JaLCDOI 10.18926/AMO/30539
FullText URL fulltext.pdf
Author Yamashita, Syoichi|
Abstract <p>Male rats were made either anemic by blood depletion or polycythemic by red blood cell transfusion, then joined to female rats by aortic anastomoses. Sex chromosome analyses were made of the bone marrow, spleen, lymph nodes and thymus. These analyses showed a hight level of chimeric cells between 5 and 10 days after parabiosis. Anemic males had the highest rate and plethoric animals had the lowest. The chimeric rates in the bone marrow depended largely on hemopoietic avtibity. Thr findings indicate that cieculating nucleated cells maintained high hemopoietic and lymphopoietic activity.</p>
Keywords chimera parabiosis hemopoiesis lymphopoiesis.
Amo Type Article
Published Date 1980-04
Publication Title Acta Medica Okayama
Volume volume34
Issue issue2
Publisher Okayama University Medical School
Start Page 71
End Page 79
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6450518
Web of Sience KeyUT A1980JY15600001
JaLCDOI 10.18926/AMO/30398
FullText URL fulltext.pdf
Author Moriyama, Masahiro| Domoto, Haruyo| Yamashita, Syoichi| Furuno, Katsushi| Oishi, Ryozo| Kawasaki, Hiromu| Gomita, Yutaka|
Abstract <p>We examined the pharmacokinetics of phenobarbital before and during pregnancy in rats. Animals were divided into four groups: (a) control, (b) pregnant, (c) phenobarbital-treated, and (d) phenobarbital-treated pregnant groups. The increase in body weight of nonpregnant or pregnant rats was not influenced by long-term phenobarbital treatment. Plasma phenobarbital concentrations during the period of long-term phenobarbital treatment with a fixed dosage by body weight were not significantly affected by pregnancy. Furthermore, pregnancy did not affect pharmacokinetic parameters of phenobarbital between 0.25 and 24h after administration. These results suggest that pregnancy does not influence on the pharmacokinetics of long-term phenobarbital treatment at a fixed dosage by body weight.</p>
Keywords phenobarbital pharmacokinetics pregnancy plasma concentrations
Amo Type Article
Published Date 1995-10
Publication Title Acta Medica Okayama
Volume volume49
Issue issue5
Publisher Okayama University Medical School
Start Page 237
End Page 240
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 8585393
Web of Sience KeyUT A1995TC51800002