JaLCDOI 10.18926/15315
Title Alternative Effects of the spring water on the dissolution of aminophylline tablet and theophylline sustained-release preparations
FullText URL 064_060_064.pdf
Author Mimaki, Yuichi| Fujii, Yoshihiro| Furuno, Katsushi| Gomita, Yutaka| Araki, Yasunori| Tanizaki, Yoshiro|
Abstract 薬物のbioavailabilityに影響する因子の一つとして,製剤からの薬物の溶出速度が考えられる。今回,温泉水による薬物溶出への影響を知る目的で,気管支喘息治療薬のアミノフィリン製剤およびテオフィリン徐放製剤の溶出挙動について検討した。溶出試験は第12改正日本薬局方に従い,第1法(回転バスケット法)および第2法(パドル法)で行い,試験液を蒸留水および三朝温泉水として両者の溶出挙動を比較した。アミノフィリン製剤では,10分後まで 温泉水の方が有意に高い溶出率を示した。また,テオフィリン徐放製剤においても温泉水が8時間後まで蒸留水に比べて有意に高い溶出率を示した。以上の結果より,アミノフィリン製剤およびテオフィリン徐放製剤は温泉水により薬物の溶出が促進されることか示唆された。
Abstract Alternative The dissolutions of aminophylline tablet and theophylline sustained-release preparattions in Misasa spring water were examined using the rotating basket and paddle methods. The dissolution rate of aminophylline tablet with the spring water was higher than that with distilled water from starting to 10 min after the test. In theophylline sustained-release preparations, the spring water showed a facilitation on the dissolution rate in comparison to the distilled water for 8 hours after the test. These results indicate that the spring water enhanced the releasing rates of aminophylline tablet and theophylline sustained-release preparations.
Keywords 溶出試験 (Dissolutionte test) 温泉水 (Spring water) 気管支喘息治療薬 (Bronchial asthma therapeutic drug)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 60
End Page 64.
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307434
JaLCDOI 10.18926/15314
Title Alternative 気管支肺胞洗浄液中に一過性の好中球増多をきたしたアトピー型喘息
FullText URL 064_052_059.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Nakagiri, Yoshiyasu| Tada, Shinya| Kimura, Ikuro|
Abstract Clinical course of one asthma patient (64 years old, female), who had an increased proportion of neutrophils in bronchoalveolar lavage (BAL) fluid, was observed in relation to the proportion of BAL cells and ventilatory function. The patient had large asthma attacks two times during her clinical course for 15 months observed. 1. An increased proportion of BAL neutrophils and suppression of ventilatory function were found after her first large asthma attacks. The increased proportion of BAL neutrophils continued for more than 5 months. A reduction in the proportion of BAL neutrophils was found 3 months after her second large asthma attack, accompanied by improvement of clinical symptoms and ventilatory function. The numbers of total cells and neutrophils in BAL fluid were also reduced. Transient increase in number of BAL lymphocytes was found 13 months after the first large attack when the number of BAL neutrophils was markedly decreased. The number of BAL eosinophils did not change during her clinical course.
Abstract Alternative 経過中に気管支肺胞洗浄(BAL)液中に一過性の好中球増多が観察されたアトピー型喘息症例について,若干の臨床的観察を加えた。症例は,64才の女性で,臨床症状,および血清IgE高値,ハウスダストに対するIgE抗体陽性などから,アトピー型喘息と診断された。なお,経過観察し得た15ヵ月の間に2回の大発作が観察された。1.第1回の大発作後,BAL液中好中球増多と換気機能の低下が観察された。そして,このBAL液中好中球頻度は明らかな改善が見られた。BAL液中の総細胞数および好中球の絶対数も徐々に減少傾向を示し,好中球頻度と同様,第2回目の大発作3ヵ月後には著明な減少が観察された。同時にこの時期には,BAL液中リンパ球の増加も見られた。しかし,BAL液中好酸球数は15ヵ月の経過観察中ほとんど変化は見られなかった。
Keywords Bronchial asthma (気管支喘息) transient BAL neutrophilia(一過性BAL液中好中球増多) ventilatory function (換気機能)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 52
End Page 59
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307805
JaLCDOI 10.18926/15313
FullText URL 063_034_038.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Kimura, Ikuro|
Abstract The serum levels of total IgE, IgG and IgG(4) were compared among five age groups of patients with bronchial asthma. 1. The level of serum IgE was significantly higher in the patients before the age of 29 than in those between the ages of 30 and 49 (p < 0.02), between 50 and 59 (p < 0.01) and between 60 and 69 (p < 0.01). The serum IgE level tended to increase in the patients over age 70. 2. The serum level of total IgG was significantly higher in the patients over age 70 compared with the level in the 30-49 (p < 0.05) and the 60-69 year old groups (p < 0.05). 3. The serum IgG(4) level was increased with aging, although no significant difference was found among the five age groups. 4. The IgG(4) level correlated to a certain extent with the level of serum IgE. The results reveal that the levels of total IgE, IgG and IgG(4) are increased in the elderly patients over age 70, and that there is a relationship between serum levels of total IgE and IgG(4).
