start-ver=1.4
cd-journal=joma
no-vol=83
cd-vols=
no-issue=5
article-no=
start-page=914
end-page=922
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2019
dt-pub=20190217
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Mulberry juice freeze-dried powder attenuates the disease severity by the maintaining of colon mucosa in mice with DSS-induced acute colitis
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= This study aimed to evaluate the microbial compositions and gene expression related to inflammation in dextran sodium sulfate (DSS)-induced acute colitis and the effect of mulberry supplementation. Male BALB/c mice received a diet supplemented with mulberry juice freeze-dried powder (MFP) or not for 3 weeks. After 3 weeks, the mice received water containing 5% (w/v) DSS or not for 1 week. The disease activity index score in mice fed MFP was significantly decreased. A significant decrease in Bifidobacterium spp. and the Clostridium perfringens subgroup was observed in mice not fed MFP. The number of goblet cell and NLRP6 expression were observed in mice fed a diet supplemented with MFP compared with mice not fed MFP. These results may indicate that mulberry mitigates DSS-induced acute colitis by a changing the gut microbial flora and by improving mucosal conditions.
en-copyright=
kn-copyright=

en-aut-name=WangYang
en-aut-sei=Wang
en-aut-mei=Yang
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HatabuToshimitsu
en-aut-sei=Hatabu
en-aut-mei=Toshimitsu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

affil-num=1
en-affil=Graduate School of Environmental and Life Science , Okayama University
kn-affil=

affil-num=2
en-affil=Graduate School of Environmental and Life Science , Okayama University
kn-affil=
en-keyword=DSS-induced acute colitis
kn-keyword=DSS-induced acute colitis
en-keyword=Mulberry
kn-keyword=Mulberry
en-keyword=NLRP6 inflammasome
kn-keyword=NLRP6 inflammasome
en-keyword=goblet cell
kn-keyword=goblet cell
en-keyword=microbiota
kn-keyword=microbiota
END