 article-no= start-page=2146 end-page=2154 dt-received= dt-revised= dt-accepted= dt-pub-year=2015 dt-pub=20150421 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Role and Regulation of Myeloid Zinc Finger Protein 1 in Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract= Myeloid zinc finger 1 (MZF1) belongs to the SCAN-Zinc Finger (SCAN-ZF) transcription factor family that has recently been implicated in a number of types of cancer. Although the initial studies concentrated on the role of MZF1 in myeloid differentiation and leukemia, the factor now appears to be involved in the etiology of major solid tumors such as lung, cervical, breast, and colorectal cancer. Here we discuss the regulation of MZF1 that mediated its recruitment and activation in cancer, concentrating on posttranslational modification by phosphorylation, and sumoylation, formation of promyelocytic leukemia nuclear bodies and its association with co-activators and co-repressors. en-copyright= kn-copyright= en-aut-name=Eguchi Taka en-aut-sei=Eguchi en-aut-mei=Taka kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=PrinceThomas en-aut-sei=Prince en-aut-mei=Thomas kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=WegielBarbara en-aut-sei=Wegiel en-aut-mei=Barbara kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=CalderwoodStuart K. en-aut-sei=Calderwood en-aut-mei=Stuart K. kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= affil-num=1 en-affil=Department of Dental Pharmacology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University kn-affil= affil-num=2 en-affil=Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute kn-affil= affil-num=3 en-affil=Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School kn-affil= affil-num=4 en-affil=Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School kn-affil= en-keyword=CANCER kn-keyword=CANCER en-keyword=FINGER-1 kn-keyword=FINGER-1 en-keyword=INVASION kn-keyword=INVASION en-keyword=MYELOID kn-keyword=MYELOID en-keyword=NUCLEAR BODY kn-keyword=NUCLEAR BODY en-keyword=SUMO kn-keyword=SUMO en-keyword=ZINC kn-keyword=ZINC END