Keywords Total IgE IgG IgG(4) aging bronchial asthma
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 34
End Page 38
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307767
JaLCDOI 10.18926/15312
Title Alternative 老年者気管支喘息における気道炎症細胞.喘息重症度と関連した気道細胞反応の特徴
FullText URL 064_083_088.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Nakagiri, Yoshiyasu| Harada, Hideo| Kimura, Ikuro|
Abstract Cellular composition of bronchoalveolar lavage (BAL) fluid was examined in 11 elderly asthmatics over the age of 70, and the results were compared with those of 11 younger asthmatics under the age of 50. In the subjects with mild asthma, the proportion of BAL cells in the elderly subjects was 86.2% macrophages, 11.0% lymphocytes, 1.9% neutrophils, 0.9% eosinophils and 0.08% basophilic cells. The proportion of neutrophils and eosinophils in the BAL fluid was slightly higher in younger subjects with mild asthma compared with that in elderly subjects, although no significant difference was found between the two groups. In subjects with severe asthma, the proportions of lymphocytes, neutrophils, eosinophils and basophilic cells were more increased in both younger and older patients compared to those with mild asthma, and a significant increase in the number of BAL eosinophils was found in younger subjects with severe asthma compared to those with mild asthma (p < 0.05). However, no significant difference was present in the proportion of BAL cells between younger and older patients with severe asthma. The results reveal that BAL cells are more increased in subjects with suvere asthma than in those with mild asthma in both younger and older subjects, and show the possibility that this increase is more predominant in neutrophils in older subjects and in eosinophils in younger subjects.
Abstract Alternative 70才以上の老年者気管支喘息11例(平均年齢71.4才)を対象に,重症度と気道細胞反応との関連について検討を加えた。なお,対照として50才以下の喘息症例11例(平均年齢33.5才)を選んだ。1.老年者の軽症型喘息における気管支肺胞洗浄(BAL)液中の出現細胞の頻度は,マクロファージが86.2%,リンパ球が11.0%,好中球が1.9%,好酸球が0.9%,好塩基性細胞が0.08%であった。BAL液中の好中球,好酸球の頻度は若青年症例でやや高い傾向が見られたが,両群間に有意の差は見られなかった。重症例では,老年症例,若青年症例とも,軽症例に比べリンパ球,好中球,好酸球などのBAL細胞の出現頻度が増加しており,特に好酸球では若青年症例の重症例で軽症例に比べ有意に高い頻度が観察された。これらの結果は, リンパ球,好中球,好酸球などのBAL細胞は,軽症例に比べ重症例で増加してくること,そして,その増加は老年症例では好中球,若青年症例では好酸球の増加が特徴的であることを示唆しているものと考えられた。
Keywords Neutrophils (好中球) Eosinophils (好酸球) Bronchoalveolar lavage (気管支肺胞洗浄) asthma severity (喘息重症度)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 83
End Page 88
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307736
JaLCDOI 10.18926/15311
Title Alternative 抗原および Ca ionophore A23187 刺激時におけるアトピー型気管支喘息末梢血好塩基球の運動能
FullText URL 064_043_051.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Ochi, Koji| Harada, Hideo| Nakagawa, Saburo| Soda, Ryo| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract We examined histamine release and morphological changes in basophilic granulocytes from atopic subjects, in response to stimulation with antigen and Ca ionophore A23187. 1. Histamine release and a reduction in the rumber of basophils were more rapid and greater in extent at an early stage of antigen stimulation compared with Ca ionophore A23187 stimulation. 2. Morphological changes in basophils, represented by increased motility, in terms of an increased ratio of short to long axis diameter (L/S ratio), as well as the increased frequency of basophils with localized granules and those with pseudopods, were more often observed antigen stimulation than with Ca ionophore A23187 stimulation. In contrast, morphogical changes in which basophils appeared swollen, showing an increased mean cell diameter and an increased frequency of cells with 5 vacuoles or more were more predominant with Ca ionophore A23187 than with antigen stimulation. The results obtained here show that bridging of IgE receptors is essential to activate basophils and induce increased motility in these cells.
Abstract Alternative アトピー型気管支喘息末梢血好塩基球を用い,抗原および Ca ionophore A23187 刺激時のヒスタミン遊離およびその形態的変化について比較検討した。1.抗原刺激時には, Ca ionophore A23187 刺激時に比べ,好塩基球からのヒスタミン遊離および好塩基球数の減少の程度は,より急激でかつ高度であった。2.好塩基球の形態的変化,すなわち,長経/短経比の増大,限局性顆粒あるいは偽足を有する好塩基球の出現頻度の増加などの運動能の亢進を示唆する好塩基球の形態的変化は, Ca ionophore A23187 に比べ抗原刺激時により高度であった。一方,平均直径の増大,5個以上の空砲を有する好塩基球の出現頻度の増加などの,むしろ膨化傾向を示唆する好塩基球の形態的変化は,抗原刺激時に比べ, Co ionophore A23187 刺激時により高度であった。これらの結果より,抗原刺激によるIgE受容体のbridgingが,好塩基球を活性化し,運動能の亢進をひき起こすものと判断された。
Keywords histamine release (ヒスタミン遊離) increased basophil motility (好塩基球の運動能の亢進) bridging of IgE receptors (LgE 受容体) antigen (抗原) Ca ionophore A23187
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 43
End Page 51
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307677
JaLCDOI 10.18926/15310
Title Alternative 気管支喘息の臨床分類とその細胞性および液性因子の特徴
FullText URL 064_036_042.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Nakagiri, Yoshiyasu| Tada, Shinya| Kimura, Ikuro|
Abstract Characteristics of each asthma type classified by clinical symptoms and findings were studied in 72 patients with bronchial asthma. 1. Ventilatory function tests showed that the values of % MMF, % V(50) and % V(25) were significantly lower in patients with bronchiolar obstruction (type II) compared to the values of those with simple bronchoconstriction type (type Ia) and those with bronchoconstriction + hypersecretion (type Ib). 2. The proportion of neutrophils in bronchoalveolar lavage (BAL) fluid was significantly higher in type II than in type Ia and type Ib. Several patients with type Ib showed higher proportion of BAL eosinophils. 3. The release of LTC(4) from leucocytes was significantly lower in type II compared with type Ia and type Ib. There was no significant difference in the release of histamine and LTB(4) among the three asthma types.
