JaLCDOI 10.18926/15338
Title Alternative Immunotherapy in house dust mite sensitive asthma
FullText URL 063_117_122.pdf
Author Okazaki, Morihiro| Kitani, Hikaru| Mifune, Takasi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honnke, Naoko| Kusaura, Yasuhiro| Tanizaki, Yoshiro|
Abstract ダニ喘息はアトピー型喘息の典型であるが,これに対する根本療法としてアレルゲンであるハウスダストを皮下注射する免疫療法が臨床でおこなわれている。70-80%の有効性が報告されているが,その作用機序はいまだ不明である。この稿においては特異的IgE抗体,特異的IgG抗体,特異的lgG4抗体,抗イディオタイプ抗体,肥満細胞の反応性,リンパ球の役割について総説する。また新たな試みとしてのallergen antibody complexを使った免疫療法,ペプタイドを使用する治療の可能性についても言及する。
Abstract Alternative Immunotherapy with house dust extract is employed as a treatment of patients with house dust mite sensitive bronchial asthma. Although 70-80% efficacy of the treatment is reported, mechanisms of its efficacy are not clear yet. In this paper, reported studies of IgE antibody, IgG antibody, IgG4 antibody, antiidiotypic antibody, reactivity of mast cells and function of lymphocytes are reviewed. A new type of immunotherapy with allergen antibody immune complex and a potential use of influenza virus hemaglutinin peptide analogue are also referred.
Keywords ダニ喘息 (House dust mite sensitive bronchial asthma) 免疫療法 (lmmunotherapy)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 117
End Page 122
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307745
JaLCDOI 10.18926/15337
Title Alternative Pathogenic significance of IgG and IgG(4) antibodies against Candida albicans in bronchial asthma
FullText URL 064_116_124.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke|
Abstract カレジダ特異的IgG及びIgG(4)抗体が,気管支喘息の発症病態に関与しているかどうかについて検討を加えた。カンジダ特異的IgGおよびIgG(4)抗体は, 0-30才の年齢層の症例ではアトピー性素因の強い症例で,また,31-60才の年齢層の症例ではストロイド依存性重症難治性喘息症例で,さらに61才以上の高年令の症例で,その産生亢進が観察される。これらの症例におけるIgG及びIgG(4)抗体産生は,0-30才の年齢ではアトピーとの関連で,また31-60才の年齢では副腎皮質ホルモンの長期投与と関連して,さらに61才以上の症例では加齢と関連して,細胞性免疫能が低下し,そのためカンジダの発育が促進され,その結果として,IgG及びIgG(4)抗体の産生亢進が見られることが明らかにされている。すなわち,気管支喘息におけるカンジダに対するIgG系抗体の産生亢進は,cell-mediated immunityの低下と言う共通の基盤を有しており,病因的意義とは必ずしも関連していないことを述べた。
Abstract Alternative Pathogenic significance of IgG and IgG(4) antibodies against Candida albicans was discussed in patients with bronchial asthma. An increased production of IgG and IgG(4) antibodies against Candida albicans has been observed in patients with atopic between the ages of 0 and 30, those with steroid-dependent intractable asthma between 31 and 61, and elderly patients over the age of 61. The mechanism of an increased production of IgG and IgG(4) antibodies seems to be related to atopy in patients between 0 and 30, long-term glucocorticoid therapy in those with steroid-dependent intractable asthma between 31 and 60, and aging in elderly patients over age 61. Atopy, glucocorticoid therapy and aging in general suppress cell-mediated immunity, and suppressed cell-mediated immunity increases growth of C. albicans in patient's body, leading to an increased production of IgG and IgG(4) antibodies against C. albicans. These results show that an increased production of IgG and IgG(4) antibodies against C. albicans is not always related to the pathogenesis of bronchial asthma.
Keywords カンジダ (Candida) lgG抗体 (IgG antibodies) IgG(4)抗体 (IgG(4) antibodies) アトピー (Atopy) 気管支喘息 (Bronchial asthma)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 116
End Page 124
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307381
JaLCDOI 10.18926/15336
Title Alternative Significance of spa therapy in modern medicine and its social request
FullText URL 063_110_116.pdf
Author Tanizaki, Yoshiro|
Abstract ステロイド依存性重症難治性喘息を中心に,温泉療法の臨床効果,作用機序およびその社会的要請について総括的な検討を行った。1.重症型喘息に対する温泉療法としては,温泉プール水泳訓練,ヨードゾル吸入療法,鉱泥湿布療法などの有効性が高いため,これらの治療法を組合わせた複合温泉療法が現在行われている。そして,これらの温泉療法は,いずれも細気管支領域の病変(狭窄ないし閉塞)に対して有効であり,気管支肺胞洗浄法(BAL)により観察されるairway inflammationを有する症例が増えつつある現在,極めて有用な治療法の1つと考えられる。2.入院による温泉療法で軽快した後は,それぞれの地元で継続療法を行うことが症状の安定化のために必要である。3.重症型喘息は当院への入院例で見る限り,明らかに増加の傾向にあり,薬物療法の限界を越えたこれらの症例の治療には温泉療法が必要であり,周囲環境の変化や高齢化社会を迎えて,その社会的要請は年ごとに増加しつつあると考えられる。
Abstract Alternative Significance, clinical effects, action mechanisms and social request of spa therapy were discussed in relation to the treatment for patients with steroid-dependent intractable asthma (SDIA) and to modern medicine. 1. Complex spa therapy comprising swimming training in a hot spring pool, inhalation with iodine salt solution and fango therapy is highly effective in patients with SDIA. The action mechanism of complex spa therapy is clearly proved to improve the narrowing and obstruction of the small airways of those with SDIA. The complex spa therapy is more required for the treatment of asthma, because number of asthma patients with airway inflammation increases in recent years. 2. After spa therapy during admission, patients should continue their maintenance therapy to keep their asthma stable. 3. The number of patients with SDIA clearly increases, and antiasthmatic drugs except corticosteroid hormone are not effective for these patients. Thus, complex spa therapy is more necessary for the therapy of these asthma patients.
