JaLCDOI 10.18926/AMO/31611
FullText URL fulltext.pdf
Author Zhao, Dan Dan| Namba, Taketoshi| Araki, Junichi| Ishioka, Kazunari| Takaki, Miyako| Suga, Hiroyuki|
Abstract <p>Nipradilol (3,4-dihydro-8-(2-hydroxy-3-isopropylamino) propoxy-3-nitroxy-2H-1-benzopyran) is a newly synthesized chemical agent designed to possess beta-adrenoceptor blocking and vasodilating actions. Nipradilol decreased left ventricular contractility index (Emax, slope of the ventricular end-systolic pressure-volume relation), systolic pressure-volume area (PVA, a measure of ventricular total mechanical energy) and oxygen consumption in cross-circulated excised dog hearts. However, nipradilol did not decrease total coronary resistance. These results indicate that nipradilol, like propranolol, depresses myocardial mechanoenergetics and that the vasodilating action of nipradilol could not be detected in the present study.</p>
Keywords cardiac mechanics cardiac energetics coronary circulation vertricle ?-blocker
Amo Type Article
Published Date 1993-02
Publication Title Acta Medica Okayama
Volume volume47
Issue issue1
Publisher Okayama University Medical School
Start Page 29
End Page 33
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8096354
Web of Science KeyUT A1993KP18500005