JaLCDOI 10.18926/AMO/32175
FullText URL fulltext.pdf
Author Takahashi, Isao| Sano, Masayuki| Okamoto, Hideyuki| Shiromoto, Masayoshi| Nakamura, Toru| Ueno, Katsumi| Nakada, Hiroshi| Haruta, Yuro| Seto, Takumi| Yamashita, Jiro| Yorimitsu, Seiichi| Miyake, Susumu| Machida, Kenichi| Konda, Keiji| Tamura, Tetuo| Imajou, Kenji| Kimura, Ikuro|
Abstract <p>A 34-year-old woman infected with human T cell leukemia virus type-I(HTLV-I) with recurrent thrombocytopenia and various autoantibodies is described. The platelet counts fluctuated between 1.3 x 10(4)/microliters and 14.8 x 10(4)/microliters without any medical treatment, and thrombocytopenia improved with a decrease of platelet-associated IgG (PA-IgG). Autoantibodies such as rheumatoid factor, antinuclear factor, anti-Sm, anti-RNP and anti-SSA antibodies were also recognized. Marker analysis of peripheral mononuclear cells showed an increase in the proportion of CD 25+ cells, CD 3+ HLA-DR+ cells, CD4+ HLA-DR+ cells and CD8+ HLA-DR+ cells. The recurrent thrombocytopenia and development of various autoantibodies in this HTLV-I carrier are speculated to be due to the alteration of B cell functions by T cells infected with HTLV-I.</p>
Keywords recurrent thrombocytopenia HTLV-I HTLV-I carier
Amo Type Article
Published Date 1991-12
Publication Title Acta Medica Okayama
Volume volume45
Issue issue6
Publisher Okayama University Medical School
Start Page 445
End Page 449
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 1781301
Web of Sience KeyUT A1991GX45300007
JaLCDOI 10.18926/AMO/30448
FullText URL fulltext.pdf
Author Haruta, Yuro| Takahashi, Isao| Sekito, Noriko| Miyamoto, Kanji| Shimamoto, Masaaki| Wakita, Yoshiharu| Kikkawa, Kiyoshi| Nakamura, Toru| Seto, Takumi| Yamashita, Jiro| Yorimiysu, Seiichi| Miyake, Susumu| Machida, Ken-ichi| Kimura, Ikuro|
Abstract <p>A rare case of variant Philadelphia (Ph1) chromosome positive [46, XX, t (9; 22) (q34; q11), inv (9) (9q22; 22q13)] chronic myelocytic leukemia (CML) was described. The patient, 73 years old female, was hospitalized to our hospital because of leukocytosis. Hematological findings corresponded to those of CMLs. However, this case lacked hepatosplenomegaly. Southern blot analysis using a 3 breakpoint cluster region (bcr) probe revealed a bcr rearrangement. The patient has been in the chronic phase for sixteen months without treatment. Clinical and chromosomal changes are under observation in order to get accumulate data for a pathophysiological analysis of variant Ph1 positive CMLs.</p>
Keywords variant Ph1 positive chronic myelocytic leukemia bcr rearrangement
Amo Type Article
Published Date 1990-10
Publication Title Acta Medica Okayama
Volume volume44
Issue issue5
Publisher Okayama University Medical School
Start Page 283
End Page 286
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2260501
Web of Sience KeyUT A1990EG00700009