Keywords 重症型喘息 (Intractable asthma) 温泉プール水泳訓練 (Swimmlng trainlng in a hot spring pool) ヨードゾル吸入療法 (Inhalation therapy with iodine salt solution) 鉱泥湿布療法 (Fango therapy) 複合温泉療法 (Complex spa therapy)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 110
End Page 116
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307632
JaLCDOI 10.18926/15335
Title Alternative Physical therapy of patients with total hysterectomy
FullText URL 063_106_109.pdf
Author Kamimoto, Manabu| Okuda, Hiroyuki| Tanizaki, Yoshiro|
Abstract 子宮全摘術を受け,回復期に理学療法を実施した患者に,自転車エルゴメーターによる同一負荷運動時の心拍数について施行前と退院時の変化を検討した。その結果,退院時に心拍数は有意に減少した。しかし,その減少の程度は理学療法実施回数と相関しなかった。患者は水中運動を積極的に実施し,速やかに家庭生活を含めた社会生活への復帰が可能となった。退院後の外来診察時に異常も認められず,理学療法の有効性並びに安全性が確認された。
Abstract Alternative Twenty-one patients with total hysterectomy had a physical therapy program, including swimming training in a hot spring pool, muscle stretching and muscle strengthening exercise. Effects of this program were evaluated by bicycle ergometric challenge test. Maximum increased heart rate of the patients on the ergometric challenge test was significantly lower after the end of the program compared with the initial value before program (p<0.02). However, the effects of such physical therapy program on heart rate did not correlate with the frequency of the program. All patients were able to return to social work without any difficulties. These results support the efficacy of the physical therapy program in our hospital.
Keywords 子宮全摘術 (Abdominal hysterectomy) 術後理学療法 (Postoperative Physical therapy) 自転車エルゴメーター (Bicycle ergometer) 心拍数 (Heart rate)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 106
End Page 109
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307203
JaLCDOI 10.18926/15334
Title Alternative Spa therapy for bronchial asthma. Spa therapies effective for bronchial asthma and problems in future.
FullText URL 064_105_110.pdf
Author Tanizaki, Yoshiro|
Abstract 気管支喘息に対する温泉療法の作用,あるいは効果は,直接作用と間接作用,局所作用と全身作用,即時的効果と遠隔効果などに分類される。気管支喘息に対する温泉療法の直接作用としては,呼吸器症状およびそれに関連した検査成績の改善として,また間接作用としては副腎皮質機能の改善作用がみられる。一方,気管支喘息に有用な温泉療法としては,温泉プール水泳訓練,ヨードゾル吸入療法,および鉱泥湿布療法などが明らかにされており,現在これらの温泉療法を組み合わせた複合温泉療法が行われている。気管支喘息はその臨床病態より,Ia-1.Ia-2,Ib,およびII型に分類される。このうち,特にIb型やII型は薬物療法のみではコントロールし難い重症難治性喘息を多く含んでいる。温泉療法は,気管支喘息全般に有効であるばかりでなく,特に薬物療法のみではコントロール困難なIb型やII型の喘息に対しても有効である。しかし,今後新たに気管支喘息に有用な温泉療法を考案して行かねばならない。
Abstract Alternative Actions or effects of spa therapy on bronchial asthma are divided as follows : direct and indirect actions, actions for organs and whole body, and immediate and distant effects. Direct actions of spa therapy on asthma are observed in improvement of clinical symptoms and examination results related to clinical symptoms, and indirect actions of the therapy are found in improvement of suppressed function of adrenocortical glands. It has been clarified that swimming training in a hot spring pool, inhalation of iodine salt solution, and fango therepy are effective in patients with asthma. The combination of these three spa therapies is now administered for the treatment of asthma. Bronchial asthma is classified into four types accoding to clinical symptoms : Ia-1, Ia-2, Ib, and II. Type Ib and type II asthma include many of intractable asthma, and spa therapy is effective even in these intractable asthma that is difficult to control without glucocorticoids. It is necessary to develop newly devised spa therapy that is more effective in patients with asthma.
