start-ver=1.4
cd-journal=joma
no-vol=71
cd-vols=
no-issue=4
article-no=
start-page=291
end-page=299
dt-received=
dt-revised=
dt-accepted=
dt-pub-year=2017
dt-pub=201708
dt-online=
en-article=
kn-article=
en-subject=
kn-subject=
en-title=
kn-title=Association between Skeletal Muscle Depletion and Sorafenib Treatment in Male Patients with Hepatocellular Carcinoma: A Retrospective Cohort Study
en-subtitle=
kn-subtitle=
en-abstract=
kn-abstract= The effect of skeletal muscle mass (SMM) on the outcomes of sorafenib treatment for hepatocellular carcinoma (HCC) has not been established. We measured the SMM in HCC patients treated with sorafenib, evaluated the patientsf survival, and evaluated the association between skeletal muscle depletion and sorafenib treatment. Of the 97 HCC patients treated with sorafenib at our institution in the period from July 2009 to February 2015, our study included 69 patients (51 males, 18 females) who had received sorafenib for ? 8 weeks and whose follow-up data were available. SMM was calculated from computed tomography images at the mid-L3 level (cm2) and normalized to height (m2) to yield the L3 skeletal muscle index (L3-SMI, cm2/m2). The median L3-SMI value was higher in the males (43 cm2/m2) compared to the females (36 cm2/m2). In the males only, the multivariate Cox regression identified an L3-SMI <43 cm2/m2 as independently associated with higher mortality compared to an L3-SMI ?43 cm2/m2 (hazard ratio 2.315, 95% confidence interval: 1.125-4.765, p=0.023). Skeletal muscle depletion is a factor predicting poor prognosis for male patients with advanced HCC treated with sorafenib.
en-copyright=
kn-copyright=

en-aut-name=NaganumaAtsushi
en-aut-sei=Naganuma
en-aut-mei=Atsushi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=1
ORCID=

en-aut-name=HoshinoTakashi
en-aut-sei=Hoshino
en-aut-mei=Takashi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=2
ORCID=

en-aut-name=SuzukiYuhei
en-aut-sei=Suzuki
en-aut-mei=Yuhei
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=3
ORCID=

en-aut-name=UeharaDaisuke
en-aut-sei=Uehara
en-aut-mei=Daisuke
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=4
ORCID=

en-aut-name=KudoTomohiro
en-aut-sei=Kudo
en-aut-mei=Tomohiro
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=5
ORCID=

en-aut-name=IshiharaHiroshi
en-aut-sei=Ishihara
en-aut-mei=Hiroshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=6
ORCID=

en-aut-name=SatoKen
en-aut-sei=Sato
en-aut-mei=Ken
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=7
ORCID=

en-aut-name=KakizakiSatoru
en-aut-sei=Kakizaki
en-aut-mei=Satoru
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=8
ORCID=

en-aut-name=YamadaMasanobu
en-aut-sei=Yamada
en-aut-mei=Masanobu
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=9
ORCID=

en-aut-name=TakagiHitoshi
en-aut-sei=Takagi
en-aut-mei=Hitoshi
kn-aut-name=
kn-aut-sei=
kn-aut-mei=
aut-affil-num=10
ORCID=

affil-num=1
en-affil=Department of Gastroenterology, Takasaki General Medical Center, National Hospital Organization
kn-affil=

affil-num=2
en-affil=Department of Gastroenterology, Takasaki General Medical Center, National Hospital Organization
kn-affil=

affil-num=3
en-affil=Department of Gastroenterology, Takasaki General Medical Center, National Hospital Organization
kn-affil=

affil-num=4
en-affil=Department of Gastroenterology, Takasaki General Medical Center, National Hospital Organization
kn-affil=

affil-num=5
en-affil=Department of Gastroenterology, Takasaki General Medical Center, National Hospital Organization
kn-affil=

affil-num=6
en-affil=Department of Gastroenterology, Takasaki General Medical Center, National Hospital Organization
kn-affil=

affil-num=7
en-affil=Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
kn-affil=

affil-num=8
en-affil=Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
kn-affil=

affil-num=9
en-affil=Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine
kn-affil=

affil-num=10
en-affil=Department of Gastroenterology, Kusunoki Hospital
kn-affil=
en-keyword=skeletal muscle depletion
kn-keyword=skeletal muscle depletion
en-keyword=hepatocellular carcinoma
kn-keyword=hepatocellular carcinoma
en-keyword=sorafenib
kn-keyword=sorafenib
en-keyword=L3 skeletal muscle index
kn-keyword=L3 skeletal muscle index
en-keyword=prognostic factor
kn-keyword=prognostic factor
END