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ID 46937
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Author
Irie, Koichiro
Ekuni, Daisuke ORCID Kakenhi
Endo, Yasumasa
Kasuyama, Kenta
Morita, Manabu Kakenhi
Abstract
Objectives: Brain-derived neurotrophic factor (BDNF), which is produced in rat submandibular gland, is one of the most abundant neurotrophins in the central nervous system. It is generally accepted that occlusal disharmony causes stress. The purpose of the present study was to investigate whether occlusal disharmony-induced chronic stress affects BDNF levels and morphology in rat submandibular gland. Design: Eight wks old male Wistar rats (n = 21) were randomly divided into three groups of 7 rats. In a control (C) group, the rats received no treatment for 8 wks. In a molar cusp-less (OD) group, maxillary molar cusps were cut off with a dental turbine at baseline and kept for 8 wks. In a molar cusp-less + recovered cusp (OR) group, maxillary molar cusps were cut off and then were recovered after 4 wks using resin material. After the experimental period, expression of BDNF mRNA and protein as well as histological findings were evaluated in the submandibular glands. The comparisons between the groups were made using the Mann-Whitney U test with Bonferroni correction. Results: The OD group showed a significant increase in submandibular gland BDNF mRNA and protein expression after 8 wks, and plasma adrenocorticotropic hormone and corticosterone levels increased in a time-dependent manner. There were no significant differences in BDNF expression in the submandibular glands and in levels of plasma adrenocorticotropic hormone and corticosterone between the OR and C groups. Conclusions: These results indicate that psychological stress induced by occlusal disharmony reversibly induces BDNF expression in the rat submandibular gland.
Keywords
Occlusal disharmony
Brain-derived neurotrophic factor
Submandibular gland
Stress
Published Date
2011-01
Publication Title
Archives of Oral Biology
Volume
volume56
Issue
issue1
Publisher
Pergamon-Elsevier Science Ltd.
Start Page
35
End Page
40
ISSN
0003-9969
NCID
AA00548457
Content Type
Journal Article
language
英語
Copyright Holders
© 2010 Elsevier Ltd. All rights reserved.
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Refereed
True
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