Keywords 温泉療法 (Spa therapy) 温泉プール水泳訓練 (Swimming training in a hot spring pool) ヨードゾル吸入 (Inhalation of iodine salt solution) 鉱泥湿布療法 (Fango therapy) 気管支喘息 (Bronchial asthma)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 105
End Page 110
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307660
JaLCDOI 10.18926/15333
Title Alternative Spa therapy for bronchial asthma. Inhalation therapy with hot spnng water and iodine salt solution
FullText URL 064_111_115.pdf
Author Tanizaki, Yoshiro|
Abstract 慢性閉塞性呼吸器疾患,特に気管支喘息に対する温泉療法は.温泉療法そのものの効果以外に,温泉保養地の周囲環境が疾患に極めて良好であるという利点を有している。温泉水やヨードゾルによる吸入療法は,気管支喘息に対して有効であるが,治療効果をより良好なものにするためには,各喘息症例の気道内病態を十分把握しておく必要がある。板状貯留を呈する過分泌型喘息や細気管支閉塞型喘息に対しては,吸入療法の効果は一般的に低い。代表的なヨー ドゾル吸入療法の臨床効果は,気管支喘息20例中,著効4例(20%),有効11例(55%),やや有効4例(20%),無効1例であった。
Abstract Alternative In spa therapy for chronic obstructive pulmonary diseases, especially bronchial asthma, there are some advantages that the atmosphere around the health resort where spa therapy is administered is beneficial for the diseases as well as spa effects themselves. There are several kinds of inhalation methods and drugs used for inhalation. Although inhalation therapy uslng hot spring water and iodine salt solution is effective in bronchial asthma, analysis of pathophysiologlcal changes is the airways of asthma is necessary to increase effects of the therapy. Inhalation therapy is in general low in patients with hypersecretion or with bronchiolar obstruction. The clinical effects of inhalation therapy with iodine salt solution, which is one of the representative inhalation therapies, were marked in 4 (20%), moderate in 11 (55%), slight in 4 (20%), and of no value in one of the 20 asthma patients.
Keywords 温泉療法 (Spa therapy) 吸入療法 (Inhalation therapy) 温泉水 (Hot spring water) ヨードゾル (lodine salt solution) 気管支喘息 (Bronchial asthma)   
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 111
End Page 115
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307467
JaLCDOI 10.18926/15332
Title Alternative 気管支肺胞洗浄液中リンパ球増多と患者年齢およびIgE系アレルギー反応との関連について
FullText URL 064_097_104.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kimura, Ikuro|
Abstract The proportion and number of lymphocytes in the airways were analyzed in 15 patients with a high proportion of lymphocytes in bronchoalveolar lavage (BAL) fluid (more than 30%) and in 17 patients with less than 20% of BAL lymphocytes. 1. Both atopic and nonatopic asthma patients with a high proportion of BAL lymphocytes were aged more than 50 years. In contrast, the age of patients with less than 20% of BAL lymphocytes ranged widely, from 29 to 63 years, in the two asthma types. 2. Age at onset of the disease, serum IgE levels, and ventilatory function test were not related to the proportion of BAL lymphocytes. 3. In patients with a high proportion of BAL lymphocytes, the mean proportion of these cells was 47.3% in atopic patients and 36.4% in non-atopic patients, i. e., there was no significant difference between the two asthma types. The absolute number of BAL lymphocytes in these patients was significantly higher in atopic (5.62×10(6)) than in nonatopic asthma (0.77×10(6)) (p<0.01). These findings show that an increased number of lymphocytes in the airways is clearly related to patient age and IgE-mediated allergic reaction.
Abstract Alternative 気管支肺胞洗浄(BAL)液中のリンパ球頻度が30%以上の15例および20%以下の17例の気管支喘息患者を対象に,BAL液中リンパ球頻度と年齢およびIgE系反応との関連について検討を加えた。1.BALリンパ球が高頻度(30%以上)を示す症例は,アトピー型,非アトピー型を問わず,50才以上の年齢層に多い傾向が見られた。一方,BALリンパ球20%以下の症例の年齢は,29-63才まで幅広く分布していた。2.発症年齢,血清IgE値,換気機能とBAL液中リンパ球頻度との間には関連は見られなかった。3.BAL液中リンパ球頻度が高い症例では,アトピー型では平均リンパ球頻度は47.3%,非アトピー型では36.4%であったが,両群間には有意の差は見られなかった。しかし,BAL液中のリンパ球の絶対数は,アトピー型(5.62×10(6))において,非アトピー型(0.77×10(6)) に比べ有意に高い値を示した(p<0.01)。これらの結果は,気道内リンパ球の増加は,患者年齢とIgE系反応と密接に関連していることを示唆している。
Keywords BAL lymphocytes patient age IgE-mediated allergic reaction bronchial asthma
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 97
End Page 104
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307637
JaLCDOI 10.18926/15331
Title Alternative ラット腹腔肥満細胞のCa(2+) influxおよびヒスタミン遊離に対する抗アレルギー薬アゼラスチンの抑制効果について
FullText URL 063_089_094.pdf
Author Tanizaki, Yoshiro| Ohtani, Jun| Kimura, Ikuro|
Abstract The effect of antiallergic agent, azelastine, was examined in immunogical secretory process of mast cells. 1. Azelastine significantly inhibited (45)Ca uptake by mast cells stimulated by antigen, and the maximum inhibition was attained at a concentration of 50 μg/ml showing approximately 30.5 % inhibition. 2. Azelastine also inhibite the release of histamine from mast cells by antigen. The maximal inhibitory rate was 38.1%. The effect of azelastine on (45)Ca uptake and histamine release was dose-dependent, and compatible at employed cocentration of the agent. 3. Tachpylaxis to azelastine was not found in this experimental system.
