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kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=一歯科医院におけるコーヌステレスコープ義歯と部分床義歯の予後調査の比較 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShimamuraKoichi en-aut-sei=Shimamura en-aut-mei=Koichi kn-aut-name=嶋村浩一 kn-aut-sei=嶋村 kn-aut-mei=浩一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=一次元および単分子磁性体の極低温電子物性 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KajiyoshiKoichi en-aut-sei=Kajiyoshi en-aut-mei=Koichi kn-aut-name=梶芳功系兆 kn-aut-sei=梶芳 kn-aut-mei=功系兆 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ラット創傷歯髄から単離したFIP-2 遺伝子の発現動態およびその炎症制御因子と細胞死に与える影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SenooKyoko en-aut-sei=Senoo en-aut-mei=Kyoko kn-aut-name=妹尾京子 kn-aut-sei=妹尾 kn-aut-mei=京子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ラットCYP2D1及びCYP2D2による位置選択的基質酸化反応におけるアミノ酸残基の役割 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KiryuKimio en-aut-sei=Kiryu en-aut-mei=Kimio kn-aut-name=吉栁公雄 kn-aut-sei=吉栁 kn-aut-mei=公雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=メロン果実の成熟関連形質とエチレンシグナル伝達系 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NishiyamaKiyomi en-aut-sei=Nishiyama en-aut-mei=Kiyomi kn-aut-name=西山精視 kn-aut-sei=西山 kn-aut-mei=精視 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ボツリヌスB型16S毒素のヒト腸管上皮細胞への結合活性の解析 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=JinYingji en-aut-sei=Jin en-aut-mei=Yingji kn-aut-name=金英姫 kn-aut-sei=金 kn-aut-mei=英姫 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=プラズマを利用した,窒化アルミニウム,炭化珪素,及び,窒化硼素膜作製手法の研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=MorikawaYuji en-aut-sei=Morikawa en-aut-mei=Yuji kn-aut-name=森川裕次 kn-aut-sei=森川 kn-aut-mei=裕次 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=フッ素徐放性ワンステップ接着システムのう蝕象牙質への接着性 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TyoKyouka en-aut-sei=Tyo en-aut-mei=Kyouka kn-aut-name=趙暁華 kn-aut-sei=趙 kn-aut-mei=暁華 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ビスフォスフォネートの局所投与による義歯床下組織の骨動態の変化に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HanadaShunshi en-aut-sei=Hanada en-aut-mei=Shunshi kn-aut-name=花田俊士 kn-aut-sei=花田 kn-aut-mei=俊士 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=トラクション性能に及ぼすクラウニングの影響 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SeesregdorjBayasgalan en-aut-sei=Seesregdorj en-aut-mei=Bayasgalan kn-aut-name=シュシュリックドルーチュバヤサガラン kn-aut-sei=シュシュリックドルーチュ kn-aut-mei=バヤサガラン aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=タガメと餌動物および捕食者間の種間相互作用に関する生態学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OhbaShinya en-aut-sei=Ohba en-aut-mei=Shinya kn-aut-name=大庭伸也 kn-aut-sei=大庭 kn-aut-mei=伸也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ソロ珪酸塩型層状結晶の構造歪に関する構造化学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OchiYasuo en-aut-sei=Ochi en-aut-mei=Yasuo kn-aut-name=越智康雄 kn-aut-sei=越智 kn-aut-mei=康雄 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=シリコン中の白金-水素複合欠陥における水素の運動に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=BaoNamula en-aut-sei=Bao en-aut-mei=Namula kn-aut-name=那木拉 kn-aut-sei=那 kn-aut-mei=木拉 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=ガスエンジンの燃焼排出物と性能特性に関する研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FukataniNobuhiko en-aut-sei=Fukatani en-aut-mei=Nobuhiko kn-aut-name=深谷信彦 kn-aut-sei=深谷 kn-aut-mei=信彦 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=エンドウ細胞壁における病原菌シグナル認識・応答機構の解析 -病原菌シグナルに応答するアポプラストCu/Zn-SODについて- en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KasaiTomonari en-aut-sei=Kasai en-aut-mei=Tomonari kn-aut-name=笠井智成 kn-aut-sei=笠井 kn-aut-mei=智成 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=わが国における治療決定過程の特質と手続的正義の研究 ―重症障害新生児の治療選択における医療的基準と当事者の支援― en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YamaguchiMieko en-aut-sei=Yamaguchi en-aut-mei=Mieko kn-aut-name=山口三重子 kn-aut-sei=山口 kn-aut-mei=三重子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=Vibrio vulnificus溶血毒素の分子生物学的研究 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SenoMitsutoshi en-aut-sei=Seno en-aut-mei=Mitsutoshi kn-aut-name=妹尾充敏 kn-aut-sei=妹尾 kn-aut-mei=充敏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=進行肺癌における胸水中EGFR遺伝子変異検索の有用性とゲフィチニブ臨床効果予測因子の検討 kn-title=Usefulness of EGFR mutation screening in pleural fluid to predict the clinical outcome of gefitinib treated patients with lung cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract=The importance of epidermal growth factor receptor (EGFR) gene mutation has been recognized in nonsmall cell lung cancer (NSCLC), requiring the standardization of mutation screening system including the kind of samples. Here, we examined the EGFR mutation status in 61 pleural fluid samples from NSCLC cases using direct sequencing, nonenriched PCR, mutant-enriched PCR and peptide nucleic acid-locked nucleic acid (PNA-LNA) PCR clamp assay. The mutant-enriched PCR assay detected 16 mutant cases. Among them, the nonenriched PCR assay failed to detect 3 mutant cases. Regarding the discrepancy between mutant-enriched PCR and PNA-LNA PCR clamp assays, 3 cases of exon19-deletions were detected only by mutant-enriched PCR assay and no difference at the L858R mutation. There was no difference in results between direct sequencing and nonenriched PCR assay. We also correlated the EGFR mutation with clinical outcome of gefitinib-treated 29 cases. EGFR mutations were present in 10 cases, revealing 7 partial response and 3 no change (NC). In EGFR wild-type cases, 10 revealed NC and 9 progressive disease. The responders were significantly more frequent among the EGFR mutant cases than among the wild-type (p < 0.0001). Overall survival (p = 0.0092) and progression-free survival (p = 0.018) were significantly longer among the EGFR mutant cases than among the wild-type. In summary, we evaluated the utility of EGFR mutation screening in pleural fluid using 4 assays that showed some discrepancies arising from the designs of the assays. As clinical importance, the EGFR mutation status in pleural fluid can be a biomarker for the favorable outcome of gefitinib-treated NSCLC cases. en-copyright= kn-copyright= en-aut-name=SoJun-ichi en-aut-sei=So en-aut-mei=Jun-ichi kn-aut-name=宗淳一 kn-aut-sei=宗 kn-aut-mei=淳一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=EGFR kn-keyword=EGFR en-keyword=lung cancer kn-keyword=lung cancer en-keyword=pleural fluid kn-keyword=pleural fluid en-keyword=mutant-enriched PCR kn-keyword=mutant-enriched PCR en-keyword=gefitinib kn-keyword=gefitinib END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=線虫のトロポニンIと他のトロポニン構成分及びトロポミオシンとの組織特異的相互作用 kn-title=Tissue-specific interactions of Troponin I with other TN subunits and tropomyosins isoforms in Caenorhabditis elegans en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Md. ZiaulAmin en-aut-sei=Md. Ziaul en-aut-mei=Amin kn-aut-name=エムディー ジアウルアミン kn-aut-sei=エムディー ジアウル kn-aut-mei=アミン aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒト単球におけるCD14およびToll like receptor-4発現に対するシプロフロキサシンの効果 kn-title=The effect of ciprofloxacin on CD14 and toll-like receptor-4 expression on human monocytes en-subtitle= kn-subtitle= en-abstract= kn-abstract=CD14/toll-like receptor (TLR)-4 complex on monocytes/macrophages can bind lipopolysaccharide (LPS) and transduce the signals intracellularly. An antibacterial drug, ciprofloxacin (CIP), has been reported to modulate the inflammatory and immune responses. In the present study, we examined the effects of CIP on the LPS-induced activation of monocytes isolated from human peripheral blood mononuclear cells (PBMC). CIP suppressed the expression of CD14, TLR-4, intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, and CD40 and the production of tumor necrosis factor (TNF)-alpha induced by LPS in monocytes. CIP induced the production of prostaglandin (PG)E2 and increased intracellular cyclic adenosine monophosphate (cAMP) levels. Cyclooxygenase (COX)-2 inhibitors, NS398 and indomethacin, reversed the effects of CIP on TNF-alpha production and reduced the levels of different surface antigens, whereas a protein kinase A (PKA) inhibitor, H89, did not. Therefore, CIP might regulate the TNF-alpha production induced by LPS by inhibiting the expression of LPS receptor complex, which seems to be mediated by COX-2 but not the cAMP/PKA pathway. en-copyright= kn-copyright= en-aut-name=KatsunoGotaro en-aut-sei=Katsuno en-aut-mei=Gotaro kn-aut-name=勝野剛太郎 kn-aut-sei=勝野 kn-aut-mei=剛太郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=lipopolysaccharide kn-keyword=lipopolysaccharide en-keyword=monocyte kn-keyword=monocyte en-keyword=ciprofloxacin kn-keyword=ciprofloxacin en-keyword=prostaglandin kn-keyword=prostaglandin en-keyword=CD14 kn-keyword=CD14 en-keyword=toll-like receptor-4 kn-keyword=toll-like receptor-4 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=英国における投資と雇用奨励のための政府による助成金及び援助の役割 kn-title=The Role of the Government Incentive & Assistance in Encouraging Investment and Employment in the UK en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AbdulkadirCan Tekin en-aut-sei=Abdulkadir en-aut-mei=Can Tekin kn-aut-name=アブドゥルカディールジャン テキン kn-aut-sei=アブドゥルカディール kn-aut-mei=ジャン テキン aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ゲフィチニブを投与した日本人非小細胞肺癌におけるヒト上皮成長因子受容体遺伝子異常と臨床効果の検討 kn-title=The Impact of Epidermal Growth Factor Receptor Gene Status on Gefitinib-Treated Japanese Patients with Non-Small-Cell Lung Cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract=We investigated the relationships between genetic factors and clinical outcome in Japanese non-small-cell lung cancer (NSCLC) patients treated with gefitinib. Ninety-eight NSCLC patients who had been treated with gefitinib, were screened for mutations in epidermal growth factor receptor (EGFR) exons 18-21, KRAS exon2, and polymorphisms including the CA simple sequence repeat in intron1 (CA-SSR1) and single nucleotide polymorphisms in the promoter region (-216G/T and -191C/A), using a PCR-based assay and direct sequencing. The EGFR copy number status was also evaluated using a fluorescence in situ hybridization assay. EGFR and KRAS mutations were found in 38 (38.8%) and 8 (8.2%) of the 98 patients, respectively. A high EGFR copy number status was identified in 31 (41.3%) of the 75 assessable patients. Drug-sensitive EGFR mutations limited to exon19 deletions and L858R were independent predictive factors of a stronger sensitivity to gefitinib (p = 0.0002), the overall survival (OS) (p = 0.0036), and prolonged progression-free survival (PFS) (p < 0.0001). The EGFR copy number status was not related to a sensitivity to gefitinib and prolonged OS and PFS. Regarding polymorphisms, patients with a short CA-SSR1 showed a prolonged OS as compared with those with a long length in patients with a drug-sensitive EGFR mutation, although this difference was not significant (p = 0.13). Thus, drug-sensitive EGFR mutations predict a favorable clinical outcome and a high EGFR copy number may not be related to clinical benefits in gefitinib-treated Japanese patients with NSCLC. Our findings also suggest that the CA-SSR1 length may influence the clinical outcome in patients with a drug-sensitive EGFR mutation. en-copyright= kn-copyright= en-aut-name=IchiharaShuji en-aut-sei=Ichihara en-aut-mei=Shuji kn-aut-name=市原周治 kn-aut-sei=市原 kn-aut-mei=周治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=NSCLC kn-keyword=NSCLC en-keyword=EGFR kn-keyword=EGFR en-keyword=gefitinib kn-keyword=gefitinib en-keyword=mutation kn-keyword=mutation en-keyword=amplification kn-keyword=amplification en-keyword=polymorphism kn-keyword=polymorphism END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=日本人女性コメディカルワーカーに対する10分間リラクセーションの唾液中s-IgA と気分への効果 kn-title=The Immediate Effects of 10-minute Relaxation Training on Salivary Immunoglobulin A (s-IgA) and Mood State for Japanese Female Medical Co-workers en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study examined the effects of relaxation training on salivary IgA (s-IgA) and mood state in Japanese female medical workers. Participants were enrolled and assigned to relaxation or control groups. The relaxation group Japanese female medical workers (n = 38, mean age = 33.5 years, SD = 9.6) participated in a lecture on stress for 1 h and had 10 min of relaxation training. The control group (n = 41, mean age = 35.0 years, SD = 8.6) participated in only the lecture. S-IgA was measured, and a self-report mood questionnaire administered before the lecture and then again after the relaxation training for the relaxation group. The control group was measured before and after the lecture. The results showed that s-IgA levels significantly increased after relaxation training in the relaxation group compared with the control group (p = 0.03). A marginally significant intervention effect was observed for mood state (p = 0.06) ; indicating that the relaxation group was more likely to reduce any fatigue and confusion than was the control group. These findings suggest that short-time relaxation training is effective in relaxing mood and causes changes in immunological function. en-copyright= kn-copyright= en-aut-name=TaniguchiToshiyo en-aut-sei=Taniguchi en-aut-mei=Toshiyo kn-aut-name=谷口敏代 kn-aut-sei=谷口 kn-aut-mei=敏代 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=relaxation training kn-keyword=relaxation training en-keyword=immediate eff ects kn-keyword=immediate eff ects en-keyword=female medical co-workers kn-keyword=female medical co-workers en-keyword=salivary immunoglobulin A kn-keyword=salivary immunoglobulin A END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=要介護高齢者の家族介護者における1年間の介護資源が抑うつ発症に与える影響 kn-title=The Effects of Caregiving Resources on the Incidence of Depression over One Year in Family Caregivers of Disabled Elderly en-subtitle= kn-subtitle= en-abstract= kn-abstract=The purpose of the study was to investigate the over-time effects of physical, psychological and social resources on the incidence of depression in family caregivers of the disabled elderly. Data were collected twice at a one-year interval from 1,141 primary caregivers of a disabled older person in an urban area of Japan using a self-reported questionnaire survey. The questionnaire included physical health as an indicator of physical resources, caregiving satisfaction and intention to care as indicators of psychological resources, and instrumental and emotional support network and formal home care service utilization as indicators of social resources. The mental health outcome measure was the General Health Questionnaire 12-item version (GHQ-12). Complete data on 235 non-depressed female caregivers were separated into 3 groups according to the relationship type (wife, daughter and daughter-in-law) and analyzed separately. Multivariate logistic regression models controlling for duration of caregiving, care-recipient's gender, ADL dependency and behavioral problems demonstrated that significant predictors of depression were caregiving satisfaction and intention to care in wives, caregiving satisfaction in daughters, and physical health and emotional support network in daughters-in-law. Noteworthy, intention to care increased the risk of depression in wives, while decreasing the risk of depression in daughters-in-law. The findings indicate that the effects of caregivers' resources on mental health may differ by relationship type. en-copyright= kn-copyright= en-aut-name=YajimaYuki en-aut-sei=Yajima