start-ver=1.4
cd-journal=joma
no-vol=57
cd-vols=
no-issue=
article-no=
start-page=404
end-page=413
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201705
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Biocompatible nanostructured solid adhesives for biological soft tissues
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= Over the past few years, the development of novel adhesives for biological soft tissue adhesion has gained significant interest. Such adhesives should be non-toxic and biocompatible. In this study, we synthesized a novel solid adhesive using nanostructured hydroxyapatite (HAp) and evaluated its physical adhesion properties through in vitro testing with synthetic hydrogels and mouse soft tissues. The results revealed that HAp-nanoparticle dispersions and HAp-nanoparticle-assembled nanoporous plates showed efficient adhesion to hydrogels. Interestingly, the HAp plates showed different adhesive properties depending upon the shape of their nanoparticles. The HAp plate made up of 17 nm-sized nanoparticles showed an adhesive strength 2.2 times higher than that of the conventional fibrin glue for mouse skin tissues.
en-copyright=
kn-copyright=

en-aut-name=OkadaMasahiro
en-aut-sei=Okada
en-aut-mei=Masahiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=NakaiAkira
en-aut-sei=Nakai
en-aut-mei=Akira
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=Hara EmilioSatoshi
en-aut-sei=Hara Emilio
en-aut-mei=Satoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=TaguchiTetsushi
en-aut-sei=Taguchi
en-aut-mei=Tetsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=NakanoTakayoshi
en-aut-sei=Nakano
en-aut-mei=Takayoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=MatsumotoTakuya
en-aut-sei=Matsumoto
en-aut-mei=Takuya
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

affil-num=1
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=2
en-affil=Department of Biomaterials, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=3
en-affil=Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
kn-affil=

affil-num=4
en-affil=Polymeric Biomaterials Group, RCFM, National Institute for Materials Science
kn-affil=

affil-num=5
en-affil=Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University
kn-affil=

affil-num=6
en-affil=Department of Biomaterials, Okayama University
kn-affil=
en-keyword=Hydroxyapatite
kn-keyword=Hydroxyapatite
en-keyword=Nanoparticle
kn-keyword=Nanoparticle
en-keyword=Solid adhesive
kn-keyword=Solid adhesive
en-keyword=Wet adhesion
kn-keyword=Wet adhesion
END