start-ver=1.4
cd-journal=joma
no-vol=3
cd-vols=
no-issue=
article-no=
start-page=
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2003
dt-pub=20031021
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=No association between the sigma receptor type 1 gene and schizophrenia: results of analysis and meta-analysis of case-control studies
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=<p><b>Background:</b> Several lines of evidence have supported possible roles of the sigma receptors in the etiology of schizophrenia and mechanisms of antipsychotic efficacy. An association study provided genetic evidence that the sigma receptor type 1 gene (SIGMAR1) was a possible susceptibility factor for schizophrenia, however, it was not replicated by a subsequent study. It is necessary to evaluate further the possibility that the SIGMAR1 gene is associated with susceptibility to schizophrenia.
Methods: A case-control association study between two polymorphisms of the SIGMAR1 gene, G-241T/C-240T and Gln2Pro, and schizophrenia in Japanese population, and meta-analysis including present and previous studies.<br />
<b>Results:</b>There was no significant association of any allele or genotype of the polymorphisms with schizophrenia. Neither significant association was observed with hebephrenic or paranoid subtype of schizophrenia. Furthermore, a meta-analysis including the present and previous studies comprising 779 controls and 636 schizophrenics also revealed no significant association between the SIGMAR1 gene and schizophrenia.<br />
<b>Conclusion:</b> In view of this evidence, it is likely that the SIGMAR1 gene does not confersusceptibility to schizophrenia.</p>
en-copyright=
kn-copyright=

en-aut-name=UchidaNaohiko
en-aut-sei=Uchida
en-aut-mei=Naohiko
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=UjikeHiroshi
en-aut-sei=Ujike
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=NakataKenji
en-aut-sei=Nakata
en-aut-mei=Kenji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TakakiManabu
en-aut-sei=Takaki
en-aut-mei=Manabu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NomuraAkira
en-aut-sei=Nomura
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KatsuTakeshi
en-aut-sei=Katsu
en-aut-mei=Takeshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=TanakaYuji
en-aut-sei=Tanaka
en-aut-mei=Yuji
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=ImamuraTakaki
en-aut-sei=Imamura
en-aut-mei=Takaki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=SakaiAyumu
en-aut-sei=Sakai
en-aut-mei=Ayumu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=KurodaShigetoshi
en-aut-sei=Kuroda
en-aut-mei=Shigetoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=
kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry

affil-num=2
en-affil=
kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry

affil-num=3
en-affil=
kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry

affil-num=4
en-affil=
kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry

affil-num=5
en-affil=
kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry

affil-num=6
en-affil=
kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry

affil-num=7
en-affil=
kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry

affil-num=8
en-affil=
kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry

affil-num=9
en-affil=
kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry

affil-num=10
en-affil=
kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry
END