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ID 53137
FullText URL
Author
Mizuki, Yutaka
Sakamoto, Shinji
Kodama, Masafumi
Ujike, Hiroshi
Uchitomi, Yosuke
Abstract
ObjectiveThe human Rho guanine nucleotide exchange factor 11 (ARHGEF11) gene is one of the candidate genes for type 2 diabetes mellitus (T2DM). ARHGEF11 is mapped to chromosome 1q21, which has susceptible risk loci for T2DM and schizophrenia. We hypothesized that ARHGEF11 contributes to the pathogenesis of schizophrenia. MethodWe selected eight single nucleotide polymorphisms of ARHGEF11 that had significant associations with T2DM for a case-control association study of 490 patients with schizophrenia and 500 age-matched and sex-matched controls. ResultsWe did not find any differences in allelic, genotypic associations, or minor allele frequencies with schizophrenia. Analysis of the rs6427340-rs6427339 haplotype and the rs822585-rs6427340-rs6427339 haplotype combination provided significant evidence of an association with schizophrenia (global permutations p=0.00047 and 0.0032, respectively). C-C of the rs6427340-rs6427339 haplotype and A-C-C of the rs822585-rs6427340-rs6427339 haplotype carried higher risk factors for schizophrenia (permutation p=0.0010 and 0.0018, respectively). A-C-T of the rs822585-rs6427340-rs6427339 haplotype had a possible protective effect (permutation p=0.031). ConclusionThese results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia.
Keywords
ARHGEF11
case-control study
schizophrenia
type 2 diabetes mellitus
Note
This is the accepted version of the following article: FULLCITE, which has been published in final form at http://dx.doi.org/10.1002/hup.2435
Published Date
2014-11
Publication Title
Human Psychopharmacology: Clinical and Experimental
Volume
volume29
Issue
issue6
Start Page
552
End Page
558
Content Type
Journal Article
Related Url
http://ousar.lib.okayama-u.ac.jp/metadata/53126
language
英語
Copyright Holders
© 2014 John Wiley & Sons, Ltd.
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author
Refereed
True
DOI