Abstract Alternative 抗原刺激時の,ラット腹腔肥満細胞のCa(2+) uptakeおよびヒスタミン遊離に対する,抗アレルギー薬アゼラスチンの抑制効果について検討を加えた。その結果,1.アゼラスチンは抗原刺激時の肥満細胞のCa(2+) uptakeに対して濃度依存性の抑制効果を示した。2.同様に,抗原刺激時の肥満細胞からのヒスタミン遊離に対しても,濃度依存性の抑制効果を示した。3.アゼラスチンの再暴露による抑制効果の減弱傾向は見られず,アゼラスチンでは tachyphylaxisは観察されなかった。
Keywords Azelastine (アゼラスチン) Rat mast cells (ラット肥満細胞) (45)Ca uptake (Ca(2+)uptake) Histamine release (ヒスタミン遊離)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 89
End Page 94
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307786
JaLCDOI 10.18926/15330
Title Alternative The efficacy of maternity swimming to reduce mother's weight
FullText URL 063_085_088.pdf
Author Okuda, Hiroyuki| Takatori, Akimasa| Sakata, Junko| Kamimoto, Manabu| Fujii, Junko| Dokai, Chiho| Tanizaki, Yoshiro|
Abstract 第1報において妊婦水泳に関する妊婦の認識について報告し (1) ,第2報において妊婦水泳の現状とその適応について報告した (2) 。その後,第3報において妊婦水泳が母児の循環系におぼす影響について報告し (3) ,第4報にて出産後1年間の児の予後調査を行った (4) 。今回は,妊婦水泳による体重減少効果について検討を行った。その結果,妊婦水泳前後で平均460gの体重減少がみられた。また水泳を10回以上行った妊婦において,水泳を行っている期間の体重増加が水泳を行っていない期間の体重増加に比べて有意に少なかった。これより,妊婦水泳には一定の減量効果があり,肥満妊婦の治療にも応用できると考えられた。
Abstract Alternative The efficacy of awimming to reduce mother's weight were studided retrospectively in 107 women. Each time they swum for a hour. They were given a chance of swimming at only one time in a week. Most of them reduced their weight after the swimming. The average of the weight loss was 460 gram after each time of swimming. In women who had a chance of swimming at ten times or more, the mother's weight gain in a week when they had a chance of swimming, was statistically (p<0.01) less than the weight in a week when they didn't swim. Thus, the maternity swimming was thought to have the efficacy to reduce mother's weight. If the maternlty swimming is clinically applied for the treatment of obese pregnant women, their weight will reduce efficiently.
Keywords 妊婦水泳 (Maternity Swimming) 体重減少 (Reduce mother's weight)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 85
End Page 88
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307789
JaLCDOI 10.18926/15329
Title Alternative Character, Habit and Taste of woman with coldeness in their bodies
FullText URL 063_079_084.pdf
Author Takatori, Akimasa| Okuda, Hiroyuki| Sakata, Junko| Fujii, Junko| Tanizaki, Yoshiro|
Abstract 冷え性の発現は寒冷刺激に対する血管運動性体温調節と密接に関係しているが,患者の性格・生活習慣・食事の嗜好等にも関わっていると考えられる。そこで今回は冷え性婦人100名を対象にCMl調査と35項目にのぼるアンケート調査を行った。その結果,冷え性の増悪因子として,日頃の運動不足・神経症的性格傾向・過労・食べ物の嗜好がクローズアップされ,この面での生活指導が冷え性の治療を行っていく上で,薬物的な治療と並んで重要であることか示唆された。
Abstract Alternative The character, habit and taste were studied about by means of a questionnaire survey and Cornell Medical Index in 100 women who felt cold in their part of bodies. More than 30% of the women showed the neurotic personality, They had a tendency to dislike the greasy foods, and frequently had sweet foods. More than 50% of them ordinally complained of shoulder stiffness and generalfatigue. The women who played sports weekly were less than 20%. The neurotic porsonality, the tendency to dislike the greasy foods and the lack of exercise were seemed to be the feature of their character, taste, and habit. Thus, improvement of their personality and life style may have a good effect on the coldness in women.
Keywords 冷え性 (Coldness in women) 性格 (Character) 生活習慣 (Habit) 嗜好 (Taste)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 79
End Page 84
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307750
JaLCDOI 10.18926/15328
Title Alternative Relationship between bone mineral densities of second metacarpal bone and lumber spine
FullText URL 063_099_105.pdf
Author Nakai, Mutsuo| Okuda, Hiroyuki| Akiyama, Tsuneo| Takatori, Akimasa| Tanizaki, Yoshiro|
Abstract QCTおよびDIP法による測定値の相関性について検討し,DIP法による腰椎骨塩量の推定および,スクリーニングへの適用について考察した。QCT値とΣGS/DやMClとの相関関係の検討では.対象のQCT値が低値か高値かによって相関関係がかなり異なることが明らかになった。すなわち,QCT値が低い領域は,QCT値と,ΣGS/DやMCIに明らかな正の相関関係が認められたが,一方, QCT値が高い領域では,相関関係は認められなかった。また,ΣGS/D=2.8mmAI以上,またはMCI=0.48以上の症例においては腰椎圧迫骨折の危険は小さく,ΣGS/D=1.8mmAI以下,またはMCI=0.24以下の症例においては腰椎圧迫骨折の危険が大きい可能性が示唆された。
Abstract Alternative To compare bone mineral density between second metacarpal bone and lumber spine, two measuring methods, digital image processing method (DIP) for second metacarpal bone and quantitative computed tomography (QCT) for lumber spine were employed in this study. The bone mineral density was evaluated in 89 females and the results were compared between the two methods. A correlation between the bone mineral densities by QCT and ΣGS/D was found in subjects showing low mineral density by QCT, but not in those with high mineral density. These results reveal that DIP is useful to observe bone mineral density and if ΣGS/D and MCI are enough high, almost he hasn't risk of fracture of lumber spine.
