JaLCDOI 10.18926/15155
Title Alternative MASTシステムによる気管支喘息患者の特異的IgE抗体の検討
FullText URL 065_062_068.pdf
Author Mitsunobu, Fumihiro| Kitani, Hikaru| Mifune, Takashi| Kajimoto, Kazuhiro| Yokota, Satoshi| Takada, Ichiro| Tanizaki, Yoshiro|
Abstract The serum levels of specific IgE antibodies to food allergens and inhalant allergens were evaluated in ninety five patients with bronchial asthma using the MAST system, which can measure specific IgE antibodies against sixteen different allergens with a single sample. 1. Higher positivities of specific IgE antibodies were found in inhaled allergens than in food allergens. Specific IgE antibodies against several allergens were detected in individuals more frequently in inhaled allergens than in food allergens. 2. Positivities of specific IgE antibodies against food allergens did not correlate to patients' age and patients' age at onset. In inhaled allergens, positive results in MAST system were frequently observed in patients under age of 50 and under age at onset of 60. 3. In subjects with high serum IgE levels, high positivities of specific IgE antibodies against inhaled allergens and food allergen were found. 4. The MAST system is suggested to be clinically more useful than RAST.
Abstract Alternative 気管支喘息95例を対象に,MASTシステムにより吸入抗原,食餌抗原の陽性率を検討した。その結果,吸入抗原の方が食餌抗原よりも陽性者が高率にみられ,さらに複数個の抗原に陽性の傾向が見られた。また8名の食餌抗原陽性者の内7名が吸入抗原陽性であった。MAST陽性率と年令,発症年令には食餌抗原では明らかな相関は見られなかったが,吸入抗原では,50才以下の症例に陽性率がやや高い傾向が,発症年令が60才以下の症例の陽性率が高い傾向が見られた。食餌抗原では血清IgE値が300IU/ml以上の症例で陽性者がみられ,1001IU/ml以上の症例では66.7%と比較的高率であった。一方,吸入抗原に対する陽性率は,血清IgE値が500IU/ml以上の症例で高く70%以上の陽性率であった。以上の結果より1検体同時多項目(16項目)測定可能なMASTシステムは従来のRASTに比して臨床的に有用であると考えられた。
Keywords bronchial asthma (気管支喘息) specific IgE antibodies (特異的IgE抗体) MAST system (MASTシステム)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 62
End Page 68
ISSN 0918-7839
language 英語
File Version publisher
NAID 120002307337
JaLCDOI 10.18926/15156
Title Alternative Study on the relatjonship between the bone mineral density mesured by QCT and the osteoporosis therapy.
FullText URL 065_069_076.pdf
Author Kajimoto, Kazuhiro| Takata, Ichiro| Yokota, Satoshi| Mitsunobu, Fumihiro| Mifune, Takashi| Kitani, Hikaru| Tanizaki, Yoshiro| Kobayashi, Yasuaki| Nakagiri, Yoshiyasu| Nakai, Mutsuro| Akiyama, Tsuneo|
Abstract 当院通院あるいは入院中の女性患者54例を対象に骨塩量を経時的に3回測定し検討を行った。54例の骨塩量の平均は3回とも有意差はなく,年次骨塩変化量は-3.1±14.6mg/cm(3)/yearであった。平均骨塩量の年齢別比較では40才台,50才台,60才台の順に有意な減少がみられ,60才台と70才以上との間には差は認めなかった。また50才台及び70才以上の年代で1年当たりの骨塩量の減少が大きい傾向が窺われた。身長と骨塩量との間に有意の正の相関を認めたが,体重との間には有意の相関を認めなかった。血清中Ca,P及びALPと骨塩量との検討ではいずれも有意の相関を認めなかった。骨塩変化量減少群と増加群との比較では,平均骨塩量及び背景因子の間に差を認めなかった。女性,特にステロイド療法を必要とする患者については閉経の時期にあたる40~50才台より積極的に骨粗髭症対策を考える必要性があると考えられた。また運動療法については温泉プール療法自体を再検討するとともに,骨粗髭症に特異的な運動療法の確立が必要と思われた。
Abstract Alternative Bone mineral densities (BMD) were mesured 3 times in 54 females aged 40 to 84 years old to evaluate about relationship between BMD and osteoporosis therapy or patient background factors. BMD decreased 3.1±14.6mg/cm(3) per year, and BMD values were more decreased in subjects with the age of 50's and over 70's than in those with the age of 40's and 60's. In patients with bronchial asthma or rheumatoid arthritis, treated with corticosteroids (predonisolone : 3-7.5mg/day), BMD were sigfnificantly more decreased than in patients without corticosteroid therapy. There was a significant positive correlation between BMD and body height, but no correlation between BMD and body weight, serum Ca, P, or alkaline phosphatase. No differences in background factors were found between subjects with increased BMD and those with decreased BMD. These results indicate that female patients with corticosteroids need active treatments for the prophylaxis of osteoporosis at the age of 40's or 50's.
