JaLCDOI 10.18926/792
Title Alternative In Vitro Rooting and Multiple Buds Formation from Asparagus Lateral Buds with Ancymidol
FullText URL 061_030_035.pdf
Author Mifune, Takashi| Kawauchi, Kazuhisa| Kitani, Hikaru| Sudo, Michiyasu| Tanizaki, Yoshiro|
Abstract 高齢者の増加やいわゆるcompromised hostの増加により,肺結核症の臨床像が変化してきている。肺結核に典型的な臨床像を呈さず,頻回の喀疾検査にても抗酸菌を証明できなかった6症例に対し,気管支肺胞洗浄(bronchoalveolar lavage:BAL)を施行し,得られた洗浄液・吸引液の塗抹標本から抗酸菌を証明し,気管支粘膜の変化を認めた。以上の結果より,気管支型の結核症が増加してきている可能性が考えられた。気管支肺胞洗浄は,気管支型の結核症を含め,結核症の診断に有効と考えられた。
Keywords 肺結核 (Pulmonary tuberculosis) 気管支型結核症 (Tuberculosis of mucous membrane) 気管支肺胞洗浄法 (Bronchoalveolar lavage) 抗酸菌 (Acid fast bacilli)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 30
End Page 35
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002304746
Author Matsubara, Fumie| Endou, Hiroi| Kitani, Hikaru| Tanizaki, Yoshiro|
Published Date 1991-08
Publication Title 環境病態研報告
Volume volume62
Content Type Data or Dataset
JaLCDOI 10.18926/11579
Title Alternative 気管支喘息患者末梢血好塩基球の抗ヒトIgEおよびカルシウムイオノフォァA23187に対する反応性について
FullText URL 061_016_022.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Okuda, Hiroyuki| Komagoe, Haruki| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract The release of histamine from basophils induced by anti-lgE and calcium ionophore A 23187 ( Cal) was examined in 27 patients with bronchial asthma and 7 healthy subjects, using a whole blood method. (1)The release of histamine induced by anti-IgE and CaI was significantly higher in atopic asthmatics than in non-atopic cases. (2) The histamine release with anti-lgE and CaI was significantly lower in cases with long-term steroid therapy compared to the release in cases without steroid therapy. (3) The release with anti-lgE and CaI was increased in cases with age of 0-39 years and in cases wpth age at onset of 0-39 years. (4) Anti-IgE induced release correlated to a certain extent with the release induced by CaI. These results show that basophil reactivity as expressed by histamine release changes under different conditions.
Abstract Alternative 気管支喘息27例および健康人7名を対象に,抗ヒトIgEおよびカルシウムイオノフォァA23187(CaI)刺激時の末梢血好塩基球からのヒスタミン遊離について検討を加えた。(1)抗ヒトIgEおよびCaI刺激時の好塩基球からのヒスタミン遊離は,非アトピー型喘息に比べ,アトピー型喘息において有意に高い値を示した。(2)これらの刺激物質によるヒスタミン遊離は,非使用例に比べ,ステロイド依存性喘息において低い傾向がみられた。また,年齢では39才以下,発症年齢では39才以下でヒズタミン遊離がより高い傾向がみられた。(3)血清IgE値の高い症例の好塩基球は,低い症例に比べより多くのヒスタミンを遊離する傾向がみられた。(4)全般的には,抗ヒトIgE刺激によるヒスタミン遊離とCaI刺激時の遊離との間にはある程度の相関がみられた。以上の結果より,好塩基球の反応性はいろいろの条件下でかなり異なることが示唆された。
Keywords Histamine release (ヒスタミン遊離) Basophils (好塩基球) Anti-lgE (抗ヒトIgE) Calcium ionophore A 23187 (カルシウムイオノフォァA23187) Bronchial asthma (気管支喘息)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 16
End Page 22
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002313673
JaLCDOI 10.18926/11625
Title Alternative Spa therapy for chronic respiratory diseases - in subjects admitted in 1989. -
