Acta Medica Okayama2005海面上における乱流フラックスリアルタイム観測システムの開発に関する研究ENSatoshiTakahashiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Some metric invariants of spheres and Alexandrov spacesENNobuyukiSochiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Propelling Motion of Metal ComplexesENHonglingLiuNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005炭化珪素薄膜の成長と表面・界面物性ENMasaakiHiraiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005タルトロン酸とアミン類との様々な分子間化合物の結晶構造と水素結合様式の研究ENTakeoFukunagaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Transcriptional regulation of a life-cycle dependent bidirectional promoter in Caenorhabditis elegansENTetsuyaBandoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005TDAE-フラーレン系の結晶構造と磁性ENMotoyasuFujiwaraNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005混合原子価化合物CeFe2におけるCe L端吸収・発光分光の磁気円二色性ENKanameAsakuraNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Measurement of the W+γ Production in W to Muon Decay Channel in Proton-Antiproton Collisions at √s=1.96 TeVENNahoTanimotoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Symplectic invariants arising from a Grassmannian quotient and trivalent graphsENHirokiAkazawaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Collective and Individual Excitations of Spatially Inhomogeneous Superfluid Phases in Ultracold Quantum GasesENKenMizushimaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Studies on Chemiluminescence of Hydroperoxy Imidazole DerivativesENMitsuruTsunenagaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005RecA-mediated Triple-stranded DNA Formation and Its Application to DNA AnalysisENYasushiShigemoriNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005丹波帯南東部に分布する付加コンプレックス -丹波層群の地質とテクトニクス-ENTeijiMikamiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Theoretical Study on Structural and Thermodynamic Properties of Water, Ice, and Clathrate HydrateENYujiKoyamaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005球共振法によるマントル物質の高温弾性率の測定 -β相,γ相及び透輝石の弾性率と地球構造-ENNorihitoMayamaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Homotopy theory of partial abelian monoids and the space of intervals in a Euclidean spaceENShingoOkuyamaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Physiological and biochemical responses of plant plasma membrane to toxic aluminum ionENSung-JuAhnNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005製造工程由来の製剤中の高感作性極微量ペニシリン系とセファロスポリン系化合物の分析法の開発とその応用に関する研究ENWataruTakadaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005炎症性サイトカインInterleukin-1及び Interferon-γのHGF 産生誘導調節作用に関する研究ENYoichiroTakamiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005変異原物質高感度検出株の作製と突然変異の抑制に関する研究ENEizoTakahashiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005抗腫瘍性ヌクレオシド, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106) 及び1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)uracil (EUrd) のRNA合成阻害機構の解析並びにRNA合成阻害により誘導される細胞死の分子機構の解析ENTatsushiYokogawaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005シトクロムP450-2D酵素による三環系抗うつ薬デシプラミンの代謝的活性化機構ENTakashiIsobeNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005緑膿菌の多剤排出ポンプMexVWの生化学的及び遺伝学的解析ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005細菌における異物耐性系の遺伝学的・生化学的解析ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005ビスフォスフォン酸修飾プロドラッグによる骨指向型薬物送達システムの設計とその最適化に関する研究ENHidekiHirabayashiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005緑膿菌の未解析RND型多剤排出ポンプの遺伝子クローニングと性質ENTakehikoMimaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Human dihydropyrimidine dehydrogenase遺伝子の5'-flanking regionのsequence解析;5-Fluorouracilの効果に関連する新しい多型の同定ENTakakoHasegawaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005高融点物質による油脂性坐剤からの薬物放出制御に関する研究ENToshihitoTakatoriNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Cytochrome P450 2D6とBunitrolol及びBufuralolの相互作用に関する計算化学的研究 -活性中心におけるPhe-120, Glu-216 及び Glu-222の役割-ENKazufumiMasudaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005コンドロイチン硫酸BのBリンパ球増殖促進作用および分化誘導作用に関する研究ENErikoAoyamaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005ラットの睡眠障害モデルの作製および各種催眠薬の特性ENKazuakiShinomiyaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005ジクロロメタン分解菌Ralstonia metallidurans PD11株の分解特性とバイオリアクターへの応用に関する研究ENChizukoMiyakeNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005マスト細胞の病変部位における集積およびその役割に関する研究ENYoshinoriIbaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005β-naphthoflavone前処置Hep