JaLCDOI 10.18926/15041
Title Alternative Alcohol-induced pancreatitis
FullText URL 062_052_070.pdf
Author Harada, Hideo| Tanaka, Juntaro| Ochi, Koji| Matsumoto, Shuji| Seno, Toshinobu| lzushi, Michihiro| Tanizaki, Yoshiro|
Abstract 膵炎のうちもっとも頻度が高いアルコール性膵炎(AIP)の疫学,臨床像および発生機序に関する従来の知見を総括した。AIPの大多数は慢性膵炎である。通常は長期にわたる多量の飲酒を背景に発症するが,遺伝的素因および食事因子も重要な役割を演じる。発症初期には血中膵酵素の上昇をともなう腹痛が病像を支配するが,進展すると膵外分泌不全による消化吸収障害と膵内分泌不全による糖尿病が病像を支配するようになる。アルコール性慢性膵炎は非アルコール性慢性膵炎にくらべて確診時にすでに進展した症例が多く,合併症が多く,進行が早く,予後が悪い。死亡の主たる原因は癌の併発と糖尿病の合併症で,膵炎の急性増悪発作がこれにつぐ。併発する癌のなかでは膵癌よりもむしろ上部気道および上部消化管の癌が多い。発生機序としてはDuctal-Plug説とToxic-Metabolic説が有力であるが,最近は細 胞内膵酵素活性化説とFree Radical説も注目をあびている。
Abstract Alternative This paper is to review the literature on the epidemiology, clinical pictures and etiopathogenesis of alcohol-induced pancreatitis (AIP). The incidence of AIP has been increasing worldwide, paralleling the increase in alcohol consumption. AIP manifests itself following a longterm consumption of large amounts of alcohol. There is no known threshold value of alcohol consumption in terms of the risk of developing AIP, although the logarithm of the risk of developing AIP is lineally correlated with the amount of alcohol intake. Why some alcoholics develop pancreatitis whereas others with equal consumption of ethanol are spared remains to be explained. Therefore, two additional factors are considered to play important roles in developing AIP : genetic predisposition and diet. The majority of AIP IS chronic pancreatitis (AICP), although a minority can be acute pancreatitis (AIAP). AIAP shows somewhat higher morbidity and mortality than the common variety of acute pancreatitis. If recovered from an attack, AIAP shows morphological and functional restoration. AICP manifests itself with an acute attack of abdominal pain, insidious onset of abdominal pam, or a pain-free variety. An acute attack in AICP resemble that m AIAP ; often these two can be differentiated only by follow-up studies. AICP shows no morphological and functional restoration, and often shows progressive deterioration. Abdominal pain with elevated serum pancreatic enzymes is a predominant clinical picture m the early stage of AICP, whereas in the late stage symptoms and signs deriving from exocrine insufficiency (maldigestion) and endocrine insufficiency (pancreatic diabetes) begin to dominate the clinical pictures. AICP is in the more advanced stage and shows more complications than nonalcoholic chronic pancreatitis at the time of diagnosis. In addition, AICP shows more rapid progress and higher morbidity and mortality. The incidence of microangiopathy in pancreatic diabetes resemble that in primary diabetes, being higher in patients with a longer history of diabetes, those on insulin treatment and those under poorer control. Main causes of death are development of cancer in the upper respiratory and gastrointestinal tract and diabetic complications (hypoglycemic shock, renal failure, and intractable pneumonia), and acute attack of pancreatitis leads to death less frequently. Ductal-Plug theory and classical Toxic-Metabolic theory are most popular to explain the pathogenesis of AIP ; however, increasing evidence has been reported that oxygen free radicals and intracellular activation of zymogens by lysosomal enzymes may be involved in the pathogenesis.
Keywords アルコール性膵炎 (Alcohol-induced pancreatitis) 慢性膵炎 急性膵炎
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 52
End Page 70
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307918
JaLCDOI 10.18926/11668
Title Alternative カンジダ特異的IgG(4)抗体と気管支喘息
FullText URL 062_001_004.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Takatori, Akimasa| Okuda, Hiroyuki| Harada, Hideo|
Abstract Serum levels of Candida-specific IgG(4) antibodies were examined in 66 patients with bronchial asthma, relating to patient age and asthma severity. 1. The levels of Candida-specific IgG(4) antibodies were the highest in patients with 60+years of age, compared to the levels in cases with 0-39 and 40-59 years of age. 2. In cases with 40-59 years of age, the levels of Candida-specific IgG(4) were significantly higher in cases with long-term steroid therapy (severe intractable asthma) than in cases without steroid regimen. The results suggest that increased levels of Candida-specific IgG(4) were observed in relation to patient age and asthma severity.
