start-ver=1.4
cd-journal=joma
no-vol=74
cd-vols=
no-issue=1
article-no=
start-page=983
end-page=989
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2007
dt-pub=20071231
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=An Efficient, One-Pot Synthesis of Fosfomycin Dialkyl Esters from (R)-2-Tosyloxypropanal
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=(R)-2-Tosyloxypropanal (4) was prepared from D-mannitol in a 7-step sequence (51% overall yield). Addition of dialkyl phosphonates to 4 in the presence of titanium isopropoxide and the subsequent treatment with DBU stereoselectively afforded, in one-pot, fosfomycin dimethyl (5a) and dibenzyl (5b) esters both in 58% isolated yield.
en-copyright=
kn-copyright=

en-aut-name=HanayaTadashi
en-aut-sei=Hanaya
en-aut-mei=Tadashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakamuraYuichi
en-aut-sei=Nakamura
en-aut-mei=Yuichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=YamamotoHiroshi
en-aut-sei=Yamamoto
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Okayama University

affil-num=2
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Okayama University

affil-num=3
en-affil=
kn-affil=Department of Chemistry, Faculty of Science, Okayama University
en-keyword=Fosfomycin
kn-keyword=Fosfomycin
en-keyword=Epoxidation
kn-keyword=Epoxidation
en-keyword=C-P Bond Formation
kn-keyword=C-P Bond Formation
en-keyword=Phosphonate Addition
kn-keyword=Phosphonate Addition
en-keyword=Diastereoselectivity
kn-keyword=Diastereoselectivity
END