Keywords 骨粗鬆症 (osteoporosis) 骨塩量 (bone mineral density) QCT (quantitative computed tomography) DIP法 (digital image processing method)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 99
End Page 105
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307484
JaLCDOI 10.18926/15327
Title Alternative Inhibitory effect of furosemide on histamine release from human basophils
FullText URL 063_095_098.pdf
Author Kitani, Hikaru| Kusaura, Yasuhiro| Honke, Naoko| Tanimizu, Masakuni| Mitsunobu, Fumihiro| Mifune, Takashi| Okazaki, Morihiro| Tanizaki, Yoshiro|
Abstract furosemideは利尿剤として知られているが,吸入することにより気道収縮に対して抑制的に作用することが近年報告されている。その抑制作用の機序を明らかにする目的で,furosemide添加による末梢血好塩基球からのヒスタミン遊離に対する抑制効果を検討した。健常人4例,アトピー型気管支喘息患者8例を対象として全血法で抗ヒトIgE刺激によるヒスタミン遊離を観察した。なお,furosemideの最終濃度は0,1,10,100μg/mlに調整して添加実験を行った。健常人,気管支喘息いずれにおいても,furosemide添加による末梢血好塩基球からのヒスタミン遊離に対する抑制効果はみられなかった。
Abstract Alternative Inhibitory effect of furosemide on histamine release from basophils induced by anti-IgE was examined in 4 healthy subjects and 8 patients with atopic asthma. The experiments of basophil histamine release were carried out by using whole blood method. The mean values of histamine release after 15 min preincubation with furosemide at various concentrations were not significantly decreased, in both healthy and asthmatic subjects compared to those of histamine release without furosemide. The results obtained here show that furosemide does not inhibit histamine release from basophils by the whole blood method.
Keywords 気管支喘息 (Bronchial asthma) フロセミド (Furosemide) ヒスタミン遊離 (Histamine release)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 95
End Page 98
ISSN 0913-3771
language 日本語
File Version publisher
NAID 120002307119
JaLCDOI 10.18926/15324
Title Alternative 臨床所見および検査成績からのスコアーによる喘息分類の特徴
FullText URL 063_063_068.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Takatori, Akimasa| Okuda, Hiroyuki| Kimura, Ikuro|
Abstract Twenty six patients with bronchial asthma was classified by clinical symptoms and singns (clinical diagnosis), and the classification by clinical diagnosis was compared with the classification by a score calculated from clinical findings and examinations (score diagnosis). 1. Of 12 subjects with type Ia classified by clinical diagnosis, 8 cases with 0 to 49 ml/day of expectoration were evaluated as type Ia by score diagnosis. While four type Ia cases with 50 to 99ml/day of expectoration were calssified as type Ib by score diagnosis. The increased incidence of eosinophils in bronchoalveolar lavage fluid (BALF) of these four cases was similar to the incidence in type Ib cases with hypersecretion. 2. All of 6 subjects with type Ib by clinical diagnosis were estimated as type Ib by score diagnosis. 3. Of 8 cases with type II by clinical diagnosis, 7 cases were assessed as type II by score diagnosis. One case with type II by clinical diagnosis and with the score of 10 points was evaluated as questionable type II by score diagnosis.
Abstract Alternative 気管支喘息36例を対象に,臨床病態による喘息の分類(臨床診断)を試み,この分類と臨床所見および臨床検査より求めたスコアーによる分類(スコアー分類)との比較検討を行った。1.臨床分類でIa.単純性気管支攣縮型と診断された12症例のうち,1日喀痰量0-49mlの8症例は,スコアー分類では同様にIa.型と分類された。一方,1日喀痰量50-99mlの4症例はスコアー分類ではIb.型(気管支攣縮+過分泌型)と分類された。これら4症例のBALF中好酸球増多はIb.型に類似した病態であった。2.臨床診断によりIb.型に分類された6症例はいずれもスコアー診断でもIb.型と分類された。3.臨床診断によりII.型(細気管支閉塞型)と分類された8症例のうち,7症例はスコアー診断でもII.型と分類されたが,1症例はスコアー10でII.型の診断基準に合わず,questionable II.型と診断された。
Keywords asthma classification (喘息分類) bronchoconstriction (気管支攣縮) hypersecretion (過分泌) bronchiolar obstruction (細気管支閉塞) score diagnosis (スコアー診断)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 63
End Page 68
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307348
JaLCDOI 10.18926/15322
Title Alternative 高齢者健常人および気管支喘息患者におけるカンジダ特異的IgGおよびIgG(4)抗体について
FullText URL 063_058_062.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Kotoh, Naoki| Tada, Shinya| Kimura, Ikuro|
Abstract Specific IgG and IgG(4) antibodies against Canadida albicans were exmined in 48 healthy and 69 asthmatic subjects to analyze the mechanism causing an increased production of these immunoglobulins. 1. The level of C.albicans-specific IgG and IgG(4) antibodies was higher, not significantly in IgG(4), in asthmatics under 30 years of age, compared with healthy subjects of the same age group. 2. Specific IgG and IgG(4) antibody levels in both healthy and asthmatic subjects showed a tendency to increase with aging, and significant difference was present between cases under 30 years and cases over 70 years of age. 3. Any difference in the production of specific IgG and IgG(4) was not observed in elderly cases older than 60 years between healthy and asthmatic subjects.