G2細胞における4-hydroxypropranolol硫酸抱合活性の変動機構解明ENJunkoMiyanoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005ビブリオ・バルニフィカス金属プロテアーゼ産生におけるクォーラム・センシング調節ENTomokaKawaseNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005触法精神障害者の処遇における責任能力制度の再検討ENJunkoKomotoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Etude synchronique et diachronique de la locution verbale venir de+ inf. dite ≪passé récent≫ENNatsukiIkutaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005万葉集歌人研究-大伴家持を中心にENArataMorinagaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005古墳時代の遺跡立地に関する景観考古学的研究ENHirofumiTeramuraNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005わが国における国営干拓地の地理学的研究ENAkioYamanoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005中国少数民族ミャオ族の生業形態に関する地理学的研究ENYoshikoKanamaruNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005蘭学医書の原著者とオランダの訳者たちの医学世界ENSumioIshidaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005産卵ウズラにおける飼料蛋白質含量の低減化と選抜育種に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Relationship between Photostability and Structure of CarotenoidENShinAritaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Studies on Carotenoids in the Furits of Fructus lyciiENMeilanPiaoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005中国内モンゴルにおける持続可能な牧畜業に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Molecular characterization of alcohol /aldehyde dehydrogenases involved in polyethylene glycol degradation in sphingomonadsENTakeshiOhtaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Pseudomonas syringaeのMicrobe-Associated Molecular Patterns(MAMPs)によるシロイヌナズナ防御応答解析ENYasuhiroIshigaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005糖転移酵素を活用した新規オリゴ糖の合成に関する研究ENTakashiShibuyaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005ウシ卵巣嚢腫の発生機序の解析と新たな治療法の開発ENJunichiTodorokiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005LARGE-SCALE PRODUCTION AND PURIFICATION OF BIOLOGICAL ACTIVE BOVINE INTERFERON τ: POSSIBLE APPLICATION TO INCREASE EMBRYONIC DEVELOPMENTENHitomiTakahashiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005植物病原細菌Pseudomonas syringae pv. tabaci の病原性機構の解析ENMizuriMarutaniNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005糸状菌食性線虫の生態及び病害防除への利用に関する研究ENHiroakiOkadaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005ニワトリとラットの貪食性白血球における細胞内カルシウムイオン動態に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Biosurfactants produced by a marine bacterium, Myroides sp. SM1ENManeeratSuppasilNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Biochemical and molecular biological studies on microbial degradation of polyvinyl alcoholENWilailakKlomklangNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Studies on the RNA Silencing-Mediated Resistance to Beet necrotic yellow vein virusENBagus AndikaIdaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Studies on the purification and characterization of α-mannosidase and β-xylosidase from Ginkgo biloba seeds: Application to GlycobiologyENKwan KitWooNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005STUDIES ON IMPROVEMENT OF DROUGHT RESISTANCE IN CASHEW (Anacardium occidentale L.) AT THE SEEDLING STAGEENPitonoJokoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Molecular and genetical analysis of genetic diversity and phylogenetic relationship among wheat germplasm, with diverse geographical origin, mainly from AsiaENSurya KantGhimireNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005構成モジュール特異的抗体による結合組織成長因子CTGF/Hcs24の定量と機能解析ENMasanaoMinatoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005セメント質形成過程における上皮鞘基底膜プロテオグリカンの動態に関する研究ENAzumiHirataNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005分子生物学的手法による歯周病細菌検査の臨床応用ENChiyoFujimotoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005ダイオキシン誘発マウス口蓋裂の発症機序に関する研究ENKumikoFujiwaraNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005頸骨および頭蓋骨における剥離骨膜からの新生骨形成過程の組織形態学的観察ENTakashiFujiiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005ヒト歯胚と歯原性腫瘍基底膜におけるIV型コラーゲンα鎖の局在に関する免疫組織化学的研究ENEikiFujiiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005転写調節因子Zac1の軟骨基質代謝に及ぼす影響ENNobuoTakeshitaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005高速液体クロマトグラフィーを用いたミダゾラムおよび代謝産物の血中濃度測定と蛋白結合に関する研究ENJunOmoriNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005High glucose enhances interleukin-6-induced vascular endothelial growth factor 165 expression via activation of gp130-mediated p44/42 