en-aut-mei=Yuki kn-aut-name=矢嶋裕樹 kn-aut-sei=矢嶋 kn-aut-mei=裕樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=caregivers kn-keyword=caregivers en-keyword=kin relationships kn-keyword=kin relationships en-keyword=caregiving resources kn-keyword=caregiving resources en-keyword=depression kn-keyword=depression END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=咬合接触に関与しない口蓋床の口蓋部形態が睡眠中の咬筋筋活動に与える影響 kn-title=The Design of Non-occlusal Intraoral Appliances on Hard Palate and Their Effect on Masseter Muscle Activity during Sleep en-subtitle= kn-subtitle= en-abstract= kn-abstract=This study aimed to reveal whether masseter muscle activity during sleep is affected by the difference in design of non-occlusal intraoral appliances on hard palate. Eight healthy Japanese participants were selected and wore each of the four types of appliances (horse shoe, thin, thick and medium thick) during sleep for one week with a one week interval without appliance during sleep. A masseter muscle electromyograph (EMG) was recorded during sleep. The EMG activities were analyzed by calculating the number of bursts per hour, episodes per hour, and bursts per episode. The EMG parameters with the thick type appliance were significantly lower than the baseline condition without appliance. In this study, it is suggested that a thick type appliance has an active effect on suppression of masseter muscle activity. en-copyright= kn-copyright= en-aut-name=HasegawaKoichi en-aut-sei=Hasegawa en-aut-mei=Koichi kn-aut-name=長谷川浩一 kn-aut-sei=長谷川 kn-aut-mei=浩一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=医療廃棄物処理の改善のためのシステム工学的アプローチ kn-title=System Engineering Approach for Improvement in Healthcare Waste Management en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ChaerulMochammad en-aut-sei=Chaerul en-aut-mei=Mochammad kn-aut-name=チャエルモチャマド kn-aut-sei=チャエル kn-aut-mei=モチャマド aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=変異FGFR3の恒常的リン酸化は先天性小人症の重要な因子でPLCγによるSTAT1の活性化を介して軟骨前駆細胞ATDC5のアポトーシスを誘導する kn-title=Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCγ-activated STAT1 en-subtitle= kn-subtitle= en-abstract= kn-abstract=The most frequent type of rhizomelic dwarfism, achondroplasia (ACH), is caused by mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. Mutations in FGFR3 result in skeletal dysplasias of variable severity, including mild phenotypic effects in hypochondroplasia (HCH), severe phenotypic effects in thanatophoric dysplasia types I (TDI) and II (TDII), and severe but survivable phenotypic effects in severe achondroplasia with developmental delay and acanthosis nigricans (SADDAN). To explore the molecular mechanisms that result in the different phenotypes, we investigated the kinetics of mutated versions of FGFR3. First, we assayed the phosphorylation states of the mutated FGFR3s and found that the level of phosphorylation in TDI-FGFR3 was lower than in ACH-FGFR3, although the other mutants were phosphorylated according to phenotypic severity. Second, we analyzed the duration of the phosphorylation. TDI-FGFR3 was not highly phosphorylated under ligand-free conditions, but the peak phosphorylation levels of TDI-FGFR3 and ACH-FGFR3 were maintained for 30 min after stimulation with FGF-1. Moreover, ligand-dependent phosphorylation of TDI-FGFR3, but not ACH-FGFR3, lasted for more than 8 h after FGF-1 administration. The other mutant proteins showed sustained phosphorylation independent of ligand presence. Third, we investigated the intracellular localization of the mutant proteins. Immunofluorescence analysis showed accumulations of TDII-FGFR3, SADDAN-FGFR3, and a portion of TDI-FGFR3 in the endoplasmic reticulum (ER). Based on these data, we concluded that sustained phosphorylation of FGFR3 causes chondrodysplasia, and the phenotypic severity depends on the proportion of ER-localized mutant FGFR3. In FGFR3 signaling, the transcription factor, signal transducer and activator of transcription 1 (STAT1) inhibit proliferation and induce apoptosis of chondrocytes. Here we reveal that phospholipase C gamma (PLCgamma) mediates FGFR3-induced STAT1 activation. Both PLCgamma and STAT1 were activated by FGFR3 signaling, but a dominant-negative form of PLCgamma (DN-PLCgamma) remarkably reduced STAT1 phosphorylation. Apoptosis assays revealed that the constitutively active forms of FGFR3 (TDII-FGFR3) and STAT1 (STAT1-C) induce apoptosis of chondrogenic ATDC5 cells via caspase activity. DN-PLCgamma reduced the apoptosis of ATDC5 cells expressing TDII-FGFR3, but over-expression of both DN-PLCgamma and STAT1-C induced apoptosis. Therefore, we conclude that a PLCgamma-STAT1 pathway mediates apoptotic signaling by FGFR3. en-copyright= kn-copyright= en-aut-name=HaradaDaisuke en-aut-sei=Harada en-aut-mei=Daisuke kn-aut-name=原田大輔 kn-aut-sei=原田 kn-aut-mei=大輔 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=FGFR3 kn-keyword=FGFR3 en-keyword=Skeletal dysplasia kn-keyword=Skeletal dysplasia en-keyword=Phosphorylation kn-keyword=Phosphorylation en-keyword=ER localization kn-keyword=ER localization en-keyword=STAT1 kn-keyword=STAT1 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=高分化大腸癌株HT29 in vivo治療モデルにおけるHuman Recombinant Tissue Inhibitor of Metalloproteinases-1(TIMP-1)の腫瘍増殖抑制効果の検討 kn-title=Suppression Effects of Human Recombinant Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) on Tumor Proliferation Using in Vivo Treatment Model of Well-differentiated Colon Cancer Cell Line, HT29 en-subtitle= kn-subtitle= en-abstract= kn-abstract=To investigate the suppressive effect of human recombinant TIMP-1 (rh-TIMP-1) on tumor proliferation using an in vivo xenograft system, HT29 was suspended in 0.1 ml phosphate buffered saline (PBS) and then subcutaneously injected in the back of female mice (BALB/C nu/nu). The mice were divided into 2 groups an and the tumor diameter was measured after rh-TIMP-1 (2 mg/kg) (rh-TIMP-1 group) or PBS (control group) was administered injections according to the following schedules. Schedule 1 : Beginning 2 weeks after the subcutaneous injection of HT29, an intraperitoneal injection of rh-TIMP-1 or PBS were performed twice a day (every 12 h) for 14 consecutive days. Schedule 2 : Beginning 1 week after the subcutaneous injection of HT29, an intraperitoneal injection was performed twice a day for 14 consecutive days. Schedule 3 : Intraperitoneal injections were started simultaneously with the subcutaneous injection of HT29, and then performed twice a day for 21 consecutive days. The mice were sacrificed and the tumors extirpated for immunohistochemical investigation. In addition, gelatin zymography and a cell proliferation assay were performed. With Schedule 1, the changes in the tumor diameter in the rh-TIMP-1 group followed the same course as those in the control group, and no suppressive effect on tumor proliferation was observed. However, with Schedule 3, a remarkable suppressive effect was observed throughout the treatment period. In immunostaining, more cases negative for MMP-9 were observed in the rh-TIMP-1 group than in the control group. Cases negative for CD34 were significantly more observed in the rh-TIMP-1 group than in the control group with Schedule 3. All of the results were obtained through the suppressive effect of rh-TIMP-1 on angiogenesis. en-copyright= kn-copyright= en-aut-name=OhtaniYu en-aut-sei=Ohtani en-aut-mei=Yu kn-aut-name=大谷裕 kn-aut-sei=大谷 kn-aut-mei=裕 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=MMP-2 kn-keyword=MMP-2 en-keyword=MMP-9 kn-keyword=MMP-9 en-keyword=TIMP-1 kn-keyword=TIMP-1 en-keyword=molecular targeting therapy kn-keyword=molecular targeting therapy en-keyword=angiogenesis kn-keyword=angiogenesis END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=上司の傾聴態度・スキルと部下の仕事のストレスとメンタルヘルスの関連 kn-title=Supervisors’ attitudes and skills for active listening with regard to job stress and psychological stress reactions among subordinate workers en-subtitle= kn-subtitle= en-abstract= kn-abstract=We investigated whether supervisors' listening attitudes and skills were related to working conditions and psychological stress reactions among their subordinates. The subjects included 41 male supervisors and their immediate subordinates (n=203). The supervisors completed a short version of the Active Listening Attitude Scale (ALAS) consisting of two subscales: Listening Attitude and Listening Skill for Active Listening. The subordinates rated working conditions and their psychological stress reactions using selected scales of the Job Content Questionnaire and the Brief Job Stress Questionnaire. Those subordinates who worked under supervisors with a higher score of Listening Attitude and Listening Skill reported a more favorable psychological stress reaction than those who worked under supervisors with a lower score of Listening Attitude and Listening Skill. Those subordinates who worked under supervisors with a higher score of Listening Skill reported higher worksite support than those who worked under supervisors with a lower score of Listening Skill. Those subordinates who worked under supervisors with a higher score of Listening Attitude reported higher job control than those who worked under supervisors with a lower score of Listening Attitude. A supervisor's listening attitude and skill appeared to affect psychological stress reactions predominantly among male subordinates than among female subordinates. Psychological stress reactions were lower among younger subordinates who worked under supervisors with high listening skill, while no statistically difference was observed among older subordinates. These findings suggest that a supervisor's listening attitude and skill have an effect on working conditions and psychological stress reactions among subordinates and that the effects vary according to the subordinates' sex and age. en-copyright= kn-copyright= en-aut-name=MineyamaSachiko en-aut-sei=Mineyama en-aut-mei=Sachiko kn-aut-name=峰山幸子 kn-aut-sei=峰山 kn-aut-mei=幸子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Active Listening kn-keyword=Active Listening en-keyword=Active Listening Attitude Scale (ALAS) kn-keyword=Active Listening Attitude Scale (ALAS) en-keyword=Supervisory support kn-keyword=Supervisory support en-keyword=Psychological stress reaction kn-keyword=Psychological stress reaction en-keyword=Working conditon kn-keyword=Working conditon END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=虚血後線状体に出現する神経前駆細胞の起源 kn-title=Subventricular Zone-Derived Neuroblasts Migrate and Differentiate into Mature Neurons in the Post-Stroke Adult Striatum en-subtitle= kn-subtitle= en-abstract= kn-abstract=Recent studies have revealed that the adult mammalian brain has the capacity to regenerate some neurons after various insults. However, the precise mechanism of insult-induced neurogenesis has not been demonstrated. In the normal brain, GFAP-expressing cells in the subventricular zone (SVZ) of the lateral ventricles include a neurogenic cell population that gives rise to olfactory bulb neurons only. Herein, we report evidence that, after a stroke, these cells are capable of producing new neurons outside the olfactory bulbs. SVZ GFAP-expressing cells labeled by a cell-type-specific viral infection method were found to generate neuroblasts that migrated toward the injured striatum after middle cerebral artery occlusion. These neuroblasts in the striatum formed elongated chain-like cell aggregates similar to those in the normal SVZ, and these chains were observed to be closely associated with thin astrocytic processes and blood vessels. Finally, long-term tracing of the green fluorescent-labeled cells with a Cre-loxP system revealed that the SVZ-derived neuroblasts differentiated into mature neurons in the striatum, in which they expressed neuronal-specific nuclear protein and formed synapses with neighboring striatal cells. These results highlight the role of the SVZ in neuronal regeneration after a stroke and its potential as an important therapeutic target for various neurological disorders. en-copyright= kn-copyright= en-aut-name=YamashitaToru en-aut-sei=Yamashita en-aut-mei=Toru kn-aut-name=山下徹 kn-aut-sei=山下 kn-aut-mei=徹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=zone kn-keyword=zone en-keyword=cerebral ischemia kn-keyword=cerebral ischemia en-keyword=migration kn-keyword=migration en-keyword=neurogenesis kn-keyword=neurogenesis en-keyword=regeneration kn-keyword=regeneration en-keyword=striatum kn-keyword=striatum END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ボツリヌスC型, D型における,毒素産生性を支配するファージの構造蛋白質及び種々の大きさのリコンビナント神経毒素蛋白質のワクチン効果に関する研究 kn-title=Studies on the structural protein of the toxin-converting phage and the vaccine effect of different size of recombinant neurotoxin-proteins of Clostridium botulinum type C and D en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HwangHyun-Jung en-aut-sei=Hwang en-aut-mei=Hyun-Jung kn-aut-name=黄賢正 kn-aut-sei=黄 kn-aut-mei=賢正 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=Beet necrotic yellow vein virus RNA4の生物学的機能に関する研究 kn-title=Studies on the biological properties of Beet necrotic yellow vein virus RNA4 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=RahimMuhammad Dahial en-aut-sei=Rahim en-aut-mei=Muhammad Dahial kn-aut-name=ラヒムムハンマド ダニアル kn-aut-sei=ラヒム kn-aut-mei=ムハンマド ダニアル aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=廃家電製品におけるマネージメント体制の評価に関する研究 kn-title=Studies on the Assessment of Management Frameworks for Waste Electronic Home Appliances en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=リュウシェンビン en-aut-sei=リュウ en-aut-mei=シェンビン kn-aut-name=リュウシェン兵 kn-aut-sei=リュウ kn-aut-mei=シェン兵 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=キトサンをポリマー基材とする微量元素の濃縮/捕集用樹脂及びその分析的応用に関する研究 kn-title=Studies on Novel Collection/Concentration Resins for Trace Elements Using Chitosan as Polymer Base and Their Analytical Applications en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SabarudinAkhmad en-aut-sei=Sabarudin en-aut-mei=Akhmad kn-aut-name=サバルディンアハマド kn-aut-sei=サバルディン kn-aut-mei=アハマド aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=シアニン色素やアクリジン色素のダイマーモデルの研究 kn-title=Studies on Cyanine Dye and Acridine Dye Dimer Models en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FukaiTakeshi en-aut-sei=Fukai en-aut-mei=Takeshi kn-aut-name=深井猛 kn-aut-sei=深井 kn-aut-mei=猛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=微生物二次代謝産物の生化学的変換及び化学的変換に関する研究 kn-title=Studies on Biological and Chemical Conversion of Microbial Secondary Metabolites en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ArunrattiyakornPanarrat en-aut-sei=Arunrattiyakorn en-aut-mei=Panarrat kn-aut-name=アロンラッティヤコンパナラ kn-aut-sei=アロンラッティヤコン kn-aut-mei=パナラ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ジオールデヒドラターゼ再活性化因子の構造解析およびエタノールアミンアンモニアリアーゼ再活性化因子の確認 kn-title=Structure Analysis of Diol Dehydratase-Reactivating Factor and Characterization of Ethanolamine Ammonia Lyase-Reactivating Factor en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HiedaNaoki en-aut-sei=Hieda en-aut-mei=Naoki kn-aut-name=稗田直樹 kn-aut-sei=稗田 kn-aut-mei=直樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=静的眼球反対回旋:偽回旋の因子を最小限にしたビデオ解析 kn-title=Static Ocular Counterroll: Video-based Analysis After Minimizing the False-Torsion Factors en-subtitle= kn-subtitle= en-abstract= kn-abstract=PURPOSE: To determine the validity and usefulness of a newly developed measurement