Author Kitani, Hikaru| Mifune, Takashi| Kawauchi, Kazuhisa| Okazaki, Morihiro| Tanizaki, Yoshiro| Takahashi, Hisaho| Tada, Sinya| Takahashi, Kiyoshi| Kimura, Ikuro| Ishii, Akira|
Published Date 1990-10
Publication Title 岡山医学会雑誌
Volume volume102
Issue issue9-10
Content Type Journal Article
JaLCDOI 10.18926/21145
Title Alternative Pulmonary lesions in rheumatoid arthritis-survey of chest radiographs in patients admitted with rheumatoid arthritis during last ten years
FullText URL pitsr_051_001_015.pdf
Author Tanizaki, Yoshiro| Oda, Yasuhiro| Tanaka, Juntaro| Komagoe, Haruki| Takasugi, Kiyoshi| Morinaga, Hiroshi| Harada, Hiroshi| Kimura, Ikuro|
Abstract Chest radiographs were examined in 147 patients with rheumatoid arthritis who were admitted at the Department ofInternal Medicine, Okayama University, Misasa Medical Branch during last ten years. The results were as follows. 1) Diffuse micronodular shadow on chest radiographs was shown in eighty nine out of 147 cases (60.5%), although the incidence of micronodular shadow was 47.3% in the other types except type 1, demonstrating the shadow limitted in the part of lower lung fields. The incidence in type 2 and 3, revealing micronodular shadow distributed over lung fields, was 22.4%. 2) The incidence of micronodular shadow was more frequently found in females than in males. The results obtained here was different from those previously reported. 3) The cases with type 2 and 3 tended to demonstrate a long duration of the desease, acceleration of ESR, positive rheumatoid factors, and elevation of serum γ-globulin and IgG levels, compared with the other types and cases without radiological findings. 4) Pulmonary lesions induced by treatment of gold or penicillamine were not recognized, except one suspected case with gold therapy.
Publication Title 岡山大学温泉研究所報告
Published Date 1981-03-25
Volume volume51
Start Page 1
End Page 15
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002310957
Author Inoue, Taeko| Tanizaki, Yoshiro| Morinaga, Hiroshi|
Published Date 1982-03-25
Publication Title 岡山大学温泉研究所報告
Volume volume52
Content Type Data or Dataset
JaLCDOI 10.18926/21135
Title Alternative Studies on Rat Peritoneal Mast Cells 2. Effect of BSA on Ca(2+) Uptake of Mast Cells
FullText URL pitsr_052_029_032.pdf
Author Tanizaki, Yoshiro| Tanaka, Juntaro| Komagoe, Haruki| Morinaga, Hiroshi| Kishimoto, Takumi| Kimura, Ikuro| Townley Robert G.|
Abstract To examine the effect of BSA on the cell surface of mast cells, the (45)Ca influx was observed in mast cells from actively sensitized rats and also in cells passively sensitized with IgE-containing serum before or after purification by BSA. The mast cells from actively sensitized rats showed a marked increase in the (45)Ca uptake with stimulation by ovalbumin. The value of (45)Ca uptake by the cells was 1495 ± 104 cpm / 10(5) cells. The uptake of (45)Ca by mast cells passively sensitized before or after separation through BSA was also increased in response to ovalbumin, although the degree of 45Ca uptake by the latter showed marked variation. These results may suggest that BSA affects mast cell surface when the cells are sensitized after separation by BSA.