Abstract Alternative 気管支喘息72例を対象に,その臨床病態の特徴を,気道炎症性の細胞および化学伝達物質の観察により検討した。1.気道反応の特徴を換気機能の面から検討すると,II細気管支閉塞型において,MMF,V(50)やV(25)などの小ないし細気管支領域の換気障害を示すパラメーターの値は,Ia型,Ib型に比べ 有意の低下を示した。2.気道細胞反応では,II型において,他の臨床病型に比べ,BAL液中好中球の出現頻度の有意の増加が観察された(Ia, p<0.001 ; Ib, p<0.01)。好酸球の出現頻度は,Ib過分泌型において著しい増加傾向を示す症例が見られたが,その平均出現頻度には3病型間に有意の差は見られなかった。3.好中球からのメジェー夕ー遊離では,ヒスタミン遊離は,Ia単純性気管支撃縮型において最も高い値が示されたが,推計学的には3病型間に有意の差は見られなかった。ロイコトリエンC(4)では,Ia型においてII型に比べ有意に高い遊離が観察された(p<0.05)。ロイコトリエンB(4)遊離には,3病型間に差は見られなかった。
Keywords Bronchial asthma Asthma classification BAL fluid chemical mediators
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 36
End Page 42
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307662
JaLCDOI 10.18926/15309
Title Alternative Correlations between bone mineral density measured by QCT and risk factors of Osteoporosis
FullText URL 063_030_033.pdf
Author Honke, Naoko| Kusaura, Yasuhiro| Tanimizu, Masakuni| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Kitani, Hikaru| Tanizaki, Yoshiro| Takatori, Akimasa| Okuda, Hiroyuki| Nakai, Mutsuro| Akiyama, Tsuneo|
Abstract 27~85才の女性143例における骨塩量を,定量的QCT法 (quantitative computed tomography)を用いて測定し,年令,身長,体重及び原疾患(慢性関節リウマチ),使用薬剤(ステロイド・骨強化剤)の因子の骨塩量に及ぼす影響について検討した。その結果,1)加令とともに骨塩量は低下するが,特に40才代後半から60才代にかけての低下が顕著であり,また, 他因子の影響を受けやすい。2)体型的因子としては.痩せ型で低身長の人に低値の傾向がある。3)ステロイド使用の有無における検討において,特に50才代で使用群が著明に低値であることが明らかとなった。また,薬剤の因子の考察に関しては,さらに経時的検討か必要であると思われた。
Abstract Alternative Bone mineral density (BMD) was measured in 143 females aged 27 to 85 years old to investigate the correlations between BMD and several factors such as age, height, presence of rheumatoid arthritis and corticosteroid or bone intensifying drug therapy. 1) BMD values decreased with aglng and the most remarkable decrease was observed at the age of latter half of 40's to 60's. 2) Women with slim and low stature tended to have low BMD values. 3) BMD values of women with steroid therapy were significantry lower than those without corticosteroid at the age of 50's (p<0.01). However, further study is necessary to confirm the effect of drugs on BMD.
Keywords 骨粗鬆症 (Osteoporosis) 定量的コンピューター断層法 (QCT (quantitative computed tomograpy))
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 30
End Page 33
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307603
JaLCDOI 10.18926/15308
Title Alternative 老年者気管支喘息における液性および細胞性免疫反応について
FullText URL 064_075_082.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Ochi, Koji| Harada, Hideo| Tada, Shinya| Kimura, Ikuro|
Abstract Humoral and cellular immune responses in bronchial asthma were examined by comparing the results of older asthmatics (group OA) with those of older healthy subjects (group OH) and of younger asthmatics (group YA). In humoral immune response, IgE-mediated immune system expressed by elevated serum IgE levels and IgE antibodies for house dust mite (HDm) and/or Candida albicans was clearly found in older asthmatics, while there was no finding showing the presence of IgE-mediated immune response in older healthy subjects. There was no significant difference in levels of serum IgG and IgA among the three groups. However, the serum IgM level was significantly lower in older asthmatics than in younger asthmatics. IgE antibodies to HDm and/or Candida albicans were more frequently found in older asthmatics compared with older healthy subjects. In contrast, IgG(4) antibodies to HDm were not different among the three groups. IgG(4) antibodies to Candida albicans were significantly higher in both older groups than in younger group. However, there was no significant difference between asthmatic and healthy subjects in the elderly. Delayed skin reaction to PPD was significantly more decreased in older asthmatics. These results show that bronchial asthma in the elderly is characterized by the presence of IgE-mediated immune response and by the changes of immune response with aging.