FullText URL 061_007_015.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract 1989年1月より12月までの1年間に当院へ入院した慢性呼吸器疾患患者85例(延べ90例)を対象に,その背景因子,臨床的特徴,および温泉療法の臨床効果について検討を加えた。(1)対象85例のうちわけは,気管支喘息65例,肺気腫4例,肺結核症4例,アレルギー性肉芽腫性血管炎3例,閉塞性細気管支炎3例,気管支拡張症2例,慢性気管支炎2例,過敏性肺臓炎2例であり,昨年度と異なり肺結核がやや多かったことが特徴的であった。(2)これら85症例のうち,温泉療法を受けた症例は63例(74.1%)であった。(3)温泉療 法を受けた症例の地域分布では,鳥取県からの入院症例51例では32例(62.7%)であり,同様に岡山県からの入院症例20例では19例(95.0%),その他の県からの入院症例14例で12例(85.7%)であった。4.温泉療法の臨床効果は,気管支喘息では51例中著効14例,有効27例,やや有効8例,無効2例であり,明らかな有効例は41例(80.3%)であった。
Abstract Alternative Backgrounds and immunological characteristics were studied in patients with chronic respiratory diseases admitted at Misasa Branch Hospital in 1989. At the same time, clinical effects of spa therapy were evaluated for these patients. 1. Eighty five patients with chronic respratory diseases comprised 65 patients with bronchial asthma, 4 with pulmonary emphysema, 4 with lung tuberculosis, 3 with allergic granulomatous angitis, 3 with obstructive bronchiolitis, 2 with bronchiectasia, 2 with chronic bronchitis and 2 with hypersensitivity pneumonitis. 2. Sixty three patients (74.1%) out of the 85 cases had spa therapy. 3. Out of 51 patients coming from Tottori prefecture, 32 cases (62.7%) received spa therapy. On the other hand, spa therapy was carried out for 19 cases (95.0%) out of the 20 cases from Okayama prefecture, and for 12 cases (85.7%) out of the 14 cases from the other prefectures (long distant areas). 4. Many cases with bronchial asthma showed low serum levels of IgE (lower than 200 IU/ml), and frequency of positive skin reactions to various allergens was low in the patients with bronchial asthma. Serum cortisol levels were very low in patients with steroid-dependent asthma. 5. Spa therapy was effective in 41 cases (80.3%) out of the 51 patients with bronchial asthma. Spa therapy also effective for patients with obstructive bronchiolitis, and allergic granulomatous angitis.
Keywords 気管支喘息 (Bronchial asthma) 閉塞性細気管支炎 (Obstructive bronchiolitis) 慢性気管支炎 (Chronic bronchitis) 血清コーチゾール値 (Serum cortisol level) 温泉療法 (Spa therapy)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 7
End Page 15
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313875
JaLCDOI 10.18926/11643
Title Alternative Prevalence of urinary stress incontinence in women
FullText URL 062_023_026.pdf
Author Okuda, Hiroshi| Takatori, Akimasa| Izushi, Michihiro| Yoshida, Junko| Yamagami, Keiko| Sakata, Junko| Tanizaki, Yoshiro|
Abstract 三朝分院外来を訪れた女性患者を対象に尿失禁に関する18項目のアンケート調査を行った。その結果,全体の過半数が尿失禁の経験者であった。腹圧性尿失禁が大部分を占め,高齢になるほど 経産回数が多いほど頻度が高くなる傾向がみられた。そのうちの約1割に尿漏れの頻度と程度が重かった。以上より,尿失禁について積極的な啓蒙,診断,治療の必要性が認められた。
Abstract Alternative The prevalence of urinary stress incontinence was investigated in 93 women consulting in our hospital by means of a questionnaire survey. The survey showed that 52.7% of the total cases experienced the loss of urine. 87% of the cases with the loss of urine were the cases with stress incotinence. The prevalence of incontinence increased with age up to 69.2% in the 60's. A positive correlation was found between the number of childbirths and the prevalence of incontinence.