method of static ocular counterrolling (s-OCR) that eliminates false-torsion factors and to test the Jampel hypothesis that s-OCR does not exist. METHODS: A lightweight measurement device, consisting of a video camera, a coaxial light source, and a laser pointer projecting a fixation target on the wall, was fixed to a subject's head by means of a mouthpiece. In 11 healthy adults (mean age: 30 +/- 15 years), digital images of the right eye were captured while the subject kept his head tilted at a randomly selected angle ranging from 0 degrees to 50 degrees . By a frame-by-frame analysis of movements of the corneal light reflex and the iris patterns, OCR was evaluated. RESULTS: Torsional eye movement in the opposite direction to head tilt was found in all subjects. The amount of torsion continuously increased until the head-tilt angle reached 40 degrees. The average (+/- SD) amplitude of a fitted sine curve was 7.6 +/- 3.2 degrees (range: 4.3 degrees-10.3 degrees), and the individual amplitude was significantly larger than the test-retest repeatability of the measurement (+/-1.7 degrees). CONCLUSIONS: The measurement method used in this study provided good test-retest repeatability and ease of application. The characteristics of torsional eye movements that we observed after minimizing the false-torsion factors agree with previous reports supporting the existence of s-OCR. en-copyright= kn-copyright= en-aut-name=HamasakiIchiro en-aut-sei=Hamasaki en-aut-mei=Ichiro kn-aut-name=濵﨑一郎 kn-aut-sei=濵﨑 kn-aut-mei=一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=eye movement kn-keyword=eye movement en-keyword=otolith kn-keyword=otolith en-keyword=static ocular counterroll kn-keyword=static ocular counterroll en-keyword=video-based analysis kn-keyword=video-based analysis END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=炭素質隕石中有機物の炭素・水素同位体組成とその変質過程との関係 kn-title=Stable carbon and hydrogen isotopic compositions of organic matter in carbonaceous meteorites and its implication to alteration processes en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=OhbaYasuhiro en-aut-sei=Ohba en-aut-mei=Yasuhiro kn-aut-name=大場康弘 kn-aut-sei=大場 kn-aut-mei=康弘 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=酸化鉄材料の合成および物性 kn-title=SYNTHESES AND PROPERTIES OF THE IRON OXIDES MATERIALS en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ISLAM BHUIYANMD. TAREQUL en-aut-sei=ISLAM BHUIYAN en-aut-mei=MD. TAREQUL kn-aut-name=イスラム ブイヤンエムディ タリクル kn-aut-sei=イスラム ブイヤン kn-aut-mei=エムディ タリクル aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=歯原性腫瘍におけるヘパラン硫酸結合性成長因子を放出するへパラナーゼの役割 kn-title=Role of Heparanase in the Release of Heparan Sulphate Binding Growth Factors in Odontogenic Tumors en-subtitle= kn-subtitle= en-abstract= kn-abstract=Immunolocalization of heparan sulphate(HS) and heparanase was evaluated in benign and malignant odontogenic tumors in order to know whether these molecules have potential roles in odontogenic tumorigenesis. Archival formalin-fixed, paraffin-embedded tissues of 6 human tooth germs, 7 adenomatoid odontogenic tumors, 10 ameloblastic fibromas, 20 ameloblastomas and 4 ameloblastic carcinomas were subjected to immunohistochemical staining using antibodies to HS, heparanase and BMP-4. HS was ubiquitously localized in tooth germ but heparanase and BMP-4 were observed in limited areas only. In benign epithelial tumors such as ameloblastoma and adenomatoid odontogenic tumor, these molecules were localized in neoplastic epithelium but in ameloblastic fibroma, positive reactions were observed in both epithelial and mesenchymal cells. Stromal localization of HS and BMP-4 accompanied by intense immunoexpression of epithelial heparanase was observed in ameloblastic carcinoma,and this may represent the malignant progression of ameloblastoma to ameloblastic carcinoma. Stronger intensity and more diffuse localization of heparanase in odontogenic tumors compare to that of human tooth germ was the most significant finding. Taken together, the results inferred that heparanase may be responsible for the growth and progression of odontogenic tumors by modulating the availability and function of HS binding growth factors and the derangement in immunoexpression and localization of HS and heparanase molecules may have important roles in progression of malignant odontogenic tumors. en-copyright= kn-copyright= en-aut-name=Phuu PwintHan en-aut-sei=Phuu Pwint en-aut-mei=Han kn-aut-name=プープイントハン kn-aut-sei=プープイント kn-aut-mei=ハン aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Heparanase kn-keyword=Heparanase en-keyword=Heparan sulphate kn-keyword=Heparan sulphate en-keyword=BMP-4 kn-keyword=BMP-4 en-keyword=Odontogenic tumors kn-keyword=Odontogenic tumors en-keyword=Tooth germ kn-keyword=Tooth germ en-keyword=Immunohistochemistry kn-keyword=Immunohistochemistry END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=潰瘍性大腸炎患者における大腸切除となる危険因子と適応は,患者背景により異なる kn-title=Risk Factors and Indications for Colectomy in Ulcerative Colitis Patients are Different According to Patient’s Clinical Background en-subtitle= kn-subtitle= en-abstract= kn-abstract=PURPOSE: Despite progress in medical treatment for ulcerative colitis, a considerable fraction of ulcerative colitis patients undergo colectomy. We analyzed the clinical variables of ulcerative colitis patients and determined the risk factors and indications for colectomy. METHODS: The clinical records of 981 consecutive Japanese patients with ulcerative colitis were reviewed both retrospectively and prospectively. RESULTS: Of 981 patients with ulcerative colitis, 85 patients underwent colectomy. Multivariate analysis indicated that male gender (risk ratio, 2.16; 95 percent confidence interval, 1.37-3.42), onset year during and after 2000 (risk ratio, 2.85; 95 percent confidence interval, 1.31-6.22), severe disease activity (risk ratio, 2; 95 percent confidence interval, 1.15-3.48), corticosteroid resistance (risk ratio, 7.05; 95 percent confidence interval, 4.29-11.59), and complications because of corticosteroid administration (risk ratio, 3.55; 95 percent confidence interval, 2.08-6.06) were significant risk factors for colectomy. In patients with disease duration of more than five years, only corticosteroid resistance and complications because of corticosteroid were significant risk factors for colectomy. When we stratified indications for colectomy for the 85 cases via patient disease duration, massive hemorrhage was a relatively frequent cause of colectomy in patients with a disease duration of less than five years (P = 0.091). On the other hand, colon dysplasia or cancer was a major cause for colectomy in patients with a disease duration of more than ten years (P = 0.0001). CONCLUSIONS: In ulcerative colitis patients, the risk factors and indications for colectomy were different according to the patient's clinical background. Our findings may help to predict patients with ulcerative colitis who have a high risk for colectomy. en-copyright= kn-copyright= en-aut-name=KuriyamaMotoaki en-aut-sei=Kuriyama en-aut-mei=Motoaki kn-aut-name=栗山宗彰 kn-aut-sei=栗山 kn-aut-mei=宗彰 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Ulcerative colitis kn-keyword=Ulcerative colitis en-keyword=Inflammatory bowel disease kn-keyword=Inflammatory bowel disease en-keyword=Colectomy kn-keyword=Colectomy en-keyword=Risk factor kn-keyword=Risk factor en-keyword=Indication kn-keyword=Indication END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ブタ伸展固定肺を用いた0.5-mm等方向データから得られるMPR画像の検討 kn-title=Resolution of Pulmonary Multiplanar Reconstruction Images from 0.5-mm Theoretical Isotropic Data: A Fundamental Study Using an Inflated and Fixed Lung Specimen en-subtitle= kn-subtitle= en-abstract= kn-abstract=The aim of the present study was to define the resolution of multiplanar reconstruction (MPR) of the lung from "theoretical isotropic data." Using inflated and fixed lung specimens of the pig placed in the chest wall phantom, 0.5-mm isotropic data were obtained with 2 different helical pitches: 1:7 (high-quality mode) or 1:13, (high-speed mode), and 2 different tube currents: 250 mAs (high-tube-current mode) or 100 mAs (low-tube-current mode), with or without overlapping reconstruction. MPRs were created from these axial data. The diameter of the smallest visible pulmonary artery and bronchi of these CT images were measured on the corresponding slices of the specimen. The high-speed and low-tube-current mode significantly degraded the image quality due to increased noise. The smallest visible pulmonary artery and bronchus resolved on MPRs from axial-spiral data with 0.5-mm collimation were approximately 100 micrometer and 1,000 micrometer in diameter, respectively. In conclusion, helical pitch and tube current influence the resolution of MPR of the lung. en-copyright= kn-copyright= en-aut-name=MakiDaisuke en-aut-sei=Maki en-aut-mei=Daisuke kn-aut-name=牧大介 kn-aut-sei=牧 kn-aut-mei=大介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=multiplanar reconstruction kn-keyword=multiplanar reconstruction en-keyword=computed tomography kn-keyword=computed tomography en-keyword=lung kn-keyword=lung END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=日本の精神科病院における統合失調症入院患者のQOL kn-title=Quality of life for patients with schizophrenia in a Japanese psychiatric hospital en-subtitle= kn-subtitle= en-abstract= kn-abstract=Providing a good quality of life (QOL) has recently been recognized as a central purpose of health care in psychiatry. In this study, we performed a detailed evaluation of the subjective QOL of schizophrenic inpatients and examined the relationship of QOL to various patient characteristics. This study was conducted on schizophrenic inpatients and nursing staff members in a Japanese private psychiatric hospital. As a result, only depression showed a weak, but significant, relationship with subjective QOL. Other characteristics showed no meaningful correlation to subjective QOL. Comparison between the schizophrenic group and the nursing staff group revealed that schizophrenic inpatients showed a lower QOL in the domains of physical health and social relationships. Schizophrenia itself and/or accompanying disabilities might induce lower subjective QOL. It is difficult to determine what the important factors are, except for depression, for subjective QOL of schizophrenic inpatients. However, depression should receive more attention for the QOL in the physical health and psychological health domains. en-copyright= kn-copyright= en-aut-name=KugoAki en-aut-sei=Kugo en-aut-mei=Aki kn-aut-name=久郷亜希 kn-aut-sei=久郷 kn-aut-mei=亜希 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Schizophrenia kn-keyword=Schizophrenia en-keyword=Quality of life kn-keyword=Quality of life en-keyword=Inpatient kn-keyword=Inpatient en-keyword=WHO-QOL kn-keyword=WHO-QOL en-keyword=Positive and Negative Syndrome Scale kn-keyword=Positive and Negative Syndrome Scale END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=抗アポトーシスペプチドV5を用いた培養サル肝細胞移植による急性肝不全モデルマウスの長期生存 kn-title=Prolonged Survival of Mice with Acute Liver Failure with Transplantation of Monkey Hepatocytes Cultured with an Antiapoptotic Pentapeptide V5 en-subtitle= kn-subtitle= en-abstract= kn-abstract=BACKGROUND: Because hepatocyte transplantation has been considered to be an attractive method to treat acute liver failure (ALF), efficient recovery of hepatocytes and maintenance of differentiated hepatocyte functions is of extreme importance. We here report the usefulness of an antiapoptotic pentapeptide V5, composed of Val-Pro-Met-Leu-Lys, in the monkey hepatocyte cultures. METHODS: We evaluated albumin production, metabolizing abilities of ammonia, lidocaine, and diazepam of monkey hepatocytes cultured with V5. The protein expression of apoptosis-associated molecules was analyzed using power blot analysis. An unwoven cloth inoculated with V5-treated monkey hepatocytes was transplanted on the surface of the spleen of both SCID mice and Balb/c mice suffering from ALF induced by 90% hepatectomy. RESULTS: When 100 microM V5 was utilized, ammonia-, lidocaine- and diazepam- metabolizing capacities and albumin production ability were significantly increased in V5-treated monkey hepatocytes. Such hepatocytes showed decreased Annexin V binding and increased the expression of anti-apoptotic and/or cytoprotective molecules, including Ku70, NF-kappaB, IKAP, hILP/XIAP, IkappaB, and CAS. Transplantation of the cloth containing the monkey hepatocytes significantly improved blood levels of glucose and ammonia and encephalopathy score and prolonged the survival of the mice with ALF. CONCLUSIONS: The present work clearly demonstrates the usefulness of V5 for maintaining the functions of monkey hepatocytes in tissue culture. en-copyright= kn-copyright= en-aut-name=TanakaKimiaki en-aut-sei=Tanaka en-aut-mei=Kimiaki kn-aut-name=田中公章 kn-aut-sei=田中 kn-aut-mei=公章 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=hepatocytes kn-keyword=hepatocytes en-keyword=V5 kn-keyword=V5 en-keyword=acute liver failure kn-keyword=acute liver failure en-keyword=apoptosis kn-keyword=apoptosis en-keyword=Ku70 kn-keyword=Ku70 en-keyword=hepatocyte transplantation kn-keyword=hepatocyte transplantation END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=2次式および3次式中の素数 kn-title=Primes in quadratic and cubic polynomials en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=ShimizuKen-ichi en-aut-sei=Shimizu en-aut-mei=Ken-ichi kn-aut-name=清水健一 kn-aut-sei=清水 kn-aut-mei=健一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=日本の地域在住高齢者の運動能力評価におけるVeterans Specific Activity Questionnaireの有用性 kn-title=Practicality of Veterans Specific Activity Questionnaire in Evaluation of Exercise Capacity of Community-Dwelling Japanese Elderly en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KojimaShinji en-aut-sei=Kojima en-aut-mei=Shinji kn-aut-name=小島真二 kn-aut-sei=小島 kn-aut-mei=真二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ピルフェニドンは反復抗原暴露により起こる気道過敏性,気道炎症および気道リモデリングを制御する kn-title=Pirfenidone Modulates Airway Responsiveness, Inflammation, and Remodeling after Repeated Challenge en-subtitle= kn-subtitle= en-abstract= kn-abstract=We investigated the therapeutic potential of a newly developed antifibrotic agent, pirfenidone, to regulate airway remodeling and the development of allergic airway inflammation and airway hyperresponsiveness after chronic allergen challenge. Administration of pirfenidone after sensitization but during the period of ovalbumin challenge significantly prevented the development of airway hyperresponsiveness and prevented eosinophil and lymphocyte accumulation in the airways. IL-4, IL-5, and IL-13 levels in bronchoalveolar lavage fluid and ovalbumin-specific serum IgE antibody levels were also significantly reduced. Treatment with pirfenidone significantly reduced transforming growth factor-beta1 and platelet-derived growth factor levels in bronchoalveolar lavage fluid. Pirfenidone reduced the expression of transforming growth factor-beta1, the development of goblet cell hyperplasia and subepithelial collagenization, and the increases in contractile elements in the lung. These data indicate that pirfenidone may play an important role in the treatment of asthma and has the potential reduce or prevent airway remodeling. en-copyright= kn-copyright= en-aut-name=HiranoAtsushi en-aut-sei=Hirano en-aut-mei=Atsushi kn-aut-name=平野淳 