start-ver=1.4
cd-journal=joma
no-vol=13
cd-vols=
no-issue=12
article-no=
start-page=6893
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2023
dt-pub=20230607
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Hydrothermal Preparation of Faceted Vesicles Made of Span 40 and Tween 40 and Their Characterization
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=The Span 40 (sorbitan monooleate)/Tween 40 (polyoxyethylene sorbitan monolaurate) system gives faceted vesicles with angular surfaces, rather than spherical vesicles. Herein, a continuous and facile preparation method, based on the subcritical water-assisted emulsification and solvent diffusion, was presented to yield faceted vesicles with two major and minor axes (Type A) and vesicles closer to a polyhedron (Type B). Type A, rather than Type B, vesicles were likely to be formed. From the measurements concerning & zeta;-potential, membrane fluidity, and the polarization environment of the membranes, faceted vesicles could be obtained at 0.25 wt% of the surfactant concentration. The phase-separated behavior of Span 40 and Tween 40 within vesicle membranes could explain the structural feature of faceted vesicles and calcein leakage behavior. The significant advantage is that Type A vesicles would be utilized as alternative drug carriers for others with low encapsulation efficiency, although the present technical limitations cause difficulty in the selective formation of Type A and B vesicles and the selection of adequate solvent to accelerate the solvent diffusion step.
en-copyright=
kn-copyright=

en-aut-name=ShimanouchiToshinori
en-aut-sei=Shimanouchi
en-aut-mei=Toshinori
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=KomoriYui
en-aut-sei=Komori
en-aut-mei=Yui
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=ToramotoKazuki
en-aut-sei=Toramoto
en-aut-mei=Kazuki
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HayashiKeita
en-aut-sei=Hayashi
en-aut-mei=Keita
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=YasuharaKazuma
en-aut-sei=Yasuhara
en-aut-mei=Kazuma
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=JungHo-Sup
en-aut-sei=Jung
en-aut-mei=Ho-Sup
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=KimuraYukitaka
en-aut-sei=Kimura
en-aut-mei=Yukitaka
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

affil-num=1
en-affil=Department of Environmental Chemistry and Materials, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Environmental Chemistry and Materials, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Environmental Chemistry and Materials, Okayama University
kn-affil=

affil-num=4
en-affil=National Institute of Technology, Nara College
kn-affil=

affil-num=5
en-affil=Division of Materials Science, Nara Institute of Science and Technology (NAIST)
kn-affil=

affil-num=6
en-affil=Center for Food and Bioconvergence, Department of Food Science and Biotechnology, Seoul National University
kn-affil=

affil-num=7
en-affil=Department of Environmental Chemistry and Materials, Okayama University
kn-affil=
en-keyword=vesicles
kn-keyword=vesicles
en-keyword=subcritical water
kn-keyword=subcritical water
en-keyword=emulsification
kn-keyword=emulsification
en-keyword=solvent diffusion
kn-keyword=solvent diffusion
END