Keywords 腹圧性尿失禁 (Urinary stress incontinence)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 23
End Page 26
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313351
JaLCDOI 10.18926/11650
Title Alternative Maternity swimming at M isasa Hospital of Okayama University Medical School-Fourth report. The growth and development of babies who were born from the mothers who experienced the maternity swimming
FullText URL 062_027_031.pdf
Author Okuda, Hiroshi| Takatori, Akimasa| Kondo, Yuji| Sakata, Junko| Kamimoto, Manabu| Fujii, Junko| Masui, Etsuko| Nagae, Chiho| Kawahara, Mitsuko| Tanizaki, Yoshiro|
Abstract 第1報において妊婦水泳に関する妊婦の認識について報告し,第2報において妊婦水泳の現状とその適応について報告し,第3報にて妊婦水泳が循環器系に与える影響について報告した。今回は,母親が妊婦水泳を行い出生後1年以上経過した児の発育,発達状況についてアンケート調査を行った。その結果,発育e発達状況は艮好であった。現時点で全例正常な発達をしていた。このことより我々の行っている妊婦水泳は児の発育,発達に悪影響を及ぼさないことが確かめられた。
Abstract Alternative Seventy babies were born from the mothers who experienced maternity swimming in our hospital. The growth and development of 31 babies that were over 1 years old were investigated by means of a questionnaire survey. 62.5% of the total were answered. This survey showed that no babies had problems with their growth and development. These results suggest that maternal Swimmingmight have no hazardous effects on the fetus.
Keywords 妊婦水泳 (Maternity swimming) 児の発育・発達 (Growth and Development of the child)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 27
End Page 31
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313455
JaLCDOI 10.18926/11662
Title Alternative Thermological study on the coldness women - Second report. The relationship between the change of atmospheric temperature and body surface temperature in women with complaints of coldness in limbs
FullText URL 062_016_022.pdf
Author Takatori, Akimasa| Okuda, Hiroshi| Sekiba, Kaoru| Tanizaki, Yoshiro|
Abstract 季節毎の婦人の冷え性患者における全身の皮膚表面温度分布について,サーモグラフィを用いて検討した。その結果以下のことが判明した。1)冷え性は外気温が1カ月の最高気温が20℃,最低気温が10℃,平均気温で15℃以下になると発症しやすくなる。2)外気温が前記の条件において,中間温環境下でサーモグラフィ上,軀幹部の最高温度と四肢部の最低温度の差が8℃以上ある症例では99%の確率で冷えを訴えることが明かとなった。
Abstract Alternative From January to December in 1990, whole body temperature was measured in 79 women by using a thermotracer 6T66, and was compared to the change of atmospheric temperature.The difference between the highest temperature of the body and the lowest temperature of the limbs was more than 8℃ in women with complaints of coldness of limbs. This difference was observed in 88% of the women complaining coldness when the average atmospheric temperature in a month was more than 15℃.
Keywords 婦人の冷え性 (Coldness in women) サーモグラフィ (Thermography) 気温の変化 (Change of atmospheric temperature)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 16
End Page 22
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313602
JaLCDOI 10.18926/11664
Title Alternative A dietary survey in patients with chronic pancreatitis
FullText URL 062_011_015.pdf
Author Hayashimoto, Kanae| Ochi, Koji| Harada, Hideo| Tanaka, Juntaro| Takuma, Masae| Masui, Etsuko| Tanizaki, Yoshiro| Matsumoto, Shuji| Seno, Toshinobu| Izushi, Michihiro|
Abstract 食事療法は慢性膵炎治療の基本として重要であるが,その具体的な内容についてはあまり明確にされていない。今回,筆者らは慢性膵炎例の食事に関する全国調査の一部を担当したので,その成績を報告し,問題点と対策について考察した。対象は慢性膵炎間欠期の患者56名(男44名,女12名)である。(1)エネルギー摂取量では1日1,400kcal以下が16名(29%)にみられ,肥満度80~90%が7名および80%以下が9名という栄養状態と考え合わせて,食事の回数を増やしてでも摂取エネルギーの改善をはかる必要がある。(2)蛋白質および脂質摂取量についても同様な成績であり,消化酵素剤を投与しながら量的,質的な改善をはかる必要がある。(3)糖質については質的改善をはかる必要がある。(4)ビタミンとミネラルも不足傾向にあった。野菜の摂取不足が顕著であった。(5)診断確定後も禁酒できない患者が男17名(39%),女1名(8%)にみられ,その指導が重要な課題である。