Keywords 骨粗鬆症 (Osteoporosis) 骨塩量 (Bone mineral density) 運動療法 (Exercise therapy) QCT (quantitative computed tomograpy)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 69
End Page 76
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307602
JaLCDOI 10.18926/15159
Title Alternative Effects of salbutamol and disodium cromoglycate on Specific Airway Resistance (sRaw) and Specific Conductance (sGaw) in Bronchial asthma and Rheunmatoid arthritis.
FullText URL 065_087_095.pdf
Author Yokota, Satoshi| Kitani, Hikaru| Mifune, Takashi| Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Takata, Itiro| Tanizaki, Yoshiro| Tada, Shinya| Harada, Mine|
Abstract サルブタモールまたはdisodium cromoglycate(クロモリン)吸入液を,気管支喘息(以下BA)6例,慢性関節リウマチ(以下RA)7例,正常対照5例に吸入させ,吸入前および吸入後約30分に,気道抵抗(sRaw)と気道コンダクタンス(sGaw)を,定容積型体プレチスモグラフ(Sensor Medics Corporation, Anaheim, California, made in U.S.A.)を用いて測定した。吸入前の値をsGawで比較すると,BAはRAや正常対照に比べ有意に閉塞の程度が強く,RAと正常対照の間では有意な差はなかった。サルブタモール吸入の場合,BAでは吸入後にsRawおよびsGawの有意な改善(P<0.01)がみられ,それらの改善率(%)は,RAや正常対照と比べて有意に高く(P<0.01),RAと正常対照の間では改善率の有意な差は認めなかった。クロモリン吸入の場合,いずれの群においても,sRawおよびsGawの吸入後の変化に有意差はみられなかったが,BAにおいて,sRawの改善率(%)はRAと正常対照に対して,またsGawの改善率(%)は正常対照に対して有意に高く(P<0.05),RAと正常対照の間では,sRaw,sGaw共に改善率(%)の明らかな差はみられなかった。
Abstract Alternative We examined effects of salbutamol sulfate and disodium cromoglycate (cromolyn) on specific airway resistance (sRaw) and specific conductance (sGaw) in 6 patients with bronchial asthma (BA), 7 patients with rheumatoid arthritis (RA), and 5 subjects of controls, using a constant volume, whole body plethysmograph (Sensor Medics Corporation, Anaheim, California, U.S.A.). The results before and 30 minutes after inhalation of agents were compared to evaluate their effects on sRaw and sGaw. Before inhalation, the sGaw of BA was significantly lower than that of RA or controls, and there was no difference between that of RA and normal controls. The sGaw and sRaw in BA were significantly improved (P<0.01) after inhalation of salbutamol and those improvement after inhalation were significantly higher (P<0.01) in BA than those in RA or controls, however there was no difference between those of RA and controls. Although there was no sigificant change of sGaw and sRaw in all groups between before and after inhalation of cromolyn, the improvement of sRaw after inhalation was significantly higher in BA than in RA or controls (P<0.05), and that of sGaw was significantly higher in BA than in controls (P<0.05).