Abstract Alternative 高齢者(61才以上)の健常人48名および気管支喘息患者69例を対象に,カンジダ特異的IgGおよびIgG(4)抗体を測定し,その増加の機序について若干の検討を加えた。なお,対照としては,30才以下の健常者および気管支喘息患者を選んだ。1.カンジダ特異的IgGおよびIgG(4)抗体価は,30才以下では,健常人に比べ気管支喘息症例で高い傾向が見られ,特異的IgG抗体では両者間に有意の差が見られた(p<0.05)。2.カンジダ特異的IgGおよびIgG(4)抗体は,健常人および気管支喘息症例いずれも加齢とともに増加する傾向が見られ,71才では,30才以下の症例に比べ有意に高い抗体価を示した。3.61才以上の高齢者では,特異的IgG,IgG(4)抗体いずれにおいても,健常人と気管支喘息患者との間に有意の差は見られなかった。
Keywords Candida albicans (カンジダ特異的IgG) Specific IgG IgG(4) Bronchial asthma (気管支喘息) Aging (加齢)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 58
End Page 62
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307284
JaLCDOI 10.18926/15321
Title Alternative IgE受容体を介する刺激に対する好塩基球の形態的変化の顕微鏡的観察. 抗原と抗IgE刺激の特徴とその相違点
FullText URL 063_050_057.pdf
Author Tanizaki, Yoshiro| Nakagawa, Saburo| Kimura, Ikuro|
Abstract Differences in morphological changes of basophils between antigen and anti-IgE stimulation were examined in atopic subjects in relation to histamine release. 1. Antigen- induced release of histamine was remarkably more rapid and larger at any incubation time than the release by anit-IgE, and a significant difference was found at 3 to 9 min. 2. Decrease in number of basophils induced by antigen was significantly higher for 12 to 15 min incubation time than that by anti-IgE. 3. Morphological changes of basophils representing increased motility such as an increased ratio of short to long axis diameter (L/S ratio) and an increased incidence of basophils with localized granules (LG) were more often observed in antigen stimulation compared with anti-IgE, and the L/S ratio of the cells was significantly more increased in antigen stimulation at 6 and 15 min. 4. There was no difference in morphological changes of basophils showimg swollen type (degranulation) such as an increased mean diameter (MD) of the cells between antigen and anti-IgE. These results suggest that antigen activates basophils and induces increased motility more strongly than anti-IgE, but the action on degranulation was not different between the two agents.
Abstract Alternative 抗原および抗IgE刺激時の好塩基球の形態変化の特徴について,ヒスタミン遊離との関連のもとに,顕微鏡下に経時的に観察した。1.抗原刺激時のヒスタミン遊離は,15分間のincubationのいずれの時期においても,抗IgE刺激に比べ有意に多く,incubation時間3分と9分では両者間に有意の差が見られた。2.抗原刺激時の好塩基球数の減少も抗IgE刺激に比べより高度であった。3.運動亢進により洋梨型を示す抗塩基球では,長径/短径比の増大が見られた。この長径/短径比の増大を示す好塩基球は,抗原刺激時に抗IgE刺激に比べより高頻度に見られ,特にincubation6分と15分では両者間に有意の差が見られた。4.膨化型を示す好塩基球ではその平均直径の増大が見られるが,この平均直径の増大については,抗原と抗lgE刺激との間に差は見られなかった。以上の結果より,抗原刺激では,好塩基球のactivate,運動亢進へ の過程が抗IgE刺激時と比べより高度であるが,膨化への過程には両者間に差が見られないことが示唆された。
Keywords Histamine release (ヒスタミン遊離) Morphological changes of basophils (好塩基球の形態的変化) Antigen (抗原) Anti-IgE (抗IgE) IgE receptors (IgE受容体)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 50
End Page 57
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307320
JaLCDOI 10.18926/15320
Title Alternative 気管支喘息における気道の反応性および炎症反応におよぼす加齢の影響について
FullText URL 064_089_096.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Sugimoto, Keisuke| Harada, Hideo| Kimura, Ikuro|
Abstract Ventilatory function, cellular composition in bronchoalveolar lavage (BAL) fluid and release of chemical mediators from leucocytes were examined in 25 older asthmatics (mean age 66.7 years) and 25 younger asthmatics (mean age 45.1 years) in relation to clinical asthma types. 1. Ventilatory function tests showed that the values of ventilatory parameters such as % MMF, % V(50) and % V(25) were lower in older subjects than in younger subjects, and a significant difference was found in the % V(50) value between the two age groups. Regarding clinical asthma types, the values of % MMF, % V(50), and V(25) were significantly lower in both younger and older subjects with type II. 2. In analysis of cellular composition in BAL fluid, the proportion of BAL lymphocytes was significantly lower in type II older subjects than in younger subjects with the same type. A significantly increased proportion of BAL neutrophils was observed in both younger and older subjects with type II. 3. The release of leukotriene C(4) (LTC(4)) from leucocytes was significantly lower in type II older subjects than in younger subjects with the same type, and LTC(4) release in patients with type II was also significantly lower than that in those with other asthma types in both younger and older subjects. The release of histamine and leukotriene B(4) (LTB(4)) from leucocytes was not significantly different between the two age groups. These results demonstrate that ventilatory function, cellular composition in BAL fluid, and the release of chemical mediators from leucocytes are affected by aging and clinical asthma types.