MAPK-CCAAT/enhancer binding protein signaling in gingival fibroblastsENKazuhiroOmoriNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005歯周治療後の疾患の再発や進行の予知マーカーとしての歯周病原性細菌に対する血清抗体価測定の有用性に関する研究ENNorikoSugiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Thiazolidinediones(Pioglitazone)Blocks P. gingivalis-and F. nucleatum-, but not E. coli-Lipopolysaccharide(LPS)-induced interleukin-6(IL-6) Production in AdipocytesENMayumiMorimotoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005非復位性関節円板前方転位に随伴した顎関節症(Ⅳ型:変形性顎関節症)の病態と可溶型腫瘍壊死因子受容体に関する研究ENJunjiUeharaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005ERK 1/2 MAPK を分子標的としたヒト骨肉腫細胞の分化誘導治療に関する基礎的研究ENShinsukeMatsumuraNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005歯科臨床における臨床検査の重要性の検討ENJunMatsumuraNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005ヒト bete-defensin-2 による口腔バイオフィルム形成に与える影響ENKaoriMatsumuraNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005骨芽細胞様細胞株(MC3T3-E1細胞)の細胞接着,増殖,分化および遺伝子発現に対するチタンの影響ENKentaroAkiyamaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Regulation of bone metabolism in immunosuppressant (FK506) - treated ratsENShihoKirinoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005口腔扁平上皮癌の病理発生・病態におけるIV型コラーゲンα鎖の免疫組織化学的研究ENRyoTamamuraNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005齲蝕抑制機能を有するレジン系修復材料の分子設計 -ウレタンジメタクリレート/メタクリル酸レジンをマトリックスとするフッ素徐放修復材料の開発-ENToshiakiHashimotoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Different Expression Patterns of beta-Defensins in Human Squamous Cell CarcinomasENTomohitoYoshimotoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Osteogenic Potential of Primed Preriosteum Graft in the Rat Calbarial ModelENMiwaKanouNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Experimental tooth movement uqregulates preproenkephalin mRNA in the rat trigeminal nucleus caudalis and oralisENAbdulsamad Ali BalamTarekNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Effects of spherical silica filer addition on improving the characteristics of resin-modified glass-ionomer cementENRosalinaTjandrawinataNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Viability of the Cariostat medium as a source of DNA for further analysis through Polymerase Chain ReactionENOmar Marianito ManingoRodisNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Genetic and epigenetic alterations of BRG1 promote oral cancer developmentENEsraGunduzNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Caries prediction using salivary buffer capasity test and caries sctivity test in Mongolian preschool childrenENOyuntsetsegBazarNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005最小次元オブザーバの設計法とスライディングモード制御則の双対関係およびその応用ENYoshisukeHamaiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005安全計装システムの高信頼化及び独立防御層の確率論的リスク評価ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Synthesis and Lipase-Catalyzed Kinetic Resolution of 2-AziridinemethanolsENYuLiuNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005矩形断面を持つ曲がり管内二次流に関する研究ENKenKadowakiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005正方形断面を持つ曲がり管内テイラー・ディーン流れに関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Development of an effective protein transduction technology for mammalian cellsENMidoriFutamiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005生体電気インピーダンスを用いた嚥下機能検査法の開発に関する研究ENToshimasaKusuharaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Preparation of Inorganic/Organic Biomaterials involving Essential Transition Metal Ions and BiomoleculesENNorifumiAzumaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005ガソリンエンジンの低NOx燃焼法とその燃焼診断に関する研究ENTatsuyaTanakaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Study on Surface Durability and Failure of Surface-Hardened Powder-Forged RollersENQiangZhangNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005応力・温度がけい素鋼板の磁気特性に及ぼす影響に関する研究ENMasayoshiNakaokaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005自由曲面を目標形状とする溶接ビード自動仕上げシステムの研究開発とその応用ENKeijiTanimotoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005水蒸気フラックスの長期観測システム化に関する研究ENAkiyoshiOtoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005ヘリカルな曲がり円管内の流れに関する研究ENYasutakaHayamizuNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005徐放制御を目指した機能重畳化高分子界面活性剤の創製とその製剤プロセスへの応用に関する研究ENSatoruNishinoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005横旋回気流層ガス化発電プロセスに関する基礎研究ENEiichiHaradaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Practical