このエントリーをはてなブックマークに追加
ID 11854
Eprint ID
11854
FullText URL
Thumnail K003342.pdf 198 KB
Title Alternative
歯原性腫瘍におけるヘパラン硫酸結合性成長因子を放出するへパラナーゼの役割
Author
Phuu Pwint, Han
Abstract
Immunolocalization of heparan sulphate(HS) and heparanase was evaluated in benign and malignant odontogenic tumors in order to know whether these molecules have potential roles in odontogenic tumorigenesis. Archival formalin-fixed, paraffin-embedded tissues of 6 human tooth germs, 7 adenomatoid odontogenic tumors, 10 ameloblastic fibromas, 20 ameloblastomas and 4 ameloblastic carcinomas were subjected to immunohistochemical staining using antibodies to HS, heparanase and BMP-4. HS was ubiquitously localized in tooth germ but heparanase and BMP-4 were observed in limited areas only. In benign epithelial tumors such as ameloblastoma and adenomatoid odontogenic tumor, these molecules were localized in neoplastic epithelium but in ameloblastic fibroma, positive reactions were observed in both epithelial and mesenchymal cells. Stromal localization of HS and BMP-4 accompanied by intense immunoexpression of epithelial heparanase was observed in ameloblastic carcinoma,and this may represent the malignant progression of ameloblastoma to ameloblastic carcinoma. Stronger intensity and more diffuse localization of heparanase in odontogenic tumors compare to that of human tooth germ was the most significant finding. Taken together, the results inferred that heparanase may be responsible for the growth and progression of odontogenic tumors by modulating the availability and function of HS binding growth factors and the derangement in immunoexpression and localization of HS and heparanase molecules may have important roles in progression of malignant odontogenic tumors.
Keywords
Heparanase
Heparan sulphate
BMP-4
Odontogenic tumors
Tooth germ
Immunohistochemistry
Published Date
2007-03-23
Publication Title
Content Type
Thesis or Dissertation
Grant Number
甲第3342号
Granted Date
2007-03-23
Thesis Type
博士(学術)
Grantor
岡山大学
Official Url
http://ci.nii.ac.jp/naid/110006250203/
language
日本語
File Version
none
Refereed
Unknown