Abstract Alternative Importance of diet therapy has been emphasized in chronic pancreatitis. However, concrete measures and programs of the diet therapy have remained to be studied. Therefore, Intractable Pancreatic Disease Study Group recently carried out a nation-wide questionnaire survey on the diets in patients with chronic pancreatitis under the auspIces of the Ministry of Health and Welfare. Attendant physicians were requested to report the nutritional states of their patients and the kinds and amounts of foods taken by their patients on three consecutive days. The nutritional state was evaluated by a body weight index calculated by the following formula:Body Weight Index (%) = Present Body Weight / Ideal Body Weight X 100. Daily nutritional intake (calorie, protein, fat, carbohydrate, and others) was calculated by dieticians according to the Food Exchange Table published by the Japanese Association of Diabetes. The present study constitutes a part of the group study. Patients consisted of 44 men and 12 women who fulfilled the diagnostic criteria proposed by the Japanese Society of Gastroenterology;20 men and 3 women had secondary diabetes mellitus. Following results and conclusions were obtained. (1) Average daily calorie intake of the patients was 1,759kcal as compared with 2,057kcal in the general population in Japan. Sixteen patients (28.6%) showed daily calorie intake less than 1,400 kcal and consequently poor nutritional states (6 patients with body weight indices less than 80% and 10 with 80-90%). It is important, therefore, to try to improve the daily calorie intake by increasing the frequency of diets in these patients. (2) Average daily intake of protein was 72.1 g (animal protein 38.1 g), only slightly less than 79.2 g (animal protein 41.7 g) in the general population. However, as many as 16 patients (28.6%) showed daily protein intake of less than 60 g and poor nutritional states as described above. It is important, therfore, to encourage patients to maintain the daily protein intake of more than 60 g by increasing the frequency of diets with oral administration of digestive enzymes. (3) Average daily intake of fat was 39.9 g (animal fat 23.8 g), approximately 20 g less than 58.3 g (animal fat 28.0 g) in the general population. As many as 17 patients (30.4%) showed daily fat intake of less than 30 g , and 16 of the 17 patients showed poor nutritional states as described above. It is important, therefore, to encourage patients to maintain the daily fat intake of more than 30 g (especially by increasing the amounts of vegetable oil) by increasing the frequency of diets with oral administration of digestive enzymes. (4) Average daily intake of carbohydrate was 278 g, almost equal to 289 g in the general population. However, many patients took as much as 48 g of carbohydrate in the from of cakes, plain sugar and alcohol beverages. Seventeen men (39%) and one woman (8%) had continued drinking alcohol beverages even after the diagnosis was made. It is important, therefore, to encourage patients to improve the quality of carbohydrate intake, although it is admittedly difficult to realize the ideal. (5) Intake of vitamins and minerals (especially calcium) also tended to be insufficient. Green vegetables were especially insufficient. (6) In conclusion, it is utmost important in chronic pancreatitis to perform periodical evaluation of nutritional intake and feed back the information to the treatment through a close patient-dietician-doctor relationship.
Keywords 慢性膵炎 (Chronic pancreatitis) 食事療法 (Diet therapy in chronic pancreatitis) 栄養状態 (Nutrition in chronic pancreatitis)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 11
End Page 15
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313896
JaLCDOI 10.18926/11668
Title Alternative カンジダ特異的IgG(4)抗体と気管支喘息
FullText URL 062_001_004.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Takatori, Akimasa| Okuda, Hiroyuki| Harada, Hideo|
Abstract Serum levels of Candida-specific IgG(4) antibodies were examined in 66 patients with bronchial asthma, relating to patient age and asthma severity. 1. The levels of Candida-specific IgG(4) antibodies were the highest in patients with 60+years of age, compared to the levels in cases with 0-39 and 40-59 years of age. 2. In cases with 40-59 years of age, the levels of Candida-specific IgG(4) were significantly higher in cases with long-term steroid therapy (severe intractable asthma) than in cases without steroid regimen. The results suggest that increased levels of Candida-specific IgG(4) were observed in relation to patient age and asthma severity.