Abstract Alternative 気管支喘息における液性および細胞性免疫反応について,老年者気管支喘息,老年者健常人,および若年者気管支喘息の間で比較検討を行った。1.まず,液性免疫では,血清IgE値高値,ハウスダストやカンジダに対するIgE抗体陽性などのIgE系反応は,老年者気管支喘息においては明らかに観察されたが,老年者健常人では全く観察されなかった。血清IgGおよびIgA値には3者間に有意の差は見られなかったが,血清IgMは,若年者喘息に比べ老年者喘息で有意に低い値を示した。2.ハウスダストやカンジダに対するIgE抗体は老年者喘息において老年者健常人に比べより高い頻度で陽性であったが,一方,ハウスダストに対するIgG(4)抗体は3者聞に有意の差は見られなかった。また,カンジダに対するIgG(4)抗体は,老年者喘息および健常人において,若年者喘息に比べ有意の高値を示した。しかし,老年者の喘息と健常人との間には有意の差は見られなかった。3.PPDによる遅延型皮膚反応は,若年者喘息に比べ老年者喘息において有意の減弱傾向を示した。これらの結果は,老年者喘息はIgE系反応を有していること,そして,加齢による免疫反応の変化の影響を受けること,を示している。
Keywords IgE IgG(4) Immunoglobulings (免疫グロブリン) PPD Bronchial asthma (気管支喘息) 加齢
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 75
End Page 82
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307261
JaLCDOI 10.18926/15307
Title Alternative 気管支喘息におけるハウスダストアレルギー. 血清IgE値とIgE抗体価と年齢との関連
FullText URL 064_031_035.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Ochi, Koji| Harada, Hideo| Tada, Shinya| Kimura, Ikuro|
Abstract Serum IgE levels and IgE antibody values in relation to patient age were examined in 50 patients with house dust mite (HDm) sensitive asthma, 1. IgE antibody values to HDm were highest in patients between the ages of 10 and 19, and the values generally low in those over the age of 40. 2. High IgE antibody values to HDm were accompanied by high serum IgE levels in patients between 10 and 19. IgE antibody values and serum IgE levels were in general low in patients over age 40. In patient under age 9, serum IgE levels were less than 500 IU/ml in 5 of the 10 subjects despite an increased value of IgE antibodies to HDm. These results suggest that an increased production of IgE antibodies to HDm is usually accompanied by an increased production of total IgE in younger subjects. However, an increase in production of IgE antibodies is not always related to an increase in production of total IgE in patients under age 9. The results also show that production of IgE antibodies to HDm and total IgE is in general low in older patients despite the hyperreactivity to HDm.
Abstract Alternative ハウスダストが原因抗原であるアトピー型気管支喘息50例を対象に,血清IgE値とIgE抗体価を年齢との関連のもとに検討した。1.IgE抗体価は10-19才の年齢層の症例において最も高く,一方40才以上の症例では全般的に低い傾向が見られた。2.10-19才の年齢層の症例では,IgE抗体価の高値と同時に血清IgE値も高い値を示したが,40才以上の症例では,IgE抗休価および血清IgE値いずれも10-19才の症例に比べ全般的に低い値を示した。9才以下の症例では,IgE抗体価の高値にもかかわらず,血清IgE値は比較的低く,500IU/ml以下を示した症例が10例中5例に観察された。これらの結果は,若年症例では,IgE抗体の産生亢進と総IgEの産生亢進が同時に見られること が多いが,9才以下ではIgE抗体産生亢進に総IgE産生亢進が必ずしもともなわない場合があることを示している。また,40才以上の症例では,ハウスダストに対する過敏性は有しているものの,IgE抗体価および血清IgEは全般的に低い値を示す傾向が示唆された。
Keywords Serum IgE (血清IgE) IgE antibodies (IgE抗体) house dust mite (ダニ) bronchial asthma (気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 31
End Page 35
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307674
JaLCDOI 10.18926/15306
Title Alternative 気管支喘息における気道内への好中球の出現とその意義 換気機能と関連して
FullText URL 063_025_029.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuharu| Kimura, Ikuro|
Abstract Ventilatory function was compared between two age-matched asthma groups : group A (study group) consists of 8 patients with bronchial asthma with marked neutrophilia (20% or more) in the BAL fluid and group B (control group) of 8 patients with neutrophils (less than 5% of total BAL cells). The values of six ventilatory parameters were lower in group A than in group B, and a significant difference was found in FEV(1.0%), % MMF, % V(50) and % V(25) between groups A and B. Of these parameters, the value of % V(25) was markedly decreased in group A compared with group B. The results show that ventilatory dysfunction in airways, especially in small airways, is closely correlated to increased number of neutrophils in BAL fluid.
Abstract Alternative 気管支喘息を対象に,年令をmatchさせた2つのグループ,すなわち,気管支肺胞洗浄液(BALF)中の好中球の出現頻度が20%以上の8症例(グループA)と,BALF中の好中球の出現頻度が5%以下の8症例(グループB)における換気機能について比較検討を行った。6つの換気パラメーターは,全般的にグループAにおいてグループBに比べ低い傾向が見られ,FEV(1.0%),% MMF,% V(50)および% V(25)値は,いずれもグループAにおいて有意に低い値が示された。これらのパラメーターのうち,% V(25)値はグループBに比べグループAにおいて著明に低い値が示された。これらの結果は,気道における換気障害,特に小ないし細気管支領域の換気障害は,BALF中の好中球の出現頻度とある程度関連していることを示すものと考えられた。
Keywords ventilatory function (換気機能) neutrophils in BAL fluid (好中球, BAL) small airways (細気管支) bronchial asthma (気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 25
End Page 29
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307993
JaLCDOI 10.18926/15305
Title Alternative 気管支喘息における気道炎症反応の臨床的意義。慢性閉塞性細気管支炎との比較検討
FullText URL 064_024_030.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Ochi, Koji| Harada, Hideo| Tada, Shinya| Kimura, Ikuro|
Abstract Clinical significanoce of airway inflammation was assessed in 28 patients with bronchial asthma, and the results were compared with those in 9 patients with chronic obstructive bronchiolitis (COB). 1. Total cell number in bronchoalveolar lavage(BAL) fluid was markedly increased in patients with COB (51.0×10(6)), which was significantly greater than that in those with bronchial asthma (9.6×10(6) ). 2. The proportion of BAL macrophages was significantly higher in patients with bronchial asthma than in those with COB. However, the, absolute number of BAL macrophages was not significantly different between them. 3. The proportion of BAL lymphocytes was higher in patients with bronchial asthma than in those with COB, but this difference was not signifcant. In contrast, the absolute number of BAL lymphocytes was significantly greater in patients with COB than in those with bronchial asthma. 4. The proportion and the number of BAL neutrophils were markedly increased in patients with COB compared to those with bronchial asthma. 5. The proportion and the number of BAL eosinophils were higher in patients with bronchial asthma than in those with COB, although these defferences were not significant. The results suggest that airway inflammation in bronchial asthma is not so intensive as that in COB.