Abstract Alternative 66例の気管支喘息症例を対象に,血清中カンジダ特異的lgG(4)抗体を測定し,その血中レベルと年齢および喘息の重症度との関連について検討を加えた。1.血清カンジダ特異的IgG(4)値は,0~39才,40~59才の年齢層にくらべ,60才以上の年齢層において高く,年齢によりその値が変動することが 示唆された。2.40~59才の年齢層では,血清カンジダ特異的IgG(4)は,ステロイド非使用例にくらべ,ステロイド依存性重症難治性喘息症例で有意の高値を示し,この年齢層では,カンジダ特異的IgG(4)抗体がその発症病態に関連している可能性が示唆された。以上,カンジダ特異的IgG(4)抗体の上昇は,高年齢層の症例(60才以上)では全般的に,また40~59才の年齢層で重症型喘息症例において観察されることが明らかにされた。
Keywords Candida (カンジダ) Sepcific IgG(4) (特異的IgG(4)) Bronchial asthma (気管支喘息) Aging (加齢) Asthma severity (喘息重症度)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 1
End Page 4
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002313495
Author Matsubara, Fumie| Endou, Hiroi| Kitani, Hikaru| Tanizaki, Yoshiro|
Published Date 1991-08
Publication Title 環境病態研報告
Volume volume62
Content Type Data or Dataset
JaLCDOI 10.18926/11643
Title Alternative Prevalence of urinary stress incontinence in women
FullText URL 062_023_026.pdf
Author Okuda, Hiroshi| Takatori, Akimasa| Izushi, Michihiro| Yoshida, Junko| Yamagami, Keiko| Sakata, Junko| Tanizaki, Yoshiro|
Abstract 三朝分院外来を訪れた女性患者を対象に尿失禁に関する18項目のアンケート調査を行った。その結果,全体の過半数が尿失禁の経験者であった。腹圧性尿失禁が大部分を占め,高齢になるほど 経産回数が多いほど頻度が高くなる傾向がみられた。そのうちの約1割に尿漏れの頻度と程度が重かった。以上より,尿失禁について積極的な啓蒙,診断,治療の必要性が認められた。
Abstract Alternative The prevalence of urinary stress incontinence was investigated in 93 women consulting in our hospital by means of a questionnaire survey. The survey showed that 52.7% of the total cases experienced the loss of urine. 87% of the cases with the loss of urine were the cases with stress incotinence. The prevalence of incontinence increased with age up to 69.2% in the 60's. A positive correlation was found between the number of childbirths and the prevalence of incontinence.
Keywords 腹圧性尿失禁 (Urinary stress incontinence)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 23
End Page 26
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313351
JaLCDOI 10.18926/11650
Title Alternative Maternity swimming at M isasa Hospital of Okayama University Medical School-Fourth report. The growth and development of babies who were born from the mothers who experienced the maternity swimming
FullText URL 062_027_031.pdf
Author Okuda, Hiroshi| Takatori, Akimasa| Kondo, Yuji| Sakata, Junko| Kamimoto, Manabu| Fujii, Junko| Masui, Etsuko| Nagae, Chiho| Kawahara, Mitsuko| Tanizaki, Yoshiro|
Abstract 第1報において妊婦水泳に関する妊婦の認識について報告し,第2報において妊婦水泳の現状とその適応について報告し,第3報にて妊婦水泳が循環器系に与える影響について報告した。今回は,母親が妊婦水泳を行い出生後1年以上経過した児の発育,発達状況についてアンケート調査を行った。その結果,発育e発達状況は艮好であった。現時点で全例正常な発達をしていた。このことより我々の行っている妊婦水泳は児の発育,発達に悪影響を及ぼさないことが確かめられた。
Abstract Alternative Seventy babies were born from the mothers who experienced maternity swimming in our hospital. The growth and development of 31 babies that were over 1 years old were investigated by means of a questionnaire survey. 62.5% of the total were answered. This survey showed that no babies had problems with their growth and development. These results suggest that maternal Swimmingmight have no hazardous effects on the fetus.
Keywords 妊婦水泳 (Maternity swimming) 児の発育・発達 (Growth and Development of the child)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 27
End Page 31
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313455
JaLCDOI 10.18926/11662
Title Alternative Thermological study on the coldness women - Second report. The relationship between the change of atmospheric temperature and body surface temperature in women with complaints of coldness in limbs
FullText URL 062_016_022.pdf
Author Takatori, Akimasa| Okuda, Hiroshi| Sekiba, Kaoru| Tanizaki, Yoshiro|
Abstract 季節毎の婦人の冷え性患者における全身の皮膚表面温度分布について,サーモグラフィを用いて検討した。その結果以下のことが判明した。1)冷え性は外気温が1カ月の最高気温が20℃,最低気温が10℃,平均気温で15℃以下になると発症しやすくなる。2)外気温が前記の条件において,中間温環境下でサーモグラフィ上,軀幹部の最高温度と四肢部の最低温度の差が8℃以上ある症例では99%の確率で冷えを訴えることが明かとなった。
Abstract Alternative From January to December in 1990, whole body temperature was measured in 79 women by using a thermotracer 6T66, and was compared to the change of atmospheric temperature.The difference between the highest temperature of the body and the lowest temperature of the limbs was more than 8℃ in women with complaints of coldness of limbs. This difference was observed in 88% of the women complaining coldness when the average atmospheric temperature in a month was more than 15℃.