Synthesis of Optically Active Fluorine-Containing 1-Phenylethylamines Based on Highly Regioselective Hydrogenolysis of Bis(1-phenylethyl)amine DerivativesENMasatomiKanaiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Studies of N-Oxyl Derivatives Mediated Electrooxidation of Alcohols in WaterENJunKubotaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005有限要素法を用いた電磁機器の位相最適化手法に関する基礎的研究ENYoshifumiOkamotoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005多結晶金属の引張塑性変形に伴う微視的変形挙動に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Nonlinear Control of Underactuated Linked Mechanical SystemsENTomohiroHenmiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005日本の製造業における集積効果に関する実証研究ENAkihiroOtsukaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005STUDIES ON FERTILIZATION OF PIG OOCYTES BY INTRACYTOPLASMIC INJECTION OF FREEZE-DRIED AND SALT-STORED SPERMATOZOAENIn-KiuKwonNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005劣悪条件下での荒廃地緑化における肥料木と緑化牧草類の混植に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005高感度液体流れ分析システム構築と非金属元素の超微量化学分析に関する研究ENNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005STUDIES ON THE DEVELOPMENT OF NEW TECHNOLOGIES FOR PRESERVATION OF PIG GAMETESENKi-EunParkNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005被毛異常突然変異マウスの病態および原因遺伝子に関する研究ENKentaroMasujinNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Studies on Influence Analysis in Cox Proportional Hazards ModelsENJi MinSungNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Synthesis of two- and three dimensional organic-inorganic hybrids for inducing biomineralizationENYukiShirosakiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Deposition of bioactive titania layers under ambient conditions due to hydrolysis of inorganic saltsENFanXiaoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005廃棄物の安全性評価と有害物質による応答性遺伝子の特定ENAyaYamadaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Studies on Hotspots Detection for Multivariate Spatial Data using EchelonsENHan PyoHongNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Successive and quantitative monitoring of tropospheric aerosols with an autonomous polarization Mie lidarENKengoIokibeNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005TTF型骨格をもつ有機伝導体の極低温物性研究ENKiyonoriKatoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005In vitro response of osteoblast-like and odontoblast-like cells to unsubstituted and substituted apatitesENMihoInoueNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Tissue expression and molecular function of four troponin I isoforms in Caenorhabditis elegansENRuksanaRaziaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Synthetic study of 3,3',4-tri-O-methylellagic acid and some related compoundsENAshraful AlamMohammedNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Effect of Spur-Dike Permeability on Flow and Scouring under Stable and Surge Flow ConditionENTomasz MarekMioduszewskiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Research on Underground Dams – Design and Construction ConceptsENKwabenaKankam-YeboahNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Studies on Equilibria and Thermodynamics of Weak Ion Association between Inorganic Anions and Symmetrical Tetraalkylammonium Ions in Aqueous and Aqueous-Organic MediaENJoseph MbunaJuliusNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Studies on the participation of the histamine H3 receptor in allergic skin responses in miceENMaria AlejandraHossen SuárezNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Development of Novel Polymeric Film Preparations That Can Improve Skin Permeation of Propranolol Hydrochloride by Use of EnhancersENAmnuaikitChomchanNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005A study on the physiological, biochemical and molecular responses of plants to aluminum and phosphorus stressesENAyalewLigabaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Flood Hazard Assessment using Synthetic Aperture Radar Data with GIS: A Case Study of Greater Dhaka, BangladeshENAshraf MahmmoodDewanNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Human Monocyte-derived Dendritic Cells Pulsed with Wild-field name="type" p53 Protein Efficiently Induce Cytotoxic T-lymphocytes against p53 overexpressing Human Cancer CellsENNaoyukiTokunagaPURPOSE: Dendritic cells are the most potent antigen-presenting cells for initiating cellular immune