start-ver=1.4 cd-journal=joma no-vol=135B cd-vols= no-issue=1 article-no= start-page=5 end-page=9 dt-received= dt-revised= dt-accepted= dt-pub-year=2005 dt-pub=20050505 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=A functional glutathione S-transferase P1 gene polymorphism is associated with methamphetamine-induced psychosis in Japanese population en-subtitle= kn-subtitle= en-abstract= kn-abstract=Several lines of evidence suggest that oxidative stress plays a role in the mechanisms of action of methamphetamine (MAP) in the human brain. Given the role of glutathione S-transferases (GSTs) in the protection against oxidative stress, genes encoding the GSTs have been considered as candidates for association studies of MAP abuse. This study was undertaken to investigate the role of the functional polymorphism of GSTP1 gene exon 5 (Ile105Val) in the pathogenesis of MAP abuse. Genotyping for GSTP1 gene polymorphism exon 5 (Ile105Val) in 189 MAP abusers and 199 normal controls was performed by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP). Association between GSTP1 gene polymorphism and clinical features (prognosis of psychosis (transient-type and prolonged-type), spontaneous relapse (positive and negative), and poly-substance abuse) of MAP abusers was evaluated. Significant differences in the frequency of both alleles (P = 0.026, odds ratio: 1.70, 95% confidence intervals (CI) 1.06-2.72) and genotypes (P = 0.029) between MAP abusers and controls were detected. In particular, a significant difference in both genotype frequency (P = 0.013) and allele frequency (P = 0.014, odds ratio: 1.84, 95% CI 1.13-2.97) between MAP abusers with psychosis (transient-type and prolonged-type) and controls was detected. Our findings suggest that the polymorphism (Ile 105Val) on exon 5 of the GSTP1 gene may contribute to a vulnerability to psychosis associated with MAP abuse in Japanese population. en-copyright= kn-copyright= en-aut-name=HashimotoTasuku en-aut-sei=Hashimoto en-aut-mei=Tasuku kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=1 ORCID= en-aut-name=HashimotoKenji en-aut-sei=Hashimoto en-aut-mei=Kenji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=2 ORCID= en-aut-name=MatsuzakaDaisuke en-aut-sei=Matsuzaka en-aut-mei=Daisuke kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=3 ORCID= en-aut-name=ShimizuEiji en-aut-sei=Shimizu en-aut-mei=Eiji kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=4 ORCID= en-aut-name=SekineYoshimoto en-aut-sei=Sekine en-aut-mei=Yoshimoto kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=5 ORCID= en-aut-name=YoshiyaInada en-aut-sei=Yoshiya en-aut-mei=Inada kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=6 ORCID= en-aut-name=IwataNakao en-aut-sei=Iwata en-aut-mei=Nakao kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=7 ORCID= en-aut-name=HaranoMutsuo en-aut-sei=Harano en-aut-mei=Mutsuo kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=8 ORCID= en-aut-name=KomiyamaTokutaro en-aut-sei=Komiyama en-aut-mei=Tokutaro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=9 ORCID= en-aut-name=YamadaMitsuhiko en-aut-sei=Yamada en-aut-mei=Mitsuhiko kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=10 ORCID= en-aut-name=SoraIchiro en-aut-sei=Sora en-aut-mei=Ichiro kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=11 ORCID= en-aut-name=UjikeHiroshi en-aut-sei=Ujike en-aut-mei=Hiroshi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=12 ORCID= en-aut-name=IyoMasaomi en-aut-sei=Iyo en-aut-mei=Masaomi kn-aut-name= kn-aut-sei= kn-aut-mei= aut-affil-num=13 ORCID= affil-num=1 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine affil-num=2 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine affil-num=3 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine affil-num=4 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine affil-num=5 en-affil= kn-affil=Department of Psychiatry and Neurology, Hamamatsu University School of Medicine affil-num=6 en-affil= kn-affil=Department of Psychiatry, Nagoya University Graduate School of Medicine affil-num=7 en-affil= kn-affil=Department of Psychiatry, Fujita Health University School of Medicine affil-num=8 en-affil= kn-affil=Department of Neuropsychiatry, Kurume University School of Medicine affil-num=9 en-affil= kn-affil=National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry (NCNP) affil-num=10 en-affil= kn-affil=National Institute of Mental Health, NCNP affil-num=11 en-affil= kn-affil=Division of Psychobiology, Tohoku University Graduate School of Medicine affil-num=12 en-affil= kn-affil=Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry affil-num=13 en-affil= kn-affil=Department of Psychiatry, Chiba University Graduate School of Medicine en-keyword=methamphetamine kn-keyword=methamphetamine en-keyword=psychosis kn-keyword=psychosis en-keyword=drug abuse kn-keyword=drug abuse en-keyword=genetic factor; polymorphism kn-keyword=genetic factor; polymorphism END