JaLCDOI 10.18926/AMO/31736
FullText URL fulltext.pdf
Author Gomita, Yutaka| Ichimaru, Yasuyuki| Ohizumi, Norihide| Yamada, Hirotoshi| Moriyama, Mimehiro| Araki, Yasunori|
Abstract <p>The anti-ulcer action of clotiazepam (a thienodiazepine derivative) was studied in mice subjected to non-physical and physical stimuli in a communication box. There were two groups of mice: the &#34;sender&#34; mice that received electric shocks on the feet and responded by squealing and jumping, and the &#34;responder&#34; mice that were affected by the senders' responses without receiving shocks on the feet. Gastric ulcers resulted in both groups. The effect of clotiazepam was compared with that of diazepam. The incidence of gastric ulcers was suppressed by clotiazepam at a dose of 3 mg/kg, per os, in &#34;responder&#34; and &#34;sender&#34; mice, and by diazepam at a dose of 1 mg/kg, per os, in &#34;responder&#34; mice. These results suggest that clotiazepam has a suppressive action against gastric ulcers produced by non-physical or physical stimuli, although its potency is slightly weaker than that of diazepam.</p>
Keywords gastric ulcer clotiazepam non-physical and physical stimuli mice
Amo Type Article
Published Date 1987-12
Publication Title Acta Medica Okayama
Volume volume41
Issue issue6
Publisher Okayama University Medical School
Start Page 275
End Page 278
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 2894110
Web of Sience KeyUT A1987L530300006