kn-aut-sei=平野 kn-aut-mei=淳 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Mutation kn-keyword=Mutation en-keyword=Carcinogenesis kn-keyword=Carcinogenesis en-keyword=Multivariate analysis kn-keyword=Multivariate analysis en-keyword=Case-control study kn-keyword=Case-control study END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=マウス下垂体および子宮におけるインターロイキン18の作用の解析 kn-title=Physiological roles of interleukin-18 in the mouse uterus and pituitary en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KusumotoKenji en-aut-sei=Kusumoto en-aut-mei=Kenji kn-aut-name=楠本憲司 kn-aut-sei=楠本 kn-aut-mei=憲司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=中部中新統上部—上部中新統下部チェンムアン層の古環境変遷 kn-title=Paleoenvironments of the late Middle to early Late Miocene Chiang Muan Formation in northern Thailand en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=FukuchiAkira en-aut-sei=Fukuchi en-aut-mei=Akira kn-aut-name=福地亮 kn-aut-sei=福地 kn-aut-mei=亮 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=イヌ死体肺移植における心停止後ヘパリン投与の至適時間 kn-title=Optimal Time for Post-mortem Heparinization in Canine Lung Transplantation with Non-heart-beating Donors en-subtitle= kn-subtitle= en-abstract= kn-abstract=BACKGROUND: We previously reported that post-mortem heparinization by closed-chest cardiac massage is beneficial in lung transplantation from non-heart-beating donors by preventing formation of microthrombi. In this study, we evaluated the optimal time for post-mortem heparinization in canine lung transplantation from non-heart-beating donors. METHODS: Left lung transplantation was performed in 25 weight-matched pairs of mongrel dogs. Donors were killed with an intravenous injection of potassium chloride and left at room temperature for 2 hours. The cadaver donors were assigned randomly to one of five study groups. In Group H0, heparin sodium (1,000 U/kg) was given intravenously before cardiac arrest. In Groups H10, H30, H45 and H60, heparin sodium (1,000 U/kg) was given intravenously 10, 30, 45 and 60 minutes after cardiac arrest, respectively, followed by closed-chest cardiac massage for 2 minutes. After 2 hours of cardiac arrest, donor lungs were flushed with low-potassium dextran glucose solution and preserved for 60 minutes. After left lung allotransplantation, the right pulmonary artery was ligated, and recipient animals were followed up for 3 hours. Uni- and multivariate repeat analyses were utilized for statistical assessment. RESULTS: After transplantation, gas exchange was significantly worse in Groups H45 and H60 than in Groups H0, H10 and H30. Thrombin/anti-thrombin III complex concentration during warm ischemia was significantly higher in Groups H30, H45 and H60 than in Groups H0 and H10. CONCLUSIONS: The optimal time for post-mortem heparinization in lung transplantation from non-heart-beating donors is approximately 30 minutes after cardiac arrest. en-copyright= kn-copyright= en-aut-name=OkazakiMikio en-aut-sei=Okazaki en-aut-mei=Mikio kn-aut-name=岡﨑幹生 kn-aut-sei=岡﨑 kn-aut-mei=幹生 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=B型肝炎ウイルスGenotype CにおけるX領域Codon38変異は発癌のリスクファクターである kn-title=Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma en-subtitle= kn-subtitle= en-abstract= kn-abstract=BACKGROUND/AIMS: The hepatitis B virus (HBV) genotype C is associated with the development of hepatocellular carcinoma (HCC). In addition, the HBV X gene, which encodes the pleiotropic transactivator HBx, has also been associated with the development of HCC. In this study, we investigated whether nucleotide changes in the X gene of genotype C are associated with the development of HCC. METHODS/RESULTS: We sequenced the X gene in age- and sex-matched 39 HBV-infected patients with HCC and 36 HBV-infected patients without HCC. A novel nucleotide change that resulted in a proline to serine substitution at codon 38 in HBx (codon-38 change) was preferentially found in patients with HCC. Then, sera were collected from a new group of age- and sex-matched 52 patients with HCC and 51 patients without HCC. In this cohort also, the codon-38 change was associated with HCC. Multiple logistic regression analysis showed the prevalence of the codon-38 change was significantly associated with HCC in all patients (P=0.001, odds ratio: 4.89). CONCLUSION: The codon-38 change in genotype C is an independent risk factor for the development of HCC and may serve as a useful molecular marker for predicting the clinical outcomes in patients infected with HBV. en-copyright= kn-copyright= en-aut-name=MuroyamaRyosuke en-aut-sei=Muroyama en-aut-mei=Ryosuke kn-aut-name=室山良介 kn-aut-sei=室山 kn-aut-mei=良介 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Mutation kn-keyword=Mutation en-keyword=Carcinogenesis kn-keyword=Carcinogenesis en-keyword=Multivariate analysis kn-keyword=Multivariate analysis en-keyword=Case-control study kn-keyword=Case-control study END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=11Rを用いた新しいタンパク質導入法―脳血管障害を治療するための効果的な新しい薬物伝達システム― kn-title=Novel Protein Transduction Method by Using 11R-An Effective New Drug Delivery System for the Treatment of Cerebrovascular Diseases- en-subtitle= kn-subtitle= en-abstract= kn-abstract=BACKGROUND AND PURPOSE: A motif of 11 consecutive arginines (11R) is reported to be one of the most effective protein transduction domains for introducing proteins into the cell membrane. We therefore examined the transduction efficiency of 11R in cerebral arteries. METHODS: Basilar arteries (BAs) obtained from rats were incubated with either 11R-enhanced green fluorescent protein (11R-EGFP) or EGFP without 11R. After incubation, expression of 11R-EGFP or EGFP in BA serial sections was observed by fluorescence microscope. In an additional in vivo experiment, 11R-EGFP or EGFP was injected into the cisterna magna with or without subarachnoid hemorrhage. The 11R-EGFP or EGFP was injected just after the autologous blood injection, and then the expression of 11R-EGFP or EGFP in BA sections was also observed by fluorescence microscope. RESULTS: The 11R-EGFP signal was much stronger than that of EGFP in all layers of the rat BA, in both in vivo and ex vivo experiments. Moreover, the 11R-EGFP was transduced into the BA immediately (2 hours after the injection). Interestingly, 11R-fused fluorescent protein was transduced especially into the tunica media of the BA. CONCLUSIONS: The 11R-fused fluorescent protein effectively penetrates into all layers of the rat BA, especially into the tunica media. This is the first study to our knowledge to demonstrate the successful transduction of a protein transduction domain fused protein into the cerebral arteries. en-copyright= kn-copyright= en-aut-name=OgawaTomoyuki en-aut-sei=Ogawa en-aut-mei=Tomoyuki kn-aut-name=小川智之 kn-aut-sei=小川 kn-aut-mei=智之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=新規環状過酸化抗マラリア薬:熱帯熱マラリア原虫(Plasmodium falciparum)に対する作用機序の解析研究 kn-title=New Antimalarial Endoperoxides: Action and Resistance Analysis Against Plasmodium falciparum Malaria Parasites en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Mohamed ALYNagwa Shaban en-aut-sei=Mohamed ALY en-aut-mei=Nagwa Shaban kn-aut-name=モハメド アリナグワ シャバン kn-aut-sei=モハメド アリ kn-aut-mei=ナグワ シャバン aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=十脚甲殻類における孵化と熱ストレス反応の分子機構 kn-title=Molecular aspects of hatching and heat stress response in decapod crustaceans en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=GusevOleg en-aut-sei=Gusev en-aut-mei=Oleg kn-aut-name=グセフオレグ kn-aut-sei=グセフ kn-aut-mei=オレグ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=塩基性線維芽細胞増殖因子と内皮細胞による人工臓器デバイス移植部位における血管維持 kn-title=Maintenance of Neovascularization at the Implantation Site of an Artificial Device by bFGF and Endothelial Cell Transplant en-subtitle= kn-subtitle= en-abstract= kn-abstract=Development of a subcutaneously implantable bioartificial pancreas (BAP) with immunoisolatory function could have a great impact on the treatment of diabetes mellitus. We have developed an implantable BAP device with an ethylene vinyl alcohol (EVAL) membrane. In the present study, we used basic fibroblast growth factors (bFGF), which was incorporated in a carrier for sustained release, in order to induce neovascularization when the device was implanted subcutaneously. To maintain the vasculature thus formed, a cell infusion port was attached to the BAP device, through which the device was filled with human liver vascular endothelial cell line TMNK-1, and the vasculature could be adequately maintained. Mice were divided into the following three groups. In group 1, a bFGF-free BAP device was implanted subcutaneously. In group 2, a sustained-release bFGF-impregnated BAP device was implanted. In group 3, a sustained-release bFGF-impregnated BAP device was implanted, and 3 x 10(6) TMNK-1 cells were infused into the implanted device every week. Neovascularization induced in the subcutaneous tissue around the implanted BAP device was macroscopically examined and histologically evaluated. In addition, the tissue blood flow was measured using a laser blood flow meter. In mice in group 3, neovascularization was significantly induced and maintained until week 8 postimplantation. It was confirmed by scanning electron microscopy that infused TMNK-1 cells adhered to the inner polyethylene surface of the device. It was demonstrated that the use of bFGF and vascular endothelial TMNK-1 cells induced and maintained adequate vasculature and tissue blood flow surrounding the implantable bag-type BAP device. We believe that the present study will contribute to BAP development for the treatment of diabetes. en-copyright= kn-copyright= en-aut-name=MikiAtsushi en-aut-sei=Miki en-aut-mei=Atsushi kn-aut-name=三木厚 kn-aut-sei=三木 kn-aut-mei=厚 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=bioartificial pancreas kn-keyword=bioartificial pancreas en-keyword=human vascular endothelial cells kn-keyword=human vascular endothelial cells en-keyword=basic fibroblast growth factor kn-keyword=basic fibroblast growth factor en-keyword=neovascularization kn-keyword=neovascularization END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=白血病細胞におけるHLAクラスIの発現欠失・低下についての検討 kn-title=Loss or down-regulation of HLA class I expression at the allelic level in freshly isolated leukemic blasts en-subtitle= kn-subtitle= en-abstract= kn-abstract=Loss or down-regulation of human leukocyte antigen (HLA) class I expression has been demonstrated in a variety of solid tumors. To date, such altered HLA expression has not been studied extensively in freshly isolated leukemic blasts. If it occurs, leukemic cells could escape T-cell surveillance as a consequence. Genotypes of nine leukemic cell lines were determined using a polymerase chain reaction for HLA classes I and II. Cells were also examined for HLA beta2-microglobulin, and allele-specific HLA protein expression using flow cytometry. Next, 44 samples of freshly isolated leukemic blasts from 43 patients with malignant hematological diseases were examined for allele-specific HLA expression using flow cytometry. Microsatellite analysis was performed to determine heterozygosity in the HLA region on chromosome 6. Genotype analysis for HLA class I together with microsatellite analysis demonstrated loss of HLA haplotype in HL-60 cells. No loss of HLA haplotype was observed in 44 samples of freshly isolated leukemic blasts. As reported previously, flow cytometric analysis rarely demonstrated loss or down-regulation of HLA expression at initial diagnosis (3/39; 7.7%); however, this was evident in two of five cases in relapse (40.0%), which contrasts with previous reports. In one patient with acute leukemia, HLA-A2 cell surface expression was present at initial diagnosis, lost at relapse, and completely restored after 48 h of culture in the presence of interferon-gamma. These results suggest loss of allele-specific HLA expression may be involved in the pathogenesis of relapse in patients with leukemia. The findings should be valuable in designing new strategies for clinical immunotherapy. en-copyright= kn-copyright= en-aut-name=MasudaKozo en-aut-sei=Masuda en-aut-mei=Kozo kn-aut-name=増田浩三 kn-aut-sei=増田 kn-aut-mei=浩三 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=REVERSE-TRANSCRIPTASE kn-keyword=REVERSE-TRANSCRIPTASE en-keyword=HISTOCOMPATIBILITY LEUKOCYTE ANTIGEN kn-keyword=HISTOCOMPATIBILITY LEUKOCYTE ANTIGEN en-keyword=TELOMERASE kn-keyword=TELOMERASE en-keyword=CHRONIC MYELOID-LEUKEMIA kn-keyword=CHRONIC MYELOID-LEUKEMIA en-keyword=CYTOTOXIC T-LYMPHOCYTES kn-keyword=CYTOTOXIC T-LYMPHOCYTES en-keyword=TUMOR-CELL LINES kn-keyword=TUMOR-CELL LINES en-keyword=HAPLOTYPE LOSS kn-keyword=HAPLOTYPE LOSS en-keyword=LARYNGEAL CARCINOMAS kn-keyword=LARYNGEAL CARCINOMAS en-keyword=GENETIC ALTERATIONS kn-keyword=GENETIC ALTERATIONS en-keyword=SURFACE EXPRESSION kn-keyword=SURFACE EXPRESSION en-keyword=CERVICAL-CANCER kn-keyword=CERVICAL-CANCER END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=肝外組織由来正常細胞はラット移植肝における肝細胞再生へわずかに寄与する kn-title=Limited Contribution of Cells of Intact Extrahepatic Tissue Origin to Hepatocyte Regeneration in Transplanted Rat Liver en-subtitle= kn-subtitle= en-abstract= kn-abstract=BACKGROUND: It is now well established that various adult somatic tissues harbor multipotent stem cells that can differentiate into a broad variety of cell types of all three germ layer origins. It remains controversial, however, whether they are a reservoir of cells utilized for emergent tissue repair or simply a vestige of evolution and, if the former is the case, to what extent they can potentially contribute to reconstitution of a specific organ. To get an insight in such a direction, we examined the extent of contribution of naive intact cells of extrahepatic origin to hepatocyte reconstitution in the transplanted liver with or without injury in the rat. METHODS: Liver from wild-type donor rats was transplanted to green fluorescent protein (GFP)-transgenic rats, and GFP-positive hepatocytes were examined with or without liver injury. RESULTS: The proportion of GFP-positive hepatocytes in the transplanted noninjured liver linearly increased by 0.0048% per week, that is, approximately 5 x 10(3) hepatocytes of extrahepatic origin were generated per day. Liver injury induced by treatment with 2-acetylaminofluorene and CCl4 or the additional application of hepatocyte growth factor did not further increase the percentage of GFP-positive hepatocytes. CONCLUSION: The present results indicate that cells derived from nonmanipulated extrahepatic tissues appreciably contribute, though limitedly, to hepatocyte reconstitution in the liver of the rat. en-copyright= kn-copyright= en-aut-name=TomiyamaKoji en-aut-sei=Tomiyama en-aut-mei=Koji kn-aut-name=冨山浩司 kn-aut-sei=冨山 kn-aut-mei=浩司 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=EGF+FGF2髄腔内投与によるALSモデルマウス脊髄での神経幹細胞増殖効果 kn-title=Intrathecal Injection of Epidermal Growth Factor and Fibroblast Growth Factor 2 Promotes Proliferation of Neural Precursor Cells in the Spinal Cords of Mice With Mutant Human SOD1 Gene en-subtitle= kn-subtitle= en-abstract= kn-abstract=We investigated three steps of neural precursor cell activation--proliferation, migration, and differentiation--in amyotrophic lateral sclerosis spinal cord treated with intrathecal infusion of epidermal growth factor (EGF) and fibroblast growth factor 2 (FGF2) into the