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ID 8360
Eprint ID
8360
FullText URL
Thumnail K002620.pdf 122 KB
Title Alternative
大腸・直腸リンパ腫におけるAPI2-MALT1融合遺伝子の発現
Author
Sakugawa, Sumie
Abstract
The API2-MALT1 fusion gene was originally identified from a t(11;18)(q21;q21) translocation, a specific chromosomal abnormality that is found in mucosa-associated lymphoid tissue (MALT) lymphoma. Gastric MALT lymphomas positive for the API2-MALT1 fusion gene do not respond to Helicobacter pylori–eradication therapy, but otherwise, the incidence and clinicopathological behavior of colorectal MALT lymphoma with this genetic abnormality are unclear. We examined the API2-MALT1 fusion by multiplex RT-PCR method in 47 cases of MALT lymphoma and 13 cases of diffuse large B-cell lymphoma and evaluated the relevance of API2-MALT1 positivity to the clinical and pathological features. The mean ages of MALT lymphoma and diffuse large B-cell lymphoma patients were 65 (range, 37–87 y) and 58 (range, 14–85 y) years, respectively. API2-MALT1 fusion genes were detected in seven cases (15%) of MALT lymphoma and one case (8%) of diffuse large B-cell lymphoma. In MALT lymphomas, the tumor size in API2-MALT1–positive cases was 62 plusminus 39 mm (mean plusminus SD), statistically larger than that in API2-MALT1–negative cases (25 plusminus 19 mm; P < .01). The API2-MALT1–positive cases demonstrated more advanced clinical stages and a male predominance, compared with API2-MALT1–negative cases. Thus, API2-MALT1–positive tumors should be cared for as a more aggressive subgroup and be followed for a longer time.
Keywords
API2
Large intestine
MALT1
MALT lymphoma
RT-PCR
Published Date
2004-03-25
Publication Title
Content Type
Thesis or Dissertation
Grant Number
甲第2620号
Granted Date
2004-03-25
Thesis Type
博士(医学)
Grantor
岡山大学
Official Url
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14681324&dopt=Abstract
language
日本語
File Version
none
Refereed
Unknown