Keywords 気道抵抗 (sRaw) 気道コンダクタンス (sGaw) 気管支喘息 (bronchial asthma) 慢性関節リウマチ (rheumatoid arthritis) 気管支拡張作用 (the effect of bronchodialation)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 87
End Page 95
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307239
JaLCDOI 10.18926/15160
Title Alternative A case report of mixed connective tissue disease.
FullText URL 065_096_100.pdf
Author Takata, Ichiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Matsumura, Tadashi| Yokota, Satoshi| Tanizaki, Yoshiro|
Abstract 症例は50歳女性で,1991年頃より両肘関節の疼痛とレイノー現象を自覚するようになり前医にて慢性関節リウマチ(Rheumatoid arthritis, 以下RAと略)との診断を受け加療受けるも症状の改善なく,当科を受診した。典型的な慢性関節リウマチの症状に乏しく,他の膠原病の存在を疑って検索したところ,抗RNP抗体陽性等の所見から,混合性結合組織病(mixed connective tissue disease, 以下MCTDと略)と診断した。MCTDは初診時に慢性関節リウマチと誤診される例が多く,慢性関節リウマチに非典型的な症状を伴う場合は,MCTDが鑑別診断として重要と考えられた。
Abstract Alternative A 50-year-old woman, diagnosed as rheumatoid arthritis (RA) in 1991, had been treated with Lobenzarit disodium and non steroidal anti-inflammatory drugs (NSAIDs) before administration at our hospital. Despite the treatment with these drugs, her symptoms did not improve. She was admitted to our hospital for her progressive bilateral elbow joint pain and Raynaud's phenomenon. Although abnormal values of laboratory examinations such as an increased ESR (64mm/1hr), increased level of serum IgG (2854mg/㎗) and a positive RA test were shown, the clinical features of classical RA were not clear. There, she was diagnosed as mixed connective tissue disease (MCTD), because of high level of anti-RNP antibody in serum, Raynaud's phenomenom, multiple arthritis and constrictive ventilatory disturbance. Her symptoms and the results of labolatory examinations were clearly improved by glucocorticoid therapy.
Keywords 混合性結合組織病 (MCTD) 慢性関節リウマチ (Rheumatoid arthritis) 抗RNP抗体 (Anti-RNP antibody)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 96
End Page 100
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307772
JaLCDOI 10.18926/15161
Title Alternative Clinical studies on polypoid lesions of the colon.
FullText URL 065_101_106.pdf
Author Takata, Ichiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Matsumura, Tadashi| Yokota, Satoshi| Tanizaki, Yoshiro| Ochi, Koji| Harada, Hideo| Akiyama, Tsuneo| Nakai, Mutsuo|
Abstract 1990年4月より1994年3月末までの間に岡山大学医学部附属病院三朝分院で経験した早期大腸癌を含む大腸ポリープ88例を対象に,病理組織診断,性別,年齢構成,存在部位,精査動機について検討を行い,以下の成績を得た。(1)ポリープの69.2%は腺腫,13.2%は腺癌(早期癌)であった。(2)男女とも加齢による大腸ポリープ及び大腸癌の頻度の増加がみられた。(3)50歳未満の若年者では右側結腸にポリープが発見されることは稀であったが50歳以上では6.5%に認められ,高齢者における積極的なtotal colonoscopyによる観葉が重要であることが再確認された。(4)精査動機では便潜血陽性が最多を占め,便潜血は大腸ポリープのスクリーニングにおいて有用であることが示された。またフォローアップ目的に大腸ファイバーを施行しポリープや早期癌を発見した例も多く,フォローアップの必要性が示唆された。
Abstract Alternative Polypoid lesions, taken by a colon fiberscope, were examined in 88 patients with polyp, who were admitted to Misasa Medical Branch, Okayama University Medical School for last 4 years. (1) Pathohistological examination of the polypoid lesions resulted in 69.2% of adenoma and 13.2% of adenocarcinoma (early cancer) ; (2) 35.5% of the polypoid lesions was detected in the sigmoid colon, 32.7% in the rectum, 16.8% in the transverse colon, 4.7% in the descending colon, 3.7% in the caecum, 1.9% in the ascending colon ; (3) The number of patients with polypoid lesion or colon cancer was increased with aging ; (4) Patients with the age under 50 years did not have polypoid lesion in the right hemicolon, while 6.5% of elder patients over age 50 has polypoid lesions in the right hemicolon ; (5) Occult blood in stool was the most popular motivation for receiving colonoscopic examinations ; (6) The second popular motivation for colonoscopy was for follow up after previous examinations. These results suggest that patients with age over 50 should be examined more carefully by total colonoscopy, and a hemoccult test in stool is an effective method for screening colonic polypoid lesions and after detection of polypoid lesions or polypectomy, reexamination by total colonoscopy is important at regular intervals.