lumbar spinal cord region of normal and symptomatic transgenic (Tg) mice with a mutant human Cu/Zn superoxide dismutase (SOD1) gene. We observed that 5-bromodeoxyuridine (BrdU) + nestin double-labeled neural precursor cells increased in the spinal cords of Tg mice compared with non-Tg mice, with a much greater increase produced by EGF and FGF2 treatment. The number of BrdU + nestin double-labeled cells was larger than that of BrdU + ionized calcium-binding adapter molecule-1 (Iba1), BrdU + glial fibrillary acidic protein (GFAP), or BrdU + highly polysialylated neural cell adhesion molecule (PSA-NCAM) double-labeled cells, but none expressed neuronal nuclear antigen (NeuN). On further analysis of the gray matter of Tg mice, the number of BrdU + nestin and BrdU + PSA-NCAM double-labeled cells increased more in the ventral horns than the dorsal horns, which was again greatly enhanced by EGF and FGF2 treatment. Because neural precursor cells reside close to the ependyma of central canal, the present study suggests that proliferation and migration of neural precursor cells to the ventral horns is greatly activated in symptomatic Tg mice and is further enhanced by EGF and FGF2 treatment and, furthermore, that the neural precursor cells preferentially differentiate into neuronal precursor cells instead of astrocytes in Tg mice with EGF and FGF2 treatment. en-copyright= kn-copyright= en-aut-name=OhtaYasuyuki en-aut-sei=Ohta en-aut-mei=Yasuyuki kn-aut-name=太田康之 kn-aut-sei=太田 kn-aut-mei=康之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=neural precursor cells kn-keyword=neural precursor cells en-keyword=epidermal growth factor kn-keyword=epidermal growth factor en-keyword=fibroblast growth factor 2 kn-keyword=fibroblast growth factor 2 en-keyword=spinal cord kn-keyword=spinal cord en-keyword=amyotrophic lateral sclerosis kn-keyword=amyotrophic lateral sclerosis END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=多価不飽和脂肪酸の神経芽腫細胞(Neuro2a)におけるアポトーシス抑制効果 kn-title=Inhibitory Effect of Polyunsaturated Fatty Acids on Apoptosis Induced by Etoposide, Okadaic Acid and AraC in Neuro2a Cells en-subtitle= kn-subtitle= en-abstract= kn-abstract=Neuronal apoptosis is involved in neurodegenerative diseases such as Alzheimer's disease and Parkinson.s disease. An efficient means of preventing it remains to be found. Some n-3 polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA, 22 : 6n-3) and eicosapentaenoic acid (EPA, 20 : 5n-3) have been reported to be protective against the neuronal apoptosis and neuronal degeneration seen after spinal cord injury (SCI) [1]. However, it is unclear which kinds of PUFAs have the most potent ability to inhibit neuronal apoptosis and whether the simultaneous treatment of PUFAs inhibits the apoptosis. In the present study, we compared the abilities of various n-3- and n-6- PUFAs to inhibit the apoptosis induced after the administration of different apoptotic inducers, etoposide, okadaic acid, and AraC, in mouse neuroblastoma cells (Neuro2a). Preincubation with DHA (22 : 6n-3), eicosapentaenoic acid (EPA, 20 : 5n-3), alpha-linolenic acid (alpha-LNA, 18 : 3n-3), linoleic acid (LA, 18 : 2n-6), arachidonic acid (AA, 20 : 4n-3), and gamma-linolenic acid (gamma-LNA, 18 : 3n-6) significantly inhibited caspase-3 activity and LDH leakage but simultaneous treatment with the PUFAs had no effect on the apoptosis of Neuro2a cells. There were no significant differences of the anti-apoptotic eff ect among the PUFAs. These results suggest that PUFAs may not be effective for inhibiting neuronal cell death after acute and chronic neurodegenerative disorders. However, dietary supplementation with PUFAs may be beneficial as a potential means to delay the onset of the diseases and/or their rate of progression. en-copyright= kn-copyright= en-aut-name=WuYumei en-aut-sei=Wu en-aut-mei=Yumei kn-aut-name=武玉梅 kn-aut-sei=武 kn-aut-mei=玉梅 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=polyunsaturated fatty acid (PUFA) kn-keyword=polyunsaturated fatty acid (PUFA) en-keyword=neurodegenerative disease kn-keyword=neurodegenerative disease en-keyword=caspase kn-keyword=caspase en-keyword=neuronal apoptosis kn-keyword=neuronal apoptosis en-keyword=DHA kn-keyword=DHA END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=重症患者ではヘム代謝が増加する:呼気一酸化炭素、動脈血一酸化炭素ヘモグロビンと血清ビリルビンIXαの相関 kn-title=Increased heme catabolism in critically ill patients: correlation among exhaled carbon monoxide, arterial carboxyhemoglobin, and serum bilirubin IXα concentrations en-subtitle= kn-subtitle= en-abstract= kn-abstract=It has been reported that exhaled carbon monoxide (CO) concentrations and arterial carboxyhemoglobin (CO-Hb) concentration in blood may be increased in critically ill patients. However, there was no study that examined correlation among amount of CO in exhaled air, CO-Hb concentrations in erythrocytes, and bilirubin IXalpha (BR) in serum, i.e., the three major indexes of heme catabolism, within the same subject. Here, we examined CO concentrations in exhaled air, CO-Hb concentrations in arterial blood, and BR levels in serum in 29 critically ill patients. Measurements of exhaled CO, arterial CO-Hb, and serum total BR have been done in the intensive care unit. As control, exhaled CO concentration was also measured in eight healthy volunteers. A median exhaled CO concentration was significantly higher in critically ill patients compared with control. There was significant correlation between CO and CO-Hb and CO and total BR level. We also found CO concentrations correlated with indirect BR but not direct BR. Multivariate linear regression analysis for amount of exhaled CO concentrations also showed significant correlation with CO-Hb and total BR, despite the fact that respiratory variables of study subjects were markedly heterogeneous. We found no correlation among exhaled CO, patients' severity, and degree of inflammation, but we found a strong trend of a higher exhaled CO concentration in survivors than in nonsurvivors. These findings suggest there is an increased heme breakdown in critically ill patients and that exhaled CO concentration, arterial CO-Hb, and serum total BR concentrations may be useful markers in critically ill conditions. en-copyright= kn-copyright= en-aut-name=MorimatsuHiroshi en-aut-sei=Morimatsu en-aut-mei=Hiroshi kn-aut-name=森松博史 kn-aut-sei=森松 kn-aut-mei=博史 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=heme oxygenase kn-keyword=heme oxygenase en-keyword=oxidative stress kn-keyword=oxidative stress END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=部分潅水および制限潅水によるマスカット・オブ・アレキサンドリアブドウの品質向上と水利用効率の改善 kn-title=Improving the Water Use Efficiency and Quality of Muscat of Alexandria Grapes by Partial Root-zone Drying and Regulated Deficit Irrigation en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=El-AnsaryDiaa Osama en-aut-sei=El-Ansary en-aut-mei=Diaa Osama kn-aut-name=エル アンサリイーディア オサマ kn-aut-sei=エル アンサリイー kn-aut-mei=ディア オサマ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒト初乳由来分泌型IgAはボツリヌスB型16S毒素と結合し,毒素のT84細胞への結合を抑制する kn-title=Human milk SIgA binds to botulinum type B 16S toxin and limits toxin adherence on T84 cells en-subtitle= kn-subtitle= en-abstract= kn-abstract=Botulinum neurotoxin produced by Clostridium botulinum type B is in the form of a complex of 12S and 16S toxins. Food-borne botulism is caused by these complex toxins which are ingested orally and absorbed from the digestive tract. Here, we show that the human milk SIgA binds to the type B16S toxin. The binding of SIgA to 16S toxin and HA was inhibited by carbohydrates such as galactose, suggesting that the interaction of carbohydrate side chain of the SIgA with the HA of the 16S toxin is important for SIgA-16S complex formation. We also demonstrate that SIgA inhibits the attachment of 16S toxin to intestinal epithelial cells. These data suggest that the interaction of antigen nonspecific SIgA with 16S toxin has a large influence on the absorption of 16S toxin from the intestinal epithelium, and that SIgA may provide insight into developing a therapeutic agent for type B food-borne botulism. en-copyright= kn-copyright= en-aut-name=MatsumuraTakuhiro en-aut-sei=Matsumura en-aut-mei=Takuhiro kn-aut-name=松村拓大 kn-aut-sei=松村 kn-aut-mei=拓大 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Clostridium kn-keyword=Clostridium en-keyword=Botulinum kn-keyword=Botulinum en-keyword=Botulism kn-keyword=Botulism en-keyword=Hemagglutinin kn-keyword=Hemagglutinin en-keyword=Neurotoxin kn-keyword=Neurotoxin en-keyword=Toxin kn-keyword=Toxin en-keyword=Secretory IgA kn-keyword=Secretory IgA en-keyword=Immunoglobulin kn-keyword=Immunoglobulin en-keyword=Galactose kn-keyword=Galactose en-keyword=Innate immunity kn-keyword=Innate immunity END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒスタミンH4受容体アゴニストは、抗原特異的ヒトT細胞応答においてH4アゴニスト作用以上の働きをする kn-title=Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T cell responses en-subtitle= kn-subtitle= en-abstract= kn-abstract=Histamine not only mediates immediate allergic reactions, it also regulates cellular immune responses. H4R is the most recently identified histamine receptor (HR). In the present study, we examined the in vitro effect of histamine and H4R agonists on the responses of human T cells to purified protein derivative from Mycobacterium tuberculosis (PPD) and to Cry j1, the major allergen of Cryptomeria japonica pollen. Dimaprit, clobenpropit and clozapine, which are H4R agonists, dose-dependently blocked both PPD-induced interferon-gamma and Cry j1-induced interleukin-5 production by both peripheral blood mononuclear cells (PBMCs) and antigen-specific T-cell lines. However, the addition of thioperamide, an H3R/H4R antagonist, as well as a mixture of d-chlropheniramine, famotidine and thioperamide, did not reverse the inhibition. Pretreatment of PBMCs with SQ22536 and 8-bromoadenosine-3',5'-cyclic monophosphorothioate, Rp-isomer, had varying abilities to reverse the inhibitory effects of H4R agonists, except for clobenpropit. Moreover, the addition of H4R agonists induced annexin-V expression on PBMCs, especially in CD19(+) and CD4(+) cells. cDNA microarray analysis revealed that, among 16,600 genes tested, increased expression following treatment with clozapine was seen in 0 x 8% of the genes, whereas decreased expression was seen in 3 x 0% of the genes. These results suggest that H4R agonists inhibit antigen-specific human T-cell responses, although H4R does not appear to be important for this effect. In addition, the present study indicated that there may be orphan receptors or HR subtypes which can bind dimaprit, clobenpropit and clozapine, and that can exert an inhibitory effect on antigen-specific cellular responses via a cAMP/cAMP-dependent protein kinase-dependent, apoptotic pathway. en-copyright= kn-copyright= en-aut-name=SugataYuji en-aut-sei=Sugata en-aut-mei=Yuji kn-aut-name=菅田裕士 kn-aut-sei=菅田 kn-aut-mei=裕士 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=cytokine kn-keyword=cytokine en-keyword=histamine kn-keyword=histamine en-keyword=H4R kn-keyword=H4R en-keyword=human studies kn-keyword=human studies en-keyword=T cell kn-keyword=T cell END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ミャンマー国におけるC型肝炎ウイルスの遺伝子型の分布:6型が優位であり、新しい6型のサブタイプが存在する kn-title=Hepatitis C Virus Genotype Distribution in Myanmar: Predominance of Genotype 6 and Existence of New Genotype 6 Subtype en-subtitle= kn-subtitle= en-abstract= kn-abstract=Aim: This study was performed to determine the prevalence and distribution of hepatitis C virus (HCV) genotypes in Myanmar. Methods: A total of 1333 peripheral blood samples were collected from four different border cities of Myanmar. The anti-HCV antibody-positive serum samples were identified. HCV was genotyped by reverse transcriptase polymerase chain reaction, direct DNA sequencing and phylogenetic analysis on the partial core genome. Results: The overall prevalence of HCV infection was 11.6% (154/1333). Regionally, it was 13.5% (47/349) in the north-eastern city, 12.8% (64/501) in the north-western city, 4.2% (16/380) in the southern city and 26.2% (27/103) in the western city. HCV was genotyped in 145/154 (94.2%) samples. Genotype 6 was the most prevalent genotype in this study (71/145, 49%), followed by genotype 3 (57/145, 39.3%), genotype 1 (16/145, 11%), and genotype 2 (1/145, 0.7%). Genotype 6 was mostly found in the northern cities and genotype 3 in the southern and western cities of Myanmar. Multiple HCV genotypes/subtypes were successfully characterized as 1a, 1b, 2a, 3a, 3b, 6m, 6n, and a new 6 subtype. Among them, subtype 6n was the most predominant subtype (38.6%), followed by subtype 3b (29.7%), 3a (9.6%), 6m (9%), 1b (6.9%), 1a (4.1%), new 6 subtype (1.4%) and 2a (0.7%). Subtype 6n was more widely distributed in the northern cities whereas subtype 3b was more common in the western city. The newly discovered genotype 6 subtype was from the northern cities. Conclusions: The results indicate there are regional differences of HCV genotype distribution in Myanmar. There is a distinct geographic variation from other South-East Asian countries in terms of the existence of the new genotype 6 subtype. en-copyright= kn-copyright= en-aut-name=Aye AyeLwin en-aut-sei=Aye Aye en-aut-mei=Lwin kn-aut-name=エイ エイルイン kn-aut-sei=エイ エイ kn-aut-mei=ルイン aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=DNA sequencing kn-keyword=DNA sequencing en-keyword=genotype kn-keyword=genotype en-keyword=hepatitis C virus kn-keyword=hepatitis C virus en-keyword=Myanmar kn-keyword=Myanmar en-keyword=phylogenetic analysis kn-keyword=phylogenetic analysis END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヘリコバクター・ピロリ熱ショック蛋白60は、単核球細胞中でのTLR2とMAPキナーゼ経路を介し,サイトカインIL-8の分泌を引き起こす kn-title=Helicobacter pylori heat-shock protein 60 induces interleukin-8 via a toll-like receptor (TLR) 2 and mitogen-activated protein (MAP) kinase pathway in human monocytes en-subtitle= kn-subtitle= en-abstract= kn-abstract=Previous reports have indicated that Helicobacter pylori heat-shock protein 60 (H. pylori-HSP60), as an immunodominant antigen, induces interleukin (IL)-8 production in human monocytes. The exact mechanism by which H. pylori-HSP60 induces IL-8 production in monocytes has not been fully elucidated. In the present study, the downstream pathway by which H. pylori-HSP60 induces IL-8 secretion in human monocytic cell lines was investigated. Intact H. pylori, heat-killed H. pylori and H. pylori recombinant HSP60 (rHpHSP60) all induced the secretion of IL-8 and the activation of mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK) and p38, but not c-Jun N-terminal kinase (JNK), up to 24 h in NOMO1 cells. The specific inhibitors PD98059 and U0126 (for ERK1/2 signalling) and SB203580 (for p38 MAPK signalling) down-regulated IL-8 secretion from rHpHSP60-treated NOMO1 cells. An anti-Toll-like receptor (TLR)2 antibody or TLR2 small interfering RNA (siRNA) partially inhibited the secretion of IL-8, and anti-TLR2 antibody also suppressed activation of ERK and p38 MAPK in rHpHSP60-treated NOMO1 cells. These reactions were associated with nuclear factor-kappaB (NF-kappaB)-mediated transcriptional activation, since U0126, SB203580 and the anti-TLR2 antibody decreased NF-kappaB activation. Taken together, the results suggest that ERK and p38 MAPK signalling linked to the TLR2 recognition receptor in human monocytes may be an important pathway in H. pylori-HSP60-induced IL-8 secretion. en-copyright= kn-copyright= en-aut-name=ZhaoYing en-aut-sei=Zhao en-aut-mei=Ying kn-aut-name=趙瑩 kn-aut-sei=趙 kn-aut-mei=瑩 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=GASTRIC EPITHELIAL-CELLS kn-keyword=GASTRIC EPITHELIAL-CELLS en-keyword=CYTOKINE MESSENGER-RNA kn-keyword=CYTOKINE MESSENGER-RNA en-keyword=HEAT-SHOCK PROTEINS kn-keyword=HEAT-SHOCK PROTEINS en-keyword=KAPPA-B ACTIVATION kn-keyword=KAPPA-B ACTIVATION en-keyword=PROINFLAMMATORY CYTOKINES kn-keyword=PROINFLAMMATORY CYTOKINES en-keyword=ENDOTHELIAL-CELLS kn-keyword=ENDOTHELIAL-CELLS en-keyword=MONGOLIAN GERBILS kn-keyword=MONGOLIAN GERBILS en-keyword=LYMPHOID-TISSUE kn-keyword=LYMPHOID-TISSUE en-keyword=TLR 2 kn-keyword=TLR 2 en-keyword=MACROPHAGES kn-keyword=MACROPHAGES END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=日本の東京における粒子状物質による健康影響評価 kn-title=Health Impact Assessment of Particulate Matter in Tokyo, Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract=Among industrialized countries, Japan still maintains an old set of guidelines for particulate matter (PM); therefore, we assessed the public health impacts of PM exposure in various situations using data from the Tokyo metropolitan area. Subjects were 7.8 million people aged older than 30 years. Based on a linear relationship between exposure and health effects, we estimated attributable cases of mortality caused by PM. Even at the recent exposure level, the number of deaths will occur after both short- and long-term exposure. When the guideline for PM2.5 (particles < 2.5 microm in diameter) long-term exposure was set at 12 microg/m3, we could prevent 8% of all causes mortality or 6,700 deaths in the Tokyo metropolitan area per year. This assessment shows that guidelines for long-term exposure, especially for PM2.5, should be recommended in Japan. en-copyright= kn-copyright= en-aut-name=YorifujiTakashi en-aut-sei=Yorifuji en-aut-mei=Takashi kn-aut-name=賴藤貴志 kn-aut-sei=賴藤 kn-aut-mei=貴志 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=線虫C.