Keywords 婦人の冷え性 (Coldness in women) サーモグラフィ (Thermography) 気温の変化 (Change of atmospheric temperature)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 16
End Page 22
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313602
JaLCDOI 10.18926/15167
Title Alternative A case of rheumatoid arthritis with hypoproteinemia probably induced by diseasemodifying antirheumatic drug, D-Penicillamine
FullText URL 062_080_083.pdf
Author Kitani, Hikaru| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Tanizaki, Yoshiro|
Abstract 症例は52歳女性で,慢性関節リウマチ(RA)はclassical,stageIV, class 2であった。症状は進行性で加療を行うも改善がみられなかった。平成元年11月RA症状の増悪のための再入院後,Penicillamine 100~200 mg,Sulfasalazine 500mgを合せて投与を行ったところ,血沈,CRP等の検査所見は改善傾向を示したが入院時には正常値であった血清蛋白量がその後5.1g/dlまで低下し,下肢浮腫が出現,その後さらに血清蛋白量は4.1g/dlにまで減少した。治療により蛋白量は5.8g/dlにまで回復したが,低蛋白血症の原因としてはD-Penicillamineの関与が疑われた。
Abstract Alternative A patient with classical rheumatoid arthritis was treated with D-Penicillamine and other drugs. In the course of treatment, the episodes of hypoproteinemia were found twice. The first hypoproteinemia was improved almostly by supportive therapy and withdrawl of administration of medicines, including D-Penicillamine. The second hypoproteinemia was severe and resistant to the treatment. It was suggested that the agent eliciting hypoproteinemia in this case might be D-Penicillamine.
Keywords 慢性関節リウマチ (Rheumatoid arthritis) 低蛋白血症 (Hypoproteinemia) D-ペニシラミン (D-Penicittamine) 抗リウマチ剤 (Disease-modifying antirheumatic drug)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 80
End Page 83
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307840
JaLCDOI 10.18926/15065
Title Alternative The biochemical and biological activities of JUN.
FullText URL 062_071_075.pdf
Author Mitsunobu, Fumihiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Asaumi, Noboru| Tanizaki, Yoshiro|
Abstract c-junはニワトリの癌ウイルスから分離された癌遺伝子(v-jun)のproto-oncogeneであり,その遺伝子産物は細胞内転写促進因子AP-1の主成分である。v-jun,c-junのトランスフォーム能を検討するために,我々はv-jun,ニワトリc-jun遺伝子さらにJUN遺伝子の種々の組換え体を複製能を持つレトロウイルスベクター(RCAS)に挿入し,CEF細胞(ニワトリ胎児線維芽細胞)にトランスフェクションした。その結果4か所存在する両者の構造的相違のうち,アミノ末端近くの27アミノ酸の欠損と3' untranslated regionの欠損が十分なトランスフォーム能と転写促進能発現に必須であることが明らかとなった。これらの部分がどのように機能発現に関与しているかは,これからの研究を待たねばならない。
Abstract Alternative V-jun is the oncogene which was isolated from the avian transforming virus ASV17. C-jun is the proto-oncogene of v-jun. The product of the proto-oncogene, c-jun, is a major component of the AP-1 transcription complex. AP-1 regulates the transcription of several genes through its ability to bind specifically to the sequence TGACTCA and variations of this motif. In order to assess the transforming capability of c-jun protein, we have introduced v-jun, the chicken c-jun proto-oncogene and several mutants into a replication competent avian retroviral expression vector (RCAS). Each of those was expressed in CEF and assayed for transformation by focus formation. Analysis of the results reveals that deletion of a region of 27 amino acids near the amino terminus of c-jun and deletion of 3' untranslated sequences are critical in activating the full oncogenic potential of jun.
