start-ver=1.4 cd-journal=joma no-vol=54 cd-vols= no-issue=2 article-no= start-page=117 end-page=141 dt-received= dt-revised= dt-accepted= dt-pub-year=2018 dt-pub=20180419 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Microfluidic paper-based analytical devices with instrument-free detection and miniaturized portable detectors en-subtitle= kn-subtitle= en-abstract= kn-abstract= icrofluidic paper-based analytical devices (mu PADs) have attracted much attention over the past decade because they offer clinicians the ability to deliver point-of-care testing and onsite analysis. Many of the advantages of mu PADs, however, are limited to work in a laboratory setting due to the difficulties of processing data when using electronic devices in the field. This review focuses on the use of mu PADs that have the potential to work without batteries or with only small and portable devices such as smartphones, timers, or miniaturized detectors. The mu PADs that can be operated without batteries are, in general, those that allow the visual judgment of analyte concentrations via readouts that are measured in time, distance, count, or text. Conversely, a smartphone works as a camera to permit the capture and processing of an image that digitizes the color intensity produced by the reaction of an analyte with a colorimetric reagent. Miniaturized detectors for electrochemical, fluorometric, chemiluminescence, and electrochemiluminescence methods are also discussed, although some of them require the use of a laptop computer for operation and data processing. en-copyright= kn-copyright= en-aut-name=KanetaTakashi en-aut-sei=Kaneta en-aut-mei=Takashi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=AlahmadWaleed en-aut-sei=Alahmad en-aut-mei=Waleed kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=VaranusupakulPakorn en-aut-sei=Varanusupakul en-aut-mei=Pakorn kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= affil-num=1 en-affil=Department of Chemistry, Graduate School of Natural Science and Technology, Okayama University kn-affil= affil-num=2 en-affil=Approaches for Food Applications Research Group, Faculty of Science, Chulalongkorn University kn-affil= affil-num=3 en-affil=Approaches for Food Applications Research Group, Faculty of Science, Chulalongkorn University kn-affil= en-keyword=Microfluidic paper-based analytical device kn-keyword=Microfluidic paper-based analytical device en-keyword=paper-based analytical device kn-keyword=paper-based analytical device en-keyword=point-of-care testing kn-keyword=point-of-care testing en-keyword=onsite analysis kn-keyword=onsite analysis END