Abstract Alternative 25例の老年者気管支喘息と25例の若壮年者喘息症例を対象に,換気機能,気道内細胞成分の頻度,白血球からの化学伝達物質遊離などの気道反応と関連した要素について,喘息の臨床病型との関連のもとに検討を加えた。 1. % MMF, % V(50), % V(25)などの換気パラメーターは老年症例において全般的に低く, % V(50)では若壮年症例に比べ有意の低値を示した。臨床病型別では,II型喘息において,両年齢群とも他の病型に比べ% MMF, % V(50)及び% V(25)値は有意に低い傾向が見られた。 2. 気管支肺胞洗浄(BAL)液中のリンパ球頻度は,II型の老年症例において若壮年症例に比べ有意に低い値を示した。BAL液中好中球頻度は,いずれの年齢群においても,他の病型に比べ有意に高い値を示した。 3. 白血球からのLTC(4)遊離は,II型の老年症例において若壮年症例に比べ,また他の臨床病型に比べ有意に低い値を示した。ヒスタミンおよびLTB(4)遊離には両年歯群間に有意の差は見られなかった。これらの結果は,換気機能,気道内細胞成分の頻度,白血球からの化学伝達物質遊離などが,加齢や臨床病態により影響を受けることをある程度示しているものと考えられた。
Keywords Ventilatory function (換気機能) Cellular composition in BAL fluid (気道内細胞成分) chemical mediators (化学伝達物質) aging (加齢) clinical asthma type (臨床病型)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 89
End Page 96
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307744
JaLCDOI 10.18926/15319
Title Alternative Effects of vitamin D and exercise on bone mineral density (BMD) measuured by QCT
FullText URL 064_071_074.pdf
Author Hiramatsu, Junnichi| Kawaraya, Masashi| Yokota, Satoshi| Sugimoto, Keisuke| Mitsunobu, Fumihiro| Mifune, Takashi| Kajimoto, Kazuhiro| Kitani, Hikaru| Tanizaki, Yoshiro| Nakai, Mutsuro| Akiyama, Tsuneo|
Abstract 40才~84才(平均64.1才)の患者38例における骨塩量を,ある期間(1~15カ月,平均8.2カ月)をおいて2回,定量的QCT(quantitative computed tomography)法を用いて測定し,その経時的変化によって,骨粗鬆症に対する治療法の効果判定を試みた。その結果,(1)全体として骨塩量に有意の増加は認められなかった。(2)骨強化剤使用例についても骨塩量に有意の増加は認められなかった。(3)運動療法施行者においても骨塩量に有意の増加は認められなかった。以上のことから骨粗鬆症の治療においては,約1年弱の経過では著明な反応は得られにくいものと思われた。ただし,一部の運動療法施行者,骨強化剤使用者において,骨塩量の著明な上昇が認められており,さらに経時的な観察が必要と思われた。
Abstract Alternative Bone mineral density (BMD) was measured twice in 38 patients aged 40 to 84 years old for the last one year to evalute the effects of vitamin D and exercise on BMD. 1) In all patients, The BMD did not significantly increase. 2) In patients with vitamin D for osteoprosis, the BMD did not significantly increse compared to those without the drug. 3) In patients with exercise therapy, the BMD did not show any significant increase compared to those without exercise.
Keywords 骨粗鬆症 (Osteoprosis) 定量的QCT法 (QCT) 加齢 (Aging) 運動療法 (Exercise) ビタミンD (Vitamin D)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 71
End Page 74
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307358
JaLCDOI 10.18926/15318
Title Alternative 老令者の気管支喘息,各臨床病型における換気機能の特徴
FullText URL 063_044_049.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Takatori, Akimasa| Okuda, Hiroyuki| Kimura, Ikuro|
Abstract Ventilatory function was examined in 20 elderly patients with bronchial asthma in relation to clinical asthma types, and the results were compared with those of younger asthmatics. 1. Ventilatory parameters such as FEV(1.0%), % PEFR, % MMF, % V(50) and % V(25), which repressent obstructive ventilatory dysfunction, were in general lower in older asthmatics than in the youger cases. 2. The values of % V(50) and % V(25), representing ventilatory dysfunction in small airways, were significantly lower in the older subjects with type Ib and II compared to the younger cases with same types. 3. Markedly decreased values in ventilatory parameters, particularly in % MMF, % V(50) and % V(25) were observed in both older and younger subjects with type II. The results suggest that ventilatory function decreases with aging and the decrease is related to the pathophysiological changes in the airways.
