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ID 52019
FullText URL
Author
Noda, Yohei
Yoshinobu, Junko
Abstract
Conclusion: Bone marrow-derived cells can be engrafted in the olfactory bulb and a few cells can differentiate into mitral/tufted cells in the olfactory bulb. Objectives: To investigate whether bone marrow-derived cells can be engrafted into the olfactory bulb and differentiate into neurons and glial cells after methimazole administration. Methods: Bone marrow of GFP (green fluorescence protein) mice was transplanted into lethally irradiated recipient mice. Immunostaining was performed to confirm the cell types of bone marrow-derived cells expressing GFP. Results: GFP-positive cells were observed in the olfactory bulb at 2 days after methimazole administration. The number of dendritic GFP-positive cells increased up to 30 days after methimazole administration and then decreased. Double immunostaining for GFP and Iba1 or TBX21 showed that a large population of the GFP-positive cells had characteristics of microglia/macrophages and a few cells had characteristics of mitral/tufted cells.
Keywords
Transplantation
regeneration
olfaction
mitral cells
microglia
Published Date
2013-09
Publication Title
Acta Oto-laryngologica
Volume
volume133
Issue
issue9
Start Page
951
End Page
956
ISSN
0001-6489
Content Type
Journal Article
Official Url
http://dx.doi.org/10.3109/00016489.2013.803153
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/51950
language
英語
File Version
author
Refereed
True
DOI
Web of Sience KeyUT