Abstract Alternative 66例の気管支喘息症例を対象に,血清中カンジダ特異的lgG(4)抗体を測定し,その血中レベルと年齢および喘息の重症度との関連について検討を加えた。1.血清カンジダ特異的IgG(4)値は,0~39才,40~59才の年齢層にくらべ,60才以上の年齢層において高く,年齢によりその値が変動することが 示唆された。2.40~59才の年齢層では,血清カンジダ特異的IgG(4)は,ステロイド非使用例にくらべ,ステロイド依存性重症難治性喘息症例で有意の高値を示し,この年齢層では,カンジダ特異的IgG(4)抗体がその発症病態に関連している可能性が示唆された。以上,カンジダ特異的IgG(4)抗体の上昇は,高年齢層の症例(60才以上)では全般的に,また40~59才の年齢層で重症型喘息症例において観察されることが明らかにされた。
Keywords Candida (カンジダ) Sepcific IgG(4) (特異的IgG(4)) Bronchial asthma (気管支喘息) Aging (加齢) Asthma severity (喘息重症度)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 1
End Page 4
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002313495
Author Matsubara, Fumie| Endou, Hiroi| Sudo, Michiyasu| Tanizaki, Yoshiro|
Published Date 1990-09
Publication Title 環境病態研報告
Volume volume61
Content Type Data or Dataset
JaLCDOI 10.18926/11691
Title Alternative Clinical significance of eosinophilic leucocytes in onset mechanisms of bronchial asthma
FullText URL 061_089_097.pdf
Author Tanizaki, Yoshiro| Sudo, Michiyasu| Kitani, Hikaru| Kawauchi, Kazuhisa| Mifune, Takashi| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract 末梢血好酸球が気管支喘息の発症病態にどのように関与しているかについて,1.末梢血好酸球の変動,2.好酸球の局所出現,3,好酸球とアレルギー反応,4.アレルギー反応と好酸球の機能,5.好酸球と喘息の臨床病態の各項目で検討した。その結果,気管支喘息では,全般的に末梢血好酸球増多がみられ,同時にアレルギー反応局所への遊走が観察されること,末梢気 道では,ある程度肺胞マクロファージの出現と逆相関にあること,リンパ球との関連もある程度認められることなどが示された。そして,局所出現した好酸球は,IgE抗体の関与の程度により,その機能が異なる可能性が示唆された。また臨床病型別の検討では,アトピー型ではいずれの臨床山型においても好酸球の出現率は明かな増加傾向を示したが,非アトピー型では,Ib.気管支攣縮+過分二型においてのみ好酸球増多が著明であった。
Abstract Alternative Participation of eosinophil leucocytes in onset mechanisms of bronchial asthma was discussed in following sections ; 1. changes in number of eosinophils in the peripheral blood, 2. emergence of eosinophils in local allergic reaction sites, 3. eosinophils and allergic reactions, 4. different functions of eosinophils III allergic reactions, 5. eosinophils and clinical types of bronchial asthma. The results showed that eosinophilia in the peripheral blood was generally observed in patients with bronchial asthma. In these cases, eosinophils migrated into local allergic reaction sites. A reversed correlation was present between number of eosinophils and macrophages, and number of eosinophils correlated to a certain extent with number of lymphocytes in the small airways and alveolar region. Function of eosinophils was shown to be different between IgE-and non-IgE-mediated reactions, by measurement of arylsulfatase activity III BALF. Marked eosinophilia in BALF was observed in any clinical types of atopic asthma, although eosinophils were increased only in bronchoconstriction + hypersecretion type (type II) of non-atopic asthma.