Keywords 癌遺伝子 (Oncogene) JUN遺伝子 (JUN gene) レトロウイルスベクター (Retrovirus Vector) トランスフェクション (Transfection) トランスフォーム (Transform)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 71
End Page 75
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307874
JaLCDOI 10.18926/11664
Title Alternative A dietary survey in patients with chronic pancreatitis
FullText URL 062_011_015.pdf
Author Hayashimoto, Kanae| Ochi, Koji| Harada, Hideo| Tanaka, Juntaro| Takuma, Masae| Masui, Etsuko| Tanizaki, Yoshiro| Matsumoto, Shuji| Seno, Toshinobu| Izushi, Michihiro|
Abstract 食事療法は慢性膵炎治療の基本として重要であるが,その具体的な内容についてはあまり明確にされていない。今回,筆者らは慢性膵炎例の食事に関する全国調査の一部を担当したので,その成績を報告し,問題点と対策について考察した。対象は慢性膵炎間欠期の患者56名(男44名,女12名)である。(1)エネルギー摂取量では1日1,400kcal以下が16名(29%)にみられ,肥満度80~90%が7名および80%以下が9名という栄養状態と考え合わせて,食事の回数を増やしてでも摂取エネルギーの改善をはかる必要がある。(2)蛋白質および脂質摂取量についても同様な成績であり,消化酵素剤を投与しながら量的,質的な改善をはかる必要がある。(3)糖質については質的改善をはかる必要がある。(4)ビタミンとミネラルも不足傾向にあった。野菜の摂取不足が顕著であった。(5)診断確定後も禁酒できない患者が男17名(39%),女1名(8%)にみられ,その指導が重要な課題である。
Abstract Alternative Importance of diet therapy has been emphasized in chronic pancreatitis. However, concrete measures and programs of the diet therapy have remained to be studied. Therefore, Intractable Pancreatic Disease Study Group recently carried out a nation-wide questionnaire survey on the diets in patients with chronic pancreatitis under the auspIces of the Ministry of Health and Welfare. Attendant physicians were requested to report the nutritional states of their patients and the kinds and amounts of foods taken by their patients on three consecutive days. The nutritional state was evaluated by a body weight index calculated by the following formula:Body Weight Index (%) = Present Body Weight / Ideal Body Weight X 100. Daily nutritional intake (calorie, protein, fat, carbohydrate, and others) was calculated by dieticians according to the Food Exchange Table published by the Japanese Association of Diabetes. The present study constitutes a part of the group study. Patients consisted of 44 men and 12 women who fulfilled the diagnostic criteria proposed by the Japanese Society of Gastroenterology;20 men and 3 women had secondary diabetes mellitus. Following results and conclusions were obtained. (1) Average daily calorie intake of the patients was 1,759kcal as compared with 2,057kcal in the general population in Japan. Sixteen patients (28.6%) showed daily calorie intake less than 1,400 kcal and consequently poor nutritional states (6 patients with body weight indices less than 80% and 10 with 80-90%). It is important, therefore, to try to improve the daily calorie intake by increasing the frequency of diets in these patients. (2) Average daily intake of protein was 72.1 g (animal protein 38.1 g), only slightly less than 79.2 g (animal protein 41.7 g) in the general population. However, as many as 16 patients (28.6%) showed daily protein intake of less than 60 g and poor nutritional states as described above. It is important, therfore, to encourage patients to maintain the daily protein intake of more than 60 g by increasing the frequency of diets with oral administration of digestive enzymes. (3) Average daily intake of fat was 39.9 g (animal fat 23.8 g), approximately 20 g less than 58.3 g (animal fat 28.0 g) in the general population. As many as 17 patients (30.4%) showed daily fat intake of less than 30 g , and 16 of the 17 patients showed poor nutritional states as described above. It is important, therefore, to encourage patients to maintain the daily fat intake of more than 30 g (especially by increasing the amounts of vegetable oil) by increasing the frequency of diets with oral administration of digestive enzymes. (4) Average daily intake of carbohydrate was 278 g, almost equal to 289 g in the general population. However, many patients took as much as 48 g of carbohydrate in the from of cakes, plain sugar and alcohol beverages. Seventeen men (39%) and one woman (8%) had continued drinking alcohol beverages even after the diagnosis was made. It is important, therefore, to encourage patients to improve the quality of carbohydrate intake, although it is admittedly difficult to realize the ideal. (5) Intake of vitamins and minerals (especially calcium) also tended to be insufficient. Green vegetables were especially insufficient. (6) In conclusion, it is utmost important in chronic pancreatitis to perform periodical evaluation of nutritional intake and feed back the information to the treatment through a close patient-dietician-doctor relationship.
