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ID 31132
JaLCDOI
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Author
Fujiwara, Takuzo
Sakagami, Kenichi
Uda, Masashi
Orita, Kunzo
Abstract

The antidonor immune response was examined in a one haplotype-mismatched renal transplant recipient with an allograft that had been well-functioning for more than 10 years. Although the relative response of the mixed lymphocyte reaction (MLR) was (45.8)% and the MLR responder cells stimulated by donor cells produced measurable amounts of interleukin-2 (IL-2) (11.6 U/ml), the cytotoxic T lymphocytes (CTL) could not be generated against donor cells, even with exogenous IL-2. These results indicate that antidonor CTL precursors were either deleted or inactivated in this recipient.

Keywords
renal transplantation
long-term stable recipient
cytotoxic T lymphocytes
Amo Type
Article
Published Date
1994-02
Publication Title
Acta Medica Okayama
Volume
volume48
Issue
issue1
Publisher
Okayama University Medical School
Start Page
63
End Page
65
ISSN
0386-300X
NCID
AA00508441
Content Type
Journal Article
language
英語
File Version
publisher
Refereed
True
PubMed ID
Web of Sience KeyUT