エレガンスにおける新規非コードDNA配列のゲノム分布と転写調節の解析 kn-title=Genomic distribution of and transcriptional control by a novel non-coding DNA in Caenorhabditis elegans en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=TakashimaYasuo en-aut-sei=Takashima en-aut-mei=Yasuo kn-aut-name=高島康郎 kn-aut-sei=高島 kn-aut-mei=康郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=口腔癌における染色体2q21-37部位の微調欠失マッピング kn-title=Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer en-subtitle= kn-subtitle= en-abstract= kn-abstract=We analysed the loss of heterozygosity (LOH) of long arm of chromosome 2 by using 16 polymorphic microsatellite markers in 39 matched oral normal and cancer tissues, and defined the deletional mapping of the region with putative tumor suppressor genes. LOH was detected at least one location in 33 of 39 (85%) tumor tissues. Frequent deletions were detected at the locations of microsatellite markers, D2S2304 (35%), D2S111 (40%), D2S155 (35%), D2S1327 (29%), D2S164 (29%), D2S125 (68%) and D2S140 (32%). Three preferentially deleted regions at 2q21-24, 2q33-35 and 2q37.3 were observed. Several candidate tumor suppressor genes in these regions such as LRP1B, CASP8, CASP10, BARD1, ILKAP, PPP1R7, and ING5, are located. Further molecular analysis of each gene should be performed to clarify their roles in oral carcinogenesis. en-copyright= kn-copyright= en-aut-name=CengizBeyhan en-aut-sei=Cengiz en-aut-mei=Beyhan kn-aut-name=チェンギスベイハン kn-aut-sei=チェンギス kn-aut-mei=ベイハン aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Oral cancer kn-keyword=Oral cancer en-keyword=2q kn-keyword=2q en-keyword=2q21-24 kn-keyword=2q21-24 en-keyword=2q33-35 kn-keyword=2q33-35 en-keyword=2q37.3 kn-keyword=2q37.3 en-keyword=Loss of heterozygosity kn-keyword=Loss of heterozygosity en-keyword=ING5 kn-keyword=ING5 en-keyword=CASP8 kn-keyword=CASP8 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=界面活性剤添加水溶液の直管およびヘリカル管内流動時における流動抵抗低減と熱伝達に関する実験・数値解析的研究 kn-title=Experimental and Numerical Study on Flow Drag Reduction and Heat Transfer of Surfactant Solutions in Straight and Helical Pipes en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=WaelIbrahim Ahmed Aly en-aut-sei=Wael en-aut-mei=Ibrahim Ahmed Aly kn-aut-name=ワエルイブラヒム アーメッド アリ kn-aut-sei=ワエル kn-aut-mei=イブラヒム アーメッド アリ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ロフィンペルオキシド類の化学発光反応の解明 kn-title=Elucidation of Chemiluminescence Reaction of Lophine Peroxides en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=RuGonho en-aut-sei=Ru en-aut-mei=Gonho kn-aut-name=盧公ホウ kn-aut-sei=盧 kn-aut-mei=公ホウ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=齲蝕原性連鎖球菌の病原性要因に関するScutellaria baicalensis Georigiの影響 kn-title=Effects of Scutellaria Baicalensis Georgi on Virulence Factors of Mutans Streptococci en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=DanShun-en en-aut-sei=Dan en-aut-mei=Shun-en kn-aut-name=段春燕 kn-aut-sei=段 kn-aut-mei=春燕 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=モルヒネ単回投与ラットにおけるナロキソン誘発場所嫌悪性試験に対するグルタミン酸受容体の関与 kn-title=Effect of glutamate receptor antagonists on place aversion induced by naloxone in single-dose morphine-treated rats en-subtitle= kn-subtitle= en-abstract= kn-abstract=The neurobiological mechanism underlying the negative motivational component of withdrawal from acute opiate dependence is far from understood. Our objectives were to determine whether the glutamatergic system is involved in the motivational component of morphine withdrawal in acutely dependent rats and such an involvement is associated with dopaminergic neurotransmission. We examined the effects of various kinds of glutamate receptor antagonists on conditioned place aversion (CPA) induced by naloxone-precipitated withdrawal from a single morphine exposure 24 h before. Furthermore, the influence of pretreatment with the dopamine receptor antagonist haloperidol on those effects of glutamate receptor antagonists was also investigated. CPA was attenuated in a dose-dependent manner by all glutamate receptor antagonists examined including the NMDA receptor antagonists (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5,10-imine maleate (MK-801) and phencyclidine hydrochloride (PCP), AMPA receptor antagonist 1-(4-aminophenyl)4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride (GYKI 52466), and metabotropic receptor antagonists (+/-)-2-amino-3-phosphonopropionic acid (AP-3) and (+/-)-alpha-methyl-4-carboxyphenylglycine (MCPG). The effects of MK-801, GYKI 52466 and MCPG were blocked by haloperidol.These results suggest that the glutamatergic system involving multiple classes of receptors plays a role in the motivational component of withdrawal from acute morphine dependence, and the function of the glutamatergic system would be closely associated with dopaminergic neurotransmission. en-copyright= kn-copyright= en-aut-name=KawasakiYoichi en-aut-sei=Kawasaki en-aut-mei=Yoichi kn-aut-name=河崎陽一 kn-aut-sei=河崎 kn-aut-mei=陽一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=morphine kn-keyword=morphine en-keyword=acute dependence kn-keyword=acute dependence en-keyword=naloxone kn-keyword=naloxone en-keyword=withdrawal kn-keyword=withdrawal en-keyword=conditioned place aversion kn-keyword=conditioned place aversion en-keyword=glutamate receptor antagonist kn-keyword=glutamate receptor antagonist en-keyword=dopamine kn-keyword=dopamine END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ヒスタミンN-メチル基転移酵素阻害薬,アモジアキンのP. acnes-LPS誘発性肝炎におよぼす効果 kn-title=Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice en-subtitle= kn-subtitle= en-abstract= kn-abstract=We examined whether treatment with amodiaquine, a potent inhibitor of histamine N-methyltransferase protects mice from Propionibacterium acnes (P. acnes)-primed and lipopolysaccharide (LPS)-induced hepatitis. The subcutaneous injection of amodiaquine (2 and 5 mg/kg) significantly increased the histamine levels in the liver in comparison to saline treated mice. Pretreatment with amodiaquine also improved the survival rate of the hepatitis mice, and this improvement was partially associated with the decrease in serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT). Amodiaquine partially suppressed increases of tumor necrosis factor (TNF)-alpha in the serum and TNF-alpha mRNA expression in the liver, whereas the expression of interleukin (IL)-18, interferon (IFN)-gamma and IL-12 in the liver was not changed by amodiaquine treatment. In conclusion, the present findings suggested that the elevation of endogenous histamine by amodiaquine may thus play a protective role through the regulation of TNF-alpha production in endotoxin-induced hepatic injury mice. en-copyright= kn-copyright= en-aut-name=YokoyamaAkira en-aut-sei=Yokoyama en-aut-mei=Akira kn-aut-name=横山玲 kn-aut-sei=横山 kn-aut-mei=玲 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Amodiaquine kn-keyword=Amodiaquine en-keyword=Propionibacterium acnes kn-keyword=Propionibacterium acnes en-keyword=Lipopolysaccharide kn-keyword=Lipopolysaccharide en-keyword=Hepatitis kn-keyword=Hepatitis END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=都市近郊域における竹林の拡大様式と過程に関する生態学的研究 kn-title=Ecological study on expansion pattern and process of bamboo forests in urban fringes of Japan en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=SaroinsongFabiola Baby en-aut-sei=Saroinsong en-aut-mei=Fabiola Baby kn-aut-name=サロインソンファビオラ ベイビ kn-aut-sei=サロインソン kn-aut-mei=ファビオラ ベイビ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=球状シリカフィラー添加によるレジンモディファイドグラスアイオノマーセメントの機械的強さの改良 kn-title=EFFECTS OF SPHERICAL SIRICA FILLER ADDITION ON IMPROVING THE MECHANICAL CHARACTERISTICS OF REZIN-MODIFIED GLASS-IONOMER CEMENT en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=HatanakaKenji en-aut-sei=Hatanaka en-aut-mei=Kenji kn-aut-name=畑中乾志 kn-aut-sei=畑中 kn-aut-mei=乾志 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=トポイソメラーゼIIβの発現抑制は骨髄性白血病細胞株においてオールトランスレチノイン酸(ATRA)による分化誘導あるいは増殖停止に引き続いてアポトーシスを誘導する kn-title=Downregulation of topoisomerase IIβ in myeloid leukemia cell lines leads to activation of apoptosis following all-trans retinoic acid-induced differentiation/growth arrest en-subtitle= kn-subtitle= en-abstract= kn-abstract=Among the topoisomerase (topo) II isozymes (alpha and beta), topo IIbeta has been suggested to regulate differentiation. In this study, we examined the role of topo IIbeta in all-trans retinoic acid (ATRA)-induced differentiation of myeloid leukemia cell lines. Inhibition of topo IIbeta activity or downregulation of protein expression enhanced ATRA-induced differentiation/growth arrest and apoptosis. ATRA-induced apoptosis in topo IIbeta-deficient cells involved activation of the caspase cascade and was rescued by ectopic expression of topo IIbeta. Gene expression profiling led to the identification of peroxiredoxin 2 (PRDX2) as a candidate gene that was downregulated in topo IIbeta-deficient cells. Reduced expression of PRDX2 validated at the mRNA and protein level, in topo IIbeta-deficient cells correlated with increased accumulation of reactive oxygen species (ROS) following ATRA-induced differentiation. Overexpression of PRDX2 in topo IIbeta-deficient cells led to reduced accumulation of ROS and partially reversed ATRA-induced apoptosis. These results support a role for topo IIbeta in survival of ATRA-differentiated myeloid leukemia cells. Reduced expression of topo IIbeta induces apoptosis in part by impairing the anti-oxidant capacity of the cell owing to downregulation of PRDX2. Thus, suppression of topo IIbeta and/or PRDX2 levels in myeloid leukemia cells provides a novel approach for improving ATRA-based differentiation therapy. en-copyright= kn-copyright= en-aut-name=ChikamoriKen-ichi en-aut-sei=Chikamori en-aut-mei=Ken-ichi kn-aut-name=近森研一 kn-aut-sei=近森 kn-aut-mei=研一 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=retinoids kn-keyword=retinoids en-keyword=differentiation kn-keyword=differentiation en-keyword=topoisomerase IIbeta kn-keyword=topoisomerase IIbeta en-keyword=apoptosis kn-keyword=apoptosis en-keyword=myeloid leukemia kn-keyword=myeloid leukemia en-keyword=peroxiredoxin 2 kn-keyword=peroxiredoxin 2 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=胸腺由来ドナーT細胞が慢性GVHDを起こす kn-title=Donor-derived Thymic-dependent T cells Cause Chronic Graft-versus-Host Disease en-subtitle= kn-subtitle= en-abstract= kn-abstract=Chronic graft-versus-host disease (GVHD) is the most common cause of poor long-term outcomes after allogeneic bone marrow transplantation (BMT), but the pathophysiology of chronic GVHD still remains poorly understood. We tested the hypothesis that the impaired thymic negative selection of the recipients will permit the emergence of pathogenic T cells that cause chronic GVHD. Lethally irradiated C3H/HeN (H-2k) recipients were reconstituted with T-cell-depleted bone marrow cells from major histocompatibility complex [MHC] class II-deficient (H2-Ab1-/-) B6 (H-2b) mice. These mice developed diseases that showed all of the clinical and histopathological features of human chronic GVHD. Thymectomy prevented chronic GVHD, thus confirming the causal association of the thymus. CD4+ T cells isolated from chronic GVHD mice were primarily donor reactive, and adoptive transfer of CD4+ T cells generated in these mice caused chronic GVHD in C3H/HeN mice in the presence of B6-derived antigen-presenting cells. Our results demonstrate for the first time that T cells that escape from negative thymic selection could cause chronic GVHD after allogeneic BMT. These results also suggest that self-reactivity of donor T cells plays a role in this chronic GVHD, and improvement in the thymic function may have a potential to decrease chronic GVHD. en-copyright= kn-copyright= en-aut-name=SakodaYukimi en-aut-sei=Sakoda en-aut-mei=Yukimi kn-aut-name=佐古田幸美 kn-aut-sei=佐古田 kn-aut-mei=幸美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=BONE-MARROW-TRANSPLANTATION kn-keyword=BONE-MARROW-TRANSPLANTATION en-keyword=MINOR HISTOCOMPATIBILITY ANTIGENS kn-keyword=MINOR HISTOCOMPATIBILITY ANTIGENS en-keyword=CONSENSUS DEVELOPMENT PROJECT kn-keyword=CONSENSUS DEVELOPMENT PROJECT en-keyword=WORKING GROUP-REPORT kn-keyword=WORKING GROUP-REPORT en-keyword=TERM FOLLOW-UP kn-keyword=TERM FOLLOW-UP en-keyword=SELF-TOLERANCE kn-keyword=SELF-TOLERANCE en-keyword=CORTICAL EPITHELIUM kn-keyword=CORTICAL EPITHELIUM en-keyword=HUMAN SCLERODERMA kn-keyword=HUMAN SCLERODERMA en-keyword=RANDOMIZED-TRIAL kn-keyword=RANDOMIZED-TRIAL en-keyword=CLINICAL-TRIALS kn-keyword=CLINICAL-TRIALS END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=甲状腺MALT lymphomaでは,他の臓器のMALT lymphomaと同様免疫グロブリン遺伝子がVH4に偏っているが,甲状腺Diffuse large B-cell lymphomaでは同じ傾向がみられない kn-title=Deviated VH4 immunoglobulin gene usage is found among thyroid mucosa-associated lymphoid tissue lymphomas, similar to the usage at other sites, but is not found in thyroid diffuse large B-cell lymphomas en-subtitle= kn-subtitle= en-abstract= kn-abstract=It remains unclear whether or not diffuse large B-cell lymphomas of extranodal sites arise from mucosa-associated lymphoid tissue (MALT) lymphomas. We studied the clinicopathological features of MALT lymphoma and diffuse large B-cell lymphoma in the thyroid gland, with special reference to VH usage of immunoglobulin gene rearrangement, to clarify the relationships between these two types of