Keywords 慢性膵炎 (Chronic pancreatitis) 食事療法 (Diet therapy in chronic pancreatitis) 栄養状態 (Nutrition in chronic pancreatitis)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 11
End Page 15
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002313896
JaLCDOI 10.18926/15097
Title Alternative Possible participation of viral infection in the onset mechanisms of bronchial asthma
FullText URL 062_076_079.pdf
Author Mifune, Takashi| Mitunobu, Fumihiro| Okazaki, Morihiro| Kitani, Hikaru| Tanizaki, Yoshiro|
Abstract ウイルスなどの気道感染により,気管支喘息症状が発症したり,あるいは増悪したりすることが知られている。自験例は65歳の女性で,上気道炎症状に引き続いて,気管支喘息が発症した。臨床症状の軽快とともに気道過敏性・IgE値は低下し,感染による気道過敏性の亢進,IgE型アレルギー反応の機序が関与していると考えられた。これらの結果は喘息患者は気道感染(特にウイルス感染)の予防が必要であり,感染した場合には抗喘息剤とともに抗炎症剤の使用が有用である可能性を示している。
Abstract Alternative It is well known that respiratory infection induces asthma attacks. In this paper one case showing possible participation of viral infection in the onset mechanisms of bronchial asthma was reported. A 65-year-old woman was admitted to Misasa Hospital because of moderate asthma attacks. The attacks appeared after upper respiratory infection. Bronchial hyperactivity were increased when she admitted at the hospital, and decreased with the improvement of the asthma symptoms. It is suggested from her clinical course that repiratory infection (especially by virus) may affect the bronchial hyperactivity and IgE synthesis.
Keywords 気道感染 (Respiratory infection, Virus infection) 気道過敏性 (Bronchial hypersensitivity) lgEアレルギー反応 (Allergic reaction mediated by IgE)
Publication Title 環境病態研報告
Published Date 1991-08
Volume volume62
Start Page 76
End Page 79
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307679
JaLCDOI 10.18926/15322
Title Alternative 高齢者健常人および気管支喘息患者におけるカンジダ特異的IgGおよびIgG(4)抗体について
FullText URL 063_058_062.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kotoh, Naoki| Tada, Shinya| Kimura, Ikuro|
Abstract Specific IgG and IgG(4) antibodies against Canadida albicans were exmined in 48 healthy and 69 asthmatic subjects to analyze the mechanism causing an increased production of these immunoglobulins. 1. The level of C.albicans-specific IgG and IgG(4) antibodies was higher, not significantly in IgG(4), in asthmatics under 30 years of age, compared with healthy subjects of the same age group. 2. Specific IgG and IgG(4) antibody levels in both healthy and asthmatic subjects showed a tendency to increase with aging, and significant difference was present between cases under 30 years and cases over 70 years of age. 3. Any difference in the production of specific IgG and IgG(4) was not observed in elderly cases older than 60 years between healthy and asthmatic subjects.
Abstract Alternative 高齢者(61才以上)の健常人48名および気管支喘息患者69例を対象に,カンジダ特異的IgGおよびIgG(4)抗体を測定し,その増加の機序について若干の検討を加えた。なお,対照としては,30才以下の健常者および気管支喘息患者を選んだ。1.カンジダ特異的IgGおよびIgG(4)抗体価は,30才以下では,健常人に比べ気管支喘息症例で高い傾向が見られ,特異的IgG抗体では両者間に有意の差が見られた(p<0.05)。2.カンジダ特異的IgGおよびIgG(4)抗体は,健常人および気管支喘息症例いずれも加齢とともに増加する傾向が見られ,71才では,30才以下の症例に比べ有意に高い抗体価を示した。3.61才以上の高齢者では,特異的IgG,IgG(4)抗体いずれにおいても,健常人と気管支喘息患者との間に有意の差は見られなかった。
Keywords Candida albicans (カンジダ特異的IgG) Specific IgG IgG(4) Bronchial asthma (気管支喘息) Aging (加齢)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 58
End Page 62
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307284
JaLCDOI 10.18926/15321
Title Alternative IgE受容体を介する刺激に対する好塩基球の形態的変化の顕微鏡的観察. 抗原と抗IgE刺激の特徴とその相違点
FullText URL 063_050_057.pdf
Author Tanizaki, Yoshiro| Nakagawa, Saburo| Kimura, Ikuro|
Abstract Differences in morphological changes of basophils between antigen and anti-IgE stimulation were examined in atopic subjects in relation to histamine release. 1. Antigen- induced release of histamine was remarkably more rapid and larger at any incubation time than the release by anit-IgE, and a significant difference was found at 3 to 9 min. 2. Decrease in number of basophils induced by antigen was significantly higher for 12 to 15 min incubation time than that by anti-IgE. 3. Morphological changes of basophils representing increased motility such as an increased ratio of short to long axis diameter (L/S ratio) and an increased incidence of basophils with localized granules (LG) were more often observed in antigen stimulation compared with anti-IgE, and the L/S ratio of the cells was significantly more increased in antigen stimulation at 6 and 15 min. 4. There was no difference in morphological changes of basophils showimg swollen type (degranulation) such as an increased mean diameter (MD) of the cells between antigen and anti-IgE. These results suggest that antigen activates basophils and induces increased motility more strongly than anti-IgE, but the action on degranulation was not different between the two agents.