Keywords 大腸ポリープ (Polyp of the colon) 大腸早期癌 (Early cancer of the colon) 便潜血 (Occult blood in stool)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 101
End Page 106
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307396
JaLCDOI 10.18926/15162
Title Alternative Clinical opplication of a newly developed radiographic system including a fluoroscope equiped with CCD and digital image processor
FullText URL 065_107_114.pdf
Author Akiyama, Tsuneo| Nakai, Mutsuo| Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Mifune, Takashi| Tanizaki, Yoshiro| Ochi, Koji| Riaz, Chowdhury| Satou, Masataka| Ukon, Hiroe|
Abstract 画像の入力部に世界初100万画素の多画素・高精細のCCD(電荷結合素子)を用いたテレビカメラを搭載したX線テレビ装置とDigital・Radiography装置を導入し,主に消化管検査を中心に多目的に任用した。このシステムは従来のscreen/filmシステムの持つ膨大な情報量を確保しながらCCDカメラのメリットを最大限に生かしており,DRシステムの特長であるリアルタイムのCRT撮影画像表示,透視像のFREEZE確認,動態解析,画像処理等を導入することにより診断能の向上がはかれた。更に,従来X線フィルム・撮像管に比較して被曝量の大幅な低減が期待できた。また,デジタルであるため撮影像をHDに保管すると共にMODにも記録・再生が可能である。今後,PACSやフイルムレス電子媒体保管への展開の可能性についても確認できた。
Abstract Alternative We have clinically applied a newly developed radiographic system which was introduced into our institute in April 1994. This system consists of a fluoroscope, CCD (charge-coupled device) which had a million matrix, and digital image processor. This system has following advantages comparison with a conventional radiographic system ; (1) doses of x-ray exposuce during examination is less, (2) a sharp fluoroscopic image can be obtained by real-time image processing, (3) radiographic images can be kept in the recording device such as hard disc (HD) and magnetic optical disc (MOD) since this has a digital radiographic system. By connecting this system with main online system, it is expected to be able to see the various diagnostic images simulataneously as well as laboratory data at different spots of the hospital which is now available in other hospltal.
Keywords 増感紙/フイルム (Screen/Film) 光電子増倍管 (Image・Intensifier (l・I)) デジタル・イメージング (Digital・Imaging) 電荷結合素子 (CCD) 光磁気ディスク (MOD) デジタルラジオグラフィ (Digital Radiography)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 107
End Page 114
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307511
JaLCDOI 10.18926/15163
Title Alternative Relationship between vertebral transformation (or fracture) and bone mineral density in lumbar vertebrae.
FullText URL 065_115_118.pdf
Author Nakai, Mutsuo| Akiyama, Tsuneo| Kajimoto, Kazuhiro| Mitsunobu, Fumihiro| Mifune, Takashi| Tanizaki, Yoshiro|
Abstract QCTによる腰椎海綿骨骨塩量と,圧迫骨折を含む,椎体(第11胸椎~第4腰椎)の変形率の関係を検討した。椎体変形率と腰椎QCT値の間の強い相関関係が確認され,椎体変形者全体の50%はQCT値70mg/cm(3)以下に分布し,90%は125mg/cm(3)以下に分布した。さらに,この70mg/cm(3)付近での椎体変形者の割合は50%であり,125mg/cm(3)付近での椎体変形の割合は10%であった。QCTによる腰椎海綿骨骨塩量測定値は,腰椎の変形および骨折の危険性を予 測する良好な指標であることが確認できた。
Abstract Alternative In 360 females, Bone mineral density (BMD) in lumbar vertebrae (L2-L4) was assessed by quantitative computed tomography (QCT), and the values obtained were compared with the frequency of vertebral transformation or fracture as assessed by lateral scan image (scanogram) by X-ray CT. A correlation was observed between the frequency of vertebral transformation (or fracture) and lumbar BMD values : BMD under 125mg/cm(3) was observed over 90% of women with vertebral transformation, and BMD under 70mg/cm(3) was found about 50% of them. These results suggest that decrease in BMD in lumbar vertebrae leads to vertebral transformation or fracture. Thus, measurement of BMD by QCT would be very useful in predicting vertebral transformation or fractures.
