JaLCDOI 10.18926/AMO/32296
FullText URL fulltext.pdf
Author Takacs, Istvan| Zeher, Margit| Urban, Laszio| Szegedi, Gyula| Semsei, Imre|
Abstract <p>The majority of the t(14;18) chromosome translocations that occur in non-Hodgkin centroblastic-centrocytic follicular lymphoma can be detected by various methods. During the translocation process the bcl-2 gene located on chromosome 18 (18q21) is translocated to the JH region of the immunoglobulin gene of chromosome 14 (14q32). The most frequent type of bcl-2 translocations is the mbr type, whereas the immunoglobulin gene breaks mainly at the JH1-6 exons. About one of the 10(5) cells bearing the translocation can already be detected by using nested polymerase chain reaction (PCR). Eight patients suffering from follicular lymphoma were included in this study, which considered the usefulness of the PCR method. The results are in good agreement with those obtained by conventional diagnostic methods. Translocation can be detected, however, in patients with non-malignant diseases such as Sjogren's syndrome (about 5% of the patients) and in a patient with Whipple disease. In addition, translocation was detected in lymphocytes of peripheral blood of a healthy donor. Since lymphomas are detected in patients with Sjogren's syndrome with a relative high frequency, an early diagnosis of the translocation could improve the treatment of the disease. Nevertheless, a diagnosis of lymphoma is valid only in cases of bone marrow translocation-positivity.</p>
Keywords t(14;18) chromosome translocation lymphoma early diagnoses Sjogren's syndrome
Amo Type Article
Published Date 2000-10
Publication Title Acta Medica Okayama
Volume volume54
Issue issue5
Publisher Okayama University Medical School
Start Page 185
End Page 192
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 11061567
Web of Science KeyUT 000090098600001