Abstract Alternative 抗原および抗IgE刺激時の好塩基球の形態変化の特徴について,ヒスタミン遊離との関連のもとに,顕微鏡下に経時的に観察した。1.抗原刺激時のヒスタミン遊離は,15分間のincubationのいずれの時期においても,抗IgE刺激に比べ有意に多く,incubation時間3分と9分では両者間に有意の差が見られた。2.抗原刺激時の好塩基球数の減少も抗IgE刺激に比べより高度であった。3.運動亢進により洋梨型を示す抗塩基球では,長径/短径比の増大が見られた。この長径/短径比の増大を示す好塩基球は,抗原刺激時に抗IgE刺激に比べより高頻度に見られ,特にincubation6分と15分では両者間に有意の差が見られた。4.膨化型を示す好塩基球ではその平均直径の増大が見られるが,この平均直径の増大については,抗原と抗lgE刺激との間に差は見られなかった。以上の結果より,抗原刺激では,好塩基球のactivate,運動亢進へ の過程が抗IgE刺激時と比べより高度であるが,膨化への過程には両者間に差が見られないことが示唆された。
Keywords Histamine release (ヒスタミン遊離) Morphological changes of basophils (好塩基球の形態的変化) Antigen (抗原) Anti-IgE (抗IgE) IgE receptors (IgE受容体)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 50
End Page 57
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307320
JaLCDOI 10.18926/15324
Title Alternative 臨床所見および検査成績からのスコアーによる喘息分類の特徴
FullText URL 063_063_068.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Takatori, Akimasa| Okuda, Hiroyuki| Kimura, Ikuro|
Abstract Twenty six patients with bronchial asthma was classified by clinical symptoms and singns (clinical diagnosis), and the classification by clinical diagnosis was compared with the classification by a score calculated from clinical findings and examinations (score diagnosis). 1. Of 12 subjects with type Ia classified by clinical diagnosis, 8 cases with 0 to 49 ml/day of expectoration were evaluated as type Ia by score diagnosis. While four type Ia cases with 50 to 99ml/day of expectoration were calssified as type Ib by score diagnosis. The increased incidence of eosinophils in bronchoalveolar lavage fluid (BALF) of these four cases was similar to the incidence in type Ib cases with hypersecretion. 2. All of 6 subjects with type Ib by clinical diagnosis were estimated as type Ib by score diagnosis. 3. Of 8 cases with type II by clinical diagnosis, 7 cases were assessed as type II by score diagnosis. One case with type II by clinical diagnosis and with the score of 10 points was evaluated as questionable type II by score diagnosis.
Abstract Alternative 気管支喘息36例を対象に,臨床病態による喘息の分類(臨床診断)を試み,この分類と臨床所見および臨床検査より求めたスコアーによる分類(スコアー分類)との比較検討を行った。1.臨床分類でIa.単純性気管支攣縮型と診断された12症例のうち,1日喀痰量0-49mlの8症例は,スコアー分類では同様にIa.型と分類された。一方,1日喀痰量50-99mlの4症例はスコアー分類ではIb.型(気管支攣縮+過分泌型)と分類された。これら4症例のBALF中好酸球増多はIb.型に類似した病態であった。2.臨床診断によりIb.型に分類された6症例はいずれもスコアー診断でもIb.型と分類された。3.臨床診断によりII.型(細気管支閉塞型)と分類された8症例のうち,7症例はスコアー診断でもII.型と分類されたが,1症例はスコアー10でII.型の診断基準に合わず,questionable II.型と診断された。
Keywords asthma classification (喘息分類) bronchoconstriction (気管支攣縮) hypersecretion (過分泌) bronchiolar obstruction (細気管支閉塞) score diagnosis (スコアー診断)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 63
End Page 68
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307348
JaLCDOI 10.18926/15327
Title Alternative Inhibitory effect of furosemide on histamine release from human basophils
FullText URL 063_095_098.pdf
Author Kitani, Hikaru| Kusaura, Yasuhiro| Honke, Naoko| Tanimizu, Masakuni| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Tanizaki, Yoshiro|
Abstract furosemideは利尿剤として知られているが,吸入することにより気道収縮に対して抑制的に作用することが近年報告されている。その抑制作用の機序を明らかにする目的で,furosemide添加による末梢血好塩基球からのヒスタミン遊離に対する抑制効果を検討した。健常人4例,アトピー型気管支喘息患者8例を対象として全血法で抗ヒトIgE刺激によるヒスタミン遊離を観察した。なお,furosemideの最終濃度は0,1,10,100μg/mlに調整して添加実験を行った。健常人,気管支喘息いずれにおいても,furosemide添加による末梢血好塩基球からのヒスタミン遊離に対する抑制効果はみられなかった。
Abstract Alternative Inhibitory effect of furosemide on histamine release from basophils induced by anti-IgE was examined in 4 healthy subjects and 8 patients with atopic asthma. The experiments of basophil histamine release were carried out by using whole blood method. The mean values of histamine release after 15 min preincubation with furosemide at various concentrations were not significantly decreased, in both healthy and asthmatic subjects compared to those of histamine release without furosemide. The results obtained here show that furosemide does not inhibit histamine release from basophils by the whole blood method.