Abstract Alternative 気管支喘息28例および慢性閉塞性細気管支炎9例を対象に,気道炎症反応の臨床的意義について検討を加えた。1.気管支肺胞洗浄(BAL)液中の総細胞数は,慢性閉塞性細気管支炎において著明に増加しており(51.0×10(6)),気管支喘息(9.6×10(6))との間に有意の差が見られた。2.BAL液中マクロファージの頻度は気管支喘息において,慢性閉塞性細気管支炎に比べ有意に高い値を示したが,絶対数での比較では両疾患群間に有意の差は見られなかった。 3.BAL液中リンパ球の頻度は,気管支喘息においてやや高い傾向が見られたが,絶対数の比較では慢性閉塞性細気管支炎において有意に高い値であった。 4.BAL液中の好中球は,その頻度および絶対数とも慢性閉塞性細気管支炎において著明に増加しており,これは気管支喘息と比べ有意に高い値であった。 5.BAL液中好酸球の頻度および絶対数は,気管支喘息においてやや高い値であったが,両疾患群間に有意の差は見られなかった。以上の結果より,気管支喘息における気道炎症反応は,慢性閉塞性細気管支炎ほど高度ではない ことが明らかにされた。
Keywords airway inflammation (気道炎症反応) bronchial asthma (気管支喘息) chronic obstructive bronchiolitis (慢性閉塞性細気管支炎) lymphocytes (リンパ球) neutrophils (好中球)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 24
End Page 30
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307730
JaLCDOI 10.18926/15304
Title Alternative 気管支喘息における気道内への好酸球の出現とその意義. 過分泌と関連して.
FullText URL 063_014_018.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro|
Abstract A correlation between the proportion of eosinophils in bronochoalveolar lavage (BAL) fluid and amount of expectoration was examined in patients with atopic asthma. The subjects were divided into two groups : cases with high proportion (20% of more) (group A) and low proportion (less than 5%) (group B) of eosinophils in the BAL fluid. Any significant difference was not paesent in the value of each ventilatory parameter between the two groups. The amount of expectoration/day was significantly higher in group A compared with group B (p<0.001). These results suggest that eosinophilia in BAL fluid correlates to mucus hypersecretion in the airways of patients with atopic asthma.
Abstract Alternative アトピー型気管支喘息のなかから,気管支肺胞洗浄液(BALF)中の好酸球の出現頻度が20%以上の症例(グループA)と5%以下の症例(グループB)の2群を選び出し,それぞれの換気機能および喀痰量を比較検討した。その結果,換気機能には両群間に有意の差は見られなかったが,1日喀痰量は,BALF中好酸球の著明増多を示すグループAにおいて有意に多い傾向が見られた。これらの結果は,BALF中好酸球増多と過分泌との間にはある程度の関連があることを示しているものと考えられた。
Keywords Eosinophilia (好酸球) Hypersecretion (過分泌) BAL fluid (BAL) bronchial asthma (気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 14
End Page 18
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307156
JaLCDOI 10.18926/15303
Title Alternative 気管支喘息におけるActivated Tリンパ球について,喘息発作との関連
FullText URL 064_011_016.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Harada, Hideo| Tada, Shinya| Kimura, Ikuro|
Abstract The number of CD4(+) T-Iymphocytes, CD4/CD8 ratio, and the number of IL2R(+) T-Iymphocytes (CD25) were examined in 14 patients with bronchial asthma, and the results were compared in three different asthma stages : symptom-free stage, wheeze stage, and attack stage. 1. The proportion of blood CD4(+) T-lymphocytes was more decreased in patients with asthma attacks than in those without symptoms. The CD4/CD8 ratio was also more decreased in patients with attacks than in those without symptoms. However, these differences were not significant. 2. The proportion of blood activated T cells (IL2R(+) cells, CD25) was significantly increased in patients with attacks than in those without symptoms. The proportion of activated T cells in 5 asthma patients was 2.9±0.8% in symptom-free stage and 6.6±1.1% in attack stage(p<0.001). These findings show that numbers of activated T-lymphocytes in peripheral blood were increased during asthma attacks, and this increase suggests the participation of activated T cells in the pathogenesis of asthma.