Keywords 骨粗鬆症 (osteoporosis) 骨塩量 (bone mineral density) QCT (quantitative computed tomography) 腰椎 (lumbar vertebrae)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 115
End Page 118
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307136
JaLCDOI 10.18926/15315
Title Alternative Effects of the spring water on the dissolution of aminophylline tablet and theophylline sustained-release preparations
FullText URL 064_060_064.pdf
Author Mimaki, Yuichi| Fujii, Yoshihiro| Furuno, Katsushi| Gomita, Yutaka| Araki, Yasunori| Tanizaki, Yoshiro|
Abstract 薬物のbioavailabilityに影響する因子の一つとして,製剤からの薬物の溶出速度が考えられる。今回,温泉水による薬物溶出への影響を知る目的で,気管支喘息治療薬のアミノフィリン製剤およびテオフィリン徐放製剤の溶出挙動について検討した。溶出試験は第12改正日本薬局方に従い,第1法(回転バスケット法)および第2法(パドル法)で行い,試験液を蒸留水および三朝温泉水として両者の溶出挙動を比較した。アミノフィリン製剤では,10分後まで 温泉水の方が有意に高い溶出率を示した。また,テオフィリン徐放製剤においても温泉水が8時間後まで蒸留水に比べて有意に高い溶出率を示した。以上の結果より,アミノフィリン製剤およびテオフィリン徐放製剤は温泉水により薬物の溶出が促進されることか示唆された。
Abstract Alternative The dissolutions of aminophylline tablet and theophylline sustained-release preparattions in Misasa spring water were examined using the rotating basket and paddle methods. The dissolution rate of aminophylline tablet with the spring water was higher than that with distilled water from starting to 10 min after the test. In theophylline sustained-release preparations, the spring water showed a facilitation on the dissolution rate in comparison to the distilled water for 8 hours after the test. These results indicate that the spring water enhanced the releasing rates of aminophylline tablet and theophylline sustained-release preparations.
Keywords 溶出試験 (Dissolutionte test) 温泉水 (Spring water) 気管支喘息治療薬 (Bronchial asthma therapeutic drug)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 60
End Page 64.
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307434
JaLCDOI 10.18926/15333
Title Alternative Spa therapy for bronchial asthma. Inhalation therapy with hot spnng water and iodine salt solution
FullText URL 064_111_115.pdf
Author Tanizaki, Yoshiro|
Abstract 慢性閉塞性呼吸器疾患,特に気管支喘息に対する温泉療法は.温泉療法そのものの効果以外に,温泉保養地の周囲環境が疾患に極めて良好であるという利点を有している。温泉水やヨードゾルによる吸入療法は,気管支喘息に対して有効であるが,治療効果をより良好なものにするためには,各喘息症例の気道内病態を十分把握しておく必要がある。板状貯留を呈する過分泌型喘息や細気管支閉塞型喘息に対しては,吸入療法の効果は一般的に低い。代表的なヨー ドゾル吸入療法の臨床効果は,気管支喘息20例中,著効4例(20%),有効11例(55%),やや有効4例(20%),無効1例であった。
Abstract Alternative In spa therapy for chronic obstructive pulmonary diseases, especially bronchial asthma, there are some advantages that the atmosphere around the health resort where spa therapy is administered is beneficial for the diseases as well as spa effects themselves. There are several kinds of inhalation methods and drugs used for inhalation. Although inhalation therapy uslng hot spring water and iodine salt solution is effective in bronchial asthma, analysis of pathophysiologlcal changes is the airways of asthma is necessary to increase effects of the therapy. Inhalation therapy is in general low in patients with hypersecretion or with bronchiolar obstruction. The clinical effects of inhalation therapy with iodine salt solution, which is one of the representative inhalation therapies, were marked in 4 (20%), moderate in 11 (55%), slight in 4 (20%), and of no value in one of the 20 asthma patients.