Keywords 気管支喘息 (Bronchial asthma) フロセミド (Furosemide) ヒスタミン遊離 (Histamine release)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 95
End Page 98
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307119
Author Matsubara, Fumie| Endou, Hiroi| Kitani, Hikaru| Tanizaki, Yoshiro|
Published Date 1992-06
Publication Title 岡大三朝分院研究報告
Volume volume63
Content Type Data or Dataset
JaLCDOI 10.18926/15338
Title Alternative Immunotherapy in house dust mite sensitive asthma
FullText URL 063_117_122.pdf
Author Okazaki, Morihiro| Kitani, Hikaru| Mifune, Takasi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honnke, Naoko| Kusaura, Yasuhiro| Tanizaki, Yoshiro|
Abstract ダニ喘息はアトピー型喘息の典型であるが,これに対する根本療法としてアレルゲンであるハウスダストを皮下注射する免疫療法が臨床でおこなわれている。70-80%の有効性が報告されているが,その作用機序はいまだ不明である。この稿においては特異的IgE抗体,特異的IgG抗体,特異的lgG4抗体,抗イディオタイプ抗体,肥満細胞の反応性,リンパ球の役割について総説する。また新たな試みとしてのallergen antibody complexを使った免疫療法,ペプタイドを使用する治療の可能性についても言及する。
Abstract Alternative Immunotherapy with house dust extract is employed as a treatment of patients with house dust mite sensitive bronchial asthma. Although 70-80% efficacy of the treatment is reported, mechanisms of its efficacy are not clear yet. In this paper, reported studies of IgE antibody, IgG antibody, IgG4 antibody, antiidiotypic antibody, reactivity of mast cells and function of lymphocytes are reviewed. A new type of immunotherapy with allergen antibody immune complex and a potential use of influenza virus hemaglutinin peptide analogue are also referred.
Keywords ダニ喘息 (House dust mite sensitive bronchial asthma) 免疫療法 (lmmunotherapy)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 117
End Page 122
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307745
JaLCDOI 10.18926/15335
Title Alternative Physical therapy of patients with total hysterectomy
FullText URL 063_106_109.pdf
Author Kamimoto, Manabu| Okuda, Hiroyuki| Tanizaki, Yoshiro|
Abstract 子宮全摘術を受け,回復期に理学療法を実施した患者に,自転車エルゴメーターによる同一負荷運動時の心拍数について施行前と退院時の変化を検討した。その結果,退院時に心拍数は有意に減少した。しかし,その減少の程度は理学療法実施回数と相関しなかった。患者は水中運動を積極的に実施し,速やかに家庭生活を含めた社会生活への復帰が可能となった。退院後の外来診察時に異常も認められず,理学療法の有効性並びに安全性が確認された。
Abstract Alternative Twenty-one patients with total hysterectomy had a physical therapy program, including swimming training in a hot spring pool, muscle stretching and muscle strengthening exercise. Effects of this program were evaluated by bicycle ergometric challenge test. Maximum increased heart rate of the patients on the ergometric challenge test was significantly lower after the end of the program compared with the initial value before program (p<0.02). However, the effects of such physical therapy program on heart rate did not correlate with the frequency of the program. All patients were able to return to social work without any difficulties. These results support the efficacy of the physical therapy program in our hospital.
Keywords 子宮全摘術 (Abdominal hysterectomy) 術後理学療法 (Postoperative Physical therapy) 自転車エルゴメーター (Bicycle ergometer) 心拍数 (Heart rate)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 106
End Page 109
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307203
JaLCDOI 10.18926/15318
Title Alternative 老令者の気管支喘息,各臨床病型における換気機能の特徴
FullText URL 063_044_049.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Takatori, Akimasa| Okuda, Hiroyuki| Kimura, Ikuro|
Abstract Ventilatory function was examined in 20 elderly patients with bronchial asthma in relation to clinical asthma types, and the results were compared with those of younger asthmatics. 1. Ventilatory parameters such as FEV(1.0%), % PEFR, % MMF, % V(50) and % V(25), which repressent obstructive ventilatory dysfunction, were in general lower in older asthmatics than in the youger cases. 2. The values of % V(50) and % V(25), representing ventilatory dysfunction in small airways, were significantly lower in the older subjects with type Ib and II compared to the younger cases with same types. 3. Markedly decreased values in ventilatory parameters, particularly in % MMF, % V(50) and % V(25) were observed in both older and younger subjects with type II. The results suggest that ventilatory function decreases with aging and the decrease is related to the pathophysiological changes in the airways.
