start-ver=1.4
cd-journal=joma
no-vol=7
cd-vols=
no-issue=9
article-no=
start-page=1902089
end-page=
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2020
dt-pub=20200507
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Titanium as an Instant Adhesive for Biological Soft Tissue
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract=A variety of polymer‐ and ceramic‐based soft‐tissue adhesives have been developed as alternatives to surgical sutures, yet several disadvantages regarding the mechanical properties, biocompatibility, and handling hinder their further application particularly when applied for immobilization of implantable devices. Here, it is reported that a biocompatible and tough metal, titanium (Ti), shows instant and remarkable adhesion properties after acid treatment, demonstrated by ex vivo shear adhesion tests with mouse dermal tissues. Importantly, in vivo experiments demonstrate that the acid‐treated Ti can easily and stably immobilize a device implanted in the mouse subcutaneous tissue. Collectively, the acid‐treated Ti is shown as a solid‐state instant adhesive material for biological soft tissues, which can have diverse applications including immobilization of body‐implantable devices.
en-copyright=
kn-copyright=

en-aut-name=OkadaMasahiro
en-aut-sei=Okada
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HaraEmilio Satoshi
en-aut-sei=Hara
en-aut-mei=Emilio Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Yabetsushi
en-aut-sei=Yabe
en-aut-mei=tsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=OkadaKei
en-aut-sei=Okada
en-aut-mei=Kei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=ShibataYo
en-aut-sei=Shibata
en-aut-mei=Yo
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=Torii Yasuhiro
en-aut-sei=Torii 
en-aut-mei=Yasuhiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=NakanoTakayoshi
en-aut-sei=Nakano
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=MatsumotoTakuya
en-aut-sei=Matsumoto
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

affil-num=1
en-affil=Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Okayama University
kn-affil=

affil-num=5
en-affil=Department of Conservative Dentistry, Division of Biomaterials and Engineering, Showa University School of Dentistry
kn-affil=

affil-num=6
en-affil=Department of Comprehensive Dentistry, Okayama University Hospital
kn-affil=

affil-num=7
en-affil=Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University
kn-affil=

affil-num=8
en-affil=Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=
en-keyword=acid treatment
kn-keyword=acid treatment
en-keyword=adhesive
kn-keyword=adhesive
en-keyword=hydrophobic interaction
kn-keyword=hydrophobic interaction
en-keyword=soft tissue
kn-keyword=soft tissue
en-keyword=titanium
kn-keyword=titanium
END