Keywords 温泉療法 (Spa therapy) 吸入療法 (Inhalation therapy) 温泉水 (Hot spring water) ヨードゾル (lodine salt solution) 気管支喘息 (Bronchial asthma)   
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 111
End Page 115
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307467
JaLCDOI 10.18926/15334
Title Alternative Spa therapy for bronchial asthma. Spa therapies effective for bronchial asthma and problems in future.
FullText URL 064_105_110.pdf
Author Tanizaki, Yoshiro|
Abstract 気管支喘息に対する温泉療法の作用,あるいは効果は,直接作用と間接作用,局所作用と全身作用,即時的効果と遠隔効果などに分類される。気管支喘息に対する温泉療法の直接作用としては,呼吸器症状およびそれに関連した検査成績の改善として,また間接作用としては副腎皮質機能の改善作用がみられる。一方,気管支喘息に有用な温泉療法としては,温泉プール水泳訓練,ヨードゾル吸入療法,および鉱泥湿布療法などが明らかにされており,現在これらの温泉療法を組み合わせた複合温泉療法が行われている。気管支喘息はその臨床病態より,Ia-1.Ia-2,Ib,およびII型に分類される。このうち,特にIb型やII型は薬物療法のみではコントロールし難い重症難治性喘息を多く含んでいる。温泉療法は,気管支喘息全般に有効であるばかりでなく,特に薬物療法のみではコントロール困難なIb型やII型の喘息に対しても有効である。しかし,今後新たに気管支喘息に有用な温泉療法を考案して行かねばならない。
Abstract Alternative Actions or effects of spa therapy on bronchial asthma are divided as follows : direct and indirect actions, actions for organs and whole body, and immediate and distant effects. Direct actions of spa therapy on asthma are observed in improvement of clinical symptoms and examination results related to clinical symptoms, and indirect actions of the therapy are found in improvement of suppressed function of adrenocortical glands. It has been clarified that swimming training in a hot spring pool, inhalation of iodine salt solution, and fango therepy are effective in patients with asthma. The combination of these three spa therapies is now administered for the treatment of asthma. Bronchial asthma is classified into four types accoding to clinical symptoms : Ia-1, Ia-2, Ib, and II. Type Ib and type II asthma include many of intractable asthma, and spa therapy is effective even in these intractable asthma that is difficult to control without glucocorticoids. It is necessary to develop newly devised spa therapy that is more effective in patients with asthma.
Keywords 温泉療法 (Spa therapy) 温泉プール水泳訓練 (Swimming training in a hot spring pool) ヨードゾル吸入 (Inhalation of iodine salt solution) 鉱泥湿布療法 (Fango therapy) 気管支喘息 (Bronchial asthma)
Publication Title 岡大三朝分院研究報告
Published Date 1993-06
Volume volume64
Start Page 105
End Page 110
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307660
JaLCDOI 10.18926/15518
Title Alternative Clinical significance of spa therapy in patients with steroid-dependent intractable asthma
FullText URL 065_119_127.pdf
Author Tanizaki, Yoshiro| Kitani, Hikaru| Mifune, Takashi| Mitsunobu, Fumihiro| Kajimoto, Kazuhiro| Yokota, Satoshi| Takata, Ichiro|
Abstract 気管支喘息のなかでも,副腎皮質ホルモン依存性の喘息は,もっとも重症難治性であり,薬物療法のみでコントロールすることは極めて困難である。著者らの現在までの成績では,このようなステロイド依存性重症難治性喘息に対して,温泉療法は有効であった。このことは,喘息の治療,とりわけ重症難治例の治療には温泉療法が必要不可欠であることを示している。今回は,その臨床的有用性および機序について,若干の考察を加えた。1.臨床病型では,Ib型やII型に重症難治症例が多く,温泉療法はこれらの病型に対して有効であった。2.年齢別検討では,発症年齢では30才以上,また現年齢では40才以上の症例に対して温泉療法は有効であった。3.温泉療法による換気機能の改善では,小ないし細気管支領域の閉塞の改善がより高度であった。4.温泉療法により,気道過敏性が低下することが観察された。5.温泉療法により,高度に低下した副腎皮質機能の改善が見られた。5.ヨードゾル吸入,鉱泥湿布療法,温泉プール水泳ないし歩行訓練などが,喘息の治療に適した温泉療法と判断された。