Publication Title 岡山大学温泉研究所報告
Published Date 1982-03-25
Volume volume52
Start Page 29
End Page 32
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002311041
JaLCDOI 10.18926/21134
Title Alternative Studies on Rat Peritoneal Mast Cells 1. Purification of Mast Cells From Rat Peritoneal Cavity
FullText URL pitsr_052_023_028.pdf
Author Tanizaki, Yoshiro| Tanaka, Juntaro| Komagoe, Haruki| Morinaga, Hiroshi| Kishimoto, Takumi| Kimura, Ikuro| Townley Robert G.|
Abstract To get a high recovery rate of mast cells from the rat peritoneal cavity, a new modified method was discussed using BSA density gradient. Three procedures, peritoneal lavage, washing of peritoneal cells and purification by BSA, were tested in this study, and the numbers of total cells and mast cells in each procedure were calculated. The recovery rate was the highest in BSA density gradient purification of the cells washed once with low speed centrifugation. The recovery rate was 73.7% and the number of mast cells taken from one rat was approximately 1.5×10(6). The purity of the cells with this procedure was 95.0% (range from 93.0 to 96.0%).
Publication Title 岡山大学温泉研究所報告
Published Date 1982-03-25
Volume volume52
Start Page 23
End Page 28
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002310940
JaLCDOI 10.18926/21133
Title Alternative Effect of Hot-Air Room Treatment on Peripheral Leucocytes in Guinea Pigs 2. Effect of 30 Min. Hot-Air Room Treatment for 22 Days on Leucocytes Count
FullText URL pitsr_052_013_022.pdf
Author Tanizaki, Yoshiro| Tanaka, Juntaro| Komagoe, Haruki| Oda, Yasuhiro| Nishimura, Yoshiko|
Abstract Numerical changes of peripheral leucocytes after a hot-air room treatment was observed in guinea pigs during the 22 days' successive treatment. The results were as follows. 1. Number of various leucocytes was generally decreased after the hot-air room treatment, followed by recovery to the value before treatments during 22 days' observations. 2. Numbers of total leucocytes, lymphocytes and eosinophils, which were decreased after the treatment, gradually recovered to the value before treatments during the daily hot-air room treatment. On the other hand, the recovery of neutrophils or monocytes to the count before treatment was more rapidly. The value in numerical changes of neutrophils became smaller as the hot-air room treatments were performed for many days. 3. Numerical changes of basophils and Kurloff cells did not show any definite tendency after the hot-air room treatment. 4. Numbers of total leucocytes, neutrophils, lymphocytes and eosinophils were increased and monocyte count was slightly decreased after the 22days hot-air room treatment. No change was observed in the counts of basophils and Kurloff cells.
Publication Title 岡山大学温泉研究所報告
Published Date 1982-03-25
Volume volume52
Start Page 13
End Page 22
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002310934
JaLCDOI 10.18926/21132
Title Alternative Effect of Hot-Air Room Treatment on Peripheral Leucocytes in Guinea Pigs 1. Effect of Single 30 Min. Hot-Air Room Treatment on Leucocytes Count
FullText URL pitsr_052_001_011.pdf
Author Oda, Yasuhiro| Nishimura, Keiko| Komagoe, Haruki| Tanizaki, Yoshiro|
Abstract Effect of hot-air room treatment on peripheral leucocytes was examined in guinea pigs by observing the numerical changes after the treatment. The results were as follows. 1. Number of totalleucocytes was decreased immediately after hot-air room treatment with a room temperature of 43℃, humidity of 75-87% and rapidly increased from 30 to 120 min after the treatment. Numerical changes of neutrophils showed a same tendency as that of total leucocytes. 2. Lymphocyte count was not changed or slightly decreased after the hot-air room treatment. 3. Number of basophils was decreased 30 min after the treatment and then increased, differing from that of eosinophils which showed a decreased tendency 120 min after the treatment. 4. Numbers of monocytes and Kurloff cells were slightly increased after the treatment.
Publication Title 岡山大学温泉研究所報告
Published Date 1982-03-25
Volume volume52
Start Page 1
End Page 11
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002311011
JaLCDOI 10.18926/21121
Title Alternative Clinical problems of long-term steroid regimen for bronchial asthma, with reference to steroid-dependent cases
FullText URL pitsr_053_045_049.pdf
Author Komagoe, Haruki| Sudo, Michiyasu| Okada, Chiharu| Tanizaki, Yoshiro| Morinaga, Hiroshi| Kitani, Hikaru| Goda, Yoshinori| Tada, Shinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract Adverse side effects of steroid therapy were investigated in 32 asthmatic patients. Thirty-two patients were classified into three groups according to steroid therapy for the past five years; group 1 has been treated with continuous steroid therapy, group 2 with occasional steroid therapy and group 3 without steroid therapy. The results were as follows. 1. Group 1 showed a low level of serum cortisol at 8-9 a. m. The serum concentration of cortisol in patients with daily steroid regimen was lower as compared to that in patients with alternateday steroid therapy. 2. The daily profile of serum cortisol was low in the steroid dependent asthmatic patients, and little increase of serum cortisol level after the administration of prednisolone was shown in group 1. 3. Serum IgG and IgM levels were significantly low in steroid dependent asthmatic patients. 4. The level of serum potassium was low in group 1.
Publication Title 岡山大学温泉研究所報告
Published Date 1983-03-25
Volume volume53
Start Page 45
End Page 49
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002311040
JaLCDOI 10.18926/21120
Title Alternative Clinical effects of swimming training in a hot spring pool on bronchial asthma
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Murashima, Makoto| Okada, Chiharu| Morinaga, Hiroshi| Kobashi, Hidetoshi| Tada, Shinya| Kimura, Ikuro|
Abstract Five severe bronchial asthma patients with glucocorticoid therapy have had free swimming training in the hot spring pool at Misasa Medical Branch. The clinical effect of the swimming training was evaluated after 3 months' training. 1. A slight increase in pulse rate and blood pressure was observed immediately after 30 minutes, swimming, although no significant increase in the two parameters was shown 30 min. after the training. 2. No significant fall in ventilatory function tests such as % FVC, FEV(1.0)%, V(50) and V(25) was demonstrated following the swimming training in a hot spring pool. The results suggest that the free swimming training in a hot spring pool does not induce bronchoconstriction. 3. Clinical efficacy of the swimming training on bronchial asthma was evaluated according to a treatment score, an attack score and an asthmatic score. These scores were decreased during the swimming training. The results obtained in this study showed that free swimming training in a hot spring pool is one of the most suitable therapies for severe bronchial asthma patients.
Publication Title 岡山大学温泉研究所報告
Published Date 1983-03-25
Volume volume53
Start Page 35
End Page 43
ISSN 0369-7142
language 日本語
File Version publisher
NAID 40000321171
JaLCDOI 10.18926/21119
Title Alternative 好塩基球からのヒスタミン遊離に関する研究. 2. ハウスダスト抗原および抗ヒトIgEによるヒスタミン遊離
FullText URL pitsr_053_029_033.pdf
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Mifune, Masaaki| Morinaga, Hiroshi| Kitani, Hikaru| Goda, Yoshinori| Tada, Shinya| Kimura, Ikuro|
Abstract IgE-mediated release of histamine from whole blood was examined in two healthy and four asthmatic subjects by dose-dependent fashion. The significantly increased amount of histamine was released from basophils of both healthy and asthmatic subjects by a limited concentration of anti-IgE. Antigen (house dust) caused histamine release only from basophils of asthmatics who are sensitive to house dust. Basophils from one patients with asthma released no significant amount of histamine by anti-IgE.
Abstract Alternative 好塩基球からのIgE-mediated histamine releaseの機序を,健康人(2名)および気管支喘息(4例)それぞれの代表例で比較検討した. 抗ヒトIgEの添加濃度別検討では,健康人および外因性喘息例いずれも有意のヒスタミン遊離の増加をしめしたが,Max. % histamine releaseをひきおこす抗ヒトIgEの濃度は比較的限られた範囲内にある傾向がみられた. 一方内因性喘息例では,いずれの抗ヒトIgE濃度でも有意のヒスタミン遊離はみられなかった. ハウスダスト抗原の添加濃度別検討では,ハウスダストが抗原である気管支喘息症例においてdose-dependentなヒスタミン遊離が観察されたが,使用された抗原濃度の範囲ではMax. % releaseをひきおこす至適濃度は明らかでなかった.
Publication Title 岡山大学温泉研究所報告
Published Date 1983-03-25
Volume volume53
Start Page 29
End Page 33
ISSN 0369-7142
language 英語
File Version publisher
NAID 120002310980
JaLCDOI 10.18926/21118
Title Alternative 好塩基球からのヒスタミン遊離に関する研究. 1 自動分析装置による全血からのヒスタミン遊離の測定
FullText URL pitsr_053_023_028.pdf
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Mifune, Masaaki| Morinaga, Hiroshi| Ohtani, Jun| Kitani, Hikaru| Goda, Yoshinori| Tada, Shinya| Kimura, Ikuro|
Abstract Histamine released from whole blood was determined by an automated fiuorometric histamine analysis system. The increased release of histamine from basophils by anti-IgE was observed in ten healthy subjects and 12 extrinsic asthma patients, while the release in 11 intrinsic asthma patients was significantly less as compared to that in healthy and extrinsic asthma subjects. House dust extract caused a significant increase in the histamine release from basophils of the extrinsic asthma patients who are sensitive to house dust. It was concluded from this study that histamine released from basophils could be easily determined by an automated analysis system and that the method is useful for the diagnosis and study of allergy.
Abstract Alternative ヒスタミン自動分析装置により,健康人10名,気管支喘息23例の全血からのヒスタミン遊離を測定した. 抗ヒトIgEを添加した際のヒスタミン遊離は,健康人および外因性気管支喘息症例では有意の増加傾向を示したが,一方内因性喘息症例では遊離増加はほとんどみられなかった. ハウスダスト抗原添加では,ハウスダストが抗原である気管支喘息症例においてのみ全血からの有意のヒスタミン遊離の増加が観察された. 以上の結果より,ヒスタミン自動分析装置による全血からの遊離ヒスタミンの測定は,気管支喘息の病態解明の1手段として極めて有用であると考えられる.
Publication Title 岡山大学温泉研究所報告
Published Date 1983-03-25
Volume volume53
Start Page 23
End Page 28
ISSN 0369-7142
language 英語
File Version publisher
NAID 120002310945
JaLCDOI 10.18926/21106
Title Alternative 好塩基球からのヒスタミン遊離に関する研究. 3. 抗ヒトIgE に対する好塩基球の反応性と末梢血好酸球増多
FullText URL pitsr_054_035_038.pdf
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Mifune, Masaaki| Morinaga, Hiroshi| Nakagawa, Saburo| Kitani, Hikaru| Kimura, Ikuro|
Abstract Histamine release from basophils induced by anti-IgE was examined in 14 asthmatic subjects with blood eosinophilia. The subjects were divided into two groups; group I (with blood eosinophilia, positive skin test and positive RAST to house dust) and group II (with blood eosinophilia, negative skin test to various allergens and negative RAST to house dust). 1. Serum IgE levels in group I were much higher than those in group II. 2. Maximum percent histamine release induced by anti-IgE was much higher in group I than in group II. 3. Dose-response curve of anti-IgE-induced histamine release in group I showed consistent increase as anti-IgE concentrations increased. while, dose-response curve in group II was very low. These findings suggested that blood eosinophilia in group I might be elicited relating to IgE-mediated reaction. However, mechanism causing eosinophilia in group II was not clear in the present study.
Abstract Alternative 末梢血好酸球増多を示す気管支喘息14症例について,抗ヒトIgE による好塩基球からのヒスタミン遊離を検討した. ハウスダストに対する皮内反応およびRASTが陽性を示す症例群(groupI)では,血清IgE値が高く,また抗ヒトIgEによるMax. % ヒスタミン遊離も高く(50.7士5.0%),そのdoseresponse curveは抗ヒトIgE添加濃度が高くなるにつれて上昇する傾向を示した.一方種々のアレルゲンエキスに対する皮内反応が陰性で,かつRAST も陰性を示す症例群(group II)では,血清IgE値が低く,また抗ヒトIgEによるMax. % ヒスタミン遊離も低く(10.5士1.7%),そのdose-response curveは全般的に低く,抗ヒトIgE添加濃度が高いところではむしろ抑制される傾向を示した.
Publication Title 岡山大学温泉研究所報告
Published Date 1984-03-25
Volume volume54
Start Page 35
End Page 38
ISSN 0369-7142
language 英語
File Version publisher
NAID 120002310989
JaLCDOI 10.18926/21103
Title Alternative Effects of swimming training in the hot spring pool on ventilatory function in bronchial asthma
FullText URL pitsr_054_013_018.pdf
Author Sudo, Michiyasu| Komagoe, Haruki| Okada, Chiharu| Nakago, Jitsuo| Tanizaki, Yoshiro| Morinaga, Hiroshi|
Abstract Effect of free swimming training in the hot spring pool (30℃) on ventilatory function were observed in nine patients with intractable asthma by measuring FVC, FEV(1.0), PEFR, MMF, V(50), V(25). 1. Swimming in the hot spring pool for three months allowed the reduction of glucocorticoid used for their asthma attack. 2. Although FVC was not affected by swimming training, EEV(1.0), PEFR, MMF, V(50), V(25) which represent obstructive ventilatory function were gradually improved by swimming training. The results show that free swimming training in the hot springpool is clinically available in intractable asthma.
Publication Title 岡山大学温泉研究所報告
Published Date 1984-03-25
Volume volume54
Start Page 13
End Page 18
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002310964
Author Inoue, Taeko| Tanizaki, Yoshiro| Morinaga, Hiroshi|
Published Date 1984-11-30
Publication Title 岡山大学温泉研究所報告
Volume volume55
Content Type Data or Dataset
JaLCDOI 10.18926/21095
Title Alternative Spa therapy for patients with chronic obstructive lung disease
FullText URL pitsr_055_007_010.pdf
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Morinaga, Hiroshi| Kitani, Hikaru| Nakagawa, Saburo| Kimura, Ikuro|
Abstract Histamine releasse from basophils induced by house dust and C. albicans was examined in 30 patients with bronchial asthma. House dust and C. albicans caused a significant amount of histamine release in subjects with a RAST score to corresponding allergen. A close correlation was found between house dust- and anti-IgE-induced histamine release. However, histamine release induced by C. albicans was considerably different from the release induced by anti-IgE.
Abstract Alternative ハウスダストあるいはカンジダが特異抗原である気管支喘息30例を対象に,それぞれの抗原刺激時の好塩基球からのヒスタミン遊離を,抗ヒトIgEによる遊離と比較検討した. 1. ハウスダストが原因抗原である症例の好塩基球からのヒスタミン遊離は,抗原刺激時41.8%,抗ヒトIgE刺激時40.8%であった. 2. カンジダが原因抗原である症例の好塩基球からのヒスタミン遊離は,抗原刺激時27.1%,抗ヒトIgE刺激時32.2%であった. 3. ハウスダストと抗ヒトIgEによる好塩基球からのヒスタミン遊離は,ほぼ同様の値を示した. 一方カンジダと抗ヒトIgEによるヒスタミン遊離の間には有意の 相関関係はみられなかった.
Publication Title 岡山大学温泉研究所報告
Published Date 1984-11-30
Volume volume55
Start Page 7
End Page 10
ISSN 0369-7142
language 英語
File Version publisher
NAID 120002310939
JaLCDOI 10.18926/21094
Title Alternative Spa therapy for patients with chronic obstructive lung disease
FullText URL pitsr_055_001_006.pdf
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Nakago, Jitsuo| Morinaga, Hiroshi| Ohtani, Jun| Kimura, Ikuro|
Abstract Thirty-six patients with chronic obstructive lung disease (34 cases with bronchial asthma, one case with chronic bronchiolitis and one case with pulmonary emphysema) have received spa therapy. Clinical effects of sa therapy on patients with bronchial asthma depended on patient age and asthma types classified by allergic reactions and clinical symptoms. Spa therapy was effective in the cases with ages more than 31 years and the cases with non-atopic type of bronchial asthma. Regarding asthma type classified by clinical symptoms, spa therapy was more effective in the cases with bronchiolar obstructive type and the cases with bronchospasm + hypersecretion type than in the cases with bronchospasm type of bronchial asthma.
Publication Title 岡山大学温泉研究所報告
Published Date 1984-11-30
Volume volume55
Start Page 1
End Page 6
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002311032
JaLCDOI 10.18926/21084
Title Alternative Spa therapy for patients with chronic obstructive lung disease
FullText URL pitsr_056_023_026.pdf
Author Sudo, Michiyasu| Komagoe, Haruki| Tanizaki, Yoshiro| Morinaga, Hiroshi|
Abstract During last three years, 41 patients with chronic obstructive lung disease (39 cases with bronchial asthma and 2 cases with chronic bronchiolitis) received spa therapy at Department of Medicine, Okayama University Medical School, Misasa Medical Branch. 1. Twenty three (56%) out of 41 cases came from Okayama prefecture and 10 cases (24.4%) from Tottori prefecture for spa therapy. In twenty five (61.0%) out of 41 cases, their ages were over 50 years. 2. Thirty nine patients with bronchial asthma were divided into three asthma types classified by clinical symptoms : Ia ; 16 cases (41.0%), Ib; 13 cases (33.3%) and II ; 10 cases (25.7%). Pulmonary function tests for these patients showed that small airways obstruction was most remarkable in type II asthma. 3. The mean serum IgE level of all asthmatic patients (39 cases) was 653.9U/ml. In skin test by allergens, positive immediate skin reaction was shown in 18 cases (46.2%) by Candida and 12 cases (30.8%) by house dust. Specific IgE anti-bodies were found in 9 cases (23.1%) for house dust and 3 cases (7.7%) for Candida.
Publication Title 岡山大学温泉研究所報告
Published Date 1985-03-30
Volume volume56
Start Page 23
End Page 26
ISSN 0369-7142
language 日本語
File Version publisher
NAID 120002311025
JaLCDOI 10.18926/21083
Title Alternative 好塩基球からのヒスタミン遊離に関する研究. 5.臨床的評価
FullText URL pitsr_056_017_021.pdf
Author Tanizaki, Yoshiro| Komagoe, Haruki| Sudo, Michiyasu| Morinaga, Hiroshi|
Abstract 過去3年間にわたり,気管支喘息患者末梢血好塩基球からのヒスタミン遊離について,ヒスタミン自動分析装置を用いて全血法により検討を加えてきた. 1. 抗ヒトIgE によるヒスタミン遊離は,症例間で著しい差がみられた. この際血清IgE値が高値を示す症例では全般的に高度なヒスタシソ遊離がみられたが,血清IgE値が正常かまたはむしろ低値を示す症例のヒスタミン遊離は,かなり高度なものから全くみられないものまでさまざまであった. 2.ハウスダストやカンジダなどの抗原物質によるヒスタミン遊離は,特異的IgE抗体依存性であり,抗体価が上昇するにつれヒスタミン遊離は高度となる傾向がみられた. しかし,ハウスダストとカンジダによるヒスタミン遊離には若干の差がみられた. すなわち,ハウスダストと抗ヒトIgE によるヒスタミン遊離の間には密接な関連がみられたが,カンジダと抗ヒトIgEの間には全く関連がみられなかった. またカンジダによるヒスタミン遊離においては,IgE系反応以外の反応が関与する可能性が一部示唆された.
Publication Title 岡山大学温泉研究所報告
Published Date 1985-03-30
Volume volume56
Start Page 17
End Page 21
ISSN 0369-7142
language 英語
File Version publisher
NAID 120002310985
Author Matsubara, Fumie| Endo, Hiroi| Sudo, Michiyasu| Tanizaki, Yoshiro|
Published Date 1989-07
Publication Title 環境病態研報告
Volume volume60
Content Type Data or Dataset
JaLCDOI 10.18926/19808
Title Alternative Clinical studies on serum cortisol levels in patients with intractable asthma
FullText URL 060_061_066.pdf
Author Araki, Hiroyuki| Kitani, Hikaru| Sudo, Michiyasu| Tanizaki, Yoshiro| Tada, Sinya| Takahashi, Kiyoshi| Kimura, Ikuro|
Abstract 重症難治性喘息におけるステロイド剤の副腎皮質機能,免疫能に及ぼす影響を調べるため,喘息患者65例を過去3年間のステロイド剤使用状況により,Ⅰ群:依存性症例,Ⅱ群:時に使用する症例,Ⅲ群:非使用例の3群に分け,血清コルチゾール値,末梢血リンパ球数及び血清免疫グロブリンについて検討した。結果は,血清コルチゾール値:Ⅰ群4.0μg/dℓ,Ⅲ群11.6μg/dℓ,末梢血リンパ球数:Ⅰ群1,659/mm(3)Ⅲ群2,150/mm(3),I gG:Ⅰ群1,062mg/dℓ,Ⅲ群1.501mg/dℓ,IgA:Ⅰ群218mg/dℓ,Ⅲ群279mg/dℓ,IgM:Ⅰ群148mg/dℓ,Ⅲ群227mg/dℓとⅠ群はⅢ群に比べ有意に低い平均値を示しステロイド剤の副腎皮質機能,免疫能への抑制作用が窺われた。また末梢血リンパ球数の減少は,高齢者のステロイド依存性例に顕著であった。
Abstract Alternative In order to investigate adverse effects of steroid therapy on adrenocortical function and immune function, serum cortisol levels, peripheral lymphocytes' counts and serum immuno-globulin levels were examined in 65 asthmatic patients. The asthmatic patients were classified into 3 groups according to steroid therapy for the past 3 years ; group Ⅰ has been treated with continuous steroid therapy, group Ⅱ with occasional steroid therapy and group Ⅲ without steroid therapy. The results were as follows. 1. The mean of serum cortisol levels was lower significantly in group Ⅰ as compared with that in group Ⅲ, (groupⅠ:4.0μg/dℓ, groupⅢ:11.6μg/dℓ). 2. The average count of peripheral lymphocytes was more decreased in group Ⅰ than in group Ⅲ. The difference between the two groups was significantly, (group Ⅰ:1659/mm(3), group Ⅲ:2150/mm(3)). 3. The average levels of serum immunoglobinlins such as IgG, IgA and IgM was  significantly lower in group Ⅰ compared with that in group Ⅲ, (group Ⅰ :IgG 1062mg/dℓ, IgA 218mg/dℓ, IgM 148mg/dℓ, group Ⅲ: IgG 1501mg/dℓ, IgA 279mg/de, IgM 227mg/dℓ). The results suggested that long-tetm steroid therapy remarkably suppressed adrenocortical function and immune function in patients with asthma.
Keywords 重症難治性喘息 (Intractable asthma) 血清コルチゾール (Serum cortisol) 末梢血リンパ球 (Peripheral lymphocytes) 血清免疫グロブリン (Serum immunoglobuiin)
Publication Title 環境病態研報告
Published Date 1989-07
Volume volume60
Start Page 61
End Page 66
ISSN 09133771
language 日本語
File Version publisher
NAID 120002309108