Abstract Alternative 気管支喘息14例を対象に,末梢血CD4(+)リンパ球の頻度,CD4/CD8比およびIL2R(+)Tリンパ球の頻度について,喘息発作との関連のもとに検討を加えた。1.CD4(+)リンパ球の頻度は,非発作時の症例で最も高く,喘鳴のみの症例,発作の見られる症例へと順次低くなる傾向が見られたが,推計学的には有意の差は見られなかった。CD4/CD8比も同様に,非発作時に最も高く,発作を有する症例では非発作時に比べ低い値を示したが,推計学的には有意の差は見られなかった。2.IL2R(+)Tリンパ球(activated Tリンパ球)の頻度は,非発作時の症例で最も低く(3.5±1.1%),喘鳴のみをともなう症例(3.8±1.1%),発作の見られる症例(5.8±1.9%)へと順次高くなる傾向を示し,発作のある症例では,非発作および喘鳴のみの症例に比べ有意に高い値 を示した。また,非発作時と発作のある時期にIL2R(+)Tリンパ球を観察し得た5症例では,非発作時2.9±0.8%,発作のある時期6.6±1.1%であり,発作のある時期に有意の高値を示した(p<0.001)。これらの結果は,発作のある時期にはactivated Tリンパ球の頻度が増加すること,そして,この増加はactivated Tリンパ球が喘息発作の病態と密接な関連を有していることを示唆するものと考えられた。
Keywords CD4(+) T cells (CD4(+)リンパ球) CD4/CD8 ratio (CD4/CD8比) IL2R(+) T cells (IL2R(+)Tリンパ球) bronchial asthma (気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 11
End Page 16
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307394
JaLCDOI 10.18926/15301
Title Alternative 気管支喘息における副腎皮質ホルモン長期投与による免疫抑制と気管支肺胞洗浄液中好中球増多との関連
FullText URL 064_017_023.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Harada, Hideo| Kimura, Ikuro|
Abstract Cellular composition of bronchoalveolar lavage (BAL) fluid was compared between two age-matched steroid-dependent intractable asthma (SDIA) groups : 17 group A patients (serum IgG level < 1000mg/dℓ) whose immunity was regarded as being suppressed by long-term glucocorticoid therapy and 17 group B patients (serum IgG level > 1200mg/dℓ). 1. The levels of serum IgA and IgM were significantly decreased in group A compared to the levels in group B patients. 2. The number of blood lymphocytes was also significantly lower in group A than in group B patients. However, the number of blood neutrophils was not different between the two asthma groups. 3.The number of BAL lymphocytes was significantly lower in group A than in group B patients. 4. BAL neutrophilia (more than 1.5×10 (4)/mℓ) was observed in 6 of the 17(35.3%) patients in group A, but not observed in any patients in group B. The number of BAL neutrophils was significantly greater in group A than in group B patients. These results suggest that there is a correlation between immunosuppression by glucocorticoids and BAL neutrophilia in patients with bronchial asthma.
Abstract Alternative ステロイド依存性重症難治性喘息を,免疫抑制の見られる症例(血清IgG値1000mg/dℓ以下)(グループA)と抑制の見られない症例(血清IgG値1200mg/dℓ以上)(グループB)の2群に分け,気管支肺胞洗浄液中の細胞成分について比較検討した。1.血清IgAおよびIgM値は,グループBに比べ免疫抑制の見られるグループAにおいて有意に低い値であった。2.末梢血リンパ球数は,グループAにおいて,グループBに比べ有意に少ない傾向が見られた。しかし,末梢血好中球数は両群間に有意の差は見られなかった。3.BAL液中リンパ球数は,グループBに比べ免疫抑制の見られるグループAにおいて有意に少 ない数であった。4.BAL液中好中球増多(1.5×10(4)/mℓ以上)を示す症例は, グループAの17例中6例(35.3%)に見られたが,グループBでは全く 見られなかった。また,BAL液中好中球数は,グループAにおいてグループBに比べ有意に多い数であった。以上の結果により,副腎皮質ホルモン長期投与 による免疫抑制とBAL液中好中球増多とはある程度関連があることが明らかにされた。
Keywords immunosuppression (免疫抑制) BAL neutrophilia (BAL好中球増多) glucocorticoids (副腎皮質ホルモン) bronchial asthma (気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 17
End Page 23
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307882
JaLCDOI 10.18926/15300
Title Alternative Clinical effects of spa therapy on bronchial asthma.
FullText URL 063_007_013.pdf
Author Mifune, Takashi| Kusaura, Yasuhiro| Honke, Naoko| Tanimizu, Masahiro| Mitunobu, Fumihiro| Okazaki, Morihiro| Kitani, Hikaru| Tanizaki, Yoshiro|
Abstract ステロイド依存性重症難治性喘息を中心に,喘息に対する温泉療法の臨床効果を,症例の背景因子に基づいて検討した。1.現年令あるいは発症年令が高い症例でより有効であった。2.非アトピー性の症例において有効率が高率であった。3.臨床病型別では,細気管支閉塞型において最も有効率が高く,17例中16例(94.1%)が有効であった。4.ステロイド減量効果は.71症例中43例(60.6%)で認められた。細気管支閉塞型の症例でステロイド減量不能の症例を多く認めた。
Abstract Alternative Clinical effects of spa therapy were studied in 93 patients in relation to allergological-characteristics. Forty-seven of the 93 patients were steroid-dependent intractable asthma. 1. Spa therapy was effective in the patients over the age of 41 and over 41 at onset. 2. Spa therapy was more effective in nonatopic patients than in atopic. 3. Regarding clinical classification of asthma type (simple bronchoconstriction type, bronchoconstriction + hypersecretion type and bronchiolar obstruction type), spa therapy was most effective in the patients with bronchioar obstruction type (94.1%). 4. In 43 of the 71 patients (60.6%), the dose of corticosteroid used was reduced by spa therapy. In the patient with bronchiolar obstruction type, reduction of corticosteroid by spa therapy was observed with a low propor-
Keywords 気管支喘息 (Bronchial asthma) 温泉療法 (Spa therapy) 臨床病型 (clinical asthmaty)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 7
End Page 13
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307411
JaLCDOI 10.18926/15299
Title Alternative ステロイド依存性重症難治性喘息に対する温泉療法の重要性。過去10年間の181例を対象に。
FullText URL 064_001_010.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Yokota, Satoshi| Hiramatsu, Junichi| Kawaraya, Masashi| Ochi, Koji| Harada, Hideo| Tada, Shinya| Kimura, Ikuro|
Abstract Characteristics of 181 patients with steroid-dependent intractable asthma (SDIA) who were admitted to our hospital and had spa therapy for last 10 years were examined in relation to the methods of spa therapy. For last 10 years, three kinds ofspa therapies were administered: spa therapy A (swimming training in a hot spring pool) in the first atage (1982-1985), spa therapy B (swimming training + inhalation of iodine salt solution) in the middle stage (1986 -1989), and spa therapy C (swimming training + inhalation of iodine salt solution + fango therapy) in the last stage (1990-1991) of this study. 1. The number of patients with SDIA who were admitted to our hospital and had spa therapy tended to increase from 2 in 1986 to 35 in 1991. 2. The number of SDIA patients over the age of 60 or over the age at onset of 40 tended to increase from the first stage to the last stage. 3. The proportion of patients from distant areas (prefectures other than Tottori) was decreasing for the last stage, although the number of these patients was increasing in recent years. 4. The proportions of patients divided by serum IgE levels and by clinical asthma types did not change for last 10 years. 5. The proportion of type Ib and type II asthma was considerably high in patients with SDIA for last 10 years. 6. Clinical effects of spa therapy were observed in 21 of the 30 (70.0%)patients with SDIA in the first stage (1982-1985) with spa therapy A, 68 of the 83 (74.7%) patients with SDIA in the middle stage (1986-1989) with spa therapy B, and 61 of the 68 (89.7%) patients with SDIA in the last stage (1990-1991) with spa therapy C.