Keywords 好酸球 (Eosinophils) 肺生検 (Lung biopsy) 気管支肺胞洗浄 (Bronchoalveolar lavage) 臨床病型 (Clinical type) 気管支喘息 (Bronchial asthma)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 89
End Page 97
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313427
JaLCDOI 10.18926/11707
Title Alternative Maternity swimming at Misasa Hospital of Okayama University Medical School. -Third report. The physiological changes before and after the maternity swimming-
FullText URL 061_041_045.pdf
Author Okuda, Hiroyuki| Takatori, Akimasa| Kondou, Yuuji| Sakata, Junnko| Yoshida, Sachie| Tanizaki, Yoshiro|
Abstract 第一報において妊婦水泳に関する妊婦の認識について報告し,第二報において妊婦水泳の現状とその適応について報告したが,その後も症例は順調に増加しており,現在までの参加人数は49名に達した。今回は妊婦水泳が母体と胎児の循環器系にどのような影響を与えるかを調べるために,妊婦水泳の前後におけるnon stress test(NST)と母体の血圧と脈拍数の変化を分析した。対象は妊娠5カ月以降の21名の正常妊婦とした。1.母体の脈拍数は水泳後に増加するものが約80%と明らかに多かったが,血圧は水泳前後で大きな差はみられなかった。2.NSTでは,水泳後に胎児基準心拍数の増加するものが妊娠中期で55.2%,後期で62.3%と多かった。胎児心拍数のlong term variability(LTV)は水泳後に減少するものが妊娠後期で 48.4%を占めた。3.胎動回数は水泳前後でほぼ一定であった。腹緊回数が水泳後に増加した例が妊娠後期で42.4%を占めた。これらの結果のうち,水泳後の胎児基準心拍数の増加とLTVの減少について生理学的見地より若干の考察を加えた。
Abstract Alternative The physiological changes before and after the maternity swimming were retrospectivelly analyzed in 151 records. Following findings were observed after maternity swimming: 1. An increase in maternal pulse rate was observed in 116 cases (76.8%) out of all the cases. 2. Maternal blood pressure increased in 81 cases (53.6%) and decreased in 60 cases (39.7%). 3. An Increase In baseline of fetal heart rate was found in 92 cases (60.9%). 4. Long term variability (LTV) decreased in 67 case s (44.3%) and increased in 21 cases (13.9%). 5. The number of cases with increased fetal movement was almost similar to the number of cases with decreased movement. 6. The rate of uterine contraction increased in 66 cases (43.7%), but there were no cases to need any treatment. The conclusion was as follows: 1. No dangerous changes were observed in non stress test (NST), maternal pulse rate and maternal blood pressure. 2. The increase of baseline of fetal heart rate and the decrease of LTV were characteristic changes of NST after the maternity swimming.
Keywords 妊婦水泳 (Maternity swimming) 胎児心拍数 (Fetal heart rate)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 41
End Page 45
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313490
JaLCDOI 10.18926/11823
Title Alternative Clinical aspects of chronic obstructive lungdisease with small airways obstruction. -Comparison between bronchial asthma and chronic obstructive bronchiol itis-
FullText URL 061_023_029.pdf
Author Sudo, Michiyasu| Mifune, Takashi| Kawauchi, Kazuhisa| Kitani, Hikaru| Tanizaki, Yoshiro|
Abstract 細気管支に病変を有すると考えられる気管支喘息(細気管支閉塞型(II型)のアトピー型)と慢性閉塞性細気管支炎の違いについて臨床的に検討を加えた。(1)年令ではやや慢性閉塞性細気管支炎でやや低年令,発症年令では気管支喘息でやや低年令を示したが有意な差はみられなかった。(2)アレルギー学的検討では気管支喘息は明らかに1型アレルギー反応の関与が推測されたが,一方慢性閉塞性細気管支炎では1型アレルギー反応の関与はほとんどみられなかった。(3)Bronchoaiveolar lavage fluid(BALF)中出現細胞の検討では慢性閉塞性細気管支炎において気管支喘息に比べ好中球の有意の増加が観察され,出現率が55%以上の症例ではほぼ全例が慢性閉塞性細気管支炎であった。(4)換気機能による検討では%肺活量,1秒率では差は認められなかったが,気管支喘息で%V50,%V25のような細気管支の閉塞を示すパラメーターの低下傾向がやや高度であった。(5)胸部X線では気管支喘息では,X線上明らかなび四三陰影は認められず,一方慢性閉塞性細気管支炎では過膨脹所見も,び漫性情粒状陰影ともみられる症例が多く認められた。
Abstract Alternative Subjects with bronchial asthma with bronchiolar obstruction (type II) and cases with chronic obstructive bronchiolitis (COB) were compared by clinical characteristics and ezaminations. (1) The mean age was slightly younger in cases with COB than in asthma cases. The mean age at onset was slightly younger in asthma cases than in cases with COB. (2) The cases with asthma showed positive immediate allergic reactions. However the cases with COB didnot show any positive reactions. (3) The frequency of neutro phils in BALF was significantly higher in the cases with COB than in the cases with asthma. The majority of cases with COB showed the high frequency of neutrophils more than 55% in BALF. (4) In the ventilatory function tests the values of % FVC and FEV(1.0%) were not different between the cases with asthma and the cases with COB. The values of % V(50) and % V(25) which represent small airway obstruction were slightly more decreased in cases with asthma than in the cases with COB. (5) Any abnormalities in roentgenograms of the cases with asthma were not distinctly observed, while the cases with COB showed overinflation and diffuse small round opacities.
