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ID 16421
Eprint ID
16421
FullText URL
Thumnail 95_1201.pdf 339 KB
Title Alternative
Studies on human peripheral monocyte-mediated cytotoxicity Part II. Monocyte-mediated cytolysis in malignant cell
Author
Yamashita, Jiro
Abstract
The human peripheral monocyte-mediated cytolytic acitivity against tumor cells derived from human squamous cell-type lung cancer was measured in 16 healthy donors, 24 patients with bronchogenic carcinoma, 6 patients with malignant lymphoma and 8 patients with sarcoidosis. The activity was significantly depressed in patients with bronchogenic carcinoma (p<0.05) and in patients with malignant lymphoma (p<0.01). However, there was no significant difference between normal controls and patients with sarcoidosis. There was no significant difference monocyte-mediated cytolytic activities according to clinical stage and histologic type in lung cancer patients. A statistically significant positive correlation between phogocytic acitivity and cytolytic activity of monocytes, between monocyte-mediated cytolytic activity and cytostatic activity was observed in lung cancer patients. The data suggest that monocyte-mediated cytolytic activity in tumor bearing hosts is suppressed, and this lower activity effects the immunological surveillance and host defence mechanism against malignant tumors.
Keywords
肺癌
単球
腫瘍細胞溶解作用
Published Date
1983-12-30
Publication Title
岡山医学会雑誌
Publication Title Alternative
Journal of Okayama Medical Association
Volume
volume95
Issue
issue11-12
Publisher
岡山医学会
Publisher Alternative
Okayama Medical Association
Start Page
1201
End Page
1207
ISSN
0030-1558
NCID
AN00032489
Content Type
Journal Article
Official Url
https://www.jstage.jst.go.jp/article/joma1947/95/11-12/95_11-12_1201/_article/-char/ja/
Related Url
http://www.okayama-u.ac.jp/user/oma/index.html
language
日本語
Copyright Holders
岡山医学会
File Version
publisher
Refereed
True
Eprints Journal Name
joma