Abstract Alternative 最近10年間に三朝分院へ入院し,温泉療法を受けたステロイド依存性重症難治性喘息181例を対象に,温泉療法の方法との関連のもとに,対象患者の背景について検討を加えた。最近10年間に3種類の温泉療法が行われた。温泉療法A(温泉プール水泳訓練)は初期(1982-1985),温泉療法B(水泳訓練+ヨードゾル吸入)は中期(1986-1989),また,温泉療法C(水泳訓練+ヨードゾル吸入+鉱泥湿布療法)は後期(1990-1991)に行われた。1.当院へ入院し,温泉療法を受けたステロイド依存性重症難治性喘息(SDIA)患者の数は,1986年の2例から1991年の35例へと増加の傾向を示した。2.SDIA患者のうち,60才以 上の症例および40才以降の発症症例の数は,1986年以降急激な増加傾向を示した。3.鳥取県以外の他県(遠隔地)からの入院患者の頻度は,近年減少の傾向を示したが,その絶対数は増加の傾向であった。4.血清IgE値はいずれの時期においても200IU/mℓ以下の症例が多い傾向が見られた。5.臨床病型では,通常の喘息に比べIb型およびII型の頻度が高い傾向が見られた。6.温泉療法の臨床効果は,温泉療法Aが行われた初期では70.0%,温泉療法Bの中期では74.7%,温泉療法Cの後期では89.7%であった。
Keywords swimming training in a hot spring pool (温泉プール水泳訓練) inhalation of iodine salt solution (ヨードゾル吸入) fango therapy (鉱泥湿布療法) SDIA
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 1
End Page 10
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307391
JaLCDOI 10.18926/15298
Title Alternative ステロイド依存性重症難治性喘息に対する複合温泉療法の作用機序
FullText URL 063_001_006.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Takatori, Akimasa| Okuda, Hiroyuki| Ochi, Koji| Harada, Hideo| Kimura, Ikuro|
Abstract Effects of complex spa therapy, which comprises swimming training in a hot spring pool, inhalation of iodine salt solution and fango therapy, were analyzed in patients with steroid-dependent intractable asthma (SDIA) by comparison between the subjects with and without efficacy of the therapy. 1. The complex spa therapy was effective in the patients with lower levels of FEV(1.0%) and % PEFR. 2. The complex spa therapy was not always effective in the patients with a low value of % V(25), which represents depressed airflow in the small airways. 3. The efficacy of the complex spa therapy was found in the patients showing a low value of % V(25) accompanied by BAL neutrophilia, but not found in those without increased proportion (more than 10% ) of neutrophils in BAL fluid. The results reveal that the complex spa therapy is effective in patients with SDIA showing low values of FEV(1.0%) and % PEFR, and in those with a low value of % V(25) and BAL neutrophilia.
Abstract Alternative ステロイド依存性重症難治性喘息を対象に,温泉プール水泳訓練,ヨードゾル吸入療法.鉱泥湿布療法からなる複合温泉療法の臨床効果の解析を行った。1.複合温泉療法は,FEV(1.0%)および% PEFR値の低い症例により有効であった。2.複合温泉療法は、細気管支領域の換気障害を示すと考えられる% V(25)値が低い症例に対して,必ずしも有効ではなかった。3.複合温泉療法の効果は,BAL液中好中球増多(10%以上)が見られ、かつ% V(25)値が低い症例により有効であったが、同様に% V(25)値が低くても,BAL液中に好中球増多 が見られない症例に対しては,有効ではなかった。以上の結果より,複合温泉療法はFEV(1.0%)や% PEFR値の低く,またBAL液中好中球増多が見られ,かつ% V(25)値が低いようなステロイド依存性重症難治性喘息に対して有効性が高いことが示唆された。
Keywords complex spa therapy (複合温泉療法) ventilatory function (換気機能) BAL neutrophilia (BAL好中球増多) bronchial asthma (気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 1
End Page 6
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307537
JaLCDOI 10.18926/15167
Title Alternative A case of rheumatoid arthritis with hypoproteinemia probably induced by diseasemodifying antirheumatic drug, D-Penicillamine
FullText URL 062_080_083.pdf
Author Kitani, Hikaru| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Tanizaki, Yoshiro|
Abstract 症例は52歳女性で,慢性関節リウマチ(RA)はclassical,stageIV, class 2であった。症状は進行性で加療を行うも改善がみられなかった。平成元年11月RA症状の増悪のための再入院後,Penicillamine 100~200 mg,Sulfasalazine 500mgを合せて投与を行ったところ,血沈,CRP等の検査所見は改善傾向を示したが入院時には正常値であった血清蛋白量がその後5.1g/dlまで低下し,下肢浮腫が出現,その後さらに血清蛋白量は4.1g/dlにまで減少した。治療により蛋白量は5.8g/dlにまで回復したが,低蛋白血症の原因としてはD-Penicillamineの関与が疑われた。
Abstract Alternative A patient with classical rheumatoid arthritis was treated with D-Penicillamine and other drugs. In the course of treatment, the episodes of hypoproteinemia were found twice. The first hypoproteinemia was improved almostly by supportive therapy and withdrawl of administration of medicines, including D-Penicillamine. The second hypoproteinemia was severe and resistant to the treatment. It was suggested that the agent eliciting hypoproteinemia in this case might be D-Penicillamine.
