JaLCDOI 10.18926/AMO/30369
FullText URL fulltext.pdf
Author Ito, Toshio| Itoshima, Tatsuya| Ukida, Minoru| Tobe, Kazuo| Kiyotoshi, Shozo| Kawaguchi, Keiji| Ogawa, Hiromichi| Yamamoto, Harumi| Hattori, Shuzo| Kitadai, Masahiro| Mizutani, Shigeki| Tsuchiya, Takahiro| Kita, Keiji| Tanaka, Ryoji| Nagasima, Hideo|
Abstract <p>The whole body including extended processes of Ito's fat-storing cells was observed by scanning electron microscopy in rat liver injured with lithocholic acid (LCA). Necrotic foci developed in the midlobular zone 48 h after LCA administration. Demonstration of Ito cell bodies around the foci was probably facilitated by easy detachment of hepatocytes from Ito cells. The body and the processes were located mainly between the sinusoidal endothelium and hepatocytes; sometimes they were between hepatocytes. Ito cells often were proximate to collagen fiber bundles and sometimes were attached to them. The cell body was flatly round or elliptic, 7 to 12 micron in diameter. Its surface was finely undulated with microvillous projections about 0.1 micron in length. Branching patterns of the processes resembled a fern-leaf mantling the sinusoidal endothelium. The trunks of the processes were about 2 micron in diameter and 20-30 micron in length. These processes tapered, branching into thinner processes, with the most peripheral being 0.1 micron in diameter. Ito cells and their branching processes likely strengthen sinusoidal walls and control blood flow in the sinusoids.</p>
Keywords ito cell fat-storing cell lithocholic acied liver cell necrosis scanning electron microscopy
Amo Type Article
Published Date 1984-02
Publication Title Acta Medica Okayama
Volume volume38
Issue issue1
Publisher Okayama University Medical School
Start Page 1
End Page 9
ISSN 0386-300X
NCID AA00508441
Content Type Journal Article
language 英語
File Version publisher
Refereed True
PubMed ID 6702480
Web of Science KeyUT A1984SF03000001