Keywords 細気管支 (Bronchiole) 気管支喘息 (Bronchial asthma) 細気管支閉塞型 (Bronchiolar obstruction type) 慢性閉塞性細気管支炎 (Chronic obstructive bronchiolitis)
Publication Title 環境病態研報告
Published Date 1990-09
Volume volume61
Start Page 23
End Page 29
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313789
Author Mitsunobu, Fumihiro| Mifune, Takashi| Kitani, Hikaru| Okazaki, Morihiro| Tanizaki, Yoshiro|
Published Date 1993
Publication Title 岡山医学会雑誌
Volume volume105
Issue issue3-4
Content Type Journal Article
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Sugimoto, Keisuke|
Published Date 1993
Publication Title 岡山医学会雑誌
Volume volume105
Issue issue3-4
Content Type Journal Article
Author Mitsunobu, Fumihiro| Kitani, Hikaru| Mifune, Takashi| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Tanizaki, Yoshiro|
Published Date 1993
Publication Title 岡山医学会雑誌
Volume volume105
Issue issue5-6
Content Type Journal Article
Author Mifune, Takashi| Kawaraya, Masashi| Hiramatsu, Junichi| Yokota, Satoshi| Sugimoto, Keisuke| Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Kitani, Hikaru| Tanizaki, Yoshiro|
Published Date 1993
Publication Title 岡山医学会雑誌
Volume volume105
Issue issue5-6
Content Type Journal Article
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Soda, Ryo| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Published Date 1993
Publication Title 岡山医学会雑誌
Volume volume105
Issue issue5-6
Content Type Journal Article
JaLCDOI 10.18926/14493
Title Alternative Motility of basophilic granulocytes and histaminerelease
FullText URL 062_047_051.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Nakagawa, Saburo| Soda, Ryo| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract 各種刺激物質添加時の好塩基球の形態的変化―運動亢進と膨化,脱顆粒―と化学伝達物質遊離との関連を中心に若干の知見をのべた。まず,抗原刺激時には,(1)運動亢進をきたし,洋梨状を示す好塩基球と膨化,脱顆粒を示す好塩基球の2種類が観察されること,(2)アトピー型喘息の好塩基球は健康人と比べて全般的に運動が抑制されていること,(3)運動亢進の状態としては,random movementとoriented movementがあり,抗原に対応した特徴的な運動亢進はoriented movementであること,(4)運動亢進と膨化,脱顆粒は,連続した一連のものではなく,それぞれ独立した過程を持っていること,などが観察されている。また,刺激物質の種類によって,好塩基球の形態的変化や化学伝達物質遊離の状態が異なることについても報告した。
Abstract Alternative Morphological changes of basophilic leucocytes from atopic asthmatics were observed in relation to histamine release after the cells were challeuged by a specific allergen, anti-IgE and Ca ionophore A 23187 . 1. Increase in motility and degranulation of basophilic granulocytes were observed after the stimulation with antigen and anti-IgE. The incidence of basophils with oriented movement was siguificantly increased at 36 min and reached the peak at 12-15 min after addition of antigen. 2. A decreased number of basophils, increased cell diameter and increased ratio of the short to long axis diameters were observed with a significant amount of histamine release after antigen and anti-IgE stimulation. 3. Compared to cell reactions to antigen and anti-IgE, Ca ionophore A 23187 stimulation showed more decreased motility and greater increase in the diameter of the cells.
Keywords 好塩基球 (Basophils) 抗原 (Antigen) 運動亢進 (lncreased motility) 脱顆粒 (Degranulation) ヒスタミン遊離 (Histamine release)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 47
End Page 51
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002308512
Author Tanizaki, Yoshiro| Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Hamada, Masanori| Iwagaki, Naofumi| Fujii, Makoto| Takata, Shingo|
Published Date 2004-12-01
Publication Title 岡大三朝医療センター研究報告
Volume volume75
Content Type Departmental Bulletin Paper