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ID 32683
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Author
Sakagami, Kenichi
Shiozaki, Shigehiro
Takasu, Shinji
Matsuno, Tsuyoshi
Fujiwara, Takuzo
Kusaka, Satoshi
Uda, Masashi
Matsuoka, Junji
Naomoto, Yoshio
Gouchi, Akira
Hamazaki, Keisuke
Tanaka, Shinichiro
Orita, Kunzo
Abstract

A retrospective study was carried out in 110 cadaveric kidney transplant recipients to compare the effects of low doses of cyclosporine (CsA), azathioprine (AZP) and steroids (triple-drug therapy) with those of higher doses of steroids plus AZP (conventional immunosuppression). Graft survival rate in the triple-drug therapy was 77%, 69%, and 69% at 1, 3, and 5 years, respectively. This was significantly better than 48%, 34%, and 29% in conventional immunosuppression. The incidence of acute rejection episodes was significantly lower in the triple-drug therapy than in conventional immunosuppression (25% vs 58%). In conclusion, our study shows that triple-drug therapy using low-dose cyclosporine is the safest of the immunosuppressive regimens and provides a beneficial effect on the long-term survival of cadaveric kidney transplants.

Keywords
cadaveric kindney transplantation
cyclosporine
triple-drug therapy
Amo Type
Article
Published Date
1992-02
Publication Title
Acta Medica Okayama
Volume
volume46
Issue
issue1
Publisher
Okayama University Medical School
Start Page
53
End Page
56
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT