start-ver=1.4
cd-journal=joma
no-vol=243
cd-vols=
no-issue=
article-no=
start-page=313
end-page=321
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2013
dt-pub=20130415
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Effect of GBR12909 on affective behavior: Distinguishing motivational behavior from antidepressant-like and addiction-like behavior using the runway model of intracranial self-stimulation
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Rationale: It was recently demonstrated that the priming stimulation effect (PSE) in the runway model of intracranial self-stimulation (ICSS) can be used as a model system to study the motivational effects of drugs. However, the characteristics of this navel experimental model have not been fully clarified. 

Objective: To elucidate the involvement of dopamine uptake inhibition in motivated behavior and the difference in experimental characteristics between closely related experimental models, we investigated the effects of the dopamine uptake inhibitor GBR12909 in the runway ICSS model, in the forced swimming test (FST), and on conditioned place preference (CPP). In addition, the role of dopamine receptor signaling in the runway model was evaluated using dopamine receptor agonists and antagonists. 

Results: GBR12909 dose-dependently increased running speed on the runway and decreased immobility time in the FST without affecting the time spent in the drug-associated compartment in CPP tests. The effect of GBR12909 in the runway model was inhibited by pre-treatment with the dopamine receptor antagonists haloperidol and raclopride. The dopamine receptor agonists SKF38393 and quinpirole dose-dependently decreased running speed.

Conclusions: These results demonstrate that GBR12909 displays motivation-enhancing and antidepressant-like effects without place conditioning effects. In addition, the mechanisms of PSE enhancement in the runway ICSS model are different from those underlying closely associated experimental models and are mediated by increases in dopamine signaling.
en-copyright=
kn-copyright=

en-aut-name=EsumiSatoru
en-aut-sei=Esumi
en-aut-mei=Satoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=SagaraHidenori
en-aut-sei=Sagara
en-aut-mei=Hidenori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakamotoAkihiko
en-aut-sei=Nakamoto
en-aut-mei=Akihiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=KawasakiYoichi
en-aut-sei=Kawasaki
en-aut-mei=Yoichi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=GomitaYutaka
en-aut-sei=Gomita
en-aut-mei=Yutaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=SendoToshiaki
en-aut-sei=Sendo
en-aut-mei=Toshiaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Pharmacy, Okayama University Hospital

affil-num=2
en-affil=
kn-affil=Department of Pharmaceutical Information Sciences, Matsuyama University

affil-num=3
en-affil=
kn-affil=Department of Pharmacy, Okayama University Hospital

affil-num=4
en-affil=
kn-affil=Department of Pharmacy, Okayama University Hospital

affil-num=5
en-affil=
kn-affil=School of Pharmacy, Shujitsu University

affil-num=6
en-affil=
kn-affil=Department of Pharmacy, Okayama University Hospital
en-keyword=Motivation
kn-keyword=Motivation
en-keyword=Intracranial Self-stimulation
kn-keyword=Intracranial Self-stimulation
en-keyword=Forced swimming test
kn-keyword=Forced swimming test
en-keyword=Conditioned place preference
kn-keyword=Conditioned place preference
en-keyword=GBR12909
kn-keyword=GBR12909
en-keyword=Quinpirole
kn-keyword=Quinpirole
END