Abstract Alternative 60才以上の老年気管支喘息20例(平均年令;66.7才)を対象に,その換気機能について,臨床病態別に59才以下の症例(平均年令;44.9才)との比較検討を行った。1.FFV(1.0%), % PEFR, % MMF, % V50, % V25などの閉塞性換気障害を表すパラメーターは,59才以下の症例に比べ老年症例で全般的に低い傾向が見られた。2.小ないし細気管支領域の換気榛能を反映すると考えられる% V(50)および% V(25)は,Ib型およびII型喘息を示す老年症例において,59才以下の症例に比べ,有意に低い値を示した。3.II型喘息症例では,59才以下および老年症例のいずれにおいても, % MMF, % V(50)および% V(25)は他の臨床病型にくらべ著明に低い値を示した。これらの結果は,気管支喘息における換気機能は,加令とともに低下傾向を示すこと,そしてその低下は臨床病態と関連していることを示しているものと考えられた。
Keywords Ventilatory function (換気機能) small airways (細気管支) clinical asthma types (臨床病型) elderly asthmatics (老年者気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 44
End Page 49
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307531
JaLCDOI 10.18926/15331
Title Alternative ラット腹腔肥満細胞のCa(2+) influxおよびヒスタミン遊離に対する抗アレルギー薬アゼラスチンの抑制効果について
FullText URL 063_089_094.pdf
Author Tanizaki, Yoshiro| Ohtani, Jun| Kimura, Ikuro|
Abstract The effect of antiallergic agent, azelastine, was examined in immunogical secretory process of mast cells. 1. Azelastine significantly inhibited (45)Ca uptake by mast cells stimulated by antigen, and the maximum inhibition was attained at a concentration of 50 μg/ml showing approximately 30.5 % inhibition. 2. Azelastine also inhibite the release of histamine from mast cells by antigen. The maximal inhibitory rate was 38.1%. The effect of azelastine on (45)Ca uptake and histamine release was dose-dependent, and compatible at employed cocentration of the agent. 3. Tachpylaxis to azelastine was not found in this experimental system.
Abstract Alternative 抗原刺激時の,ラット腹腔肥満細胞のCa(2+) uptakeおよびヒスタミン遊離に対する,抗アレルギー薬アゼラスチンの抑制効果について検討を加えた。その結果,1.アゼラスチンは抗原刺激時の肥満細胞のCa(2+) uptakeに対して濃度依存性の抑制効果を示した。2.同様に,抗原刺激時の肥満細胞からのヒスタミン遊離に対しても,濃度依存性の抑制効果を示した。3.アゼラスチンの再暴露による抑制効果の減弱傾向は見られず,アゼラスチンでは tachyphylaxisは観察されなかった。
Keywords Azelastine (アゼラスチン) Rat mast cells (ラット肥満細胞) (45)Ca uptake (Ca(2+)uptake) Histamine release (ヒスタミン遊離)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 89
End Page 94
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307786
JaLCDOI 10.18926/15328
Title Alternative Relationship between bone mineral densities of second metacarpal bone and lumber spine
FullText URL 063_099_105.pdf
Author Nakai, Mutsuo| Okuda, Hiroyuki| Akiyama, Tsuneo| Takatori, Akimasa| Tanizaki, Yoshiro|
Abstract QCTおよびDIP法による測定値の相関性について検討し,DIP法による腰椎骨塩量の推定および,スクリーニングへの適用について考察した。QCT値とΣGS/DやMClとの相関関係の検討では.対象のQCT値が低値か高値かによって相関関係がかなり異なることが明らかになった。すなわち,QCT値が低い領域は,QCT値と,ΣGS/DやMCIに明らかな正の相関関係が認められたが,一方, QCT値が高い領域では,相関関係は認められなかった。また,ΣGS/D=2.8mmAI以上,またはMCI=0.48以上の症例においては腰椎圧迫骨折の危険は小さく,ΣGS/D=1.8mmAI以下,またはMCI=0.24以下の症例においては腰椎圧迫骨折の危険が大きい可能性が示唆された。
Abstract Alternative To compare bone mineral density between second metacarpal bone and lumber spine, two measuring methods, digital image processing method (DIP) for second metacarpal bone and quantitative computed tomography (QCT) for lumber spine were employed in this study. The bone mineral density was evaluated in 89 females and the results were compared between the two methods. A correlation between the bone mineral densities by QCT and ΣGS/D was found in subjects showing low mineral density by QCT, but not in those with high mineral density. These results reveal that DIP is useful to observe bone mineral density and if ΣGS/D and MCI are enough high, almost he hasn't risk of fracture of lumber spine.
Keywords 骨粗鬆症 (osteoporosis) 骨塩量 (bone mineral density) QCT (quantitative computed tomography) DIP法 (digital image processing method)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 99
End Page 105
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307484