start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=10
article-no=
start-page=1435
end-page=1443
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2016
dt-pub=201604
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Predictive Values of Egg-Specific IgE by Two Commonly Used Assay Systems for the Diagnosis of Egg Allergy in Young Children: A Prospective Multicenter Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=Background: Specific IgE (sIgE) is often used to predict oral food challenge (OFC) outcomes in food allergy, but interpretation of the results may vary depending on the assay method employed and the patient population tested. The aim of this study was to use two commercial assay systems to determine egg-sIgE values predictive of allergy within the most common populations treated at pediatric clinics.
Methods: In a multicenter prospective study, 433 children with suspected or confirmed egg allergy underwent oral challenge (OFC) using cooked egg (CE) and raw egg (RE) powders to diagnose either true allergy in 1-year-old (group A, n = 220) or tolerance in 2- to 6-year-old (group B, n = 213). Egg white (EW)- and ovomucoid (OM)-sIgE values were measured using the ImmunoCAP(®) sIgE (ImmunoCAP) and the IMMULITE(®) 2000 3 gAllergy(™) (3gAllergy) systems. Children were recruited from six primary care clinics and 18 hospitals in Japan.
Results: Receiver-operating characteristic (ROC) curve analysis yielded similar areas under the curve (AUC) for the two assays (0.7-0.8). The optimal cutoff values and the probability curves (PCs) of the sIgE by the two assays to predict CE and RE OFC outcomes were determined for both groups. Values for 3gAllergy were higher than for ImmunoCAP; however, correlation of sIgE and predicted probability calculated by PCs were strong between the two methods.
Conclusions: Cutoff values and PCs for egg-sIgE established using both ImmunoCAP and 3gAllergy may be useful for predicting egg allergy in early childhood patient populations.
en-copyright=
kn-copyright=
en-aut-name=FuruyaK.
en-aut-sei=Furuya
en-aut-mei=K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=
en-aut-name=NagaoM.
en-aut-sei=Nagao
en-aut-mei=M.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=
en-aut-name=SatoY.
en-aut-sei=Sato
en-aut-mei=Y.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=
en-aut-name=ItoS.
en-aut-sei=Ito
en-aut-mei=S.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=
en-aut-name=FujisawaT.
en-aut-sei=Fujisawa
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=
en-aut-name=IPAD3g investigators
en-aut-sei=IPAD3g investigators
en-aut-mei=
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=
affil-num=1
en-affil=Allergy Center and Institute for Clinical Research, Mie National Hospital
kn-affil=
affil-num=2
en-affil=Allergy Center and Institute for Clinical Research, Mie National Hospital
kn-affil=
affil-num=3
en-affil=Department of Global Clinical Research, Graduate School of Medicine, Chiba University
kn-affil=
affil-num=4
en-affil=Department of Food Science and Nutrition, Faculty of Human Life and Science, Doshisha Women's College of Liberal Arts
kn-affil=
affil-num=5
en-affil=Allergy Center and Institute for Clinical Research, Mie National Hospital
kn-affil=
affil-num=6
en-affil=
kn-affil=
en-keyword=egg allergy
kn-keyword=egg allergy
en-keyword=oral food challenge
kn-keyword=oral food challenge
en-keyword=predictive value
kn-keyword=predictive value
en-keyword=probability curve
kn-keyword=probability curve
en-keyword=specific IgE
kn-keyword=specific IgE
END