responses. Dendritic cells are attractive immunoregulatory cells for cancer immunotherapy, and their efficacy has been investigated in clinical trials. The tumor suppressor gene p53 is pivotal in the regulation of apoptosis, and p53-based immunization is an attractive approach to cancer immunotherapy because of the accumulation of p53 protein in malignant but not in normal cells. It has been shown that dendritic cells transduced with an adenoviral wild-type p53 (wt-p53) construct mediate the antitumor immune responses against p53-overexpressing tumor cells. We examined whether monocyte-derived human dendritic cells pulsed with the purified full-length wt-p53 protein were also capable of inducing the specific antitumor responses against p53-overexpressing tumors in vitro. EXPERIMENTAL DESIGN: Immature dendritic cells generated in the presence of interleukin-4 and granulocyte/macrophage colony-stimulating factor from monocytes of HLA-A2- or HLA-A24-positive healthy individuals were pulsed with the purified p53 protein. Uptake of p53 protein by human dendritic cells was assessed by Western blotting and immunohistochemical staining using anti-p53 antibody. Induction of p53-specific CTL response was also evaluated by the cytotoxic assay against p53-overexpressing human tumor cells. RESULTS: Both Western blot and immunohistochemical analysis showed the accumulation of p53 protein in human immature dendritic cells. T cells obtained from HLA-A2- or HLA-A24-positive healthy donors were stimulated twice with p53 protein-pulsed dendritic cells and then applied to the cytotoxicity assay against p53-overexpressing target cells. The CTL activity was specific for p53-overexpressing tumor cells and MHC class I restricted. Moreover, the CTL activity generated by p53 protein-pulsed dendritic cells was nearly identical with that induced by adenoviral wt-p53-transduced dendritic cells. CONCLUSIONS: Our results indicate that monocyte-derived human dendritic cells pulsed with the wt-p53 protein could induce the specific antitumor effect against p53-overexpressing tumors and that this in vitro model offers a new and more simple approach to the development of p53-based immunotherapy.No potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005ARIX gene polymorphisms in patients with congenital superior oblique muscle palsyENYanJiangNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Novel Action of Activin and Bone Morphogenetic Protein in Regulating Aldosterone Production by Human Adrenocortical CellsENJiroSuzukiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Out-of-hospital Cardiac Arrest in Okayama City (Japan): Outcome Report according to the "Utstein Style"ENHoeiHayashiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Immunohistochemical Localization of Klotho Protein in Brain, Kidney, and Reproductive Organs of MiceENShun-AiLiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) MotifENHirokiNojimaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Time-dependent Changes of Plasma Osteopontin Levels in Patients with Anterior Wall Acute Myocardial Infarction after Successful Reperfusion: Correlation with Left Ventricular Volumes and FunctionENChisatoSuezawaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1α in non-small cell lung cancersENYujiHiramiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Establishment of hepatitis C virus replicon cell lines possessing interferon-resistant phenofield name="type"ENKatsuyukiNambaNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Blood flow-dependent changes in intrarenal nitric oxide levels during anesthesia with halothane or sevofluraneENKazuhitoKusudoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Regression of capillary network in atrophied soleus muscle induced by hindlimb unweightingENHidemiFujinoNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005The effect of formaldehyde gas exposure in a murine allergic contact hypersensitivity modelENKazuyasuFujiiNo potential conflict of interest relevant to this article was reported.Acta Medica Okayama2005Hepatocyte Growth Factor Gene Therapy Reduces Ventricular Arrhythmia in Animal Models of Myocardial IschemiaENAkihisaYumotoIt was recently reported that gene therapy using hepatocyte growth factor (HGF) has the potential to preserve cardiac function after myocardial ischemia. 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