start-ver=1.4
cd-journal=joma
no-vol=41
cd-vols=
no-issue=5
article-no=
start-page=816
end-page=823
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2008
dt-pub=2008
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Spaceflight results in increase of thick filament but not thin filament proteins in the paramyosin mutant of Caenorhabditis elegans
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=We have investigated the effect of microgravity during spaceflight on body-wall muscle fiber size and muscle proteins in the paramyosin mutant of Caenorhabditis elegans. Both mutant and wild-type strains were subjected to 10 days of microgravity during spaceflight and compared to ground control groups. No significant change in muscle fiber size or quantity of the protein was observed in wild-type worms; where as atrophy of body-wall muscle and an increase in thick filament proteins were observed in the paramyosin mutant unc-15(e73) animals after spaceflight. We conclude that the mutant with abnormal muscle responded to microgravity by increasing the total amount of muscle protein in order to compensate for the loss of muscle function.
en-copyright=
kn-copyright=

en-aut-name=AdachiR.
en-aut-sei=Adachi
en-aut-mei=R.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=TakayaT.
en-aut-sei=Takaya
en-aut-mei=T.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=KuriyamaK.
en-aut-sei=Kuriyama
en-aut-mei=K.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=HigashibataA.
en-aut-sei=Higashibata
en-aut-mei=A.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=IshiokaN.
en-aut-sei=Ishioka
en-aut-mei=N.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=KagawaH.
en-aut-sei=Kagawa
en-aut-mei=H.
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=
kn-affil=Laboratory of Bioscience, Faculty of Engineering, Iwate University

affil-num=2
en-affil=
kn-affil=Division of Translational Research, Kyoto Medical Center, National Hospital Organization

affil-num=3
en-affil=
kn-affil=Office of Space Flight and Operations, Japan Aerospace Exploration Agency

affil-num=4
en-affil=
kn-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency

affil-num=5
en-affil=
kn-affil=Institute of Space and Astronautical Science, Japan Aerospace Exploration Agency

affil-num=6
en-affil=
kn-affil=Biomolecular Science, Graduate School of Natural Science and Technology, Okayama University
en-keyword=Spaceflight
kn-keyword=Spaceflight
en-keyword=Microgravity
kn-keyword=Microgravity
en-keyword=Myosin heavy chain
kn-keyword=Myosin heavy chain
en-keyword=Paramyosin
kn-keyword=Paramyosin
en-keyword=C. elegans
kn-keyword=C. elegans
en-keyword=Mutation
kn-keyword=Mutation
END