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ID 52907
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Author
Inoue, Kaoru
Nakajima, Kei
Tachikawa, Tetsuhiko
Yamazaki, Hiromichi
Isobe, Tomohide
Sugawara, Ayaka
Ogawa, Miho
Tanaka, Chie
Saito, Masahiro
Kasugai, Shohei
Takano-Yamamoto, Teruko
Inoue, Takashi
Tezuka, Katsunari
Kuboki, Takuo Kakenhi
Yamaguchi, Akira
Tsuji, Takashi
Abstract
Bio-hybrid artificial organs are an attractive concept to restore organ function through precise biological cooperation with surrounding tissues in vivo. However, in bio-hybrid artificial organs, an artificial organ with fibrous connective tissues, including muscles, tendons and ligaments, has not been developed. Here, we have enveloped with embryonic dental follicle tissue around a HA-coated dental implant, and transplanted into the lower first molar region of a murine tooth-loss model. We successfully developed a novel fibrous connected tooth implant using a HA-coated dental implant and dental follicle stem cells as a bio-hybrid organ. This bio-hybrid implant restored physiological functions, including bone remodelling, regeneration of severe bone-defect and responsiveness to noxious stimuli, through regeneration with periodontal tissues, such as periodontal ligament and cementum. Thus, this study represents the potential for a next-generation bio-hybrid implant for tooth loss as a future bio-hybrid artificial organ replacement therapy.
Published Date
2014-08-13
Publication Title
Scientific Reports
Volume
volume4
ISSN
2045-2322
Content Type
Journal Article
language
英語
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
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