lymphomas. In addition, t(11; 18) (q21; q21) translocation was examined by multiplex reverse transcription-polymerase chain reaction. We examined 58 patients with primary thyroid lymphoma: 31 (male seven and female 24) with MALT lymphoma and 27 (male three and female 24) with diffuse large B-cell lymphoma. Interestingly, the sequence of VH genes revealed that the two subtypes differed significantly in their use of the VH4 family (P < 0.05). Of the seven MALT lymphomas, three used the VH4 family and the other four used the VH3 family, whereas eight out of nine diffuse large B-cell lymphoma used the VH3 family, one used the VH1 family, and none used the VH4 family. It was also interesting that, in one diffuse large B-cell lymphoma patient with MALT lymphoma, the diffuse large B-cell lymphoma component used the VH3 family and the MALT lymphoma component used the VH4 family. These data imply that, in a subset of cases, these two subtypes do not share a common origin and that at least some diffuse large B-cell lymphomas have a de novo origin. No t(11; 18) (q21; q21) was detected in thyroid lymphomas, which are different from MALT lymphoma of the stomach, lungs, large intestine and ocular adnexa. This strongly indicated that the presence of t(11; 18) (q21; q21) in MALT lymphoma is organ-specific. en-copyright= kn-copyright= en-aut-name=SatoYumiko en-aut-sei=Sato en-aut-mei=Yumiko kn-aut-name=佐藤由美子 kn-aut-sei=佐藤 kn-aut-mei=由美子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=diffuse large B-cell lymphoma kn-keyword=diffuse large B-cell lymphoma en-keyword=mucosa-associated lymphoid tissue lymphoma kn-keyword=mucosa-associated lymphoid tissue lymphoma en-keyword=PCR kn-keyword=PCR en-keyword=RT-PCR kn-keyword=RT-PCR en-keyword=thyroid gland kn-keyword=thyroid gland en-keyword=VH family kn-keyword=VH family END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ErbB1低親和性ベータセルリン変異体の創製 kn-title=Creation of the human betacellulin mutein with low affinity for ErbB1 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=NagaokaTadahiro en-aut-sei=Nagaoka en-aut-mei=Tadahiro kn-aut-name=永岡唯宏 kn-aut-sei=永岡 kn-aut-mei=唯宏 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=中等度左主幹部病変に対する治療法を決定するための冠動脈内圧測定 kn-title=Coronary pressure measurement to determine treatment strategy for equivocal left main coronary artery lesions en-subtitle= kn-subtitle= en-abstract= kn-abstract=It is often hard to select a treatment strategy for equivocal left main coronary artery (LMCA) disease. We investigated the usefulness of coronary pressure (CP) measurement for determining the treatment strategy in intermediate LMCA disease. We measured CP in 15 consecutive patients with equivocal LMCA disease (age 67.6 +/- 7.5 years, 14 males). Myocardial fractional flow reserve (FFRmyo) was obtained as the ratio of CP distal to the lesion/aortic pressure under maximal coronary dilation. Patients with FFRmyo > or = 0.75 and <0.75 received medical therapy and coronary artery bypass grafting (CABG), respectively, and were followed up for 32.5 +/- 9.7 (20-47) months. Eight patients received medical therapy and 7 patients underwent CABG in accordance with the FFRmyo criteria noted above. FFRmyo of the LMCA was 0.91 +/- 0.01 and 0.61 +/- 0.03 in patients who received medical and surgical therapy, respectively. Neither reference vessel diameter, minimal lumen diameter, nor percent diameter stenosis was significantly different between patients who received medical and surgical therapy. During the follow-up period, no patients with medical therapy showed symptoms due to the LMCA lesion. Similarly, 5 of 7 patients with CABG showed improvement of symptoms and the remaining 2 patients were hospitalized with congestive heart failure. No cardiac death was recorded in the patients with medical or surgical therapy. In conclusion, the present results clearly demonstrated that CP is clinically useful for determining the treatment strategy for equivocal LMCA lesions but coronary angiography is not. en-copyright= kn-copyright= en-aut-name=SuemaruShunji en-aut-sei=Suemaru en-aut-mei=Shunji kn-aut-name=末丸俊二 kn-aut-sei=末丸 kn-aut-mei=俊二 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Coronary artery disease kn-keyword=Coronary artery disease en-keyword=Follow-up kn-keyword=Follow-up en-keyword=Catheterization kn-keyword=Catheterization en-keyword=Angiography kn-keyword=Angiography en-keyword=Revascularization kn-keyword=Revascularization END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=造影超音波検査は膵腫瘍評価のために微細な血流を検出する kn-title=Contrast-enhanced ultrasonography depicts small tumor vessels for the evaluation of pancreatic tumors en-subtitle= kn-subtitle= en-abstract= kn-abstract=OBJECTIVE: The aim of this study is to evaluate the efficacy of contrast-enhanced ultrasonography for the diagnosis of pancreatic tumors. MATERIALS AND METHODS: Contrast-enhanced ultrasonography with Levovist was performed on 62 consecutive patients (53 with pancreatic cancer, 4 with islet cell tumor, 3 with inflammatory pancreatic tumor, and 2 with metastatic tumor). The vascular and perfusion image phases of the tumors were evaluated and compared with the findings of contrast-enhanced computed tomography. RESULTS: Contrast-enhanced ultrasonography showed tumor vessels around and/or in the tumor at the vascular image phase in 79% of pancreatic cancer patients (42/53). At the perfusion image phase, 96% of pancreatic cancers (51/53) were classified as hypo-enhancement type. However, tiny spotty or irregular heterogeneous enhanced lesions were found in 84% of hypo-enhanced pancreatic cancer patients (43/51). The presence of small vessels at the vascular image phase was closely correlated with the presence of these intratumor regional enhanced lesions at the perfusion image phase (kappa coefficient=0.42). The sensitivity of contrast-enhanced ultrasonography (100%) for pancreatic cancer was superior to that of contrast-enhanced computed tomography (91%), but no significant difference was observed between the two (McNemar test: p=0.063). CONCLUSION: Contrast-enhanced ultrasonography with Levovist successfully visualizes fine vessels and enhancement in pancreatic tumors, and is useful for evaluating pancreatic tumors. en-copyright= kn-copyright= en-aut-name=OkamotoYuko en-aut-sei=Okamoto en-aut-mei=Yuko kn-aut-name=岡本裕子 kn-aut-sei=岡本 kn-aut-mei=裕子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Contrast-enhanced ultrasonography kn-keyword=Contrast-enhanced ultrasonography en-keyword=Pancreatic tumors kn-keyword=Pancreatic tumors en-keyword=Levovist kn-keyword=Levovist END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=同時性多発大腸癌は腫瘍発生部位により臨床的特徴が異なる kn-title=Clinical characteristics of synchronous colorectal cancer are different according to tumour location en-subtitle= kn-subtitle= en-abstract= kn-abstract=AIMS: The purpose of this study was to investigate the clinical characteristics of synchronous cancer patients, with particular attention given to variations in tumour location. METHODS: A retrospective evaluation of 249 synchronous cancer cases out of 3061 consecutive colorectal cancer patients. RESULTS: Multivariate analysis of risk factors for synchronous cancer according to tumour location revealed that male gender was a significant risk for synchronous lesions in the left colon only (odds ratio=2.05, 95% confidence interval 1.34-3.13). Meanwhile, aging was a risk factor for synchronous cancer in the right colon only (odds ratio=1.05, 95% confidence interval 1.02-1.08), and in both sides of the colon (odds ratio=1.03, 95% confidence interval 1.01-1.05), but not in the left colon only (odds ratio=0.98, 95% confidence interval 0.97-1.00). In addition, patients with synchronous lesions in the right colon only tended to have adenomas in the right colon, while those with synchronous lesions in the left colon only tended to have adenomas in the left colon (each P value <0.05). CONCLUSION: The risk factors and status of concurrent adenomas of synchronous cancer cases varied according to tumour location, suggesting that the colonic site susceptible to neoplasia varies according to patient characteristics. en-copyright= kn-copyright= en-aut-name=FukatsuHirotoshi en-aut-sei=Fukatsu en-aut-mei=Hirotoshi kn-aut-name=深津裕寿 kn-aut-sei=深津 kn-aut-mei=裕寿 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Colonoscopy kn-keyword=Colonoscopy en-keyword=Synchronous colorectal cancer kn-keyword=Synchronous colorectal cancer en-keyword=Tumour location kn-keyword=Tumour location END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=T細胞性造血器腫瘍において過剰発現が認められるHelios short isoformの機能解析 kn-title=Characterization of the short isoform of Helios overexpressed in patients with T-cell malignancies en-subtitle= kn-subtitle= en-abstract= kn-abstract=In an earlier report, we demonstrated overexpression of a short isoform of Helios, Hel-5, which lacks three of four N-terminal zinc fingers, in patients with adult T-cell leukemia/lymphoma. Here, we characterized Hel-5 using immunoprecipitation, and gel shift and luciferase promoter assays, and found that Hel-5 lacks the repressor function observed with a full-length isoform of Helios. Moreover, Hel-5 associates with the full-length isoforms of the Ikaros gene family, Ikaros, Aiolos and Helios, and inhibits their DNA binding activity when present in excess, leading to dominant-negative effects on the full-length isoforms of the Ikaros gene family. Our results suggest a critical role for Helios in the mechanism of leukemogenesis. en-copyright= kn-copyright= en-aut-name=TabayashiTakayuki en-aut-sei=Tabayashi en-aut-mei=Takayuki kn-aut-name=多林孝之 kn-aut-sei=多林 kn-aut-mei=孝之 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Mutation kn-keyword=Mutation en-keyword=Carcinogenesis kn-keyword=Carcinogenesis en-keyword=Multivariate analysis kn-keyword=Multivariate analysis en-keyword=Case-control study kn-keyword=Case-control study END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=クリ胴枯病菌病原性衰退系統9B21から分離され、粒子として感染性を有する新規レオウイルスの性格付け kn-title=Characterization of a novel reovirus isolated in a hypovirulent stain (9B21) of the chestnut blight fungus that is infectious as particles en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=Supyani en-aut-sei=Supyani en-aut-mei= kn-aut-name=スピヤニ kn-aut-sei=スピヤニ kn-aut-mei= aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=日本における潰瘍性大腸炎の臨床的特徴の変化;1981年から2000年までの病院通院患者844名の解析 kn-title=Change of Clinical Characteristics of Ulcerative Colitis in Japan; Analysis of 844 Hospital Based Patients from 1981 to 2000 en-subtitle= kn-subtitle= en-abstract= kn-abstract=Although the number of ulcerative colitis patients has increased rapidly in Japan, few reports have been published regarding their clinical aspects. We investigated the clinical characteristics and chronological change of ulcerative colitis in Japanese patients. METHODS: Patients diagnosed with ulcerative colitis during the period from 1981 to 2000 were registered and their clinical profiles were analyzed. The chronological changes in clinical aspects, such as onset age, sex distribution, severity, extent of disease, clinical course, and corticosteroid use, were also determined. RESULTS: A total of 844 patients were registered, composed of 431 men and 413 women, with a median onset age of 34 years. The proportion of mild colitis and proctitis was significantly larger in patients with an onset at over 60 years of age, relative to those with an onset at less than 30 years (P<0.016). The proportion of ulcerative colitis patients with old age onset (P=0.09), male sex (P<0.01), mild colitis (P<0.01), proctitis (P<0.01), one-attack-only type (P<0.01), and not-treated-with-corticosteroid (P<0.01) demonstrated a chronological increase from 1981 to 2000. CONCLUSIONS: The distinctive clinical features and chronological change were seen in Japanese ulcerative colitis patients in recent years. Our data can help understand clinical aspects of ulcerative colitis patients in Asia, where the incidence of ulcerative colitis is still increasing. en-copyright= kn-copyright= en-aut-name=FujimotoTsuyoshi en-aut-sei=Fujimoto en-aut-mei=Tsuyoshi kn-aut-name=藤本剛 kn-aut-sei=藤本 kn-aut-mei=剛 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title= kn-title=CCN2/CTGFによるコラーゲン特異的分子シャペロンHSP47/関節リウマチ関連抗原RA-A47発現変動とその意義 en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=YaoMayumi en-aut-sei=Yao en-aut-mei=Mayumi kn-aut-name=矢尾真弓 kn-aut-sei=矢尾 kn-aut-mei=真弓 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=骨再生研究に利用する幹細胞候補-KUSA/A1細胞-の生物学的検討 kn-title=Biological Analysis of a Candidate Stem Cell -KUSA/A1 cell- for Bone Tissue Engineering en-subtitle= kn-subtitle= en-abstract= kn-abstract=The basic principle of bone induction for tissue engineering is to use stem cells, growth factors and organic matrix. KUSA/A1 cell is an example of bone marrow stromal stem cell, capable of differentiating into osteoblasts, chondrocytes and myotubes under inducing conditions. It has been reported that mature KUSA/A1 osteoblasts cultured in osteogenic condition, were able to induce a few bone formation in collagen hybridized PLGP sponge in vivo. This may be due to their low proliferation potential thereby not being able to obtain sufficient number of cells to promote large tissue repair. Because of this, in order to use KUSA/A1 cells with high cell proliferation activity to induce large amount of new bone, we evaluated whether KUSA/A1 cells in non-induction condition will maintain their immature stage. The result demonstrated that KUSA/A1 cells cultured in α-MEM maintained their immature stage in vitro. We further examined the osteoblastic differentiation under the influence of the host microenvironment in intraperitoneal diffusion chamber. The results indicated that immature KUSA/A1 cells in vivo cell culture differentiated into osteoblasts and produced mineralized bone-like tissue. Finally, we evaluated the effect of honeycomb scaffold to produce abundant bone formation using KUSA/A1 cells implanted in subcutaneous tissues of SCID mice. 1x10^6KUSA/Al cells with honeycomb scaffold showed abundant new bone formation. While, 5x10^6KUSA/Al cells alone showed only few small islands of new bone formation. This study support that KUSA/A1 cell is a good candidate as stem cells for basic research in bone tissue engineering. en-copyright= kn-copyright= en-aut-name=Rodriguez AndreaPaola en-aut-sei=Rodriguez Andrea en-aut-mei=Paola kn-aut-name=ロドリゲス アンドレラパオラ kn-aut-sei=ロドリゲス アンドレラ kn-aut-mei=パオラ aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Biological analysis kn-keyword=Biological analysis en-keyword=Stem cell kn-keyword=Stem cell en-keyword=Bone formation kn-keyword=Bone formation en-keyword=Carrier chamber culture kn-keyword=Carrier chamber culture END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=イヌモデルにおける両側自己肺温存部分肺移植術 kn-title=Bilateral native lung-sparing lobar transplantation in a canine model en-subtitle= kn-subtitle= en-abstract= kn-abstract=OBJECTIVE: Bilateral living-donor lobar lung transplantation has become an accepted approach in response to the cadaveric lung donor shortage. Because only one lobe is implanted in each chest cavity, this procedure is usually confined to patients of small size. The purpose of this study was to develop a technique of bilateral native lung-sparing lobar transplantation that can be applied to large adult