Abstract Alternative It is very difficult or sometimes impossible for phisicians to control steroid-dependent intractable asthma (SDIA) without glucocorticoids because of the severity of asthma and low responsiveness to usual antiasthma drugs. Our previous studies have shown that spa therapy improves the symptoms and signs of patients with SDIA, suggesting that spa therapy is highly required for the treatment of SDIA. In this article, the effects and action mechanisms of spa therapy on SDIA were summarized according to the results previously described. 1. Spa therapy is more effective in patients with hypersecretion (type Ib) and bronchiolar obstruction (type II) than in those with simple bronchoconstriction (type Ia). 2. Spa therapy is more effective in patients with the age at onset over 30, and in those with the age over 40 years. 3. Obstructive dysfunction in small airways is more improved compared to that in medium or large airways by spa therapy for asthma patients. 4. Bronchial hyperresponsiveness of asthma patients is suppressed by spa therapy. 5. Markedly suppressed function of adrenocortical glands is improved by spa therapy. 6. Complex spa therapy including swimming training in a hot spring pool, inhalation of iodine salt solution and fango therapy is effective and clinically useful for the treatment of asthma patients.
Keywords 重症難治性喘息 (intractable asthma) 換気機能 (ventilatory function) ヨードゾル吸入 (inhalation of iodine salt solution) 鉱泥湿布療法 (fango therapy) 温泉プール水泳訓練 (swimming training in a hot spring pool)
Publication Title 岡大三朝分院研究報告
Published Date 1994-09
Volume volume65
Start Page 119
End Page 127
ISSN 0918-7839
language 日本語
File Version publisher
NAID 120002307310
JaLCDOI 10.18926/21120
Title Alternative Clinical effects of swimming training in a hot spring pool on bronchial asthma
FullText URL 053_035_043.pdf
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Murashima, Makoto| Okada, Chiharu| Morinaga, Hiroshi| Kobashi, Hidetoshi| Tada, Shinya| Kimura, Ikuro|
Abstract Five severe bronchial asthma patients with glucocorticoid therapy have had free swimming training in the hot spring pool at Misasa Medical Branch. The clinical effect of the swimming training was evaluated after 3 months' training. 1. A slight increase in pulse rate and blood pressure was observed immediately after 30 minutes, swimming, although no significant increase in the two parameters was shown 30 min. after the training. 2. No significant fall in ventilatory function tests such as % FVC, FEV(1.0)%, V(50) and V(25) was demonstrated following the swimming training in a hot spring pool. The results suggest that the free swimming training in a hot spring pool does not induce bronchoconstriction. 3. Clinical efficacy of the swimming training on bronchial asthma was evaluated according to a treatment score, an attack score and an asthmatic score. These scores were decreased during the swimming training. The results obtained in this study showed that free swimming training in a hot spring pool is one of the most suitable therapies for severe bronchial asthma patients.
Publication Title 岡山大学温泉研究所報告
Published Date 1983-03-25
Volume volume53
Start Page 35
End Page 43
ISSN 0369-7142
language 日本語
File Version publisher
NAID 40000321171
Author Mitsunobu, Fumihiro| Hosaki, Yasuhiro| Ashida, Kozo| Hamada, Masanori| Yamaoka, Kiyonori| Tanizaki, Yoshiro|
Published Date 2004-12-01
Publication Title 岡大三朝医療センター研究報告
Volume volume75
Content Type Departmental Bulletin Paper