Abstract Alternative 60才以上の老年気管支喘息20例(平均年令;66.7才)を対象に,その換気機能について,臨床病態別に59才以下の症例(平均年令;44.9才)との比較検討を行った。1.FFV(1.0%), % PEFR, % MMF, % V50, % V25などの閉塞性換気障害を表すパラメーターは,59才以下の症例に比べ老年症例で全般的に低い傾向が見られた。2.小ないし細気管支領域の換気榛能を反映すると考えられる% V(50)および% V(25)は,Ib型およびII型喘息を示す老年症例において,59才以下の症例に比べ,有意に低い値を示した。3.II型喘息症例では,59才以下および老年症例のいずれにおいても, % MMF, % V(50)および% V(25)は他の臨床病型にくらべ著明に低い値を示した。これらの結果は,気管支喘息における換気機能は,加令とともに低下傾向を示すこと,そしてその低下は臨床病態と関連していることを示しているものと考えられた。
Keywords Ventilatory function (換気機能) small airways (細気管支) clinical asthma types (臨床病型) elderly asthmatics (老年者気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 44
End Page 49
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307531
JaLCDOI 10.18926/15317
Title Alternative Diagonosis of pancreatic cyst using post-ERCP CT examination.
FullText URL 064_065_070.pdf
Author Ochi, Koji| Harada, Hideo| Matsumoto, Shuji| Seno, Tosinobu| Tanaka, Juntaro| Riaz Chowdhury| Mizushima, Takaaki| Sugimoto, Keisuke| Mitsunobu, Fumihiro| Tanizaki, Yoshiro| Nakai, Mutsuo| Akiyama, Tsuneo| Hasuoka, Hideaki|
Abstract ERCP直後にCTを撮影するERCP後CTはERCPの際に膵内に注入された造影剤をCTで検出するため,ERCPでは得られない情報が得られる利点がある。われわれはERCP後CTが診断や治療方針の決定に有用であった膵嚢胞の4例を経験した。膵嚢胞では主膵管との連絡,嚢胞の部位,性状診断にERCP後CTは有用な検査法であり,文献的考察を含めて報告した。
Abstract Alternative Post-ERCP CT (computed tomography (CT) examination performed immediately after endoscopic retrograde cholangiopancreatography) detects the contrast medium injected into the pancreatic duct and cystic lesions at the time of ERCP and, therefore, has the advantage of obtaining information which cannot be obtained by ERCP alone. We have experienced four cases of pancreatic cysts in which post-ERCP CT was useful for diagnosis and in deciding on treatment plans. The post-ERCP CT was proved to be a useful method for examining the site and characteristics of the cysts which communicated with the main pancreatic duct.
Keywords ERCP (Endoscopic retrograde cholangiopancreatography) CT (Computed tomography) 膵嚢胞 (pancreatic cyst)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 65
End Page 70
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307547
JaLCDOI 10.18926/15316
Title Alternative 老年者の気管支喘息. アレルギー反応と気道細胞反応
FullText URL 063_039_043.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Okazaki, Morihiro| Mifune, Takashi| Mitsunobu, Fumihiro| Tanimizu, Masakuni| Honke, Naoko| Kusaura, Yasuhiro| Ochi, Koji| Harada, Hideo| Kimura, Ikuro|
Abstract Clinical features of bronchial asthma in the elderly were analyzed by observlng IgE-mediated allerglc reactions evaluated by immediate skin reaction and specific IgE antibodies to allergens, ventilatory function and cellular composition in bronchoalveolar lavage (BAL) fluid. 1. The frequency of positive immediate skin reaction and positive RAST score to allergens was in general low in the elderly patients over age 70. 2. Ventilatory function was widely variegated, and fifteen cases (60%) of the 25 Subjects showed considerably high values of FEV(l.0%), % PEFR, % MMF, % V(50) and % V(25), and the mean value of FEV(1.0%) in these cases was 71.3%. 3. The decreased value of % V(25) was related to BAL neutrophilia in 2 cases, but any correlation was not found between BAL neutrophilia and decreased value of % V(25) in 9 csese of the eleven subjects who had the BAL examination. The results show that in asthma of elderly patients, IgE-mediated allergic reactions are weak, and that a decreased value of % V(25) can be observed without BAL neutrophilia.
Abstract Alternative 70才以上の老年者気管支喘息の特徴について,アレルゲンに対する即時型皮膚反応および特異的IgE抗体,換気機能,気管支肺胞洗浄液(BAL)中の細胞成分などにより検討した。1.アレルゲンに対する即時型皮膚反応および特異的IgE抗体の陽性率は,全般的にかなり低い傾向を示した。2.換気機能にはかなりのばらつきが見られたが,25例中15例(60%)では,,いずれの換気パラメー ターもかなり高い値を示し,これらの症例の平均FEV(1.0%)は71.3%であった。3.BALを施行した11例中,% V(25)値の低下とBAL中好中球増多との間に関連の見られた症例は2例のみで,他の9例では% Ⅴ(25)値の高度な低下にもかかわらず,BAL中の好中球増多は見られなかった。これらの結果より,老年者気管支喘息では,IgEにmediateされるアレルギー反応は全般的に弱いこと,またBAL液中好中球増多なしに% V(25)値の高度な低下が出現してくることが示された。
Keywords elderly subjects (老年者) lgE-mediated allergic reaction (IgE系反応) ventilatory function (換気機能) BAL neutrophilia (BAL好中球) bronchial asthma (気管支喘息)
Publication Title 岡大三朝分院研究報告
Published Date 1992-06
Volume volume63
Start Page 39
End Page 43
ISSN 0913-3771
language 英語
File Version publisher
NAID 120002307727