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ID 31040
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Author
Yabe, Yoshiro
Matsumoto, Kyoko
Ogura, Hajime
Abstract

To establish an experimental persistent infection of the brain with human adenoviruses, adenovirus type 6 (ad 6) was inoculated intracerebrally into young adult hamsters. Hamsters appeared languid for a few days after inoculation, but recovered rapidly. By cocultivation of tissue fragments with HeLa cells, ad 6 was always recovered from the brains of hamsters throughout their lives, as long as 29 months, indicating the establishment of a lifelong persistent infection. Except for the first few days after inoculation, however, attempts to recover virus by inoculation of tissue extracts onto HeLa cells or by cultivation of tissue fragments alone were unsuccessful.

Keywords
adenovirus type 6
persistent infection
hamster brain
Amo Type
Article
Published Date
1988-02
Publication Title
Acta Medica Okayama
Volume
volume42
Issue
issue1
Publisher
Okayama University Medical School
Start Page
45
End Page
47
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT