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ID 14751
Eprint ID
14751
FullText URL
Title Alternative
気管支喘息における長期間喫煙による病態的変化の若年者と高齢者の比較
Author
Mitsunobu, Fumihiro Kaken ID researchmap
Hosaki, Yasuhiro
Hamada, Masanori
Iwagaki, Naofumi
Fujii, Makoto
Tanizaki, Yoshiro
Abstract
Influence of long-term clgarette smoking on the paphophysiological changes of the disease was compared between younger and older patients with asthma. 1. The frequency of positive RAST score against inhalant allergens was significantly higher in ex-smokers than in never-smokers in older patients with astham, but not in younger subjects. 2. Ventilatory parameters such as % FVC and FEV 1.0% were not sig-nificantly different between ex-smokers and never-smokers either in younger or older patients, although a significant difference in these values was observed between younger and older subjects. 3. The % DLco was significantly lower in ex-smokers than in never-smokers both in yonger and older patients. 4. The parameters associated with hyperinflation asuch as % RV and % LAA of the lungs on HRCT were significantly higher in older patients than in younger subjects, and also significantly larger in ex-smokers than in never-smokers in older patients, but % RV was not different between ex-smokers and never-smokers in young subjects. 5. Bronchial hyperresponsiveness (BH) was significantly more increased in ex-smokers than in never-smokers in older patients, but not in younger subjects. There was a significant difference in BH be-tween younger and older patients. 6. LTB4 generation was significantly larger in ex-smokers than in never-smokers in older patients, and LTC4 generation was more in-creased in ex-smokers both in younger and older subjects. The results show that significant differences between ex-smokers and never-smokers were observed in % DLco, LTC4 generation and % LAA both in younger and older subjects, and in IgE an-tibodies production, % RV, BH and LTB4 generation only in older subjects. In contrast, the values of % FVC and FEV1.0% were not different between ex-smokers and never-smok-ers either in younger or older subjects. A significant difference between younger and older subjects was found in all other parameters except % DLco and LTC4 generation.
Keywords
cigarette smoking
% RV
% LAA of he lungs on HRCT
asthma
bronchial hyperresponsiveness
Published Date
2004-12-01
Publication Title
岡大三朝医療センター研究報告
Publication Title Alternative
Annual reports of Misasa Medical Center, Okayama University Medical School / Misasa Medical Center, Okayama University Medical School
Volume
volume75
Publisher
岡山大学医学部附属病院三朝医療センター
Publisher Alternative
Okayama University Medical School / Misasa Medical Center, Okayama University Medical School
Start Page
27
End Page
36
ISSN
1348-1258
NCID
AA11840279
Content Type
Departmental Bulletin Paper
language
英語
File Version
publisher
Refereed
False
Eprints Journal Name
mmc