patients. METHODS: Bilateral native lung-sparing lobar transplantation was performed in 12 pairs of dogs. In donor animals the right middle, lower, and cardiac lobes were separated as a right graft, and the left lower lobe was separated as a left graft. In recipient animals these 2 grafts were implanted in the natural anatomic position with sparing native right upper, left upper, and middle lobes. In an acute study (n = 6), transplanted graft function was assessed for 3 hours after ligation of the pulmonary artery branches to the native spared lobes. In a chronic study (n = 6) the immunosuppressed recipients were observed for 3 weeks to assess the quality of bronchial healing and long-term pulmonary function. RESULTS: Morphologic adaptation of the 2 grafts was found to be excellent. All 6 animals in the acute study showed excellent pulmonary function. Five of 6 animals in the chronic study survived for 3 weeks, with excellent pulmonary function and satisfactory bronchial healing. CONCLUSION: Bilateral native lung-sparing lobar transplantation was technically possible and associated with excellent pulmonary function and good bronchial healing in a canine experimental model. en-copyright= kn-copyright= en-aut-name=SugimotoSeiichiro en-aut-sei=Sugimoto en-aut-mei=Seiichiro kn-aut-name=杉本誠一郎 kn-aut-sei=杉本 kn-aut-mei=誠一郎 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=ALLOTRANSPLANTATION kn-keyword=ALLOTRANSPLANTATION en-keyword=EXPERIENCE kn-keyword=EXPERIENCE END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=近視学童における部分的干渉測定法を用いた眼軸長測定について:測定のリピータビリティと屈折要素との比較 kn-title=Axial Length Measurement Using Partial Coherence Interferometry in Myopic Children: Repeatability of the Measurement and Comparison with Refractive Components en-subtitle= kn-subtitle= en-abstract= kn-abstract=PURPOSE: To evaluate the test-retest repeatability of axial length (AL) measurements made with the IOLMaster in children with a wide range of myopic refractive errors, and to clarify the relationship between the AL and other refractive components. METHODS: The subjects were 95 children (mean age +/- SD, 10.8 +/- 1.3 years; range, 7-13 years; mean refractive error; -4.37 +/- 1.43 D; range, -1.50 to -8.19 D) who participated in a myopia-control trial. The AL of the right eye was measured three times using an IOLMaster, and the mean value was regarded as the representative measurement. After 5 min, the measurement was performed again, and the repeatability was evaluated by analyzing the distribution of differences between the two measurements. The relationships between the AL and age, cycloplegic autorefraction (RE), and corneal radius of curvature (CR) were also examined. RESULTS: The repeatability of the IOLMaster measurements was +/-0.05 mm (corresponding to a refractive error of +/-0.12 D) and was not affected by age or RE. AL was negatively correlated with RE (RE = -0.68 x AL + 12.74, r = -0.37) and positively correlated with CR (CR = 0.21 x AL + 2.53, r = 0.69). The highest correlation was found between the ratio of AL to CR and RE (AL/CR = -0.04 x RE + 3.08, r = -0.76). No association was observed between age and AL, nor between CR and RE. CONCLUSIONS: The IOLMaster provides high repeatability in AL measurement in myopic children. The associations between AL and each refractive component found in this study were consistent with those in previous studies that used the ultrasound A-mode method, except for slightly higher AL/CR ratios in our study. en-copyright= kn-copyright= en-aut-name=KimuraShuhei en-aut-sei=Kimura en-aut-mei=Shuhei kn-aut-name=木村修平 kn-aut-sei=木村 kn-aut-mei=修平 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=axial length kn-keyword=axial length en-keyword=myopic children kn-keyword=myopic children en-keyword=partial coherence interferometry kn-keyword=partial coherence interferometry en-keyword=refractive components kn-keyword=refractive components en-keyword=repeatability kn-keyword=repeatability END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=T細胞依存性免疫応答における抗原刺激されたB細胞の胚中心への移行の解析 kn-title=Analysis of an antigen-stimulated B cell migration into germinal centers during a T-dependent immune response en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=KouyamaEmi en-aut-sei=Kouyama en-aut-mei=Emi kn-aut-name=香山絵美 kn-aut-sei=香山 kn-aut-mei=絵美 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ラットL5脊髄神経結紮によるフォルマリンに対する疼痛行動変化:行動学的および分子学的検討 kn-title=Altered Response to Formalin by L5 Spinal Nerve Ligation in Rats: A Behavioral and Molecular Study en-subtitle= kn-subtitle= en-abstract= kn-abstract=BACKGROUND: The status of neuropathic pain alters the responsiveness to formalin injection in rats. However, the mechanism by which this alteration occurs is unknown. METHODS: We used immunocytochemistry to examine the expression of brain-derived neurotrophic factor (BDNF) and calcitonin gene-related peptide (CGRP) in the spinal cord of rats with L5 spinal nerve ligation (SNL)-induced neuropathy, and investigated the expression of c-Fos in the spinal cord after injection of formalin in the hindpaw of rats with SNL. RESULTS: Four weeks after SNL, the withdrawal threshold was significantly lower in the SNL group than in the sham-operated (sham) group (n = 12 per group, P < 0.05). In the SNL group, expression of BDNF in the L4 (P < 0.05) and L5 (P < 0.01) superficial dorsal horn was significantly decreased compared to that in the sham group. CGRP protein in the L5 but not in the L4, dorsal horn was significantly decreased compared to that in the sham group (P < 0.01). After formalin injection, spontaneous pain responses in the SNL group were significantly decreased compared to those in the sham group (P < 0.05). Immunolabeling for c-Fos was significantly decreased in the L4 and L5 dorsal horn in the SNL group (P < 0.01). CONCLUSION: Our examination of c-Fos distribution indicates that decreased neuronal activity in the spinal cord in response to inflammatory pain may be important for altering the perception of acute pain. Decreased BDNF expression in response to SNL-induced neuropathy may be involved in this alteration. en-copyright= kn-copyright= en-aut-name=KakuRyuji en-aut-sei=Kaku en-aut-mei=Ryuji kn-aut-name=賀来隆治 kn-aut-sei=賀来 kn-aut-mei=隆治 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=ホルムアルデヒドガスに曝露された医学生における臨床症状と皮膚試験反応についての前向き研究 kn-title=A prospective study of clinical symptoms and skin test reactions in medical students exposed to formaldehyde gas en-subtitle= kn-subtitle= en-abstract= kn-abstract=Previous investigators have reported the occurrence of both allergic and non-allergic systemic complications due to exposure to formaldehyde gas. However, little is known about the pathogenic link between formaldehyde-induced clinical symptoms and patch test results, or about the long-term effects of formaldehyde exposure. In the present study, a questionnaire was administered to 143 medical students, and 60 of them were tested by patch test for formaldehyde at the beginning and end of a human anatomy laboratory course. Another group of 76 students who had finished the course 2-4 years previously were administered another questionnaire, and the patch test was carried out on 58 of them. The frequencies of skin irritation, eye soreness, lacrimation, eye fatigue, rhinorrhea, throat irritation, general fatigue and mood swings increased after repeated exposure. Two (3.3%) of 60 students became positive to 1% formaldehyde at the end of the anatomy course (one male with allergic hand dermatitis due to direct contact with formaldehyde, and one female with an atopic background with unbearable physical symptoms) while the remaining 58 showed a negative reaction throughout the study period. The vast majority of students complained of various non-allergic, physical symptoms, and recovered from such symptoms without subsequent complications. No progression to multiple chemical sensitivity was found. Students with an episode of atopic dermatitis and allergic rhinitis were susceptible to formaldehyde exposure, and developed mucocutaneous symptoms, probably due to the impaired barrier function and remodeling of the skin and mucosa. en-copyright= kn-copyright= en-aut-name=TakahashiSachiko en-aut-sei=Takahashi en-aut-mei=Sachiko kn-aut-name=髙橋祥子 kn-aut-sei=髙橋 kn-aut-mei=祥子 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=barrier function kn-keyword=barrier function en-keyword=multiple chemical sensitivity kn-keyword=multiple chemical sensitivity en-keyword=formaldehyde kn-keyword=formaldehyde en-keyword=patch test kn-keyword=patch test en-keyword=prospective and follow-up study kn-keyword=prospective and follow-up study END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=再発性尿路感染症に対する乳酸菌膣坐剤の安全性および有効性を検証するためのパイロットスタディー kn-title=A pilot study evaluating the safety and effectiveness of Lactobacillus vaginal suppositories in patients with recurrent urinary tract infection en-subtitle= kn-subtitle= en-abstract= kn-abstract=Changes in the indigenous vaginal microflora with uropathogenic bacteria can predispose women to frequently recurring bacterial cystitis. Lactobacilli used as probiotics have played an important role in preventing the colonization of pathogenic bacteria in the vagina. A prospective clinical pilot study was performed to confirm the safety and effectiveness of Lactobacillus vaginal suppositories against the recurrence of bacterial urinary tract infection (UTI). The patients enrolled in the study were instructed to administer vaginal suppositories containing the strain Lactobacillus crispatus GAI 98322. A significant reduction in the number of recurrences was noted, without any adverse complication (P=0.0007). The administration of vaginal suppositories containing L. crispatus GAI 98332 seemed to be a safe and promising treatment for the prevention of recurrent UTI. en-copyright= kn-copyright= en-aut-name=UeharaShinya en-aut-sei=Uehara en-aut-mei=Shinya kn-aut-name=上原慎也 kn-aut-sei=上原 kn-aut-mei=慎也 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=Probiotics kn-keyword=Probiotics en-keyword=Lactobacillus kn-keyword=Lactobacillus en-keyword=Urinary tract infections kn-keyword=Urinary tract infections en-keyword=Vaginal suppositories kn-keyword=Vaginal suppositories END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=EBウイルス関連皮膚疾患における痂皮を用いた非侵襲的EBウイルス潜伏感染細胞の証明 kn-title=A novel, noninvasive diagnostic probe for hydroa vacciniforme and related disorders Detection of latency-associated Epstein-Barr virus transcripts in the crusts en-subtitle= kn-subtitle= en-abstract= kn-abstract=OBJECTIVE: To establish a new diagnostic method for Epstein-Barr virus (EBV)-associated cutaneous disorders. DESIGN: Skin biopsy is usually required to confirm the latent EBV infections in cutaneous lesions of EBV-associated NK/T-cell lymphoproliferative disorders, including hydroa vacciniforme (HV) and hypersensitivity to mosquito bites (HMB). We have devised a novel, noninvasive method to detect EBV-encoded small RNA (EBER), BamHI A rightward transcripts (BARTs) in the skin crusts and scales of such patients. PATIENTS: Six patients with EBV-associated cutaneous lesions were enrolled in the present study, including three patients with HV, one with HV-like eruptions and chronic active EBV infection, and two with EBV-associated cutaneous lymphoma. MAIN OUTCOME MEASURES: RNA was extracted from the crusts obtained from the cutaneous lesions by forceps, converted to cDNA, and processed for polymerase chain reaction (PCR) amplification with a specific set of primers. The PCR products were assayed by a DNA sequencer. RESULTS: Intact RNAs were successfully extracted from the crusts as well as control materials. EBER1 and BARTs RNAs were detected in all 7 crusts, and in 6 of 7 crusts of EBV-associated cutaneous diseases, respectively. One of 23 crusts from non EBV-associated diseases was positive for EBER1 RNA. The sensitivity and specificity of our assay for latent EBV infection were 100% and 95.8% for EBER1 RNA, and 85.7% and 100% for BARTs mRNA, respectively. The correct DNA sequence for EBER1 and BARTs was confirmed in the PCR products by a direct sequencing method. CONCLUSIONS: Our procedure may be of use as a biomarker for EBV-associated cutaneous lesions, including HV, HMB, and NK/T-cell lymphomas. en-copyright= kn-copyright= en-aut-name=YamamotoTakenobu en-aut-sei=Yamamoto en-aut-mei=Takenobu kn-aut-name=山本剛伸 kn-aut-sei=山本 kn-aut-mei=剛伸 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=EB virus kn-keyword=EB virus en-keyword=Hydroa vacciniforme kn-keyword=Hydroa vacciniforme en-keyword=Noninvasive kn-keyword=Noninvasive en-keyword=EBER kn-keyword=EBER en-keyword=Crust kn-keyword=Crust END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year= dt-pub= dt-online= en-article= kn-article= en-subject= kn-subject= en-title=1型糖尿病に対する移植療法に向けたヒト膵β細胞株の樹立 kn-title=A human β-cell line for transplantation therapy to control type 1 diabetes en-subtitle= kn-subtitle= en-abstract= kn-abstract=A human pancreatic beta-cell line that is functionally equivalent to primary beta-cells has not been available. We established a reversibly immortalized human beta-cell clone (NAKT-15) by transfection of primary human beta-cells with a retroviral vector containing simian virus 40 large T-antigen (SV40T) and human telomerase reverse transcriptase (hTERT) cDNAs flanked by paired loxP recombination targets, which allow deletion of SV40T and TERT by Cre recombinase. Reverted NAKT-15 cells expressed beta-cell transcription factors (Isl-1, Pax 6, Nkx 6.1, Pdx-1), prohormone convertases 1/3 and 2, and secretory granule proteins, and secreted insulin in response to glucose, similar to normal human islets. Transplantation of NAKT-15 cells into streptozotocin-induced diabetic severe combined immunodeficiency mice resulted in perfect control of blood glucose within 2 weeks; mice remained normoglycemic for longer than 30 weeks. The establishment of this cell line is one step toward a potential cure of diabetes by transplantation. en-copyright= kn-copyright= en-aut-name=NarushimaMichiki en-aut-sei=Narushima en-aut-mei=Michiki kn-aut-name=成島道樹 kn-aut-sei=成島 kn-aut-mei=道樹 aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 en-keyword=EMBRYONIC STEM-CELLS kn-keyword=EMBRYONIC STEM-CELLS en-keyword=INSULIN-PRODUCING CELLS kn-keyword=INSULIN-PRODUCING CELLS en-keyword=PANCREATIC-ISLET CELLS kn-keyword=PANCREATIC-ISLET CELLS en-keyword=IN-VITRO kn-keyword=IN-VITRO en-keyword=GENE kn-keyword=GENE en-keyword=MICE kn-keyword=MICE en-keyword=ESTABLISHMENT kn-keyword=ESTABLISHMENT en-keyword=DIFFERENTIATION kn-keyword=DIFFERENTIATION en-keyword=IDENTIFICATION kn-keyword=IDENTIFICATION en-keyword=HYPERGLYCEMIA kn-keyword=HYPERGLYCEMIA END start-ver=1.4 cd-journal=joma no-vol= cd-vols= no-issue= article-no= start-page= end-page= dt-received= dt-revised= dt-accepted= dt-pub-year=2007 dt-pub=20070323 dt-online= en-article= kn-article= en-subject= kn-subject= en-title=日本企業におけるリスク報告の実態に関する研究 -アニュアル・レポートと有価証券報告書を中心として- kn-title=A Study of Risk Reporting on Japanese Company -Focus on the Practice in Annual Reports and Security Reports- en-subtitle= kn-subtitle= en-abstract= kn-abstract= en-copyright= kn-copyright= en-aut-name=AliMd. Mohobbot en-aut-sei=Ali en-aut-mei=Md. Mohobbot kn-aut-name=アリエムディー モホボット kn-aut-sei=アリ kn-aut-mei=エムディー モホボット aut-affil-num=1 ORCID= affil-num=1 en-affil= kn-affil=岡山大学 END