Keywords 慢性関節リウマチ (Rheumatoid arthritis) 低蛋白血症 (Hypoproteinemia) D-ペニシラミン (D-Penicittamine) 抗リウマチ剤 (Disease-modifying antirheumatic drug)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 80
End Page 83
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307840
JaLCDOI 10.18926/15163
Title Alternative Relationship between vertebral transformation (or fracture) and bone mineral density in lumbar vertebrae.
FullText URL 065_115_118.pdf
Author Nakai, Mutsuo| Akiyama, Tsuneo| Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Mifune, Takashi| Tanizaki, Yoshiro|
Abstract QCTによる腰椎海綿骨骨塩量と,圧迫骨折を含む,椎体(第11胸椎~第4腰椎)の変形率の関係を検討した。椎体変形率と腰椎QCT値の間の強い相関関係が確認され,椎体変形者全体の50%はQCT値70mg/cm(3)以下に分布し,90%は125mg/cm(3)以下に分布した。さらに,この70mg/cm(3)付近での椎体変形者の割合は50%であり,125mg/cm(3)付近での椎体変形の割合は10%であった。QCTによる腰椎海綿骨骨塩量測定値は,腰椎の変形および骨折の危険性を予 測する良好な指標であることが確認できた。
Abstract Alternative In 360 females, Bone mineral density (BMD) in lumbar vertebrae (L2-L4) was assessed by quantitative computed tomography (QCT), and the values obtained were compared with the frequency of vertebral transformation or fracture as assessed by lateral scan image (scanogram) by X-ray CT. A correlation was observed between the frequency of vertebral transformation (or fracture) and lumbar BMD values : BMD under 125mg/cm(3) was observed over 90% of women with vertebral transformation, and BMD under 70mg/cm(3) was found about 50% of them. These results suggest that decrease in BMD in lumbar vertebrae leads to vertebral transformation or fracture. Thus, measurement of BMD by QCT would be very useful in predicting vertebral transformation or fractures.
Keywords 骨粗鬆症 (osteoporosis) 骨塩量 (bone mineral density) QCT (quantitative computed tomography) 腰椎 (lumbar vertebrae)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 115
End Page 118
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307136
JaLCDOI 10.18926/15162
Title Alternative Clinical opplication of a newly developed radiographic system including a fluoroscope equiped with CCD and digital image processor
FullText URL 065_107_114.pdf
Author Akiyama, Tsuneo| Nakai, Mutsuo| Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Mifune, Takashi| Tanizaki, Yoshiro| Ochi, Koji| Riaz, Chowdhury| Satou, Masataka| Ukon, Hiroe|
Abstract 画像の入力部に世界初100万画素の多画素・高精細のCCD(電荷結合素子)を用いたテレビカメラを搭載したX線テレビ装置とDigital・Radiography装置を導入し,主に消化管検査を中心に多目的に任用した。このシステムは従来のscreen/filmシステムの持つ膨大な情報量を確保しながらCCDカメラのメリットを最大限に生かしており,DRシステムの特長であるリアルタイムのCRT撮影画像表示,透視像のFREEZE確認,動態解析,画像処理等を導入することにより診断能の向上がはかれた。更に,従来X線フィルム・撮像管に比較して被曝量の大幅な低減が期待できた。また,デジタルであるため撮影像をHDに保管すると共にMODにも記録・再生が可能である。今後,PACSやフイルムレス電子媒体保管への展開の可能性についても確認できた。
Abstract Alternative We have clinically applied a newly developed radiographic system which was introduced into our institute in April 1994. This system consists of a fluoroscope, CCD (charge-coupled device) which had a million matrix, and digital image processor. This system has following advantages comparison with a conventional radiographic system ; (1) doses of x-ray exposuce during examination is less, (2) a sharp fluoroscopic image can be obtained by real-time image processing, (3) radiographic images can be kept in the recording device such as hard disc (HD) and magnetic optical disc (MOD) since this has a digital radiographic system. By connecting this system with main online system, it is expected to be able to see the various diagnostic images simulataneously as well as laboratory data at different spots of the hospital which is now available in other hospltal.
Keywords 増感紙/フイルム (Screen/Film) 光電子増倍管 (Image・Intensifier (l・I)) デジタル・イメージング (Digital・Imaging) 電荷結合素子 (CCD) 光磁気ディスク (MOD) デジタルラジオグラフィ (Digital Radiography)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 107
End Page 114
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307511