FullText URL fulltext.pdf
Author Hagiya, Hideharu| Koyama, Toshihiro| Zamami, Yoshito| Tatebe, Yasuhisa| Funahashi, Tomoko| Shinomiya, Kazuaki| Kitamura, Yoshihisa| Hinotsu, Shiro| Sendo, Toshiaki| Rakugi, Hiromi| Kano, Mitsunobu R.|
Keywords adult intensive & critical care epidemiology geriatric medicine health & safety health policy public health
Published Date 2019-12-11
Publication Title BMJ OPEN
Volume volume9
Issue issue12
Publisher BMJ Publishing Group
Start Page e033462
ISSN 2044-6055
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © Author(s) (or theiremployer(s)) 2019.
File Version publisher
PubMed ID 31831549
DOI 10.1136/bmjopen-2019-033462
Web of Science KeyUT 000512773400250
Related Url isVersionOf https://doi.org/10.1136/bmjopen-2019-033462
FullText URL fulltext.pdf
Author Koyama, Toshihiro| Sasaki, Misato| Hagiya, Hideharu| Zamami, Yoshito| Funahashi, Tomoko| Ohshima, Ayako| Tatebe, Yasuhisa| Mikami, Naoko| Shinomiya, Kazuaki| Kitamura, Yoshihisa| Sendo, Toshiaki| Hinotsu, Shiro| Kano, Mitsunobu R.|
Published Date 2019-12-27
Publication Title Scientific Reports
Volume volume9
Publisher Nature Publishing Group
Start Page 20235
ISSN 2045-2322
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders © The Author(s) 2019
File Version publisher
PubMed ID 31882673
DOI 10.1038/s41598-019-56388-w
Web of Science KeyUT 000509351200002
Related Url isVersionOf https://doi.org/10.1038/s41598-019-56388-w
JaLCDOI 10.18926/AMO/56645
FullText URL 73_2_101.pdf
Author Iida, Atsuyoshi| Naito, Hiromichi| Yorifuji, Takashi| Zamami, Yoshito| Yamada, Akane| Koga, Tadashi| Imai, Toru| Sendo, Toshiaki| Nakao, Atsunori| Ichiba, Shingo|
Abstract Sedatives are administered during extracorporeal membrane oxygenation (ECMO) therapy to ensure patient safety, reduce the metabolic rate and correct the oxygen supply-demand balance. However, the concentrations of sedatives can be decreased due to absorption into the circuit. This study examined factors affecting the absorption of a commonly used sedative, midazolam (MDZ). Using multiple ex vivo simulation models, three factors that may influence MDZ levels in the ECMO circuit were examined: polyvinyl chloride (PVC) tubing in the circuit, use of a membrane oxygenator in the circuit, and heparin coating of the circuit. We also assessed changes in drug concentration when MDZ was re-injected in a circuit. The MDZ level decreased to approximately 60% of the initial concentration in simulated circuits within the first 30 minutes. The strongest factor in this phenomenon was contact with the PVC tubing. Membrane oxygenator use tended to increase MDZ loss, whereas heparin circuit coating had no influence on MDZ absorption. Similar results were obtained when a second dose of MDZ was injected to the second-use circuits.
Keywords sedatives ECMO polyvinyl chloride pharmacokinetics pharmacodynamics
Amo Type Original Article
Published Date 2019-04
Publication Title Acta Medica Okayama
Volume volume73
Issue issue2
Publisher Okayama University Medical School
Start Page 101
End Page 107
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
Copyright Holders CopyrightⒸ 2019 by Okayama University Medical School
File Version publisher
Refereed True
PubMed ID 31015744
FullText URL J_Pharm_Sci_130_1_24.pdf
Author Tangsucharit, Panot| Takatori, Shingo| Zamami, Yoshito| Goda, Mitsuhiro| Pakdeechote, Poungrat| Kawasaki, Hiromu| Takayama, Fusako|
Keywords Acetylcholine-induced vasodilatation CGRPergic nerves Muscarinic receptor subtypes Rat mesenteric arteries
Published Date 2016-01
Publication Title Journal of Pharmacological Sciences
Volume volume130
Issue issue1
Publisher Japanese Pharmacological Society
Start Page 24
End Page 32
ISSN 1347-8613
NCID AA11806667
Content Type Journal Article
language 英語
OAI-PMH Set 岡山大学
Copyright Holders https://creativecommons.org/licenses/by-nc-nd/4.0/deed.ja
File Version publisher
PubMed ID 26825997
DOI 10.1016/j.jphs.2015.12.005
Web of Science KeyUT 000369700500004
Related Url https://doi.org/10.1016/j.jphs.2015.12.005