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ID 8462
Eprint ID
8462
FullText URL
Thumnail K002848.pdf 102 KB
Title Alternative
肝細胞増殖因子の遺伝子治療は心筋虚血の動物モデルにおいて心室性不整脈を抑制する
Author
Yumoto, Akihisa
Abstract
It was recently reported that gene therapy using hepatocyte growth factor (HGF) has the potential to preserve cardiac function after myocardial ischemia. We speculated that this HGF gene therapy could also prevent ventricular arrhythmia. To investigate this possibility, we examined the antiarrhythmic effect of HGF gene therapy in rat acute and old myocardial infarction models. Myocardial ischemia was induced by ligation of the left descending coronary artery. Hemagglutinating virus of Japan (HVJ)-coated liposome containing HGF genes were injected directly into the myocardium fourteen days before programmed pacing. Ventricular fibrillation (VF)was induced by programmed pacing. The VF duration was reduced and the VF threshold increased after HGF gene therapy ( p< 0.01). Histological analyses revealed that the number of vessels in the ischemic border zone was greatly increased after HGF gene injection. These findings revealed that HGF gene therapy has an anti-arrhythmic effect after myocardial ischemia.
Keywords
ventricular arrhythmia
HGF (hepatocyte growth factor)
ischemia
HVJ (hemagglutinating
Note
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16049559&dopt=Abstract
Published Date
2005-03-25
Publication Title
Content Type
Thesis or Dissertation
Grant Number
甲第2848号
Granted Date
2005-03-25
Thesis Type
Doctor of Philosophy in Medical Science
Grantor
岡山大学
Official Url
http://escholarship.lib.okayama-u.ac.jp/cgi/viewcontent.cgi?article=1296&context=amo
language
日本語
File Version
none
Refereed
Unknown